scholarly journals Synthesis and Antimicrobial Screening of Quinazolone Containing Novel Heterocyclic Schiff Base and Azetidinone by Niementowski Reaction

2005 ◽  
Vol 2 (2) ◽  
pp. 101-108
Author(s):  
A. R. Desai ◽  
R. U. Roy ◽  
K. R. Desai
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Analysis ◽  
Schiff Base ◽  
Antifungal Activity ◽  
Sulfonic Acid ◽  
Antibacterial And Antifungal Activity ◽  
Antimicrobial Screening ◽  
Antibacterial And Antifungal ◽  
Phenyl Vinyl

Several 2-[2-{(4-substitutedbenzylidene)-phenyl}vinyl]-4-oxo-3,4-dihydroquinazolone-6-sulfonicacid4(a-l)and 2-[2-{4-(3-chloro-4-substituedphenyl-azetidin-2-one)-phenyl}vinyl]-4-oxo-3,4-dihydroqui-nazolone-6-sulfonic acid5(a-l)were synthesized by using conventional techniques and were screened for antibacterial and antifungal activity. The compounds showed good to moderate antimicrobial activity and were characterized on the basis of spectral analysis.

scholarly journals Synthesis , spectroscopic characterization and biological study of some new Schiff bases based on 2-hydroxybenzadehyde

2017 ◽  
Vol 13 (2) ◽  
pp. 5995-6005
Author(s):  
S. Abdelnabi ◽  
Chasib K. Bkhakh ◽  
Mouayed Y. Kadhum
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Schiff Bases ◽  
Aromatic Amines ◽  
Spectroscopic Characterization ◽  
Biological Study ◽  
Antibacterial And Antifungal Activity ◽  
Element Analysis ◽  
Antibacterial And Antifungal

Four new Schiff bases were synthesized from condensation of aldehyde ( 2-hydroxy benzaldehyde ) with aromatic amines (4-introaniline ; 4,4-oxydianiline ; 4,4-diaminodipleny sulfone and sulfanilamide) . These Schiff bases were characterized by IR, NMR , GC. mass and element analysis. Moreover, the Schiff bases were screened for their antibacterial and antifungal activity against various microorganisms and compared with standard compounds. In general , the results were indicated that some Schiff bases had good antimicrobial activity.

Bioactive Chemical Constituents and Comparative Antimicrobial Activity of Callus Culture and Adult Plant Extracts from Alternanthera tenella

2009 ◽  
Vol 64 (5-6) ◽  
pp. 373-381 ◽  
Author(s):  
Marcos J. Salvador ◽  
Paulo S. Pereira ◽  
Suzelei C. França ◽  
Regina C. Candido ◽  
Izabel Y. Ito ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Callus Culture ◽  
Culture Media ◽  
Chemical Constituents ◽  
Adult Plant ◽  
Antibacterial And Antifungal Activity ◽  
Crude Extracts ◽  
Antibacterial And Antifungal ◽  
Adult Plants

Crude extracts of a callus culture (two culture media) and adult plants (two collections) from Alternanthera tenella Colla (Amaranthaceae) were evaluated for their antibacterial and antifungal activity, in order to investigate the maintenance of antimicrobial activity of the extracts obtained from plants in vivo and in vitro. The antibacterial and antifungal activity was determined against thirty strains of microorganisms including Gram-positive and Gram-negative bacteria, yeasts and dermatophytes. Ethanolic and hexanic extracts of adult plants collected during the same period of the years 1997 and 2002 [Ribeirão Preto (SP), collections 1 and 2] and obtained from plant cell callus culture in two different hormonal media (AtT43 and AtT11) inhibited the growth of bacteria, yeasts and dermatophytes with inhibition halos between 6 and 20 mm. For the crude extracts of adult plants bioassay-guided fractionation, purification, and isolation were performed by chromatographic methods, and the structures of the isolated compounds were established by analysis of chemical and spectral evidences (UV, IR, NMR and ES-MS). Steroids, saponins and flavonoids (aglycones and C-glycosides) were isolated. The minimum inhibitory concentration (MIC) of the isolated compounds varied from 50 to 500 μg/mL

scholarly journals Synthesis and Antimicrobial Screening of Some Novel 2, 5-Disubstituted 1, 3, 4-oxadiazole Derivatives

2011 ◽  
Vol 8 (s1) ◽  
pp. S149-S154 ◽  
Author(s):  
P. Panneerselvam ◽  
G. Geete Ganesh
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Antibacterial And Antifungal Activity ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
E Coli ◽  
H Nmr ◽  
Oxadiazole Derivatives ◽  
Antibacterial And Antifungal ◽  
New Compounds

The syntheses of series of 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives are described. A total of twelve new compounds were synthesized and characterized by IR,1H-NMR and Mass spectral data. All newly synthesized compounds were screened for their antimicrobial activityi.e. antibacterial activity againstS. aureusandE. coliand antifungal activity against fungusA. nigar. CompoundsG5andG7exhibited significant both antibacterial and antifungal activity whileG2,G10andG3,G9showed antibacterial and antifungal activity respectively. These compounds were 2, 5-disubstituted 1, 3, 4-oxadiazole moiety at position two and five showed reasonable antibacterial and antifungal activity.

scholarly journals ANTIMICROBIAL ACTIVITY OF SYZYGIUM GARDNERI Thw. (MYRTACEAE).

