scholarly journals A Common Polymorphism G-50T in Cytochrome P450 2J2 Gene Is Associated with Increased Risk of Essential Hypertension in a Russian Population

2008 ◽  
Vol 24 (2) ◽  
pp. 119-126 ◽  
Author(s):  
Alexey V. Polonikov ◽  
Vladimir P. Ivanov ◽  
Maria A. Solodilova ◽  
Irina V. Khoroshaya ◽  
Mikhail A. Kozhuhov ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Family History ◽  
Arachidonic Acid Metabolism ◽  
Russian Population ◽  
Common Polymorphism ◽  
Increased Risk ◽  
History Of ◽  
Family History Of Hypertension ◽  
Polymerase Chain ◽  
First Time

The present study was designed to test whether common polymorphism G-50T within the promoter of humanCYP2J2gene is associated with increased risk of essential hypertension in a Russian population. We studied 576 unrelated subjects, including 295 patients with hypertension and 281 healthy subjects. Genotyping for polymorphism G-50T of theCYP2J2gene was performed by polymerase chain reaction and restriction fragment length polymorphism techniques. The frequency of a −50T variant allele ofCYP2J2gene was significantly higher in patients with hypertension versus healthy controls (OR 4.03 95%CI 1.80–9.04p=0.0004). The association of a −50GT genotype with hypertension remained significant after adjustment for age, gender and family history of hypertension by multivariate logistic regression (OR 4.78 95%CI 1.87–12.27p=0.001). It has been found that OR for −50GT genotype × gender interaction (OR 4.48 95%CI 1.93–10.39p=0.00048) was slightly higher than OR for −50GT genotype (OR 4.43 95%CI 1.91–10.29p=0.00052), suggesting a weak effect of gender on the risk of hypertension in the heterozygous carriers of −50GT genotype. A family history of hypertension has no effect on the association between a −50GT genotype and hypertension. In present study we demonstrate for the first time that aCYP2J2*7 allele of theCYP2J2gene is clearly associated with an increased risk of essential hypertension. Furthermore, this study highlights the importance of P-450 epoxygenase pathway of arachidonic acid metabolism in the pathogenesis of hypertensive disease.

Intracellular Na+ and Ca2+ Activities in Essential Hypertension

1982 ◽  
Vol 63 (s8) ◽  
pp. 41s-43s ◽  
Author(s):  
W. Zidek ◽  
H. Vetter ◽  
K.-G. Dorst ◽  
H. Zumkley ◽  
H. Losse
Keyword(s):  
Essential Hypertension ◽  
Family History ◽  
Secondary Hypertension ◽  
Genetic Trait ◽  
Hypertensive Patients ◽  
Intracellular Na Activity ◽  
History Of ◽  
Family History Of Hypertension ◽  
Normotensive Subjects

1. The intracellular Na+ and Ca2+ activity and Na+ concentration were measured in erythrocytes of normotensive subjects, with and without a familial disposition to hypertension, in essential hypertensive patients with and without a family history of hypertension, and in patients with secondary hypertension. 2. In normotensive subjects without a genetic trait of hypertension intracellular Na+ activity and concentration were 7.00 ± 1.38 mmol/l and 5.67 ± 0.95 mmol/l respectively. The intracellular Ca2+ activity was 4.82 ± 4.49 μmol/l. In normotensive subjects with a familial hypertensive disposition intracellular Na+ activity and concentration were 9.74 ± 1.43 mmol/l (P < 0.01) and 6.63 ± 0.88 mmol/l (P < 0.05). Intracellular Ca2+ was 9.59 ± 9.71 μmol/l (P < 0.05). 3. Essential hypertensive patients without a familial genetic trait had an elevated intracellular Na+ activity (8.35 ± 2.08 mmol/l, P < 0.05). Intracellular Na+ concentration was 6.64 ± 0.79 mmol/l (P < 0.05). The intracellular Ca2+ activity was markedly elevated to 25.33 ± 19.03 μmol/l (P < 0.01). The essential hypertensive patients with a familial disposition had an elevated intracellular Na+ activity (17.19 ± 4.37 mmol/l, P < 0.001) and Ca2+ activity (32.8 ± 32.51 μmol/l, P < 0.01). The intracellular Na+ concentration was 6.25 ± 1.23 mmol/l. 4. The results indicate that in essential hypertension intracellular Na+ activity is increased, particularly in patients with a familial disposition for hypertension. Intracellular Ca2+ is increased in essential hypertension whether or not there was a family disposition to hypertension.

