scholarly journals Understanding Stress-Related Behavioral Phenotypes: Report from the 1st International Neuroscience Summer School and the 11th International “Stress and Behavior” Conference

2008 ◽  
Vol 2008 ◽  
pp. 1-4
Author(s):  
J. L. LaPorte ◽  
V. M. Klimenko ◽  
A. V. Kalueff
Keyword(s):  
Summer School ◽  
Behavioral Neuroscience ◽  
Social Program ◽  
Medical Doctors ◽  
Behavioral Phenotypes ◽  
Stress Research ◽  
Collaborative Environment ◽  
International Stress ◽  
And Behavior

The 1st International Neuroscience Summer School and the 11th International Multidisciplinary Neuroscience and Biopsychiatry Conference on Stress and Behavior were held in St. Petersburg, Russia, during May 9–20, 2008. The summer school gathered 30 talented young scientists from 15 countries worldwide, and was dedicated to different topics of behavioral neuroscience. Many interactive courses were provided on neuropharmacology, animal phenotyping, and biopsychology. The conference's excellent scientific and social program attracted almost 500 delegates from 40 countries from many areas of stress research. The eclectic interaction between medical doctors, basic scientists, psychologists, and students made for a productive and collaborative environment, which contributed greatly to the success of the school and conference.

scholarly journals Functions of Gtf2i and Gtf2ird1 in the developing brain: transcription, DNA-binding, and long term behavioral consequences

2019 ◽  
Author(s):  
Nathan D. Kopp ◽  
Kayla R. Nygaard ◽  
Katherine B. McCullough ◽  
Susan E. Maloney ◽  
Harrison W. Gabel ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Sites ◽  
Conditioned Fear ◽  
Developing Brain ◽  
Ctcf Binding ◽  
Microdeletion Syndrome ◽  
Behavioral Phenotypes ◽  
Marble Burying ◽  
And Behavior

AbstractGtf2ird1 and Gtf2i may mediate aspects of the cognitive and behavioral phenotypes of Williams Syndrome (WS) – a microdeletion syndrome encompassing these transcription factors (TFs). Knockout mouse models of each TF show behavioral phenotypes. Here we identify their genomic binding sites in the developing brain, and test for additive effects of their mutation on transcription and behavior. Both TFs target constrained chromatin modifier and synaptic protein genes, including a significant number of ASD genes. They bind promoters, strongly overlap CTCF binding and TAD boundaries, and moderately overlap each other, suggesting epistatic effects. We used single and double mutants to test whether mutating both TFs will modify transcriptional and behavioral phenotypes of single Gtf2ird1 mutants. Despite little difference in DNA-binding and transcriptome-wide expression, Gtf2ird1 mutation caused balance, marble burying, and conditioned fear phenotypes. However, mutating Gtf2i in addition to Gtf2ird1 did not further modify transcriptomic or most behavioral phenotypes, suggesting Gtf2ird1 mutation alone is sufficient.

A Model for Capturing Product Assembly Information

2005 ◽  
Vol 6 (1) ◽  
pp. 11-21 ◽  
Author(s):  
Sudarsan Rachuri ◽  
Young-Hyun Han ◽  
Sebti Foufou ◽  
Shaw C. Feng ◽  
Utpal Roy ◽  
...  
Keyword(s):  
System Level ◽  
Assembly Model ◽  
Product Model ◽  
Collaborative Environment ◽  
Mechanical Assemblies ◽  
Proposed Model ◽  
Electromechanical Products ◽  
Definition Of ◽  
And Behavior ◽  
Product Assembly

The important issue of mechanical assemblies has been a subject of intense research over the past several years. Most electromechanical products are assemblies of several components, for various technical as well as economic reasons. This paper provides an object-oriented definition of an assembly model called the Open Assembly Model (OAM) and defines an extension to the NIST Core Product Model (NIST-CPM). The assembly model represents the function, form, and behavior of the assembly and defines both a system level conceptual model and associated hierarchical relationships. The model provides a way for tolerance representation and propagation, kinematics representation, and engineering analysis at the system level. The assembly model is open so as to enable plug-and-play with various applications, such as analysis (FEM, tolerance, assembly), process planning, and virtual assembly (using VR techniques). With the advent of the Internet more and more products are designed and manufactured globally in a distributed and collaborative environment. The class structure defined in OAM can be used by designers to collaborate in such an environment. The proposed model includes both assembly as a concept and assembly as a data structure. For the latter it uses STEP. The OAM together with CPM can be used to capture the assembly evolution from the conceptual to the detailed design stages. It is expected that the proposed OAM will enhance the assembly information content in the STEP standard. A case study example is discussed to explain the Usecase analysis of the assembly model.

scholarly journals Developmental loss of MeCP2 from VIP interneurons impairs cortical function and behavior

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
James M Mossner ◽  
Renata Batista-Brito ◽  
Rima Pant ◽  
Jessica A Cardin
Keyword(s):  
Rett Syndrome ◽  
Neurodevelopmental Disorder ◽  
Critical Role ◽  
Cell Types ◽  
Loss Of Function ◽  
Cortical Function ◽  
Behavioral Phenotypes ◽  
Pathophysiological Role ◽  
And Function ◽  
And Behavior

Rett Syndrome is a devastating neurodevelopmental disorder resulting from mutations in the gene MECP2. Mutations of Mecp2 that are restricted to GABAergic cell types largely replicate the behavioral phenotypes associated with mouse models of Rett Syndrome, suggesting a pathophysiological role for inhibitory interneurons. Recent work has suggested that vasoactive intestinal peptide-expressing (VIP) interneurons may play a critical role in the proper development and function of cortical circuits, making them a potential key point of vulnerability in neurodevelopmental disorders. However, little is known about the role of VIP interneurons in Rett Syndrome. Here we find that loss of MeCP2 specifically from VIP interneurons replicates key neural and behavioral phenotypes observed following global Mecp2 loss of function.