2015 ◽  
Vol 2 (1) ◽  
pp. 53-55
Author(s):  
Asha devi V ◽  
Shalimol A ◽  
Arumugasamy K ◽  
Nantha kumar R ◽  
Abdul kaffoor H
Keyword(s):  
Escherichia Coli ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Bacillus Subtilis ◽  
Antifungal Activity ◽  
Positive Control ◽  
Antibacterial And Antifungal Activity ◽  
Penicillium Notatum ◽  
Antibacterial And Antifungal ◽  
Alternaria Alternate

The present study was evaluated the antibacterial and antifungal activity of various extracts of S.gardneri against four different bactria and fungal strains like Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Salmonella para typhi b, Alternaria alternate, Aspergillus flavus, Penicillium notatum and Cladosporium carrionii. All the results were compared with respective positive control.

scholarly journals Synthesis and studies of the biological activity of novel pyrimido fused acridine derivatives

2006 ◽  
Vol 71 (10) ◽  
pp. 1015-1023 ◽  
Author(s):  
Bhavesh Patel ◽  
Ranjan Patel ◽  
Manish Patel
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activity ◽  
Antifungal Activity ◽  
Elemental Analysis ◽  
Potassium Carbonate ◽  
Anthranilic Acid ◽  
Phosphorus Oxychloride ◽  
Type Ii ◽  
Antibacterial And Antifungal Activity ◽  
Antibacterial And Antifungal

Anthranilic acid was reacted with various substituted 6-bromoquinazolinones in the presence of Cu-powder and anhydrous potassium carbonate in DMF to give acid intermediates (Ullmann Type-II condensation). All these acids were then cyclized in phosphorus oxychloride to give 11-chloropyrimido[4,5-b]acridin-4(3H)-ones. All the synthesized compounds were identified by conventional methods (1H-NMR, IR, elemental analysis) and were screened for their antimicrobial activity on some bacterial and fungal cultures. The results were compared with standard bactericides and fungicides. All the synthesized compounds exhibited moderate antibacterial and antifungal activity. .

scholarly journals Synthesis, antibacterial and antifungal activity of 1-[4-(1,1,3,3-tetramethylbutyl)phenoxy]-3-dialkylamino-2-propanol quaternary salts

2019 ◽  
pp. 56-62 ◽  
Author(s):  
Y. V. Korotkii ◽  
N. A. Vrynchanu ◽  
M. L. Dronova ◽  
Z. S. Suvorova ◽  
O. A. Smertenko
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Antimicrobial Agents ◽  
Dilution Method ◽  
The Novel ◽  
Antibacterial And Antifungal Activity ◽  
Antimicrobial Drugs ◽  
Quaternary Salts ◽  
Resistant Strains ◽  
Antibacterial And Antifungal

The emergence and spread of resistant strains of pathogens as well as reduction of the efficacy of current antimicrobial agents requires the development of novel antimicrobial compounds. The aim of the present study was synthesis and evaluation of antimicrobial activity of new arylaliphatic aminopropanols. The objects of the present study were 1-[4-(1,1,3,3-tetramethylbutyl)phenoxy]-3-dialkylamino-2-propanol quaternary salts (compounds I–XIV). Compounds synthesis was carried out by heating of precursor epoxide and excessive amount of appropriate amines in isopropanole, followed by treatment with excess of alkyl halides. Methods of elemental analysis, IR- and PMR-spectroscopy were used for confirmation of chemical structure. Antimicrobial activity against Staphylococcus аureus АTCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosa АТСС 27853 and Candida albicans NCTC 885/653 was determined by a broth dilution method and evaluated via minimum inhibitory concentration (MIC). Our investigation of antibacterial and antifungal activity of 1-[4-(1,1,3,3-tetra methylbutyl)phenoxy]-3-dialkylamino-2-propanol quaternary salts showed that compounds possess narrow spectrum, as well as broad spectrum action. Significant antimicrobial activity of the novel aryl aliphatic aminoalcohols indicates their potential usage as a component of new antimicrobial drugs.

scholarly journals Antibacterial and antifungal activity of an MTA-Based root canal sealer versus epoxy resin-based and methacrylate resin-based sealers