scholarly journals Sympathetic reactivity in young women with a family history of hypertension

2015 ◽  
Vol 308 (8) ◽  
pp. H816-H822 ◽  
Author(s):  
Jody L. Greaney ◽  
Evan L. Matthews ◽  
Megan M. Wenner
Keyword(s):  
Young Adults ◽  
Family History ◽  
Young Women ◽  
Cold Pressor Test ◽  
Cold Pressor ◽  
Isometric Handgrip ◽  
Pressor Test ◽  
Increased Risk ◽  
History Of ◽  
Family History Of Hypertension

Young adults with a family history of hypertension (+FH) have increased risk of developing hypertension. Furthermore, the blood pressure (BP) response to sympathoexcitatory stimuli in young adults can predict the future development of hypertension. Therefore, we hypothesized young women with a +FH would have exaggerated cardiovascular and sympathetic reactivity compared with young women without a family history of hypertension (−FH). Beat-by-beat mean arterial pressure (MAP) and muscle sympathetic nerve activity (MSNA) were measured in 14 women +FH (22 ± 1 yr, 21 ± 1 kg/m2, MAP 80 ± 2 mmHg) and 15 women −FH (22 ± 1 yr, 22 ± 1 kg/m2, MAP 78 ± 2 mmHg) during acute sympathoexcitatory maneuvers: cold pressor test, 2 min of isometric handgrip (HG) exercise at 30% of maximal voluntary contraction, and 3 min of postexercise ischemia (PEI; isolated activation of the skeletal muscle metaboreflex). During cold pressor test, the increase in BP was greater in women +FH (ΔMAP: +FH 16 ± 2 vs. −FH 11 ± 1 mmHg, P < 0.05), which was accompanied by an exaggerated increase in MSNA (ΔMSNA: +FH 17 ± 2 vs. −FH 8 ± 2 burst/min, P < 0.05). The increase in BP was greater in +FH during the last minute of HG (ΔMAP: +FH 23 ± 3 vs. −FH 12 ± 1 mmHg, P < 0.05) and during PEI (ΔMAP: +FH 17 ± 3 vs. −FH 9 ± 2 mmHg, P < 0.05). Similarly, the increase in MSNA was greater in +FH during both HG (ΔMSNA: +FH 12 ± 2 vs. −FH 6 ± 2 burst/min, P < 0.05) and PEI (ΔMSNA: +FH 16 ± 2 vs. −FH 4 ± 2 burst/min, P < 0.05). These data demonstrate that +FH women have greater BP and sympathetic reactivity compared with −FH women.

Increased Erythrocyte Lithium-Sodium Countertransport in Essential Hypertension: Its Relationship to Family History of Hypertension

1981 ◽  
Vol 61 (s7) ◽  
pp. 13s-15s ◽  
Author(s):  
M. Canali ◽  
L. Borghi ◽  
E. Sani ◽  
A. Curti ◽  
A. Montanari ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Family History ◽  
High Blood Pressure ◽  
Degree Relative ◽  
Mean Values ◽  
The Family ◽  
History Of ◽  
Family History Of Hypertension ◽  
And Control

