scholarly journals Chronic Urticaria: A Cutaneous Manifestation of Celiac Disease

2006 ◽  
Vol 20 (4) ◽  
pp. 291-293 ◽  
Author(s):  
Jessica Haussmann ◽  
Arni Sekar
Keyword(s):  
Celiac Disease ◽  
Small Bowel ◽  
Gastrointestinal Symptoms ◽  
Cutaneous Manifestation ◽  
Cutaneous Manifestations ◽  
Asymptomatic Patients ◽  
Immune Mediated ◽  
Gluten Sensitive Enteropathy ◽  
Gastrointestinal Complaints ◽  
Iron Folic Acid

Celiac disease, or gluten-sensitive enteropathy, is an immune-mediated disease of the small bowel that results in malabsorption. It classically presents with gastrointestinal symptoms including chronic diarrhea, weight loss, abdominal bloating and anorexia. It is becoming more frequently identified in asymptomatic patients with a diagnosis of deficiencies related to malabsorption of iron, folic acid, vitamin B12and vitamin D. It is increasingly identified as a cause for early or refractory osteoporosis. Occasionally, celiac disease presents with cutaneous manifestations alone. Dermatitis herpetiformis is a well-recognized cutaneous manifestation of celiac disease. Other cutaneous manifestations include alopecia, angular stomatitis and aphthous ulcerations. Described here is a case of a 24-year-old woman who presented with intermittent urticaria and gastrointestinal complaints. She was found to have celiac disease on small-bowel biopsy. Both her gastrointestinal symptoms and urticaria resolved when she was put on a gluten-free diet, suggesting that her urticaria was a cutaneous manifestation of celiac disease.

scholarly journals Celiac Disease and Dermatologic Manifestations: Many Skin Clue to Unfold Gluten-Sensitive Enteropathy

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Marzia Caproni ◽  
Veronica Bonciolini ◽  
Antonietta D'Errico ◽  
Emiliano Antiga ◽  
Paolo Fabbri
Keyword(s):  
Celiac Disease ◽  
Skin Diseases ◽  
Dermatitis Herpetiformis ◽  
Inflammatory Diseases ◽  
Cutaneous Manifestation ◽  
Cutaneous Manifestations ◽  
Intestinal Diseases ◽  
Diagnostic Aspects ◽  
Gluten Sensitive Enteropathy ◽  
Dermatologic Manifestations

Cutaneous manifestations of intestinal diseases are increasingly reported both in the adult and in the children, and this association cannot longer be considered a simple random. Besides the well-known association between celiac disease (CD) and dermatitis herpetiformis (DH), considered as the cutaneous manifestation of gluten-dependent enteropathy, is more frequently reported also the association with other mucocutaneous diseases. Among these there are both autoimmune, allergic, and inflammatory diseases, but also a more heterogeneous group called miscellaneous. The knowledge about pathogenic, epidemiological, clinical, and diagnostic aspects of CD is increasing in recent years as well as those about DH, but some aspects still remain to be defined, in particular the possible pathogenetic mechanisms involved in the association between both CD and DH and CD and other immunological skin diseases. The aim of this paper is to describe the skin diseases frequently associated with CD, distinguishing them from those which have a relationship probably just coincidental.

scholarly journals Cutaneous and Mucosal Manifestations Associated to Celiac Disease

2018 ◽  
Author(s):  
Luis Rodrigo ◽  
Valia-Patricia Beteta ◽  
Nuria Álvarez ◽  
Celia Gómez de Castro ◽  
Álvaro de Dios ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Skin Diseases ◽  
Dermatitis Herpetiformis ◽  
Wide Spectrum ◽  
Gastrointestinal Symptoms ◽  
The Other ◽  
Gluten Free ◽  
Cutaneous Manifestations ◽  
Immune Mediated ◽  
Associated Conditions

Celiac disease (CD) is an immune-mediated gluten-induced enteropathy that affects predisposed individuals of all ages. Many patients with CD do not report gastrointestinal symptoms making it difficult to reach an early diagnosis. On the other hand, CD is related to a wide spectrum of extra-intestinal manifestations, being dermatitis herpetiformis (DH) the best characterized. These associated conditions may be the clue for reaching the diagnosis of CD. Over the last years, there have been multiple reports of the association between CD and several cutaneous manifestations that may improve with a gluten-free diet (GFD). The presence of some of these skin diseases, even in absence of gastrointestinal symptoms, should give rise to an appropriate screening for CD. The aim of this paper is to describe the different cutaneous manifestations that have been associated to CD and the possible mechanisms involved.

