scholarly journals Noninvasive Diagnostic Tests for Helicobacter Pylori Infection in Children

2005 ◽  
Vol 19 (7) ◽  
pp. 433-439 ◽  
Author(s):  
Sibylle Koletzko
Keyword(s):  
Helicobacter Pylori ◽  
Breath Test ◽  
Clinical Decision Making ◽  
Age Groups ◽  
Eradication Therapy ◽  
High Sensitivity ◽  
Urea Breath Test ◽  
Helicobacter Pylori Infection ◽  
Noninvasive Test ◽  
H Pylori

Noninvasive tests can be used for the initial diagnosis of Helicobacter pylori infection and to monitor the success of eradication therapy. In populations with a low prevalence of H pylori infection (children living in North America and Europe), a high sensitivity is required to make the test valuable for clinical practice. The13C-urea breath test has been validated in children of different age groups in a significant number of infected and noninfected children in several countries and, thus far, is the only noninvasive test that fulfills sensitivity and specificity quality standards. In studies to date, enzyme immunoassays using monoclonal antibodies to detect H pylori antigen in stool provide excellent results, but the number of children tested, particularly post-treatment, is not sufficient to recommend the test. All other noninvasive stool tests or methods based on the detection of specific antibodies in serum, whole blood, urine or saliva have limited accuracy in comparison with the13C-urea breath test. Therefore, these tests cannot be recommended for clinical decision making in pediatric patients.

scholarly journals Prevalence of Helicobacter pylori infection and its Associated Risk Factors among symptomatic Residents of Sulaimani city, Kurdistan region, Iraq, 2020

2021 ◽  
pp. 1-12
Author(s):  
Seerwan Hama rashid Ali ◽  
Sabiha Sharif Salih ◽  
Taib Ahmed Hama Sour ◽  
Goran Mohammad Raouf ◽  
Araz Latif Rahim
Keyword(s):  
Risk Factors ◽  
Helicobacter Pylori ◽  
Breath Test ◽  
Human Life ◽  
Urea Breath Test ◽  
Giemsa Stain ◽  
Helicobacter Pylori Infection ◽  
Noninvasive Test ◽  
H Pylori ◽  
Gastric Sample

Helicobacter pylori (H. pylori) bacteria are a microaerobic Gram negative that colonizes in the gastric and duodenum of human. It can cause prolong infection in the human life if not treated. Many of the studies showed that infection by H. pylori can cause some important gastrointestinal illness, such as peptic ulcer, chronic gastritis, gastric adenocarcinoma and mucosa associated lymphoid tissue lymphoma. Recurrence is generally considered as H. pylori recrudescence infection after one year of eradicated treatment. There are many factors involved in the H pylori reinfection, such as the epidemiology of H. pylori infection, condition of the live, development of economical state, and health conditions. The Objectives of this study were to estimate the incidence and determine the risk factors of infection by H. pylori bacteria in dyspeptic patients in Sulaimani city. And the Aims are to estimate prevalence of the Helicobacter pylori and patients’ characteristics in Sulaimani city. This is a cross-sectional study, using a Urea breath test or stained the gastric sample with Giemsa stain, which is including adult participants aged (12-87) years during the period starting from 1 January until 31 December 2020 on Iraqi male and female patients were visiting –Center for Gastroenterology and Hepatology in Sulaimani, city, Iraq. Three hundred and four patients were included, all of them underwent Urea breath test only but eighty-one of the participants underwent endoscopy and stained the gastric sample with Giemsa stain. Urea breath test for Helicobacter pylori was positive in54.9% which have significant correlation with risk factor findings. Results: the incidence rate of H. pylori infection in our study is 54.9%, and mean age of the study participants was (40.49 ±16.39) one hundred and ninety-one cases 62.8% were female and 113 cases 37.2%were male. Infection by H. pylori bacteria is rife in dyspeptic patients; and is more common in the age group of 31-40 years. One of noninvasive test to diagnosis H. pylori is Urea breath test.  In conclusions the rate of helicobacter pylori infection in our study is 54.9% among the symptomatic patients, and the overall incidence of H. pylori UBT and Giemsa stain detection rate were 73.4 and 26.6% respectively.  

Helicobacter pylori causes gastrointestinal hemorrhage in patients with congenital bleeding disorders

2003 ◽  
Vol 89 (04) ◽  
pp. 741-746 ◽  
Author(s):  
Ann-Sofie Rehnberg ◽  
Marju Hein ◽  
Olga Hegedus ◽  
Per Lindmarker ◽  
Per Hellström ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastrointestinal Hemorrhage ◽  
Breath Test ◽  
Eradication Therapy ◽  
Urea Breath Test ◽  
Von Willebrand Disease ◽  
Bleeding Disorders ◽  
Ulcer Disease ◽  
H Pylori ◽  
One Year

