Uptake and Efflux of Noradrenaline from Platelets; a Model System for Neurogenic Mechanisms in Essential Hypertension

1979 ◽  
Vol 57 (s5) ◽  
pp. 225s-227s ◽  
Author(s):  
I. Mattiasson ◽  
B. Mattiasson ◽  
B. Hood
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Family History ◽  
Model System ◽  
Efflux Rate ◽  
Efflux Of Noradrenaline ◽  
High K ◽  
History Of ◽  
Family History Of Hypertension ◽  
Very High

1. The rate (k) of initial efflux of noradrenaline from platelets was determined in 63 individuals. A highly significant correlation was found between diastolic blood pressure and efflux rate. 2. When platelets are incubated in buffers with various Na+ concentrations in the range 110–170 mmol/l a higher Na+ concentration will give a faster efflux of noradrenaline for each concentration tested. 3. The value for k was determined in 41 normotensive first-degree relatives of hypertensive individuals and 21 persons with no family history of hypertension. Efflux rate of noradrenaline was significantly higher in the relatives and within this group was a subgroup with very high k values.

Efflux of Noradrenaline from Platelets in Normotensive Members of Hypertensive Families

1982 ◽  
Vol 62 (2) ◽  
pp. 151-155 ◽  
Author(s):  
Ingrid Mattiasson ◽  
B. Hood
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Family History ◽  
Sympathetic Neurons ◽  
A Priori ◽  
Middle Aged ◽  
Efflux Rate ◽  
Efflux Of Noradrenaline ◽  
Two Generations ◽  
History Of

1. Platelets have been used as a model of sympathetic neurons to study the storage of noradrenaline in normotensive individuals belonging to families with essential hypertension for at least two generations. 2. The initial efflux rate (k) of noradrenaline was determined in 44 young relatives (mean age 29.2 years), in 18 middle-aged relatives (mean age 46.7 years) and in 31 young controls with no known family history of essential hypertension (mean age 29.8 years). From the groups of relatives all those with definite hypertension had been excluded a priori. 3. k was significantly higher in the young relatives (22.7 ± 7.9) than in the middle-aged relatives (17.7 ± 6.4) and in the controls (15.6 ± 5.1). Of the relatives 27.3% had higher k values than any of the controls. A significant correlation was found between k and diastolic blood pressure in controls but not in young relatives.

Increased Erythrocyte Lithium-Sodium Countertransport in Essential Hypertension: Its Relationship to Family History of Hypertension

1981 ◽  
Vol 61 (s7) ◽  
pp. 13s-15s ◽  
Author(s):  
M. Canali ◽  
L. Borghi ◽  
E. Sani ◽  
A. Curti ◽  
A. Montanari ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Family History ◽  
High Blood Pressure ◽  
Degree Relative ◽  
Mean Values ◽  
The Family ◽  
History Of ◽  
Family History Of Hypertension ◽  
And Control

1. Erythrocyte lithium—sodium counter-transport was measured in 46 normotensive healthy controls without family history of hypertension, 15 subjects with essential hypertension, but without evidence of family history of high blood pressure, and 43 subjects with essential hypertension and at least one hypertensive first-degree relative. 2. Mean values (mmol h−1 l−1 of erythrocytes) were 0.248 ± 0.092 in controls, 0.258 ± 0.087 in hypertensive subjects without family history (not significant vs controls), 0.360 ± 0.115 in hypertensive subjects with family history of hypertension (P < 0.001 vs controls), 0.334 ± 0.117 in all hypertensive subjects, both with and without family history (P < 0.001 vs controls). 3. Our data confirm the finding of an increased erythrocyte lithium-sodium counter-transport, but with a significant overlap between essential hypertension and control values. Lithium-sodium countertransport is higher only in hypertensive subjects with at least one hypertensive first-degree relative. 4. We suggest that the increase of lithium-sodium countertransport in erythrocytes is not a consistent marker of essential hypertension. It seems to be associated with the family prevalence and/or the hereditability of hypertension, rather than with high blood pressure per se.

