scholarly journals Catheter with dielectric optical filter deposited upon the fiber optic end for Ramanin vivobiospectroscopy applications

2008 ◽  
Vol 22 (6) ◽  
pp. 459-466 ◽  
Author(s):  
Carlos José de Lima ◽  
Marcos Tadeu T. Pacheco ◽  
Antonio Balbin Villaverde ◽  
Renato Amaro Zângaro ◽  
Leonardo Marmo Moreira ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Raman Scattering ◽  
Biomedical Applications ◽  
Biochemical Analysis ◽  
Fiber Optic ◽  
Signal To Noise Ratio ◽  
Optical Filter ◽  
Biological Molecules ◽  
Modes Of Vibration

Raman spectroscopy (RS) is a powerful tool that allows obtaining significant biochemical information from biological tissue. The fiber optic catheter permits applicationsin vivothat present wide clinical employment. This biochemical analysis is developed through a guide light that furnishes to Raman spectroscopy system the data obtained from tissue. These Raman signals represent the modes of vibration of molecular groups that are present in the biological molecules. Raman measurements undergo the optical influence of the material that constitutes the catheter, mainly Raman scattering of the silica that composes the fiber optic, decreasing signal to noise ratio (SNR) of the resultant spectra. In this work, a dielectric optical filter called “bandpass” was deposited upon the surface of the tip of the central fiber optic (distal probe). Indeed, other six fibers without any optical filter are disposed around this central optical fiber with “bandpass”. This prototype of catheter presented significant decrease of the silica Raman scattering when compared with unfiltered catheters. The biomedical applications of this new catheter are auspicious, involving biochemical analysis and diagnosisin vivo, since the SNR improvement obtained propitiates a much more informative Raman spectrum.

scholarly journals Real-time In vivo Diagnosis of Nasopharyngeal Carcinoma Using Rapid Fiber-Optic Raman Spectroscopy

Theranostics ◽  
2017 ◽  
Vol 7 (14) ◽  
pp. 3517-3526 ◽  
Author(s):  
Kan Lin ◽  
Wei Zheng ◽  
Chwee Ming Lim ◽  
Zhiwei Huang
Keyword(s):  
Raman Spectroscopy ◽  
Nasopharyngeal Carcinoma ◽  
Real Time ◽  
Fiber Optic ◽  
In Vivo Diagnosis

scholarly journals Real-time in vivo diagnosis of laryngeal carcinoma with rapid fiber-optic Raman spectroscopy

2016 ◽  
Vol 7 (9) ◽  
pp. 3705 ◽  
Author(s):  
Kan Lin ◽  
Wei Zheng ◽  
Chwee Ming Lim ◽  
Zhiwei Huang
Keyword(s):  
Raman Spectroscopy ◽  
Real Time ◽  
Laryngeal Carcinoma ◽  
Fiber Optic ◽  
In Vivo Diagnosis

Micromachined fiber optic pressure sensor for in-vivo biomedical applications

1993 ◽  
Author(s):  
Man-shih A. Chan ◽  
Scott D. Collins ◽  
Rosemary L. Smith
Keyword(s):  
Pressure Sensor ◽  
Biomedical Applications ◽  
Fiber Optic

Defocused Spatially Offset Raman Spectroscopy in Media of Different Optical Properties for Biomedical Applications Using a Commercial Spatially Offset Raman Spectroscopy Device

2019 ◽  
Vol 74 (2) ◽  
pp. 223-232 ◽  
Author(s):  
Martha Z. Vardaki ◽  
Dana V. Devine ◽  
Katherine Serrano ◽  
Nikolaos Simantiris ◽  
Michael W. Blades ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Optical Properties ◽  
Biomedical Applications ◽  
Signal To Noise Ratio ◽  
Ordinary Least Squares ◽  
Jurkat Cells ◽  
Chemical Information ◽  
Layer System ◽  
Transparent Barrier ◽  
Thin Plastic

In this study, we show how defocused spatially offset Raman spectroscopy (SORS) can be employed to recover chemical information from media of biomedical significance within sealed plastic transfusion and culture bags using a commercial SORS instrument. We demonstrate a simple approach to recover subsurface spectral information through a transparent barrier by optimizing the spatial offset of the defocused beam. The efficiency of the measurements is assessed in terms of the SORS ratio and signal-to-noise ratio (S/N) through a simple manual approach and an ordinary least squares model. By comparing the results for three different biological samples (red blood cell concentrate, pooled red cell supernatant and a suspension of Jurkat cells), we show that there is an optimum value of the offset parameter which yields the maximum S/N depending on the barrier material and optical properties of the ensemble contents. The approach was developed in the context of biomedical applications but is generally applicable to any three-layer system consisting of turbid content between transparent thin plastic barriers (i.e., front and back bag surfaces), particularly where the analyte of interest is dilute or not a strong scatterer.

scholarly journals Studying the Degree of Tooth Enamel Mineralization through Raman Spectroscopy in Various Spectral Ranges

Biophysica ◽  
2021 ◽  
Vol 1 (3) ◽  
pp. 269-278
Author(s):  
Diana V. Prikule ◽  
Vladimir I. Kukushkin ◽  
Aleksandr V. Mitronin ◽  
Vladislav F. Prikuls
Keyword(s):  
Raman Spectroscopy ◽  
Raman Scattering ◽  
Quantitative Methods ◽  
Tooth Enamel ◽  
Incisal Edge ◽  
Enamel Mineralization ◽  
Spectral Ranges ◽  
Good Agreement

In vitro and in vivo methods of Raman spectroscopy have been developed to assess the degree of mineralization of the enamel of different functional groups. This article presents comparative studies that were carried out using scanning Raman microspectroscopy with various sources of laser excitation with wavelengths of 532, 785, and 1064 nm. It is shown that the intensity of Raman scattering of enamel can be a measure of its thickness. The obtained dependence of the Raman scattering intensity on the distance from the incisal edge is in good agreement with the literature data, where two independent methods (computer tomography and electron microscopy) are used to determine the enamel thickness values. The proposed methods can be considered as potential quantitative methods for express diagnostics of the state of tooth enamel in vivo.

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