Summary Helicobacter pylori (H. pylori) infection is associated with peptic ulcer disease and gastric cancer. The eradication of H. pylori is of special interest in patients with congenital bleeding disorders, for whom treatment of gastrointestinal hemorrhage with factor concentrates is costly. The prevalence of H. pylori varies between different populations and identification of high-risk subgroups may allow for more targeted screening and eradication of the infection. We performed a 5-year retrospective study of gastrointestinal bleeding, combined with screening and treatment for H. pylori and a long-term prospective follow-up in 168 Swedish and 23 Estonian patients with hemophilia or von Willebrand disease. The prevalence of seropositivity was lower in Sweden than in Estonia (28 versus 48%, p = 0.03), lower in native Swedes than in non-Nordic immigrants to Sweden (20 versus 76%, p = 0.0001) and lower in patients less than 40 years of age than older patients (16 versus 38%, p = 0.002). The incidence of gastrointestinal hemorrhages among the 35 Swedish patients with active H. pylori infection, confirmed by a urea breath test, was 6.0 per 100 patient-years before eradication therapy versus 1.7 during the prospective followup. A negative urea breath test one month after therapy always remained negative after one year. Screening, followed by treatment of all infected patients, yielded a reduction of direct costs over a 5-year period of 130 US-$ per screened patient. We conclude that screening and eradication therapy for infection with H. pylori in patients with congenital bleeding disorders is an effective and economic strategy.

scholarly journals Serology Is More Sensitive Than Urea Breath Test or Stool Antigen for the Initial Diagnosis of Helicobacter pylori Gastritis When Compared With Histopathology

2020 ◽  
Vol 154 (2) ◽  
pp. 255-265
Author(s):  
Dustin E Bosch ◽  
Niklas Krumm ◽  
Mark H Wener ◽  
Matthew M Yeh ◽  
Camtu D Truong ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Access To Care ◽  
Breath Test ◽  
Diagnostic Error ◽  
Urea Breath Test ◽  
Positive Serology ◽  
Noninvasive Test ◽  
Stool Antigen ◽  
And Performance ◽  
H Pylori

Abstract Objectives To assess the concordance and performance characteristics of Helicobacter pylori laboratory tests compared with histopathology and to propose algorithms for the diagnosis of H pylori that minimize diagnostic error. Methods H pylori diagnostics were reviewed from a 12-year period within a health system (2,560 cases). Analyses were performed to adjust diagnostic performance based on treatment and consensus histopathologic diagnoses among pathologists. Markers of access to care, including test cancellation frequency and turnaround time, were assessed. Costs and performance of candidate noninvasive testing algorithms were modeled as a function of disease prevalence. Results Serum H pylori IgG demonstrated a higher sensitivity (0.94) than urea breath and stool antigen tests (0.64 and 0.61, respectively). Evidence of an advantage in access to care for serology included a lower cancellation rate. Interobserver variability was higher (κ = 0.34) among pathologists for cases with a discordant laboratory test than concordant cases (κ = 0.56). A model testing algorithm utilizing serology for first-time diagnoses minimizes diagnostic error. Conclusions Although H pylori serology has modestly lower specificity than other noninvasive tests, the superior sensitivity and negative predictive value in our population support its use as a noninvasive test to rule out H pylori infection. Reflexive testing with positive serology followed by either stool antigen or urea breath test may optimize diagnostic accuracy in low-prevalence populations.

A simplified 13C-urea breath test in children with Helicobacter pylori infection: Assessment of eradication therapy and follow-up after treatment

2001 ◽  
Vol 120 (5) ◽  
pp. A579 ◽  
Author(s):  
Atsushi Sawada ◽  
Hitoshi Tajiri ◽  
Norikazu Yoshimura ◽  
Kosuke Kozaiwa ◽  
Shinobu Ida ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Breath Test ◽  
Eradication Therapy ◽  
Urea Breath Test ◽  
Helicobacter Pylori Infection ◽  
13C Urea Breath Test

scholarly journals DIAGNOSTIC ACCURACY OF UREA BREATH TEST FOR HELICOBACTER PYLORI INFECTION IN CHILDREN WITH DYSPEPSIA IN COMPARISON TO HISTOPATHOLOGY

2016 ◽  
Vol 53 (2) ◽  
pp. 108-112 ◽  
Author(s):  
Naser HONAR ◽  
Alireza MINAZADEH ◽  
Nader SHAKIBAZAD ◽  
Mahmood HAGHIGHAT ◽  
Forough SAKI ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Carbon Isotope ◽  
Sensitivity And Specificity ◽  
Breath Test ◽  
Close Association ◽  
Urea Breath Test ◽  
Helicobacter Pylori Infection ◽  
Cross Sectional ◽  
Predictive Values ◽  
H Pylori