scholarly journals A Proposed Study on how Far Anger Contributes to Initiating Essential Hypertension in Canadian Caucasian Adults with a Family History of Hypertension

2010 ◽  
Vol 4 ◽  
pp. 117954681000400 ◽  
Author(s):  
Marlene F. Shehata
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Family History ◽  
Anger Expression ◽  
Behavioral Risk ◽  
History Of ◽  
Study Population ◽  
Family History Of Hypertension ◽  
The University ◽  
Study Participants

The goal of the present correlational study is to test the hypothesis that anger initiates essential hypertension in Canadian Caucasian adults with a family history of hypertension. The study population will include a cohort of 100 men and women aged 25 to 45 years at enrollment recruited from the University of Ottawa General and Civic Hospitals. Participants who are normotensives will be included in the study given that they have a family history of hypertension. The Spielberger State Trait Anger Expression inventory (STAXI) scales will assess the three main dimensions of anger: State, Trait and Anger Expression. Using a semiautomated blood pressure machine, blood pressure measurements will be conducted by the attending nurse. It is hypothesized that during the three year study, participants with higher STAXI scores will more likely develop hypertension. Results obtained from the present study are expected to highlight the significant contribution of anger as a modifiable behavioral risk factor in the pathogenesis of hypertension.

Blood Pressure and Intra-Erythrocyte Sodium during Normal and High Salt Intake in Middle-Aged Men: Relationship to Family History of Hypertension, and Neurogenic and Hormonal Variables

1984 ◽  
Vol 66 (4) ◽  
pp. 427-433 ◽  
Author(s):  
Ottar Gudmundsson ◽  
Hans Herlitz ◽  
Olof Jonsson ◽  
Thomas Hedner ◽  
Ove Andersson ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Family History ◽  
Salt Intake ◽  
Sodium Intake ◽  
Positive Family History ◽  
Sodium Content ◽  
High Salt Intake ◽  
History Of ◽  
Family History Of Hypertension ◽  
Erythrocyte Sodium

1. During 4 weeks 37 normotensive 50-year-old men identified by screening in a random population sample were given 12 g of NaCl daily, in addition to their usual dietary sodium intake. Blood pressure, heart rate, weight, urinary excretion of sodium, potassium and catecholamines, plasma aldosterone and noradrenaline and intra-erythrocyte sodium content were determined on normal and increased salt intake. The subjects were divided into those with a positive family history of hypertension (n = 11) and those without such a history (n = 26). 2. Systolic blood pressure and weight increased significantly irrespective of a positive family history of hypertension. 3. On normal salt intake intra-erythrocyte sodium content was significantly higher in those with a positive family history of hypertension. During high salt intake intra-erythrocyte sodium content decreased significantly in that group and the difference between the hereditary subgroups was no longer significant. 4. In the whole group urinary excretion of noradrenaline, adrenaline and dopamine increased whereas plasma aldosterone decreased during the increased salt intake. 5. Thus, in contrast to some earlier studies performed in young subjects, our results indicate that moderately increased sodium intake acts as a pressor agent in normotensive middle-aged men whether there was a positive family history of hypertension or not. We confirm that men with positive family history of hypertension have an increased intra-erythrocyte sodium content, and that an increase in salt intake seems to increase overall sympathetic activity.

scholarly journals Childhood hypertension and family history of hypertension in primary school children in Port Harcourt

2013 ◽  
Vol 40 (2) ◽  
pp. 184-188
Author(s):  
BAN Okoh ◽  
EAD Alikor
Keyword(s):  
Blood Pressure ◽  
Family History ◽  
Primary School ◽  
School Children ◽  
Antihypertensive Drugs ◽  
Sampling Technique ◽  
Primary School Children ◽  
History Of ◽  
Family History Of Hypertension ◽  
Childhood Hypertension