Methodology and mechanisms for federation of heterogeneous metadata sources and ontology development in emerging collaborative environment

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Beibei Pang ◽  
Juanqiong Gou ◽  
Hamideh Afsarmanesh ◽  
Wenxin Mu ◽  
Zuopeng Zhang
Keyword(s):  
Leading Edge ◽  
Heterogeneous Data ◽  
Ontology Development ◽  
Content Type ◽  
Collaborative Environment ◽  
Ontology Language ◽  
Heterogeneous Data Sources ◽  
Information And Communication ◽  
Higher Education In China ◽  
And Behavior

Purpose Leading-edge information and communication technology provides the base to facilitate obtaining, interoperating and federating shared metadata knowledge in collaborative networks from multiple heterogeneous data sources. The purpose of this study is to develop a methodology and a set of mechanisms to support this task in the collaborative environment. Design/methodology/approach In this paper, the authors first identify and capture four main typical sources to find or generate metadata knowledge for shared data in emerging networked environments, including existing well-designed metadata, the typical ones are relational schemas of existing databases in the environment; fragmented metadata sources, i.e. metadata that can be realized from existing mission statements and example application scenarios in the environment, usually characterized by their fragmented, lightweight and behavior-intensive features; extracting metadata for simple labeled unstructured data, e.g. textual communications among its stakeholders; and semantic constraints on metadata, e.g. the temporal data behavior could be generated from governance policies in the environment. Second, the authors introduce their systematic methodology to the unification of the resulted metadata consisting of four semiautomated unification steps that gradually develops and enhances a unified ontology for the environment, formalized in web ontology language. Findings The methodology steps and their corresponding mechanisms are described and exemplified in detail in this paper. Furthermore, this paper presents the outcome of applying the authors’ methodology to an example emerging case through the generation of a unified ontology for that environment. Originality/value The addressed example application area is a real case in the field of higher education in China and therefore serves as a proof of concept and verification of the effectiveness of the authors’ proposed approach.

scholarly journals Neuroscience

2017 ◽  
Author(s):  
Elisabetta Baldi ◽  
Corrado Bucherelli
Keyword(s):  
Passive Avoidance ◽  
Broad Spectrum ◽  
Animal Species ◽  
Research Unit ◽  
Behavioral Neuroscience ◽  
Experimental Results ◽  
Explanatory Note ◽  
And Behavior ◽  
Selection Of

This bibliographic material is patrimony of our Laboratory of the Behavior Physiology. This research unit originated in 1972 by will of Aldo Giachetti (until 1990) and with the beginning of the activity of Corrado Bucherelli. In the early 1980s, with Carlo Ambrogi Lorenzini (until 2004), the cataloging became more capillary and systematic, to continue to this day. All the researchers who worked in our laboratory contributed to this collection (Giovanna Tassoni 1986-2000, Benedetto Sacchetti 1996-2002 and Elisabetta Baldi from 1991). The study of learning, memory and behavior requires to follow a broad spectrum of neuroscience topics, ranging from neuronal biochemistry to neuropsychology. The Authors’ idea of publishing this collection comes from believing that a such website, though not exhaustive, might be a useful and targeted tool for the selection of bibliographic material in the field of behavioral neuroscience. The bibliographic references present at the publication (29500), accompanied by a brief comment highlighting the contents, are organized in relation to the topics (represented by the 99 themes) constituting the publication itself. The intersection of several references will point out the topics that represent them simultaneously. Concerning neurotransmitters and neuromodulators, references to agonists, antagonists or molecules interfering with the activity of these synapses have been inserted in the pages of the implicated neurotransmitter (e.g. acetylcholine). The pages including topics that could have been dealt with separately (e.g. active and passive avoidance) are introduced by a short explanatory note. The comment of each publication highlights the animal species used. Each comment is intended to indicate the content rather than the experimental results of paper. This choice comes from wanting to provide the reader with a more objective and less speculative comment.

scholarly journals 10th Jubilee Multidisciplinary International Conference of Neuroscience and Biological Psychiatry “Stress and Behavior”

2007 ◽  
Vol 2007 ◽  
pp. 1-2
Author(s):  
Allan V. Kalueff
Keyword(s):  
Clinical Psychiatry ◽  
Neural Plasticity ◽  
Biological Psychiatry ◽  
International Conference ◽  
Stress Research ◽  
Recent Developments ◽  
Multidisciplinary Conference ◽  
And Behavior

St. Petersburg (Russia) hosted the 10th Jubilee Multidisciplinary Conference “Stress and Behavior” during May 16–20, 2007. The conference featured many foremost researchers speaking on recent developments on topics such as the role of neural plasticity, memory, learning, genetics, neuromediators, transporters, and steroids in stress research, spanning disciplines from fields ranging from neurogenetics to clinical psychiatry. The conference was attended by 700 delegates from over 40 nations.

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