scholarly journals HPV Infection in Men

2007 ◽  
Vol 23 (4) ◽  
pp. 261-272 ◽  
Author(s):  
Joel M. Palefsky
Keyword(s):  
Natural History ◽  
Hpv Vaccination ◽  
Intraepithelial Neoplasia ◽  
Visual Assessment ◽  
Hpv Infection ◽  
Hiv Positive ◽  
History Of ◽  
Sex With Men ◽  
The Impact ◽  
Cervical Human Papillomavirus

While much is known about the natural history of cervical human papillomavirus (HPV) infection and its consequences, including cervical intraepithelial neoplasia and cervical cancer, relatively little is known about the natural history of anogenital HPV infection and diseases in men. In part this reflects difficulties in penile sampling and visual assessment of penile lesions. Anal HPV infection and disease also remain poorly understood. Although HPV is transmitted sexually and infects the genitals of both sexes, the cervix remains biologically more vulnerable to malignant transformation than does the penis or anus in men. An understanding of male HPV infection is therefore important in terms of reducing transmission of HPV to women and improving women's health. However, it is also important due to the burden of disease in men, who may develop both penile and anal cancer, particularly among HIV-positive men who have sex with men. Improved sampling techniques of the male genitalia and cohort studies in progress should provide important information on the natural history of anogenital HPV infection and disease in men, including risk factors for HPV acquisition and transmission. The impact of HPV vaccination in women on male anogenital HPV infection will also need to be assessed.

scholarly journals HIV-positive MSM’s knowledge of HPV and anal cancer self-sampling: A scoping review

2018 ◽  
Vol 25 (1) ◽  
pp. 83 ◽  
Author(s):  
M.K.L. Poon ◽  
J.P.H. Wong ◽  
A.T.W. Li ◽  
M. Manuba ◽  
A. Bisignano ◽  
...  
Keyword(s):  
Anal Cancer ◽  
Scoping Review ◽  
Cancer Education ◽  
Hpv Vaccination ◽  
Cell Cancer ◽  
Hpv Infection ◽  
Hiv Positive ◽  
Policy Makers ◽  
High Prevalence ◽  
Sex With Men

Human papillomavirus (hpv) infection is the cause of anal squamous cell cancer (ascc) in 80% of cases. Available research has also shown high prevalence of anal hpv infection among men who have sex with men (msm). However, hpv vaccination is low among msm in Canada. In light of this information, we conducted a scoping review with the aim of exploring (1) the knowledge of hpv and anal cancer among hiv-positive msm and (2) the acceptability of hpv and anal cancer self-sampling in this population. In conducting the review, we searched five electronic databases for peer-reviewed articles and abstracts published in English, between 2007 and 2017. A total of 803 articles were retrieved; after accounting for duplicates (n=40) and unmet criteria (n=754), a total of 794 articles were excluded. A final total of nine articles were used in this review. Results of this review show that hiv-positive msm have limited knowledge regarding the risks of anal cancer associated with hiv and hpv coinfection. Furthermore, there is limited research on hpv and anal cancer self-sampling in this population. However, the review of available studies suggested that hiv-positive msm were open to anal cancer self-sampling. It also identified potential barriers to self-sampling. In conclusion, we provide suggestions and future directions for policy-makers and educators to develop inclusive and accessible strategies to reach hiv-positive msm regarding anal cancer education and self-screening.

scholarly journals Prevalence of Oral Human Papillomavirus Infection among Indian HIV-Positive Men Who Have Sex With Men: A Cross-Sectional Study

2020 ◽  
Author(s):  
Alexandra Lydia Hernandez ◽  
Rajiv Karthik ◽  
Murugesan Sivasubramanian ◽  
Anantharam Raghavendran ◽  
Shelly Lensing ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Hpv Infection ◽  
Sexual History ◽  
Hiv Positive ◽  
Increased Risk ◽  
Oral Hpv ◽  
Hpv Types ◽  
Sex With Men ◽  
The Impact ◽  
Hiv Positive Men

