Venular oxygen saturation is increased in young patients with type 1 diabetes and mild nonproliferative diabetic retinopathy

2020 ◽  
Vol 98 (8) ◽  
pp. 800-807 ◽  
Author(s):  
Nina C.B.B. Veiby ◽  
Aida Simeunovic ◽  
Martin Heier ◽  
Cathrine Brunborg ◽  
Naila Saddique ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Oxygen Saturation ◽  
Young Patients ◽  
Nonproliferative Diabetic Retinopathy

scholarly journals Associations between Macular OCT Angiography and Nonproliferative Diabetic Retinopathy in Young Patients with Type 1 Diabetes Mellitus

2020 ◽  
Vol 2020 ◽  
pp. 1-12 ◽  
Author(s):  
Nina C. B. B. Veiby ◽  
Aida Simeunovic ◽  
Martin Heier ◽  
Cathrine Brunborg ◽  
Naila Saddique ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Young Patients ◽  
Cross Sectional Study ◽  
Foveal Avascular Zone ◽  
Cross Sectional ◽  
Nonproliferative Diabetic Retinopathy ◽  
Capillary Plexus ◽  
Automated Software

Background/Objective. Optical coherence tomography angiography (OCTA) is increasingly used to supplement ophthalmoscopy in the diagnosis and follow-up of diabetic retinopathy. Our objective was to confirm if OCTA parameters can predict the development of nonproliferative diabetic retinopathy (NPDR) and to clarify if any single OCTA parameter is associated with NPDR independently of well-known risk factors in young type 1 diabetes (T1D) patients. Methods. OCTA of both eyes was performed in a cross-sectional study of 14 to 30-year-old individuals with at least 10-year duration of T1D and controls recruited from the Norwegian Atherosclerosis and Childhood Diabetes (ACD) study. Vessel density (VD) and foveal avascular zone (FAZ) area in the superficial and deep capillary plexus (SCP and DCP), total retinal volume (TRV), and central macular thickness (CMT) were calculated using automated software. Univariate and multivariate ordered logistic regression (OLR) models were used accordingly. Results. We included 168 control eyes and 315 T1D eyes. Lower VD in DCP (OR 0.65, 95% CI 0.51–0.83), longer diabetes duration (OR 1.51, 95% CI 1.22–1.87), and higher waist circumference (OR 1.08, 95% CI 1.02–1.14) were significantly associated with progression of NPDR. VD in SCP and DCP were significantly lower in T1D patients without diabetic retinopathy than in controls. Conclusions. Sparser VD in DCP is significantly associated with severity of NPDR, supporting that OCTA might detect the earliest signs of NPDR before it is visible by ophthalmoscopy.

Evaluation of the technical features of vitreoretinal surgery for proliferative diabetic retinopathy in young patients

Reflection ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 36-42
Author(s):  
O.V. Kolenko ◽  
◽  
Y.B. Lebedev ◽  
A.Y. Khudyakov ◽  
E.L. Sorokin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Type 1 Diabetes Mellitus ◽  
Proliferative Diabetic Retinopathy ◽  
Young Patients ◽  
Vitreoretinal Surgery ◽  
High Tendency ◽  
Type 1 Dm

Aim. To investigate the technical difficulties of performing the stages of vitreoretinal surgery, the peculiarities of the surgical technique in young patients with the proliferative stage of diabetic retinopathy (DR). Methods. Twelve patients (12 eyes) with type 1 diabetes mellitus (DM) were selected. Their average age was 26±2 years (from 19 to 30 years). There were 4 men and 8 women. All patients had DM since childhood. Selection criteria: presence of indications for vitreoretinal surgery for proliferative DR, age of patients with type 1 DM not more than 30 years, onset of DM in childhood. Results. Initially, the clinical manifestations of proliferative DR in young people with type 1 DM were distinguished by the severity of neovascular and fibrous growths, a tendency to hemorrhages, and the complexity of preoperative preparation in the form of panretinal laser coagulation, at least partial. Surgical removal of vitreoretinal adhesions and elimination of neovascularization zones differed in technical difficulties associated with their higher density and the area of retinal tissue lesion. Conclusion. Surgical treatment of proliferative DR in young patients has a number of technical difficulties associated with the density and length of fibrovascular vitreoretinal growths, the difficulty of separating them due to the high tendency of newly formed vessels to hemorrhages. Key words: proliferative diabetic retinopathy; endovitreal surgery; type 1 diabetes mellitus; young age.

