scholarly journals Serum TNF-Alpha Level Predicts Nonproliferative Diabetic Retinopathy in Children

2007 ◽  
Vol 2007 ◽  
pp. 1-5 ◽  
Author(s):  
Katarzyna Zorena ◽  
Jolanta Myśliwska ◽  
Małgorzata Myśliwiec ◽  
Anna Balcerska ◽  
Łukasz Hak ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diabetic Retinopathy ◽  
Blood Pressure Monitoring ◽  
Young Patients ◽  
Albumin Excretion Rate ◽  
High Serum ◽  
Early Introduction ◽  
Albumin Excretion ◽  
Nonproliferative Diabetic Retinopathy

The aim of this study was identification of the immunologic markers of the damage to the eye apparatus at early stages of diabetes mellitus (DM) type 1 children. One hundred and eleven children with DM type 1 were divided into two groups: those with nonproliferative diabetic retinopathy (NPDR) and without retinopathy. All the children had their daily urine albumin excretion, HbA1c, C-peptide measured, 24-hour blood pressure monitoring, and ophthalmologic examination. Levels of TNF-α, IL-6, and IL-12 in serum were measured by ELISA tests (Quantikine High Sensitivity Human by R&D Systems, Minneapolis, Minn, USA). The NPDR children demonstrated a significantly longer duration of the disease in addition to higher HbA1c, albumin excretion rate, C-reactive protein, systolic blood pressure, as well as TNF-αand IL-6 levels than those without retinopathy. The logistic regression revealed that the risk of NPDR was strongly dependent on TNF-α[(OR 4.01; 95%CI 2.01–7.96)]. TNF-αappears to be the most significant predictor among the analyzed parameters of damage to the eye apparatus. The early introduction of the TNF-αantagonists to the treatment of young patients with DM type 1 who show high serum activity of the TNF-αmay prevent them from development of diabetic retinopathy.

Venular oxygen saturation is increased in young patients with type 1 diabetes and mild nonproliferative diabetic retinopathy

2020 ◽  
Vol 98 (8) ◽  
pp. 800-807 ◽  
Author(s):  
Nina C.B.B. Veiby ◽  
Aida Simeunovic ◽  
Martin Heier ◽  
Cathrine Brunborg ◽  
Naila Saddique ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Oxygen Saturation ◽  
Young Patients ◽  
Nonproliferative Diabetic Retinopathy

scholarly journals Associations between Macular OCT Angiography and Nonproliferative Diabetic Retinopathy in Young Patients with Type 1 Diabetes Mellitus

2020 ◽  
Vol 2020 ◽  
pp. 1-12 ◽  
Author(s):  
Nina C. B. B. Veiby ◽  
Aida Simeunovic ◽  
Martin Heier ◽  
Cathrine Brunborg ◽  
Naila Saddique ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Young Patients ◽  
Cross Sectional Study ◽  
Foveal Avascular Zone ◽  
Cross Sectional ◽  
Nonproliferative Diabetic Retinopathy ◽  
Capillary Plexus ◽  
Automated Software

Background/Objective. Optical coherence tomography angiography (OCTA) is increasingly used to supplement ophthalmoscopy in the diagnosis and follow-up of diabetic retinopathy. Our objective was to confirm if OCTA parameters can predict the development of nonproliferative diabetic retinopathy (NPDR) and to clarify if any single OCTA parameter is associated with NPDR independently of well-known risk factors in young type 1 diabetes (T1D) patients. Methods. OCTA of both eyes was performed in a cross-sectional study of 14 to 30-year-old individuals with at least 10-year duration of T1D and controls recruited from the Norwegian Atherosclerosis and Childhood Diabetes (ACD) study. Vessel density (VD) and foveal avascular zone (FAZ) area in the superficial and deep capillary plexus (SCP and DCP), total retinal volume (TRV), and central macular thickness (CMT) were calculated using automated software. Univariate and multivariate ordered logistic regression (OLR) models were used accordingly. Results. We included 168 control eyes and 315 T1D eyes. Lower VD in DCP (OR 0.65, 95% CI 0.51–0.83), longer diabetes duration (OR 1.51, 95% CI 1.22–1.87), and higher waist circumference (OR 1.08, 95% CI 1.02–1.14) were significantly associated with progression of NPDR. VD in SCP and DCP were significantly lower in T1D patients without diabetic retinopathy than in controls. Conclusions. Sparser VD in DCP is significantly associated with severity of NPDR, supporting that OCTA might detect the earliest signs of NPDR before it is visible by ophthalmoscopy.

