scholarly journals Use of Recombinant Antigens for the Diagnosis of Invasive Candidiasis

2008 ◽  
Vol 2008 ◽  
pp. 1-7 ◽  
Author(s):  
Ana Laín ◽  
Natalia Elguezabal ◽  
Elena Amutio ◽  
Iñigo Fernández de Larrinoa ◽  
María Dolores Moragues ◽  
...  
Keyword(s):  
Molecular Biology ◽  
Critically Ill ◽  
Invasive Candidiasis ◽  
Critically Ill Patients ◽  
Diagnostic Method ◽  
Clinical Symptoms ◽  
Cross Reactivity ◽  
Fatal Complication ◽  
Recombinant Antigens ◽  
Fungal Extracts

Invasive candidiasis is a frequent and often fatal complication in immunocompromised and critically ill patients. Unfortunately, the diagnosis of invasive candidiasis remains difficult due to the lack of specific clinical symptoms and a definitive diagnostic method. The detection of antibodies against differentCandidaantigens may help in the diagnosis. However, the methods traditionally used for the detection of antibodies have been based on crude antigenic fungal extracts, which usually show low-reproducibility and cross-reactivity problems. The development of molecular biology techniques has allowed the production of recombinant antigens which may help to solve these problems. In this review we will discuss the usefulness of recombinant antigens in the diagnosis of invasive candidiasis.

Management of Invasive Candidiasis in Critically Ill Patients

Drugs ◽  
2004 ◽  
Vol 64 (19) ◽  
pp. 2159-2175 ◽  
Author(s):  
Stijn Blot ◽  
Koenraad Vandewoude
Keyword(s):  
Critically Ill ◽  
Invasive Candidiasis ◽  
Critically Ill Patients

scholarly journals Observations on the Application of Nursing Risk Management in the Care of Critically Ill Patients in the Respiratory Unit

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Yannan Sun
Keyword(s):  
Risk Management ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Treatment Satisfaction ◽  
Clinical Symptoms ◽  
Statistical Significance ◽  
Management Model ◽  
Control Group ◽  
Observation Group ◽  
Significant Difference

 Objective: Investigate the effectiveness of nursing risk management in the care of critically ill patients in the respiratory unit. Methods: Among the critically ill respiratory patients admitted to our hospital between May 2019 and April 2020, 78 patients were randomly selected and divided into an observation group and a control group, each consisting of 39 patients. In the observation group, a nursing risk management model was implemented, i.e., patients' clinical symptoms were observed at any time to monitor their treatment satisfaction and the effectiveness of their care and routine care was implemented for the control group. Results: The heart rate, respiratory rate, and pH of patients in the observation group were more stable than those in the control group, and their respiratory status was better, with differences in data. There was also significant statistical significance (P<0.05). The incidence of patient-provider disputes, unplanned extubation, and unplanned events were lower in the observation group compared to the control group, and their data difference was statistically significant (P<0.05). The treatment satisfaction as well as the total effective rate of patients in the observation group was also much higher than that of the control group, and there was also a statistically significant difference in the data (P<0.05). Conclusion: The nursing risk management model has a significant therapeutic effect in the care of critically ill respiratory patients. Therefore, it is worth popularizing to use in the clinical nursing of respiratory critical patients.

scholarly journals Falsely Increased Immunoassay Measurements of Total and Unbound Phenytoin in Critically Ill Uremic Patients Receiving Fosphenytoin

1999 ◽  
Vol 45 (6) ◽  
pp. 829-837 ◽  
Author(s):  
William L Roberts ◽  
Barun K De ◽  
John P Coleman ◽  
Thomas M Annesley
Keyword(s):  
Renal Insufficiency ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Cross Reactivity ◽  
Hplc Method ◽  
Phosphate Ester ◽  
Uremic Patients ◽  
Ester Prodrug