1. Erythrocyte lithium—sodium counter-transport was measured in 46 normotensive healthy controls without family history of hypertension, 15 subjects with essential hypertension, but without evidence of family history of high blood pressure, and 43 subjects with essential hypertension and at least one hypertensive first-degree relative. 2. Mean values (mmol h−1 l−1 of erythrocytes) were 0.248 ± 0.092 in controls, 0.258 ± 0.087 in hypertensive subjects without family history (not significant vs controls), 0.360 ± 0.115 in hypertensive subjects with family history of hypertension (P &lt; 0.001 vs controls), 0.334 ± 0.117 in all hypertensive subjects, both with and without family history (P &lt; 0.001 vs controls). 3. Our data confirm the finding of an increased erythrocyte lithium-sodium counter-transport, but with a significant overlap between essential hypertension and control values. Lithium-sodium countertransport is higher only in hypertensive subjects with at least one hypertensive first-degree relative. 4. We suggest that the increase of lithium-sodium countertransport in erythrocytes is not a consistent marker of essential hypertension. It seems to be associated with the family prevalence and/or the hereditability of hypertension, rather than with high blood pressure per se.

Uptake and Efflux of Noradrenaline from Platelets; a Model System for Neurogenic Mechanisms in Essential Hypertension

1979 ◽  
Vol 57 (s5) ◽  
pp. 225s-227s ◽  
Author(s):  
I. Mattiasson ◽  
B. Mattiasson ◽  
B. Hood
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Family History ◽  
Model System ◽  
Efflux Rate ◽  
Efflux Of Noradrenaline ◽  
High K ◽  
History Of ◽  
Family History Of Hypertension ◽  
Very High

1. The rate (k) of initial efflux of noradrenaline from platelets was determined in 63 individuals. A highly significant correlation was found between diastolic blood pressure and efflux rate. 2. When platelets are incubated in buffers with various Na+ concentrations in the range 110–170 mmol/l a higher Na+ concentration will give a faster efflux of noradrenaline for each concentration tested. 3. The value for k was determined in 41 normotensive first-degree relatives of hypertensive individuals and 21 persons with no family history of hypertension. Efflux rate of noradrenaline was significantly higher in the relatives and within this group was a subgroup with very high k values.

scholarly journals Association and interaction of hemoglobin glycation index with hypertension risk: a community-based cross-sectional survey

2020 ◽  
Author(s):  
Jing Mi ◽  
Jian Song ◽  
Yingying Zhao ◽  
xue-sen wu
Keyword(s):  
Family History ◽  
Interactive Effect ◽  
Cross Sectional Survey ◽  
Community Based ◽  
Cross Sectional ◽  
Hypertension Risk ◽  
Increased Risk ◽  
History Of ◽  
Family History Of Hypertension ◽  
Hemoglobin Glycation

Abstract BackgroundHemoglobin glycation index (HGI) is considered to be a convenient measurable indicator to assess the inter-individual variation of HbA1c. In the present study, we tested the relationship between HGI and risk of hypertension, and further explored the possible interacting influences of HGI with other such factors on hypertension risk among Chinese individuals.Methods The eligible subjects were chosen from a community-based cross-sectional survey in China. We collected relevant data and clinical indicators for each participant. HGI was calculated as “measured HbA1c-predicted HbA1c” and divided into four categories according to quartile. The following indicators were used to assess interactive effects：(1) relative excess risk due to interaction (RERI); (2) attributable proportion due to interaction (AP); and (3) synergy index (SI). Statistical analysis was performed using R software.ResultsSpecifically, 1777 eligible participants were selected in this cross-sectional survey. There were 433 subjects who were identified to have hypertension (24.4%). A significant increase in the prevalence of hypertension from Q1 to Q4 of HGI was observed (P<0.001). Multivariable logistic model demonstrated that subjects at the highest HGI group had a substantially increased risk of being hypertensive than subjects in the first quartile of HGI, as indicated by the OR value of 1.87(95%CI: 1.26-2.78). Moreover, a significant interaction between family history of hypertension and HGI on hypertension risk was detected (RERI:1.36,95%CI:0.11-2.63; AP: 0.43, 95%CI:0.17-0.69; and SI:2.68, 95% CI:1.10-6.48). The interactive effect between HGI and abdominal obesity was also found to be significant, as estimated by the value of RERI (1.04, 95%CI:0.24-1.85), AP (0.33, 95% CI: 0.11-0.56) and SI (1.96, 95%CI:1.01-3.79). However, in the analysis of the interaction between HGI and general obesity, only the AP value (0.28, 95%CI: 0.01-0.54) was observed to be significant.ConclusionHigh HGI was independently associated with the risk of hypertension. Moreover, HGI significantly shared interactions with obesity and family history of hypertension that influenced the risk of hypertension.

