scholarly journals Micafungin pharmacokinetic/pharmacodynamic adequacy for the treatment of invasive candidiasis in critically ill patients on continuous venovenous haemofiltration

2014 ◽  
Vol 69 (6) ◽  
pp. 1624-1632 ◽  
Author(s):  
Emilio Maseda ◽  
Santiago Grau ◽  
Maria-Jose Villagran ◽  
Carmen Hernandez-Gancedo ◽  
Araceli Lopez-Tofiño ◽  
...  
Keyword(s):  
Critically Ill ◽  
Invasive Candidiasis ◽  
Critically Ill Patients ◽  
Continuous Venovenous Haemofiltration

Management of Invasive Candidiasis in Critically Ill Patients

Drugs ◽  
2004 ◽  
Vol 64 (19) ◽  
pp. 2159-2175 ◽  
Author(s):  
Stijn Blot ◽  
Koenraad Vandewoude
Keyword(s):  
Critically Ill ◽  
Invasive Candidiasis ◽  
Critically Ill Patients

Preventing Invasive Candidiasis in High-Risk Critically Ill Patients

2013 ◽  
Vol 41 (2) ◽  
pp. 689-690 ◽  
Author(s):  
Pierre Emmanuel Charles ◽  
Rémi Bruyère
Keyword(s):  
High Risk ◽  
Critically Ill ◽  
Invasive Candidiasis ◽  
Critically Ill Patients

Clinical Aspects of Invasive Candidiasis in Critically Ill Patients

Drugs ◽  
2009 ◽  
Vol 69 (Supplement 1) ◽  
pp. 21-28 ◽  
Author(s):  
Mariano Pennisi ◽  
Massimo Antonelli
Keyword(s):  
Critically Ill ◽  
Invasive Candidiasis ◽  
Critically Ill Patients ◽  
Clinical Aspects

Evaluation of the updated “Candida score” with sepsis 3.0 criteria in critically ill patients

2019 ◽  
Author(s):  
Dongkai Li ◽  
Jiahui Zhang ◽  
Wen Han ◽  
Guangxu Bai ◽  
Wei Cheng ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Critically Ill ◽  
Invasive Candidiasis ◽  
Critically Ill Patients ◽  
Clinical Relevance ◽  
Hospital Admissions ◽  
Clinical Importance ◽  
Number Of Patients ◽  
Candida Score ◽  
Score Model

Abstract BackgroundThe Candida score proposed in 2009 was calculated on the definition of “severe sepsis”, which was removed in the Sepsis 3.0 definition. This study investigated the clinical relevance of Candida score with the updated sepsis 3.0 definition (CS-3.0) instead of severe sepsis (CS-2009) in the new admitted critically ill patients.MethodWe performed a retrospective analysis on a single‑center public database. All patients with ICU stay≥72 hours were included in this study. The Candida score was calculated based on the data collected on ICU admission. The incidence of invasive candidiasis was determined and its relationship with the CS-2009 and CS-3.0 was studied.ResultsA total of 17,666 patients were identified after screening 58,976 hospital admissions, and 436 cases (2.5%) were diagnosed with invasive candidiasis. In the infection group, the number of patients who met the Sepsis 3.0 criteria was greater than the number of patients with severe sepsis (81.2% vs. 78.4%, p<0.005). The area under curve of the CS-2009 was 0.789 (95% CI 0.765-0.813) and the CS-3.0 was 0.804 (95% CI 0.782-0.827). ConclusionOur study confirmed the clinical relevance and comparative superiority of the updated Candida score model, using the Sepsis 3.0 definition, compared with the classic sepsis/severe sepsis model, in assessment of critically ill patients. Considering the clinical importance of organ dysfunction in ICI, the sepsis 3.0 should be used as the basis for prediction of invasive candidiasis.

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