scholarly journals Molecular Biomarkers for Celiac Disease: Past, Present and Future

2020 ◽  
Vol 21 (22) ◽  
pp. 8528
Author(s):  
Aarón D. Ramírez-Sánchez ◽  
Ineke L. Tan ◽  
B.C. Gonera-de Jong ◽  
Marijn C. Visschedijk ◽  
Iris Jonkers ◽  
...  
Keyword(s):  
Small Intestine ◽  
Celiac Disease ◽  
Early Stage ◽  
Villous Atrophy ◽  
Upper Endoscopy ◽  
Gluten Free ◽  
Non Invasive ◽  
Immune Mediated ◽  
Gastrointestinal Complaints ◽  
Small Intestinal

Celiac disease (CeD) is a complex immune-mediated disorder that is triggered by dietary gluten in genetically predisposed individuals. CeD is characterized by inflammation and villous atrophy of the small intestine, which can lead to gastrointestinal complaints, malnutrition, and malignancies. Currently, diagnosis of CeD relies on serology (antibodies against transglutaminase and endomysium) and small-intestinal biopsies. Since small-intestinal biopsies require invasive upper-endoscopy, and serology cannot predict CeD in an early stage or be used for monitoring disease after initiation of a gluten-free diet, the search for non-invasive biomarkers is ongoing. Here, we summarize current and up-and-coming non-invasive biomarkers that may be able to predict, diagnose, and monitor the progression of CeD. We further discuss how current and emerging techniques, such as (single-cell) transcriptomics and genomics, can be used to uncover the pathophysiology of CeD and identify non-invasive biomarkers.

Celiac Disease Presenting as Hemolytic Anemia Mimic: A Case Report

2021 ◽  
pp. 263394472110534
Author(s):  
Anjum Siddiqui ◽  
Ruhi Khan
Keyword(s):  
Celiac Disease ◽  
Hemolytic Anemia ◽  
Clinical Presentation ◽  
Gastrointestinal Symptoms ◽  
Signs And Symptoms ◽  
Severe Anemia ◽  
Immune Mediated ◽  
Systemic Disorder ◽  
Variable Combination ◽  
Disease Specific

Celiac disease, an immune-mediated enteropathy, results from gluten ingestion in the form of wheat, rye, and barley in genetically susceptible individuals. It is a systemic disorder characterized by a variable combination of gluten-related signs and symptoms, and disease-specific antibodies in addition to enteropathy. The clinical presentation of celiac disease is extremely variable: a small proportion of patients presenting with severe gastrointestinal symptoms and malabsorption, and extraintestinal symptoms, and a large proportion having no symptoms at all. Owing to the varied clinical presentation, diagnosing celiac disease remains a challenge. We present a case of celiac disease presenting with severe anemia and clinical features suggestive of hemolytic anemia, making diagnosis even more difficult.

scholarly journals Celiac Disease Associated with a Benign Granulomatous Mass Demonstrating Self-Regression after Initiation of a Gluten-Free Diet

2017 ◽  
Vol 11 (2) ◽  
pp. 473-479
Author(s):  
Abhinav Tiwari ◽  
Himani Sharma ◽  
Khola Qamar ◽  
Zubair Khan ◽  
Umar Darr ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Small Bowel ◽  
Stromal Cells ◽  
Needle Aspiration ◽  
Tissue Reaction ◽  
Gluten Free Diet ◽  
Small Bowel Adenocarcinoma ◽  
Gluten Free ◽  
Inflammatory Mass ◽  
Immune Mediated

Celiac disease is a chronic immune-mediated enteropathy in which dietary gluten induces an inflammatory reaction predominantly in the duodenum. Celiac disease is known to be associated with benign small bowel thickening and reactive lymphadenopathy that often regresses after the institution of a gluten-free diet. A 66-year-old male patient with celiac disease presented with abdominal pain and diarrheal illness. Computerized tomography of the abdomen revealed a duodenal mass. Endoscopic ultrasound-guided fine needle aspiration of the mass revealed bizarre stromal cells which represent a nonspecific tissue reaction to inflammation. This inflammatory mass regressed after the institution of a gluten-free diet. This case report describes a unique presentation of celiac disease in the form of a granulomatous self-regressing mass. Also, this is the first reported case of bizarre stromal cells found in association with celiac disease. In addition to lymphoma and small bowel adenocarcinoma, celiac disease can present with a benign inflammatory mass, which should be serially monitored for resolution with a gluten-free diet.

