scholarly journals Work-Related Asthma in Montreal, Quebec: Population Attributable Risk in a Community-Based Study

2008 ◽  
Vol 15 (8) ◽  
pp. 406-412 ◽  
Author(s):  
Ahmet Demir ◽  
Lawrence Joseph ◽  
Margaret R Becklake
Keyword(s):  
Childhood Asthma ◽  
Airway Hyperresponsiveness ◽  
Population Attributable Risk ◽  
Occupational Exposures ◽  
Attributable Risk ◽  
The Other ◽  
Skin Tests ◽  
Adult Onset ◽  
Community Based ◽  
Work Related

BACKGROUND: Occupational exposures are an important cause of adult-onset asthma but the population attributable risk percentage (PAR%) has been less frequently studied.OBJECTIVES: To examine the distribution and determinants of adult asthma in six centres across Canada using data gathered in a community-based study.METHODS: Data were gathered in a community survey of 2959 adults using the European Community Respiratory Health Survey Protocol. A subsample of 498 subjects completed detailed health and occupational questionnaires, methacholine challenge tests and allergy skin tests. Asthma was defined in three ways: current wheeze, asthma symptoms and/or medication, and airway hyperresponsiveness. Occupational exposures were classified as sensitizers or irritants. Associations between asthma and occupational exposures were examined using logistic regression analysis. Model selection was based on the findings for current wheeze, and the same model was applied to the other definitions of asthma.RESULTS: Fifty-six per cent of subjects reported ever having had occupational exposure to sensitizers, and 9.8% to irritants. Current wheeze was associated with exposure to irritants (PAR% 4.54%), and airway hyperresponsiveness was associated with exposure to sensitizers (PAR% 30.7%). Neither a history of childhood asthma, atopy, nor confining the analysis to adult-onset asthma affected these associations. Analysis of effect modification suggested two types of work-related asthma: one due to exposure to occupational sensitizers, and the other due to exposure to irritants.CONCLUSIONS: Detailed assessment of past and current exposures is essential in the investigation of work-related asthma. Childhood asthma reactivated or aggravated by work exposures is not easy to distinguish from asthma induced by work, a misclassification that could lead to an underestimation of work-induced asthma. This should be taken into account in jurisdictions in which persons with work-aggravated asthma are not eligible for workers’ compensation.

scholarly journals Secular trends of population attributable risk of overweight and obesity for hypertension among Chinese adults from 1991 to 2011

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jian Gou ◽  
Huiying Wu
Keyword(s):  
Population Attributable Risk ◽  
Attributable Risk ◽  
Secular Trends ◽  
Overweight And Obesity ◽  
Regression Coefficients ◽  
Chinese Adults ◽  
Intervention Effect ◽  
Obesity Epidemic ◽  
The Past ◽  
Increasing Trend

AbstractWe determined if the increasing trend in hypertension can be partly attributed to increasing prevalence of overweight/obesity in China over the past two decades. Data were collected from 1991 to 2011 and the population attributable risk (PAR), which is used to estimate the intervention effect on hypertension if overweight/obese, were eliminated. Linear regression was used to evaluate the secular trends. The age-standardized prevalence of overweight and obesity increased by 26.32% with an overall slope of 1.27% (95% CI: 1.12–1.43%) per year. Hypertension also increased by 12.37% with an overall slope of 0.65% (95% CI: 0.51–0.79%) per year. The adjusted ORs of overweight/obesity for hypertension across the survey years remained unchanged; however, the trend in PAR increased steadily from 27.1 to 44.6% with an overall slope of 0.81% (95% CI: 0.34–1.28%) per year (P = 0.006). There was no significant gender difference in the slopes of increasing PAR, as measured by regression coefficients (β = 0.95% vs. β = 0.63% per year, P = 0.36). Over the past two decades, the increase in the prevalence of hypertension in China was partly attributed to the overweight/obesity epidemic, which highlights the importance of controlling weight and further reducing the burden of hypertension.