Abstract Background: Oral human papillomavirus (HPV) infection has been causally linked to a subset of oropharyngeal cancers in Western populations15-20, and both oropharyngeal cancer and oral HPV infection are increased among HIV-positive individuals24,41. India has high incidences of oral and oropharyngeal cancers, and Indian HIV-positive men who have sex with men (MSM) may be at increased risk of developing oropharyngeal cancers. However, there is little information available on the prevalence of oral HPV in this population.Methods: We tested 302 HIV-positive Indian MSM for oral HPV infection using L1 HPV DNA PCR with probes specific for 29 types and a mixture of 10 additional types. CD4+ level and plasma HIV viral load (VL) were measured. Participants completed an interviewer-administered questionnaire including a sexual history.Results: The prevalence of oral HPV was 23.7% (95% CI: 19-29%) and 2.4% of participants had oncogenic HPV types. No participants had oral HPV type 16 (HPV-16) and the prevalence of other anogenital HPV types was low. Participants with higher CD4+ levels had reduced odds of having any oral HPV infection (OR: 3.1 [1.4-6.9]) in multivariable analyses.Conclusions: This is the first report of oral HPV among Indian HIV-positive MSM. Our results show a high prevalence of oral HPV infection consistent with studies from Western populations. However, oncogenic anogenital HPV types were relatively uncommon in our study population. It is unknown what the impact of this distribution of oral HPV will be on oropharyngeal cancers. HIV-positive MSM in India should be monitored closely for oral and oropharyngeal pre-cancer and cancer.

14. Natural history of high-grade squamous intraepithelial lesions (HSIL) in homosexual men: early evidence from the Study of the Prevention of Anal Cancer (SPANC)

Sexual Health ◽  
2013 ◽  
Vol 10 (6) ◽  
pp. 576 ◽  
Author(s):  
Andrew E. Grulich ◽  
Fengyi Jin ◽  
I. Mary Poynten ◽  
Jennifer Roberts ◽  
Annabelle Farnsworth ◽  
...  
Keyword(s):  
Natural History ◽  
Anal Cancer ◽  
Cochrane Review ◽  
Intraepithelial Neoplasia ◽  
Hiv Positive ◽  
Homosexual Men ◽  
National Guidelines ◽  
Anal Swab ◽  
History Of ◽  
Hiv Negative

Background Screening for the anal cancer precursor HSIL is not recommended in national guidelines. A recent Cochrane review of HSIL treatment concluded there is no evidence of efficacy. In this context, we aimed to describe the natural history of anal HSIL, and association with human papillomavirus (HPV), in a community-recruited cohort of Australian homosexual men. Methods: The SPANC study is a three-year prospective study in men aged ≥35 years. At each visit, men undergo an anal swab for cytology and HPV genotyping (Roche Linear Array), followed by high-resolution anoscopy-aided biopsy. Anal HSIL is defined as having either anal intraepithelial neoplasia grade 2/3 on histology and/or HSIL/ASC-H on cytology. Results: Among 342 men recruited by March 2013, median age was 49 with 29% HIV positive. At baseline, prevalence of anal HSIL was 50% and 44% in the HIV-positive and HIV-negative groups, respectively (P = 0.303). Among those without HSIL at baseline, HSIL incidence was 28/100 person-years in both the HIV-positive and HIV-negative groups (P = 0.920). Among those with HSIL at baseline, the incidence of change to non-HSIL was 41 and 43/100 person-years (P = 0.851). Men with anal HPV16 at baseline were more likely to develop incident HSIL (57 vs 23/100 person-years, P = 0.010), and less likely to change to non-HSIL (18 vs 61/100 person-years, P = 0.001). Conclusions: Anal HSIL was highly prevalent in these homosexual men. Both incidence of HSIL and change to non-HSIL were common, and were closely associated with HPV16 status. HPV16 positivity may identify men with HSIL at higher risk of anal cancer.

scholarly journals Prevalence of Oral Human Papillomavirus Infection among Indian HIV-positive Men who have Sex with Men: A Cross-Sectional Study

2021 ◽  
Author(s):  
Alexandra Lydia Hernandez ◽  
Rajiv Karthik ◽  
Murugesan Sivasubramanian ◽  
Anantharam Raghavendran ◽  
Shelly Lensing ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Hpv Infection ◽  
Sexual History ◽  
Hiv Positive ◽  
Increased Risk ◽  
Oral Hpv ◽  
Hpv Types ◽  
Sex With Men ◽  
The Impact ◽  
Hiv Positive Men

Abstract Background: Oral human papillomavirus (HPV) infection has been causally linked to a subset of oropharyngeal cancers in Western populations15-20, and both oropharyngeal cancer and oral HPV infection are increased among HIV-positive individuals24,41. India has high incidences of oral and oropharyngeal cancers, and Indian HIV-positive men who have sex with men (MSM) may be at increased risk of developing oropharyngeal cancers. However, there is little information available on the prevalence of oral HPV in this population.Methods: We tested 302 HIV-positive Indian MSM for oral HPV infection using L1 HPV DNA PCR with probes specific for 29 types and a mixture of 10 additional types. CD4+ level and plasma HIV viral load (VL) were measured. Participants completed an interviewer-administered questionnaire including a sexual history.Results: The prevalence of oral HPV was 23.7% (95% CI: 19-29%) and 2.4% of participants had oncogenic HPV types. No participants had oral HPV type 16 (HPV-16) and the prevalence of other anogenital HPV types was low. Participants with higher CD4+ levels had reduced odds of having any oral HPV infection (OR: 3.1 [1.4-6.9]) in multivariable analyses. Conclusions: This is the first report of oral HPV among Indian HIV-positive MSM. Our results show a high prevalence of oral HPV infection consistent with studies from Western populations. However, oncogenic anogenital HPV types were relatively uncommon in our study population. It is unknown what the impact of this distribution of oral HPV will be on oropharyngeal cancers. HIV-positive MSM in India should be monitored closely for oral and oropharyngeal pre-cancer and cancer.