scholarly journals Serum TNF-Alpha Level Predicts Nonproliferative Diabetic Retinopathy in Children

2007 ◽  
Vol 2007 ◽  
pp. 1-5 ◽  
Author(s):  
Katarzyna Zorena ◽  
Jolanta Myśliwska ◽  
Małgorzata Myśliwiec ◽  
Anna Balcerska ◽  
Łukasz Hak ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diabetic Retinopathy ◽  
Blood Pressure Monitoring ◽  
Young Patients ◽  
Albumin Excretion Rate ◽  
High Serum ◽  
Early Introduction ◽  
Albumin Excretion ◽  
Nonproliferative Diabetic Retinopathy

The aim of this study was identification of the immunologic markers of the damage to the eye apparatus at early stages of diabetes mellitus (DM) type 1 children. One hundred and eleven children with DM type 1 were divided into two groups: those with nonproliferative diabetic retinopathy (NPDR) and without retinopathy. All the children had their daily urine albumin excretion, HbA1c, C-peptide measured, 24-hour blood pressure monitoring, and ophthalmologic examination. Levels of TNF-α, IL-6, and IL-12 in serum were measured by ELISA tests (Quantikine High Sensitivity Human by R&D Systems, Minneapolis, Minn, USA). The NPDR children demonstrated a significantly longer duration of the disease in addition to higher HbA1c, albumin excretion rate, C-reactive protein, systolic blood pressure, as well as TNF-αand IL-6 levels than those without retinopathy. The logistic regression revealed that the risk of NPDR was strongly dependent on TNF-α[(OR 4.01; 95%CI 2.01–7.96)]. TNF-αappears to be the most significant predictor among the analyzed parameters of damage to the eye apparatus. The early introduction of the TNF-αantagonists to the treatment of young patients with DM type 1 who show high serum activity of the TNF-αmay prevent them from development of diabetic retinopathy.

Features of surgery for proliferative diabetic retinopathy in young patients

2021 ◽  
pp. 113-116
Author(s):  
Y.B. Lebedev ◽  
◽  
A.Y. Khudyakov ◽  
E.L. Sorokin ◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Young Patients ◽  
Vitreoretinal Surgery ◽  
Dense Adhesion ◽  
Varying Length ◽  
Technical Features

Purpose. To investigate the technical features and difficulties of performing vitreoretinal surgery in proliferative diabetic retinopathy (DR) in young patients. Material and methods. 12 patients (12 eyes) aged 19 to 30 years, averaging 26±2 years. There were 4 men and 8 women. All patients had diabetes mellitus (DM) in childhood. The duration of type 1 diabetes ranged from 12 to 18 years. Results. Initially, 8 eyes showed combined retinal and peripapillary neovascularization with gliza on the vascular arcades. In 4 eyes, there was both diffuse hemophthalmos and preretinal clots of varying length and volume. In 8 eyes, dense adhesion of the altered posterior hyaloid membrane and the inner border membrane was revealed. In 4 eyes, vasoproliferative membranes were determined, which contributed to the development of traction effects on the retina. The most dangerous was the traction component on the macular retina. Conclusion. Surgical treatment of proliferative DR in young patients has a number of technical difficulties associated with the anatomical features of the macular interface and the features of the proliferative response to surgery. Noteworthy is the minimum time for the transition of DR to the proliferative stage. Key words: proliferative diabetic retinopathy, endovitreal surgery, type 1 diabetes mellitus.

ANALYSIS OF RETINAL CAPILLARIES IN PATIENTS WITH TYPE 1 DIABETES AND NONPROLIFERATIVE DIABETIC RETINOPATHY USING ADAPTIVE OPTICS IMAGING

Retina ◽  
2013 ◽  
Vol 33 (8) ◽  
pp. 1630-1639 ◽  
Author(s):  
Marco Lombardo ◽  
Mariacristina Parravano ◽  
Sebastiano Serrao ◽  
Pietro Ducoli ◽  
Mario Stirpe ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Adaptive Optics ◽  
Nonproliferative Diabetic Retinopathy ◽  
Adaptive Optics Imaging ◽  
Retinal Capillaries
Sign in / Sign up

Export Citation Format

Share Document