Exposure aboard high-performance Marine craft increases musculoskeletal pain and lowers contemporary work capacity of the occupants

2020 ◽  
pp. 147509022098146
Author(s):  
Manudul Pahansen de Alwis ◽  
Riccardo LoMartire ◽  
Björn O Äng ◽  
Karl Garme
Keyword(s):  
Neck Pain ◽  
Musculoskeletal Pain ◽  
High Performance ◽  
Occupational Exposures ◽  
Performance Degradation ◽  
Individual Risk ◽  
Work Related ◽  
Lower Back ◽  
And Performance ◽  
Exposure Conditions

High-Performance Marine Craft (HPMC) occupants are currently being investigated for various psychophysical impairments degrading work performance postulating that these deteriorations are related to their occupational exposures. However, scientific evidence for this is lacking and the association of exposure conditions aboard HPMC with adverse health and performance effects is unknown. Therefore, the study estimates the prevalence of musculoskeletal pain (MSP) among HPMC occupants and the association of their work exposure with MSP and performance degradation. It also presents a criterion for evaluating the self-reported exposure severity aboard three different types of mono-hull HPMC; displacement, semi-displacement and planing, on a par with the available standard criteria for objectively measurable exposures. Furthermore, another criterion is proposed to assess the performance-degradation of HPMC occupants based on self-reported fatigue symptoms and MSP. Swedish Coast Guard HPMC occupants were surveyed for MSP, fatigue symptoms as well as for work-related and individual risk indicators using a validated web-based questionnaire. Prevalence of MSP and performance-degradation during the past 12 months were assessed and presented as a percentage of the sample. Associations of exposure conditions aboard HPMC with MSP and performance-capacity were systematically evaluated using multiple logistic regression models and expressed as odds ratio (OR). Prevalence of MSP was 72% among which lower back pain was the most prevalent (46%) followed by neck pain (29%) and shoulder pain (23%) while 29% with degraded performance. Exposure to severe conditions aboard semi-displacement craft was associated with lower back (OR = 2.3) and shoulder (OR = 2.6) pain while severe conditions aboard planing craft with neck pain (OR = 2.3) and performance-degradation (OR = 2.6). MSP is common among Swedish coast guards. Severe exposure conditions aboard HPMC are significantly associated with both MSP and performance-degradation. The spine and shoulders are the most susceptible to work-related MSP among HPMC occupants which should be targeted in work-related preventive and corrective measures.

scholarly journals Community-based interventions for childhood asthma using comprehensive approaches: a systematic review and meta-analysis

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Mei Chan ◽  
Melinda Gray ◽  
Christine Burns ◽  
Louisa Owens ◽  
Susan Woolfenden ◽  
...  
Keyword(s):  
Systematic Review ◽  
Childhood Asthma ◽  
Action Plan ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Mean Difference ◽  
Cochrane Library ◽  
Care Utilization ◽  
Community Based Interventions ◽  
Community Based

Abstract Objective We conducted a systematic review and meta-analysis to determine the effectiveness of comprehensive community-based interventions with ≥ 2 components in improving asthma outcomes in children. Methods A systematic search of Medline, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Excerpta Medica Database (EMBASE), Cochrane Library and hand search of reference collections were conducted to identify any research articles published in English between 2000 and 2019. All studies reporting community-based asthma interventions with ≥ 2 components (e.g., asthma self-management education, home environmental assessment or care coordination etc.) for children aged ≤ 18 years were included. Meta-analyses were performed using random-effects model to estimate pooled odds ratio (OR) with 95% confidence intervals (CIs). Results Of the 2352 studies identified, 21 studies were included in the final analysis: 19 pre-post interventions, one randomised controlled trial (RCT) and one retrospective study. Comprehensive asthma programs with multicomponent interventions were associated with significant reduction in asthma-related Emergency Department (ED) visits (OR = 0.26; 95% CI 0.20–0.35), hospitalizations (OR = 0.24; 95% CI 0.15–0.38), number of days (mean difference = − 2.58; 95% CI − 3.00 to − 2.17) and nights with asthma symptoms (mean difference = − 2.14; 95% CI − 2.94 to − 1.34), use of short-acting asthma medications/bronchodilators (BD) (OR = 0.28; 95% CI 0.16–0.51), and increase use of asthma action plan (AAP) (OR = 8.87; 95% CI 3.85–20.45). Conclusion Community-based asthma care using more comprehensive approaches may improve childhood asthma management and reduce asthma related health care utilization.