scholarly journals Natural History of Cervical Intraepithelial Neoplasia-2 in HIV-Positive Women of Reproductive Age

2018 ◽  
Vol 79 (5) ◽  
pp. 573-579
Author(s):  
Christine Colie ◽  
Katherine G. Michel ◽  
Leslie S. Massad ◽  
Cuiwei Wang ◽  
Gypsyamber DʼSouza ◽  
...  
Keyword(s):  
Natural History ◽  
Cervical Intraepithelial Neoplasia ◽  
Intraepithelial Neoplasia ◽  
Reproductive Age ◽  
Hiv Positive ◽  
Women Of Reproductive Age ◽  
Hiv Positive Women ◽  
History Of

Epidemiology, natural history and risk factors for anal intraepithelial neoplasia

Sexual Health ◽  
2012 ◽  
Vol 9 (6) ◽  
pp. 547 ◽  
Author(s):  
François Coutlée ◽  
Alexandra de Pokomandy ◽  
Eduardo L. Franco
Keyword(s):  
Natural History ◽  
Intraepithelial Neoplasia ◽  
Anal Intercourse ◽  
Hpv Infection ◽  
Anal Intraepithelial Neoplasia ◽  
Receptive Anal Intercourse ◽  
High Grade ◽  
Cell Counts ◽  
Sex With Men ◽  
Hiv Seropositive

Studies conducted in HIV-seropositive individuals have enhanced our understanding of the natural history of anal intraepithelial neoplasia (AIN) and of factors predictive of progression to high-grade AIN, the immediate precursor to anal cancer. AIN is frequently detected in HIV-seropositive individuals. Factors that increase the risk for AIN include HIV infection, low current or nadir blood CD4+ cell counts, receptive anal intercourse, oncogenic human papillomavirus (HPV) infection, persistent anal HPV infection, multiple HPV type infections and high anal HPV viral load. This review confirms the importance of high-grade AIN in HIV-seropositive individuals and HIV-seronegative men having sex with men.

scholarly journals Impact of a Gender-Neutral HPV Vaccination Program in Men Who Have Sex with Men (MSM)

2021 ◽  
Vol 18 (3) ◽  
pp. 963
Author(s):  
Javier Díez-Domingo ◽  
Víctor Sánchez-Alonso ◽  
Rafael-J. Villanueva ◽  
Luis Acedo ◽  
José Tuells
Keyword(s):  
Vaccine Coverage ◽  
Hpv Vaccination ◽  
Herd Immunity ◽  
Hpv Infection ◽  
Vaccination Program ◽  
Force Of Infection ◽  
Long Term Effect ◽  
Gender Neutral ◽  
Sex With Men ◽  
The Impact

A major challenge in human papillomavirus (HPV) vaccine programs is the universal gender-neutral recommendation, as well as estimation of its long-term effect. The objective of this study is to predict the added benefit of male vaccination, especially in men who have sex with men (MSM), and to analyze the impact of the program on society. We propose a mathematical model of the HPV infection based on a network paradigm. Data from Spain allowed constructing the sexual network. HPV force of infection was taken from literature. Different scenarios using variable vaccine coverage in both males and females were studied. Strong herd immunity is shown in the heterosexual population, with an important decrease of HPV 6/11 infections both in men and in unvaccinated women with an only-women vaccination at 14 years of age. No impact of this program occurred in the infection incidence in MSM. This group would only benefit from a vaccination program that includes males. However, the impact at short term would be lower than in heterosexual men. The protection of MSM can only be achieved by direct vaccination of males. This may have important consequences for public health.

