Micromachined fiber optic pressure sensor for in-vivo biomedical applications

1993 ◽  
Author(s):  
Man-shih A. Chan ◽  
Scott D. Collins ◽  
Rosemary L. Smith
Keyword(s):  
Pressure Sensor ◽  
Biomedical Applications ◽  
Fiber Optic

A miniature fiber optic blood pressure sensor and its application in in vivo blood pressure measurements of a swine model

2013 ◽  
Vol 181 ◽  
pp. 172-178 ◽  
Author(s):  
Nan Wu ◽  
Ye Tian ◽  
Xiaotian Zou ◽  
Yao Zhai ◽  
Kurt Barringhaus ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pressure Sensor ◽  
Fiber Optic ◽  
Swine Model ◽  
Pressure Measurements

Micromachining Process for Fiber Optic Pressure Sensor’s Tip

2011 ◽  
Vol 52-54 ◽  
pp. 2060-2064
Author(s):  
Muzalifah Mohd Said ◽  
Muhammad Noorazlan Shah Zainudin ◽  
A.F.M. Napiah Zul ◽  
M. Noh Zarina ◽  
M. Abd Himid Afifah ◽  
...  
Keyword(s):  
Pressure Sensor ◽  
Fiber Optic ◽  
High Yield ◽  
Human Artery ◽  
Specific Level ◽  
Sensor Fabrication ◽  
Bulk Surface ◽  
Mems Technology ◽  
Base Measurement

Fiber optic interferometry pressure sensor is an excellent diaphragm-base measurement system. It is in-vivo medical device to measure local blood pressure by using endoscopic procedures via the blood vessels and the heart. The sensor must smaller than the size of human artery. This paper has concentrated on the MEMS technology in order to build the sensor tip using micromachining process to the proposed Fabry-Perot Interferometry (FPI) micro-pressure sensor. The feasibility of bulk, surface and hybrid micro-machining as viable proposition for sensor fabrication are reviewed. This paper will address the various factors involved in the manufacturing of FPI sensors, which gives high yield with a specific level of performance. The reliability of the sensor tip has been discussed.

scholarly journals Catheter with dielectric optical filter deposited upon the fiber optic end for Ramanin vivobiospectroscopy applications

2008 ◽  
Vol 22 (6) ◽  
pp. 459-466 ◽  
Author(s):  
Carlos José de Lima ◽  
Marcos Tadeu T. Pacheco ◽  
Antonio Balbin Villaverde ◽  
Renato Amaro Zângaro ◽  
Leonardo Marmo Moreira ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Raman Scattering ◽  
Biomedical Applications ◽  
Biochemical Analysis ◽  
Fiber Optic ◽  
Signal To Noise Ratio ◽  
Optical Filter ◽  
Biological Molecules ◽  
Modes Of Vibration

Raman spectroscopy (RS) is a powerful tool that allows obtaining significant biochemical information from biological tissue. The fiber optic catheter permits applicationsin vivothat present wide clinical employment. This biochemical analysis is developed through a guide light that furnishes to Raman spectroscopy system the data obtained from tissue. These Raman signals represent the modes of vibration of molecular groups that are present in the biological molecules. Raman measurements undergo the optical influence of the material that constitutes the catheter, mainly Raman scattering of the silica that composes the fiber optic, decreasing signal to noise ratio (SNR) of the resultant spectra. In this work, a dielectric optical filter called “bandpass” was deposited upon the surface of the tip of the central fiber optic (distal probe). Indeed, other six fibers without any optical filter are disposed around this central optical fiber with “bandpass”. This prototype of catheter presented significant decrease of the silica Raman scattering when compared with unfiltered catheters. The biomedical applications of this new catheter are auspicious, involving biochemical analysis and diagnosisin vivo, since the SNR improvement obtained propitiates a much more informative Raman spectrum.

Fiber Optic Pressure Sensor for Biomedical Applications

ASAIO Journal ◽  
1996 ◽  
Vol 42 (5) ◽  
pp. M500-505 ◽  
Author(s):  
NADARAJAH NARENDRAN ◽  
MARK A. CORBO ◽  
WILLIAM SMITH
Keyword(s):  
Pressure Sensor ◽  
Biomedical Applications ◽  
Fiber Optic

Biomedical applications: Pitfalls in the practice

1994 ◽  
Vol 52 ◽  
pp. 378-379
Author(s):  
J. D. Shelburne ◽  
Peter Ingram ◽  
Victor L. Roggli ◽  
Ann LeFurgey
Keyword(s):  
Operating Room ◽  
Liquid Nitrogen ◽  
Lung Tissue ◽  
Biomedical Applications ◽  
Microprobe Analysis ◽  
Tissue Sample ◽  
Cellular Level ◽  
Tissue Samples ◽  
Asbestos Fibers

At present most medical microprobe analysis is conducted on insoluble particulates such as asbestos fibers in lung tissue. Cryotechniques are not necessary for this type of specimen. Insoluble particulates can be processed conventionally. Nevertheless, it is important to emphasize that conventional processing is unacceptable for specimens in which electrolyte distributions in tissues are sought. It is necessary to flash-freeze in order to preserve the integrity of electrolyte distributions at the subcellular and cellular level. Ideally, biopsies should be flash-frozen in the operating room rather than being frozen several minutes later in a histology laboratory. Electrolytes will move during such a long delay. While flammable cryogens such as propane obviously cannot be used in an operating room, liquid nitrogen-cooled slam-freezing devices or guns may be permitted, and are the best way to achieve an artifact-free, accurate tissue sample which truly reflects the in vivo state. Unfortunately, the importance of cryofixation is often not understood. Investigators bring tissue samples fixed in glutaraldehyde to a microprobe laboratory with a request for microprobe analysis for electrolytes.

Biological and biomedical applications of collagenous biomaterials

1990 ◽  
Vol 48 (3) ◽  
pp. 856-857
Author(s):  
Yasushi P. Kato ◽  
Michael G. Dunn ◽  
Frederick H. Silver ◽  
Arthur J. Wasserman
Keyword(s):  
Biomedical Applications ◽  
Soft Tissues ◽  
Collagen Fibers ◽  
Bone Collagen ◽  
Cover Slip ◽  
Fibroblast Migration ◽  
Cellular Expression ◽  
Defect Repair

Collagenous biomaterials have been used for growing cells in vitro as well as for augmentation and replacement of hard and soft tissues. The substratum used for culturing cells is implicated in the modulation of phenotypic cellular expression, cellular orientation and adhesion. Collagen may have a strong influence on these cellular parameters when used as a substrate in vitro. Clinically, collagen has many applications to wound healing including, skin and bone substitution, tendon, ligament, and nerve replacement. In this report we demonstrate two uses of collagen. First as a fiber to support fibroblast growth in vitro, and second as a demineralized bone/collagen sponge for radial bone defect repair in vivo.For the in vitro study, collagen fibers were prepared as described previously. Primary rat tendon fibroblasts (1° RTF) were isolated and cultured for 5 days on 1 X 15 mm sterile cover slips. Six to seven collagen fibers, were glued parallel to each other onto a circular cover slip (D=18mm) and the 1 X 15mm cover slip populated with 1° RTF was placed at the center perpendicular to the collagen fibers. Fibroblast migration from the 1 x 15mm cover slip onto and along the collagen fibers was measured daily using a phase contrast microscope (Olympus CK-2) with a calibrated eyepiece. Migratory rates for fibroblasts were determined from 36 fibers over 4 days.

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