2020 ◽  
Vol 10 (3) ◽  
pp. 66-72
Author(s):  
Ali Türkyılmaz ◽  
Ali Erdemir
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Epoxy Resin ◽  
Root Canal ◽  
Root Canal Sealer ◽  
Antibacterial And Antifungal Activity ◽  
Mueller Hinton ◽  
Ah Plus ◽  
Antibacterial And Antifungal ◽  
Root Canal Sealers

Aim: The purpose of this study was to compare the antibacterial and antifungal activity of MTA Fillapex with AH 26, AH Plus, and RealSeal root canal sealers. S. aureus, E. faecalis, and C. albicans were used as test microorganisms with the agar-diffusion test (ADT) and the direct contact test (DCT).   Methodology: For the ADT, 48 Mueller-Hinton plates were divided into 3 groups according to the microorganism used. Each group was then divided into 4 subgroups according to root canal sealer. Mueller-Hinton and Sabouraud agar mediums were preferred, and inhibition zones were measured to determine the antimicrobial efficacy at designated intervals. In the DCT, 96-well microtiter plates were used. For each microorganism and each sealer, 8 consecutive wells were prepared vertically on the plate. Microbial suspensions were allowed to directly contact the sealers in each well for 1 hour at 37°C. Subsequently, microbial growth was spectrophotometrically measured at set intervals for the freshly mixed and set forms. Results: A statistically significant difference was found between the tested root canal sealers for antimicrobial effectiveness (p < 0.05). According to the ADT results, all sealers had antimicrobial activity against the tested microorganisms. MTA Fillapex demonstrated satisfying results in the ADT against all microorganisms. In the DCT, MTA Fillapex inhibited bacterial and fungal growth in all freshly mixed and set forms. However, the set forms of AH 26 and AH Plus began to lose their antimicrobial activity on the tested microorganisms after a while. Conclusion: The results showed that the MTA-based root canal sealer MTA Fillapex may be a favorable alternative sealer against bacterial and/or fungal species in clinical practice.   How to cite this article: Türkyılmaz A, Erdemir A. Antibacterial and antifungal activity of MTA-based root canal sealer versus epoxy resin-based and methacrylate resin-based sealers. Int Dent Res 2020;10(3):66-72.  https://doi.org/10.5577/intdentres.2020.vol10.no3.1   Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

Synthesis, Reactions and Antimicrobial Activity of Thieno[2,3-c]pyridazine Derivatives

2009 ◽  
Vol 2009 (10) ◽  
pp. 593-598 ◽  
Author(s):  
Fatma El Mariah
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Spectroscopic Studies ◽  
Antibacterial And Antifungal Activity ◽  
Pyridazine Derivatives ◽  
Antibacterial And Antifungal ◽  
Synthesis Reactions

The reaction of N1-(un)substituted 4-aminosulfonamide with 6-chloropyridothienopyridazine (5) and 8-chloro-pyrimidothienopyridazine (14) gave 6-substituted aminopyridothienopyridazine (9) and 8-substituted amino-pyrimidothienopyridazine (16) respectively. All of the derivatives have been characterised by analytical and spectroscopic studies and also tested for their in vitro antibacterial and antifungal activity against a variety of microorganisms.

Antimicrobial Activity of Some Novel 1-(3-(4-Chlorophenylimino)-3,4- dihydroquinoxalin-2-yl)-3-substituted phenyl-1H-pyrazole-4-carbaldehyde

2020 ◽  
Vol 18 (2) ◽  
pp. 128-134
Author(s):  
Dhanapal Visagaperumal ◽  
Vineeth Chandy
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Dilution Method ◽  
Significant Activity ◽  
Antibacterial And Antifungal Activity ◽  
Reference Drug ◽  
Mass Spectral ◽  
Diffusion Technique ◽  
Elemental Analyses ◽  
Antibacterial And Antifungal

Background: In this study, synthesis of some novel 1-(3-(4-chlorophenylimino)-3,4- dihydroquinoxalin-2-yl)-3-substituted phenyl-1H-pyrazole-4-carbaldehyde were done by cyclization of dehydrated hemiketal using VilsmeierHaack reaction. The structures of synthesized compounds were in accordance of the basis of IR, 1HNMR, Mass spectral data and elemental analyses. The synthesized compounds had given good yields and high purity. Methods: The antimicrobial activity of the synthesized compounds was preliminarily screened by paper disc diffusion technique. The determination of minimum inhibitory concentrations (MIC) of the synthesized compounds were done by using tube dilution method. Results and Conclusion: All the screened compounds showed antibacterial and antifungal activity against selected strains of Gram positive and Gram negative bacteria and two strains of fungus, respectively but exhibited considerably less activity when compared to the reference drug ciprofloxacin and Fluconazole for antibacterial and antifungal activity, respectively. Among the synthesized compounds VV5 exhibited significant activity.

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