Effect of thromboxane antagonists on ozone-induced airway responses in dogs

1990 ◽  
Vol 69 (3) ◽  
pp. 880-884 ◽  
Author(s):  
G. L. Jones ◽  
C. G. Lane ◽  
P. M. O'Byrne
Keyword(s):  
Airway Hyperresponsiveness ◽  
The Other ◽  
Receptor Antagonists ◽  
Thromboxane Receptor ◽  
Before And After ◽  
The Mean ◽  
Airway Responses ◽  
Control Infusion

Airway hyperresponsiveness after inhaled ozone in dogs may occur as a result of thromboxane release in the airway. In this study, two thromboxane receptor antagonists, L-655,240 and L-670,596, were used in doses that inhibit the response to an inhaled thromboxane mimetic, U-46619, to determine further the role of thromboxane in ozone-induced airway hyperresponsiveness. Dogs were studied on 2 days separated by 1 wk. On each day, the dogs inhaled ozone (3 ppm) for 30 min. On one randomly assigned day, 10 dogs received an infusion of L-655,240 (5 mg.kg-1.h-1) and 5 dogs received an infusion of L-670,596 (1 mg.kg-1.h-1); on the other day dogs received a control infusion. Airway responses to doubling doses of acetylcholine were measured before and after inhalation of ozone and were expressed as the concentration of acetylcholine giving a rise in resistance of 5 cmH2O.l-1.s from baseline (acetylcholine provocation concentration). The development of airway hyperresponsiveness after ozone was not inhibited by the thromboxane antagonists. The mean log difference in the acetylcholine provocative concentration before and after ozone on the L-655,240 treatment day was 0.62 +/- 0.12 (SE) and on the control day was 0.71 +/- 0.12 (P = 0.48); on the L-670,596 treatment day the mean log difference was 0.68 +/- 0.15 (SE) and on the control day it was 0.75 +/- 0.19 (P = 0.45). These results do not support an important role for thromboxane in causing ozone-induced airway hyperresponsiveness.

scholarly journals Population attributable risk of aflatoxin-related liver cancer: Systematic review and meta-analysis

2012 ◽  
Vol 48 (14) ◽  
pp. 2125-2136 ◽  
Author(s):  
Yan Liu ◽  
Chung-Chou H. Chang ◽  
Gary M. Marsh ◽  
Felicia Wu
Keyword(s):  
Systematic Review ◽  
Liver Cancer ◽  
Meta Analysis ◽  
Population Attributable Risk ◽  
Attributable Risk

scholarly journals Dimensions of social categorization: Inside the role of language

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0254513
Author(s):  
Anna Lorenzoni ◽  
Mikel Santesteban ◽  
Francesca Peressotti ◽  
Cristina Baus ◽  
Eduardo Navarrete
Keyword(s):  
Social Interactions ◽  
Basque Country ◽  
Social Categorization ◽  
The Other ◽  
Social Implications ◽  
Second Phase ◽  
Community Based ◽  
Daily Exposure ◽  
Bilingual Communities