ABSTRACT Background - Helicobacter pylori infection is the gram negative bacillus with the close association with chronic antral gastritis. Objective - In this study, we evaluate the accuracy of urea breath test (UBT) with carbon isotope 13 in comparison with histopathology of gastric antrum for detection of H. pylori infection in children with dyspepsia. Methods - This cross-sectional study was performed at specialized laboratory of Shiraz Gastroenterohepatology Research Center and Nemazee Hospital, Iran, during a 12-months period. This study investigated the sensitivity, specificity, and positive and negative predictive values of UBT in comparison with biopsy-based tests. We included a consecutive selection of 60 children who fulfilled Rome III criteria for dyspepsia. All children were referred for performing UBT with carbon isotope 13 (C13) as well as endoscopy. Biopsies were taken from antrum of stomach and duodenum. The pathologic diagnosis was considered as the standard test. Results - The mean age of the participants was 10.1±2.6 (range 7-17 years). From our total 60 patients, 28 (46.7%) had positive UBT results and 32 (53.3%) had negative UBT results. Pathologic report of 16 (57.1%) out of 28 patients who had positive UBT were positive for H. pylori and 12 (42.9%) ones were negative. Sensitivity and specificity of C13-UBT for detection of H. pylori infection were 76.2% and 69.2% respectively. Conclusion - Sensitivity and specificity of C13-UBT for detection of H. pylori infection were 76.2% and 69.2% respectively. Another multicenter study from our country is recommended.

THE EFFICACY OF THE BISMUTH-CONTAINING QUADRUPLE REGIMEN IN HELICOBACTER PYLORI INFETION

2017 ◽  
pp. 29-34
Author(s):  
Thi Khanh Tuong Tran ◽  
Quoc Bao Vu
Keyword(s):  
Helicobacter Pylori ◽  
Side Effects ◽  
Breath Test ◽  
Eradication Therapy ◽  
Urea Breath Test ◽  
Helicobacter Pylori Infection ◽  
Adherence Rate ◽  
Helicobacter Pylori Eradication ◽  
Colloidal Bismuth Subcitrate ◽  
Helicobacter Pylori Eradication Therapy

Background and Objectives: Bismuth-containing quadruple regimen is recommended as an first-line therapy in areas with high clarithromycin and metronidazole resistance as well as an option for patients who have previously failed to respond to Helicobacter pylori eradication therapy. There have been very few researches on the effectiveness of this regimen on Helicobacter pylori infection treatment in our country. The our study aimed to show the efficacy of Bismuth-based therapy for the treatment of Helicobacter pylori infection. Patients and Methods: The study was carried out on 196 patients with Helicobacter pylori infection. All of patients received a quadruple therapy consisted of Rapeprazole 20 mg bid, Colloidal bismuth subcitrate 120mg qid, Tetracycline 500mg qid and Metronidazole 500mg tid for 14 days. The diagnosis of Helicobacter Pylori infection was performed by Clotest or C13 urea-breath test. Four to eight weeks after completion of therapy, Helicobacter pylori status was rechecked by Clotest or C13 urea-breath test. Results: A total of 196 patients with Helicobacter pylori infection were recruited. The eradication rates of the Bismuth-containing quadruple regimen overall, fornaïve,previously failed to respond to Helicobacter pylori eradication therapy on intention to treat (ITT) and per-protocol (PP) analysis were 97.4-97.3%; 98.3-98.1% and 96.3-96.2%. Side effects occurred in 80.5% of subjects. The common side effects were fatigue, anorexia and nausea. The compliancerate was 98.4%. Conclusions: Bismuth-containing quadruple regimen achieved very highe radication rates. Side effects were common but not serious. The medication adherence rate was high. Key words: Bismuth-containing quadruple regimen, eradication, Helicobacter pylori infection

A 13 C-urea breath test in children with Helicobacter pylori infection: assessment of eradication therapy and follow-up after treatment

2001 ◽  
Vol 36 (9) ◽  
pp. 606-611 ◽  
Author(s):  
Norikazu Yoshimura ◽  
Hitoshi Tajiri ◽  
Atsushi Sawada ◽  
Kosuke Kozaiwa ◽  
Shinobu Ida ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Breath Test ◽  
Eradication Therapy ◽  
Urea Breath Test ◽  
Helicobacter Pylori Infection

scholarly journals Helicobacter pylori in out-patients of a general practitioner: prevalence and determinants of current infection

1997 ◽  
Vol 119 (2) ◽  
pp. 151-157 ◽  
Author(s):  
D. ROTHENBACHER ◽  
G. BODE ◽  
T. WINZ ◽  
G. BERG ◽  
G. ADLER ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
General Practitioner ◽  
Breath Test ◽  
Response Rate ◽  
Age Groups ◽  
Urea Breath Test ◽  
Age Group ◽  
Potential Risk Factors ◽  
Current Infection ◽  
H Pylori

Data on prevalence and determinants of Helicobacter pylori infection in well-defined populations are scarce. We investigated the prevalence and determinants of active H. pylori infection in a population of out-patients attending a general practitioner in Southern Germany. Infection status was determined by [13C]urea breath test. In addition, information on potential risk factors and medical history was collected.Five hundred and one of the 531 eligible patients participated in the study (response rate of 94·4%). In total, 117 of the 501 patients had a positive [13C]urea breath test (23·4%). Prevalence of H. pylori infection increased with age from 10·8% (95% CI 5·7–18·1%) in the age group 15–29 years to 30·8% (95% CI 22·1–40·6%) in the age group 60–79 years and was 20·3%, 30·4% and 28·2% for the age groups 30–39, 40–49 and 50–59 years, respectively. Education and childhood living conditions, especially the number of siblings, were identified as additional independent determinants of infection.

Sign in / Sign up

Export Citation Format

Share Document