scholarly journals Association of hemoglobin glycation index and its interaction with obesity/family history of hypertension on hypertension risk: a community-based cross-sectional survey

2020 ◽  
Author(s):  
Jing Mi ◽  
Jian Song ◽  
Yingying Zhao ◽  
xue-sen wu
Keyword(s):  
Family History ◽  
Interactive Effect ◽  
Cross Sectional Survey ◽  
Community Based ◽  
Cross Sectional ◽  
Hypertension Risk ◽  
Increased Risk ◽  
History Of ◽  
Family History Of Hypertension ◽  
Hemoglobin Glycation

Abstract BackgroundHemoglobin glycation index (HGI) is considered to be a convenient measurable indicator to assess the inter-individual variation of HbA1c. In the present study, we tested the relationship between HGI and risk of hypertension, and further explored the possible interacting influences of HGI with other such factors on hypertension risk among Chinese individuals.Methods The eligible subjects were chosen from a community-based cross-sectional survey in China.We collected relevant data and clinical indicators for each participant. HGI was calculated as “measured HbA1c-predicted HbA1c” and divided into four categories according to quartile. The following indicators were used to assess interactive effects：(1) relative excess risk due to interaction (RERI); (2) attributable proportion due to interaction (AP); and (3) synergy index (SI). Statistical analysis was performed using R software.ResultsSpecifically, 1777 eligible participants were selected in this cross-sectional survey. There were 433 subjects who were identified to have hypertension (24.4%). A significant increase in the prevalence of hypertension from Q1 to Q4 of HGI was observed (P<0.001). Multivariable logistic model demonstrated that subjects at the highest HGI group had a substantially increased risk of being hypertensive than subjects in the first quartile of HGI, as indicated by the OR value of 1.87(95%CI: 1.26-2.78). Moreover, a significant interaction between family history of hypertension and HGI on hypertension risk was detected (RERI:1.36,95%CI:0.11-2.63; AP: 0.43, 95%CI:0.17-0.69; and SI:2.68, 95% CI:1.10-6.48). The interactive effect between HGI and abdominal obesity was also found to be significant, as estimated by the value of RERI (1.04, 95%CI:0.24-1.85), AP (0.33, 95% CI: 0.11-0.56) and SI (1.96, 95%CI:1.01-3.79). However, in the analysis of the interaction between HGI and general obesity, only the AP value (0.28, 95%CI: 0.01-0.54) was observed to be significant.ConclusionHigh HGI was independently associated with the risk of hypertension. Moreover, HGI significantly shared interactions with obesity and family history of hypertension that influenced the risk of hypertension.

scholarly journals Association of hemoglobin glycation index and its interaction with obesity /family history of hypertension on hypertension risk: a community-based cross-sectional survey

2020 ◽  
Author(s):  
Jing Mi ◽  
Jian Song ◽  
Yingying Zhao ◽  
xue-sen wu
Keyword(s):  
Family History ◽  
Interactive Effect ◽  
Cross Sectional Survey ◽  
Community Based ◽  
Cross Sectional ◽  
Hypertension Risk ◽  
Increased Risk ◽  
History Of ◽  
Family History Of Hypertension ◽  
Hemoglobin Glycation