Objective: To determine the relationship between childhood hypertension and family history of hypertension in primary school children in Port Harcourt.Methods: A stratified multi-staged sampling technique was used torecruit pupils between 6-12 years of age, from thirteen primary schoolslocated in three school districts. Data was collected using a pretestedquestionnaire completed by parents / guardians. The average of three blood pressure measurements, weight and height were taken for each pupil, using standardized techniques. Hypertension was defined as average systolic and / or diastolic blood pressure greater than or equalto the 95th percentile for age, gender and height using the standard bloodpressure charts. Family history of hypertension was defined as eitherparent indicating on the submitted questionnaire that they were hypertensive (diagnosed by a physician and/or on antihypertensive drugs)or had a family history of hypertension.Results: A total of 1302 pupils with 717 (55.1%) females and 585(44.9%) males were studied, giving a female to male ratio of 1.2:1. Themean age of pupils studied was 8.82±1.91 years. Sixty one (4.7%)of the pupils examined had hypertension. Of the 1302 pupils, 316(24.3%) had a family history of hypertension. The mean systolic(p<0.001) and diastolic (p=0.220) blood pressures were higher in childrenwith a family history of hypertension than in those without. Ofthe pupils that had a family history of hypertension, 7.9% had  hypertension, while 3.7% of those that did not have a family history, werefound to be hypertensive (p=0.001).Conclusion: A family history of hypertension was associated with a higher prevalence of childhood hypertension than was seen in children without a family history of hypertension.Key words: Childhood Hypertension, Family history.

scholarly journals Evaluation of blood pressure in school children aged 12-16 years

2017 ◽  
Vol 4 (4) ◽  
pp. 1218
Author(s):  
Balakrishnan Nadesan ◽  
Mani Madhavan Sachithananthamoorthi ◽  
Sivaraman Thirumalaikumarasamy ◽  
Ezhilarasu Ramalingam
Keyword(s):  
Blood Pressure ◽  
Family History ◽  
Diastolic Blood Pressure ◽  
School Children ◽  
Diastolic Pressure ◽  
Systolic Pressure ◽  
Cross Sectional ◽  
Significant Difference ◽  
History Of ◽  
Family History Of Hypertension

Background: Hypertension is considered as a major health issue in developed as well as developing countries and its possible origin during childhood prompts pediatricians to routinely include measurement of blood pressure (BP) as an integral part of pediatric physical examination. The objectives of the study were to evaluate the normal range of blood pressure in adolescent school going students of 12-16 years, prevalence of hypertension and relationship of BP with variables like age, body mass index (BMI), socioeconomic status and family history of hypertension.Methods: A cross sectional study was undertaken for a period of one year in adolescent school children in age groups between 12-16 years. Detailed clinical examination was done in 1060 adolescent school children and BP was recorded in right upper limb and correlation of BP with BMI, family history of hypertension and diabetes were studied.Results: Mean systolic and diastolic pressure showed linear relationship with age. There was a highly statistically significant difference between mean systolic and diastolic blood pressure between lower and middle socio-economic class. Prevalence of obesity in our study was 1.13%, overweight was 7.83%. Prevalence of hypertension in obese children was 33.33% and in overweight children 18.07%. Family history of hypertension and diabetes carry a significant correlation with elevated systolic and diastolic blood pressure in adolescents.Conclusions: This study revealed that socio economic factors play a significant role in determining the blood pressure of the individual. Children of middle class have significantly elevated mean systolic pressure and mean diastolic pressure than low socio-economic groups. 

Red blood cell Na content, Na, Li-countertransport, family history of hypertension and blood pressure in school children

1988 ◽  
Vol 6 (3) ◽  
pp. 227-230 ◽  
Author(s):  
Maurizio Trevisan ◽  
Pasquale Strazzullo ◽  
Francesco Paolo Cappuccio ◽  
Michele Roberto Di Muro ◽  
Stefano De Colle ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Family History ◽  
Blood Cell ◽  
School Children ◽  
Red Blood Cell ◽  
History Of ◽  
Family History Of Hypertension
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