Abstract Background: Fosphenytoin, a phosphate ester prodrug of phenytoin, is metabolized to phenytoin in vivo. Phenytoin metabolites accumulate in renal insufficiency and cross-react in some phenytoin immunoassays. Our aim was to determine the accuracy of phenytoin immunoassays in renal patients treated with fosphenytoin. Methods: We measured phenytoin with HPLC and with the aca, ACS:180, TDx phenytoin II, Vitros, and AxSYM methods. Specimens were collected 2–120 h after fosphenytoin administration from 17 patients with renal insufficiency. Results: The AxSYM, TDx phenytoin II, ACS:180, and Vitros assays displayed falsely increased phenytoin results up to 20 times higher than the HPLC results. The aca Star results for these specimens were comparable to the HPLC results. Although fosphenytoin can cross-react with phenytoin immunoassays, no fosphenytoin was detected by a sensitive HPLC method in any sample that was tested for its presence. Conclusion: These results are consistent with the formation of one or more novel metabolites or adducts of fosphenytoin that accumulate in some critically ill patients with renal insufficiency and that display significant cross-reactivity with some, but not all, phenytoin immunoassay methods.

Preventing Invasive Candidiasis in High-Risk Critically Ill Patients

2013 ◽  
Vol 41 (2) ◽  
pp. 689-690 ◽  
Author(s):  
Pierre Emmanuel Charles ◽  
Rémi Bruyère
Keyword(s):  
High Risk ◽  
Critically Ill ◽  
Invasive Candidiasis ◽  
Critically Ill Patients

Clinical Aspects of Invasive Candidiasis in Critically Ill Patients

Drugs ◽  
2009 ◽  
Vol 69 (Supplement 1) ◽  
pp. 21-28 ◽  
Author(s):  
Mariano Pennisi ◽  
Massimo Antonelli
Keyword(s):  
Critically Ill ◽  
Invasive Candidiasis ◽  
Critically Ill Patients ◽  
Clinical Aspects

Evaluation of the updated “Candida score” with sepsis 3.0 criteria in critically ill patients

2019 ◽  
Author(s):  
Dongkai Li ◽  
Jiahui Zhang ◽  
Wen Han ◽  
Guangxu Bai ◽  
Wei Cheng ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Critically Ill ◽  
Invasive Candidiasis ◽  
Critically Ill Patients ◽  
Clinical Relevance ◽  
Hospital Admissions ◽  
Clinical Importance ◽  
Number Of Patients ◽  
Candida Score ◽  
Score Model

Abstract BackgroundThe Candida score proposed in 2009 was calculated on the definition of “severe sepsis”, which was removed in the Sepsis 3.0 definition. This study investigated the clinical relevance of Candida score with the updated sepsis 3.0 definition (CS-3.0) instead of severe sepsis (CS-2009) in the new admitted critically ill patients.MethodWe performed a retrospective analysis on a single‑center public database. All patients with ICU stay≥72 hours were included in this study. The Candida score was calculated based on the data collected on ICU admission. The incidence of invasive candidiasis was determined and its relationship with the CS-2009 and CS-3.0 was studied.ResultsA total of 17,666 patients were identified after screening 58,976 hospital admissions, and 436 cases (2.5%) were diagnosed with invasive candidiasis. In the infection group, the number of patients who met the Sepsis 3.0 criteria was greater than the number of patients with severe sepsis (81.2% vs. 78.4%, p<0.005). The area under curve of the CS-2009 was 0.789 (95% CI 0.765-0.813) and the CS-3.0 was 0.804 (95% CI 0.782-0.827). ConclusionOur study confirmed the clinical relevance and comparative superiority of the updated Candida score model, using the Sepsis 3.0 definition, compared with the classic sepsis/severe sepsis model, in assessment of critically ill patients. Considering the clinical importance of organ dysfunction in ICI, the sepsis 3.0 should be used as the basis for prediction of invasive candidiasis.

scholarly journals Micafungin pharmacokinetic/pharmacodynamic adequacy for the treatment of invasive candidiasis in critically ill patients on continuous venovenous haemofiltration

2014 ◽  
Vol 69 (6) ◽  
pp. 1624-1632 ◽  
Author(s):  
Emilio Maseda ◽  
Santiago Grau ◽  
Maria-Jose Villagran ◽  
Carmen Hernandez-Gancedo ◽  
Araceli Lopez-Tofiño ◽  
...  
Keyword(s):  
Critically Ill ◽  
Invasive Candidiasis ◽  
Critically Ill Patients ◽  
Continuous Venovenous Haemofiltration
Sign in / Sign up

Export Citation Format

Share Document