Retinal changes and alterations in blood pressure and albumin excretion rate (AER) during exercise in type 1 diabetes

1991 ◽  
Vol 11 (3) ◽  
pp. 189-193 ◽  
Author(s):  
Satish K. Garg ◽  
H. Peter Chase ◽  
William E. Jackson ◽  
Sherrie Harris ◽  
Guillermo Marshall ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 1 Diabetes ◽  
Excretion Rate ◽  
Albumin Excretion Rate ◽  
Albumin Excretion

Clinic blood pressure shows low sensitivity to detect alterations in ambulatory blood pressure monitoring in patients with type 1 diabetes

2014 ◽  
Author(s):  
Francisco Javier Vilchez-Lopez ◽  
Isabel Mateo-Gavira ◽  
Florentino Carral-San Laureano ◽  
Maria Victoria Garcia-Palacios ◽  
Jose Ortego-Rojo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 1 Diabetes ◽  
Ambulatory Blood Pressure Monitoring ◽  
Ambulatory Blood Pressure ◽  
Blood Pressure Monitoring ◽  
Clinic Blood Pressure ◽  
Pressure Monitoring ◽  
Low Sensitivity

Evaluation of baroreceptor reflex by blood pressure monitoring in unanesthetized cats

1988 ◽  
Vol 254 (2) ◽  
pp. H377-H383 ◽  
Author(s):  
G. Bertinieri ◽  
M. Di Rienzo ◽  
A. Cavallazzi ◽  
A. U. Ferrari ◽  
A. Pedotti ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Regression Coefficient ◽  
Blood Pressure Monitoring ◽  
Sinus Node ◽  
Pulse Interval ◽  
Pressure Monitoring ◽  
Physiological Conditions ◽  
Average Variation

The arterial baroreceptor control of the sinus node operating in unanesthetized conditions was evaluated in 10 cats in which blood pressure was recorded intra-arterially and scanned by a computer to identify the "spontaneous" sequences of three or more consecutive beats in which systolic blood pressure (SBP) progressively rose and pulse interval (PI) progressively lengthened (type 1 sequences) or SBP progressively fell and PI progressively shortened (type 2 sequences). Many type 1 and 2 three-beat sequences were found; four-, five-, and six-beat sequences of either type were progressively less common, and sequences longer than six beats were almost never identified. The regression coefficient was 30% greater for type 1 than for type 2 sequences. However a prominent feature of either regression coefficient was a wide scattering in each cat (average variation coefficient 50.9 +/- 5.5%). The regression coefficient values were related to some extent to the PI but not to the SBP existing at the beginning of the sequence. Sinoaortic denervation dramatically reduced the number of sequences of either type. These data validate a method for collecting a large number of observations on the baroreceptor-heart rate reflex in physiological conditions. This method may improve understanding of baroreflex involvement in integrated cardiovascular regulation.

scholarly journals INSULIN DEPENDENT DIABETES MELLITUS

2009 ◽  
Vol 16 (02) ◽  
pp. 178-186
Author(s):  
MUHAMMAD USMAN KHURSHID ◽  
MANSOOR-UL-HASSAN ALV I
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Sialic Acid ◽  
Urinary Albumin Excretion ◽  
Microvascular Complications ◽  
Urinary Albumin ◽  
Elevated Plasma ◽  
Albumin Excretion

A i m s & O b j e c t i v e s : To test the hypothesis that an increased plasma concentration of sialic acid, a marker of the acutephaseresponse, is related to the presence of diabetic retinopathy in type 1 diabetes mellitus or Insulin Dependant Diabetes Mellitus (IDDM).R e s e a r c h D e s i g n a n d M e t h o d s : We investigated the relationship between plasma sialic acid concentration and diabetic retinopathy in across-sectional survey of 1,369 people with type 1 diabetes. Subjects were participants in the IDDM Complications Study, which involveddiabetic centers of four different hospitals in Lahore. Results: There was a significantly increasing trend of plasma sialic acid with severityof retinopathy (P < 0.001 in men) and with degree of urinary albumin excretion (P < 0.001 men, P < 0.01 women). Elevated plasma sialicacid concentrations were also associated with several risk factors for diabetic vascular disease: diabetes duration, HbAlc, plasma triglycerideand cholesterol concentrations, waist-to-hip ratio, hypertension and smoking (in men), and low physical exercise (in women). In multiplelogistic regression analysis, plasma sialic acid was independently related to proliferative retinopathy and urinary albumin excretion rate inmen. Conclusions: We concluded that an elevated plasma sialic concentration is strongly related to the presence of microvascularcomplications in type 1 diabetes with retinopathy and nephropathy. Further study of acute-phase response markers and mediators asindicators or predictors of diabetic microvascular complications is therefore justified.

Sign in / Sign up

Export Citation Format

Share Document