scholarly journals Cutaneous manifestations of COVID-19

2021 ◽  
Vol 97 (2) ◽  
pp. 71-75
Author(s):  
Géza Róbert Nagy ◽  
◽  
Zsuzsanna Bata-Csörgő ◽  
Lajos Kemény
Keyword(s):  
Clinical Course ◽  
Cutaneous Manifestation ◽  
Prognostic Information ◽  
Cutaneous Manifestations ◽  
Etiological Factors ◽  
Asymptomatic Patients ◽  
Direct Association ◽  
Retiform Purpura

There has been increasing number of reports on the cutaneousmanifestations of COVID-19 patients. The skin involvements in patients with COVID-19 demonstrate various clinical entities. In our article, we summarize these cutaneous manifestations based on the literature data and on our own experiencies. While in inducing maculopapulosus exanthem, urticaria, erythema multiformeand vesicular lesions etiological factors other than SARS-COV-2 virus may play a role , vascular manifestations, such as chilblain-like lesions and retiform purpura, could have a more direct association with the virus. Cutaneous manifestation may help in identifying asymptomatic patients and could provide prognostic information on the clinical course of COVID-19.

scholarly journals Description of a clinical case of combination of celiac disease and ichthyosis in a girl

2021 ◽  
pp. 134-139
Author(s):  
A. T. Kamilova ◽  
S. I. Geller ◽  
X. T. Ubaykhodjaeva
Keyword(s):  
Celiac Disease ◽  
Clinical Case ◽  
Tissue Transglutaminase ◽  
Gastrointestinal Symptoms ◽  
Active Phase ◽  
Final Diagnosis ◽  
Nutritional Deficiencies ◽  
Small Intestinal Mucosa ◽  
Gluten Sensitive Enteropathy ◽  
Severe Degree

Abstract Introduction. Celiac disease, or gluten-sensitive enteropathy, can be defined as a persistent intolerance of wheat gliadins and other cereal prolamines in the small intestinal mucosa of genetically susceptible individuals. The clinical picture of the disease can often be misleading because it varies greatly from patient to patient, resulting in delayed diagnosis.To analyze the clinical case of a child with celiac disease and acquired ichthyosis.Results. The disease, until a final diagnosis was established, had a severe course due to gastrointestinal and dermatological disorders. From the age of 1.5 years, the child had frequent diarrhea, bloating, which is why she was repeatedly hospitalized in the hospital at the place of residence. However, there was no effect from the ongoing therapeutic measures, and other symptoms such as vomiting, peripheral edema, deficiency of height and weight, and severe peeling of the skin joined in. The diagnosis was finally confirmed at the age of 2.5 years after the test for antibodies to tissue transglutaminase IgA (fifty-fold excess relative to the norm). A genetic study revealed alleles of genes responsible for predisposition to celiac disease. The results of a biopsy of the mucous membrane of the duodenum had signs of atrophy, lymphoid infiltration, corresponding to a lesion of the small intestine according to the classification Marsh III. Microscopic examination of the skin – hyperkeratosis with a decrease in the granular layer. On the basis of the obtained data, the diagnosis was made: Celiac disease, active phase, severe course, complicated by proteinenergy insufficiency severe degree, exudative enteropathy syndrome, 2 degree anemia, concomitant diagnosis: acquired ichthyosis. The girl was prescribed a gluten-free diet, and symptomatic drug therapy was carried out. In dynamics, the condition has improved. After 6 months, at the second visit, gastrointestinal and skin symptoms were absent, physical development was age-appropriate.Conclusions. The classic form of celiac disease usually manifests itself with several major symptoms, such as diarrhea, abdominal pain, weight loss, and nutritional deficiencies. In this article we wanted to talk about a rare combination of celiac disease with ichthyosis, therefore, practitioners should be wary of a combination of skin and gastrointestinal symptoms.

scholarly journals Multiple sclerosis and celiac disease: is there an increased risk?