Abstract Background: Hemoglobin glycation index (HGI) is considered to be a convenient measurable indicator to assess the inter-individual variation of HbA1c. In the present study, we tested the relationship between HGI and risk of hypertension, and further explored the possible interacting influences of HGI with other such factors on hypertension risk among Chinese individuals.Methods : The eligible subjects were chosen from a community-based cross-sectional survey in China. We collected relevant data and clinical indicators for each participant. HGI was calculated as “measured HbA1c-predicted HbA1c” and divided into four categories according to quartile. The following indicators were used to assess interactive effects：(1) relative excess risk due to interaction (RERI); (2) attributable proportion due to interaction (AP); and (3) synergy index (SI). Statistical analysis was performed using R software.Results: Specifically, 1777 eligible participants were selected in this cross-sectional survey. There were 433 subjects who were identified to have hypertension (24.4%). A significant increase in the prevalence of hypertension from Q1 to Q4 of HGI was observed (P<0.001). Multivariable logistic model demonstrated that subjects at the highest HGI group had a substantially increased risk of being hypertensive than subjects in the first quartile of HGI, as indicated by the OR value of 1.87(95%CI: 1.26-2.78). Moreover, a significant interaction between family history of hypertension and HGI on hypertension risk was detected (RERI:1.36,95%CI:0.11-2.63; AP: 0.43, 95%CI:0.17-0.69; and SI:2.68, 95% CI:1.10-6.48). The interactive effect between HGI and abdominal obesity was also found to be significant, as estimated by the value of RERI (1.04, 95%CI:0.24-1.85), AP (0.33, 95% CI: 0.11-0.56) and SI (1.96, 95%CI:1.01-3.79). However, in the analysis of the interaction between HGI and general obesity, only the AP value (0.28, 95%CI: 0.01-0.54) was observed to be significant.Conclusion: High HGI was independently associated with the risk of hypertension. Moreover, HGI significantly shared interactions with obesity and family history of hypertension that influenced the risk of hypertension.

scholarly journals Polymorphism of MTHFR C677T Gene and the Associations with the Severity of Essential Hypertension in Northern Chinese Population

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Junli Song ◽  
Jie Hou ◽  
Qiang Zhao ◽  
Xuezhi Liu ◽  
Qian Guo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Essential Hypertension ◽  
Family History ◽  
High Risk ◽  
Methylenetetrahydrofolate Reductase ◽  
Control Strategies ◽  
Mthfr C677t ◽  
History Of ◽  
Northern Chinese ◽  
Family History Of Hypertension

Objective. Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of homocysteine metabolism and is closely related to the occurrence of hypertension. The aim of this study was to investigate the polymorphism of the (MTHFR) C677T and the factors influencing the severity of hypertension. Material and Methods. A total of 985 subjects were enrolled to analyze the polymorphisms of the MTHFR C677T gene by polymerase chain reaction (PCR). 306 people with essential hypertension were selected from 985 subjects to estimate the severity of hypertension by the ordinal multivariate logistical regression model. Results. The frequencies of CC, CT, and TT genotypes were 19.5%, 49.95%, and 30.46%, respectively. The allelic frequency of mutant T was 55.43%. The plasma homocysteine level of the homozygous TT in individuals was significantly higher than in those with CC or CT P < 0.01 . MTHFR677CT genotype, MTHFR677TT genotype, smoking, family history of hypertension, Hcy, and triglycerides (TG) were independent risk factors for the severity of hypertension (OR = 2.29, 2.24, 2.04, 1.81, 1.04, 1.26). Conclusion. MTHFR gene, smoking, family history of hypertension, Hcy, and triglycerides could be important genetic and high-risk factors of the development of severe hypertension in northern Chinese. These factors will contribute to the identification of high-risk populations of hypertension and facilitate the development of hypertension control strategies.

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