The epidemiology and natural history of anal human papillomavirus infection in men who have sex with men

Sexual Health ◽  
2012 ◽  
Vol 9 (6) ◽  
pp. 527 ◽  
Author(s):  
Dorothy A. Machalek ◽  
Andrew E. Grulich ◽  
Fengyi Jin ◽  
David J. Templeton ◽  
I. Mary Poynten
Keyword(s):  
Risk Factors ◽  
Human Papillomavirus ◽  
Natural History ◽  
English Language ◽  
Epidemiological Data ◽  
Hpv Infection ◽  
Medline Search ◽  
Infection Dynamics ◽  
History Of ◽  
Sex With Men

Studies on the epidemiology and natural history of anal human papillomavirus (HPV) infection are essential to understand the significance of this virus in the aetiology of anal cancer in men who have sex with men (MSM). This paper presents a review of studies on anal HPV in MSM. For this review, a Medline search was performed to identify English-language articles published in peer-reviewed journals on the epidemiology, natural history and risk factors for anal HPV infection in MSM. Anal HPV prevalence is high in MSM and infection with multiple HPV types is common. The available prospective data suggest detection of new anal HPV infections may also be common. However, with limited epidemiological data available on infection dynamics and associated behavioural risk factors, it is difficult to draw conclusions on how persistent anal HPV infection is in this population.

scholarly journals Influence of Human Papillomavirus Infection on the Natural History of Cervical Intraepithelial Neoplasia 1: A Meta-Analysis

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Mingzhu Liu ◽  
Xiaolong Yan ◽  
Mei Zhang ◽  
Xiaoju Li ◽  
Shugang Li ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Natural History ◽  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Negative Group ◽  
Positive Group ◽  
Increased Risk ◽  
History Of ◽  
High Risk Hpv

Objective. To provide a scientific basis for the prevention and treatment of cervical intraepithelial neoplasia grade 1 (CIN1). This study evaluated the impact of human papillomavirus (HPV) infection on the natural history of CIN1. Methods. Electronic databases of Cochrane Library, EMBASE, PubMed, CNKI, CBM, and Wanfang were searched in April 2016. The eligibility criteria were documented by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We used the Newcastle-Ottawa scale (NOS) to assess study quality. Results. Thirty-eight studies out of 3,246 identified papers were eligible for inclusion. The risk of CIN1 progression (relative risk [RR]: 3.04; 95% confidence interval [CI]: 2.41–3.83; P<0.00001) and persistence (RR: 1.48; 95% CI: 1.17–1.87; P=0.001) was higher in the HPV-positive group than HPV-negative group. Specifically, the risk of CIN1 progression (RR: 13.91; 95% CI: 3.46–55.90; P=0.000) was higher among persistent high-risk HPV-positive patients and the ratio of CIN1 regression (RR: 0.65; 95% CI: 0.59–0.71; P<0.00001) was lower in the HPV-positive group than HPV-negative group. Conclusion. HPV infection resulted in an increased risk of CIN1 progression and decreased disease reversibility. Persistent high-risk HPV infection resulted in a further increased risk of CIN1 progression.

scholarly journals Estimating the Natural History of Cervical Carcinogenesis Using Simulation Models: A CISNET Comparative Analysis

2019 ◽  
Vol 112 (9) ◽  
pp. 955-963 ◽  
Author(s):  
Emily A Burger ◽  
Inge M C M de Kok ◽  
Emily Groene ◽  
James Killen ◽  
Karen Canfell ◽  
...  
Keyword(s):  
Natural History ◽  
Hpv Vaccination ◽  
Epidemiological Data ◽  
Comparative Modeling ◽  
Age Of Acquisition ◽  
Hpv Infection ◽  
Cancer Development ◽  
Cervical Carcinogenesis ◽  
Screening Guidelines ◽  
History Of

Abstract Background The natural history of human papillomavirus (HPV)-induced cervical cancer (CC) is not directly observable, yet the age of HPV acquisition and duration of preclinical disease (dwell time) influences the effectiveness of alternative preventive policies. We performed a Cancer Intervention and Surveillance Modeling Network (CISNET) comparative modeling analysis to characterize the age of acquisition of cancer-causing HPV infections and implied dwell times for distinct phases of cervical carcinogenesis. Methods Using four CISNET-cervical models with varying underlying structures but fit to common US epidemiological data, we estimated the age of acquisition of causal HPV infections and dwell times associated with three phases of cancer development: HPV, high-grade precancer, and cancer sojourn time. We stratified these estimates by HPV genotype under both natural history and CC screening scenarios, because screening prevents cancer development that affects the mix of detected cancers. Results The median time from HPV acquisition to cancer detection ranged from 17.5 to 26.0 years across the four models. Three models projected that 50% of unscreened women acquired their causal HPV infection between ages 19 and 23 years, whereas one model projected these infections occurred later (age 34 years). In the context of imperfect compliance with US screening guidelines, the median age of causal infection was 4.4–15.9 years later compared with model projections in the absence of screening. Conclusions These validated CISNET-CC models, which reflect some uncertainty in the development of CC, elucidate important drivers of HPV vaccination and CC screening policies and emphasize the value of comparative modeling when evaluating public health policies.

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