2004 ◽  
Vol 10 (6) ◽  
pp. 711-712 ◽  
Author(s):  
S Salvatore ◽  
S Finazzi ◽  
A Ghezzi ◽  
A Tosi ◽  
A Barassi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Celiac Disease ◽  
General Population ◽  
Genetic Basis ◽  
Gastrointestinal Symptoms ◽  
Screening Methods ◽  
Serological Screening ◽  
Immune Mediated ◽  
Increased Risk ◽  
Unselected Group

Multiple sclerosis and celiac disease are both considered immune-mediated diseases. Recently, improved serological screening methods provided a higher prevalence of celiac disease (CD) in the general population worldwide and also demonstrated gastrointestinal symptoms may be lacking. The aim of this study was to determine the prevalence of (CD) in an unselected group of 95 adults with multiple sclerosis using transglutaminase antibodies. No patients showed pathological values. Different immune and genetic basis between the two diseases may represent crucial insights to explain our results.

Celiac Disease in Kosovar Albanian Children: Evaluation of Clinical Features and Diagnosis

2020 ◽  
Vol 16 (3) ◽  
pp. 241-247
Author(s):  
Atifete Ramosaj-Morina ◽  
Alije Keka-Sylaj ◽  
Arbana Baloku Zejnullahu ◽  
Lidvana Spahiu ◽  
Virgjina Hasbahta ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Disease Onset ◽  
Clinical Manifestations ◽  
Gastrointestinal Symptoms ◽  
Dominant Mode ◽  
Primary School Children ◽  
Cross Sectional ◽  
Classical Form ◽  
Wide Range ◽  
The Mean

Background: Celiac disease is an immune-mediated disorder characterized by variable clinical manifestations, specific antibodies, HLA-DQ2/DQ8 haplotypes, and enteropathy. Objectives: The aim of this study was to present the clinical spectrum and patterns of celiac disease in Kosovar Albanian children. Methods: A cross-sectional retrospective study was performed with Albanian children aged 0-18 years, treated for celiac disease in the Pediatric Clinic, University Clinical Center of Kosovo from 2005 to 2016. Results: During the study period, 63 children were treated for celiac disease. The mean age at diagnosis was 5.5 years (SD ± 3.31). The mean age at celiac disease onset was 3.3 years (SD ± 2.02), while the mean delay from the first symptoms indicative of celiac disease to diagnosis was 2.2 years (SD ± 2.09). More than 70% of the patients were diagnosed in the first 7 years of life, mainly presented with gastrointestinal symptoms, while primary school children and adolescents mostly showed atypical symptoms (p<0.001). The classical form of celiac disease occurred in 78% of the cases. Sixty (95%) patients carried HLA-DQ2.5, DQ2.2 and/or HLA-DQ8 heterodimers, and only three of them tested negative. Conclusions: Kosovo, as the majority of developing countries, is still facing the classical form of celiac disease as the dominant mode of presentation; as a result, most children with other forms of the celiac disease remain undiagnosed. : Physicians should be aware of the wide range of clinical presentations and utilize low testing thresholds in order to prevent potential long-term problems associated with untreated celiac disease.

scholarly journals Dual threat of comorbidity of celiac disease and systemic lupus erythematosus

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110122
Author(s):  
Yimin Ma ◽  
Duanming Zhuang ◽  
Zhenguo Qiao
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Celiac Disease ◽  
Lupus Erythematosus ◽  
Clinical Manifestations ◽  
Failure To Thrive ◽  
Severe Malnutrition ◽  
Systemic Lupus ◽  
Electrolyte Disorders ◽  
Diagnostic Challenge ◽  
Immune Mediated

Celiac disease (CD) is a chronic immune-mediated intestinal disease that is characterized by production of autoantibodies directed against the small intestine. The main clinical manifestations of CD are typically defined as those related to indigestion and malabsorption. These manifestations include unexplained diarrhea or constipation, abdominal pain, bloating, weight loss, anemia, failure-to-thrive in children, and decreased bone density. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by heterogeneous clinical manifestations, which may also involve the gastrointestinal tract. Comorbidity of CD and SLE is rare, and the overlapping symptoms and nonspecific clinical presentation may pose a diagnostic challenge to clinicians. We report here a case of SLE with CD, which mainly manifested as recurrent diarrhea, uncorrectable electrolyte disorders, and severe malnutrition. Through review, we hope to further improve our understanding and diagnostic level of this combination of diseases.

Sign in / Sign up

Export Citation Format

Share Document