The present pre-registration aims to investigate the role of language as a dimension of social categorization. Our critical aim is to investigate whether language can be used as a dimension of social categorization even when the languages coexist within the same sociolinguistic group, as is the case in bilingual communities where two languages are used in daily social interactions. We will use the memory confusion paradigm (also known as the Who said what? task). In the first part of the task, i.e. encoding, participants will be presented with a face (i.e. speaker) and will listen to an auditory sentence. Two languages will be used, with half of the faces always associated with one language and the other half with the other language. In the second phase, i.e. recognition, all the faces will be presented on the screen and participants will decide which face uttered which sentence in the encoding phase. Based on previous literature, we expect that participants will be more likely to confuse faces from within the same language category than from the other language category. Participants will be bilingual individuals of two bilingual communities, the Basque Country (Spain) and Veneto (Italy). The two languages of these communities will be used, Spanish and Basque (Study 1), and Italian and Venetian dialect (Study 2). Furthermore, we will explore whether the amount of daily exposure to the two languages modulates the effect of language as a social categorization cue. This research will allow us to test whether bilingual people use language to categorize individuals belonging to the same sociolinguistic community based on the language these individuals are speaking. Our findings may have relevant political and social implications for linguistic policies in bilingual communities.

scholarly journals Role of Epigenetics in the Pathogenesis, Treatment, Prediction, and Cellular Transformation of Asthma

2021 ◽  
Vol 2021 ◽  
pp. 1-18
Author(s):  
Binaya Wasti ◽  
Shao-kun Liu ◽  
Xu-Dong Xiang
Keyword(s):  
Old Age ◽  
Childhood Asthma ◽  
Developmental Trajectories ◽  
Influencing Factor ◽  
Cellular Transformation ◽  
Adult Onset ◽  
T Cell Therapy ◽  
Treatment Prediction ◽  
Genetic And Environmental Factors

Asthma is a mysterious disease with heterogeneity in etiology, pathogenesis, and clinical phenotypes. Although ongoing studies have provided a better understanding of asthma, its natural history, progression, pathogenesis, diversified phenotypes, and even the exact epigenetic linkage between childhood asthma and adult-onset/old age asthma remain elusive in many aspects. Asthma heritability has been established through genetic studies, but genetics is not the only influencing factor in asthma. The increasing incidence and some unsolved queries suggest that there may be other elements related to asthma heredity. Epigenetic mechanisms link genetic and environmental factors with developmental trajectories in asthma. This review provides an overview of asthma epigenetics and its components, including several epigenetic studies on asthma, and discusses the epigenetic linkage between childhood asthma and adult-onset/old age asthma. Studies involving asthma epigenetics present valuable novel approaches to solve issues related to asthma. Asthma epigenetic research guides us towards gene therapy and personalized T cell therapy, directs the discovery of new therapeutic agents, predicts long-term outcomes in severe cases, and is also involved in the cellular transformation of childhood asthma to adult-onset/old age asthma.

scholarly journals Adult’s Participation in Work-related Training: The Balance between Improving Job and a Desire for Learning

2016 ◽  
Vol 6 (1) ◽  
pp. 1
Author(s):  
Ana Inés Renta Davids ◽  
Manel Fandos-Garrido ◽  
José Miguel Jiménez-González ◽  
Ángel Pío González-Soto
Keyword(s):  
Factor Analysis ◽  
Quantitative Analysis ◽  
Continuing Education ◽  
Professional Training ◽  
Demographic Variables ◽  
The Other ◽  
One Dimension ◽  
Work Related ◽  
Different Types ◽  
Motivation To Participate

<p>The study draws on findings from a survey of adults in non-formal continuing education under the professional training for employment framework in Spain. Quantitative analysis was carried out to a sample of 425 respondents from three different educational providers. Firstly, a factor analysis was conducted to fourteen motives for participation items. A two-dimension model of motivation to participate was identified: one dimension oriented towards job-improvement and the other dimension oriented towards learning. Secondly, a variance analysis was conducted according to demographics variables. Results showed significant statistical differences in the first dimension according to demographic variables. This might indicates an instrumental motivation in participation in work-related training among different groups who try to cope with different types of drawbacks.</p>

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