scholarly journals Synthesis and QSAR Study of (4-Oxo-3-aryl-3,4-dihydro-quinazolin-2-ylsulfanyl)-propionic Acid arylidene/aryl-ethylidene-hydrazides via Microwave Assisted Solvent Free Reations

2004 ◽  
Vol 1 (2) ◽  
pp. 115-126
Author(s):  
M. B. Deshmukh ◽  
Savita Dhongade (Desai)
Keyword(s):  
Biological Activities ◽  
Hdl Cholesterol ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Qsar Study ◽  
Software Application ◽  
Microwave Assisted ◽  
The Relationship ◽  
Derivatives Of ◽  
Microwave Assisted Method

In the present work,s-alkylated derivatives of thio-quinazolinone were obtained using Methyl 2-chloro propionate via a solvent-free microwave-assisted method. The alkylated thio quinazolinones were further sequentially condensed with hydrazine hydrate and different aromatic aldehydes to get the hydrazides, which were studied for QSAR. The synthesized compounds were subjected to a prediction of biological activities. A software application (PASS) was used for this purpose. . The relationship between structure and different biological activities was studied and the different derivatives were recommended for the screening of some specific activities like anti-tuberculosic, anti-mycobacterial & HDL cholesterol increasing activities.

scholarly journals Synthesis and QSAR Study of Some HDL Cholesterol Increasing Quinazolinone Derivatives

2004 ◽  
Vol 1 (1) ◽  
pp. 17-31 ◽  
Author(s):  
M. B. Deshmukh ◽  
Savita Dhongade (Desai)
Keyword(s):  
Biological Activities ◽  
Alkylating Agents ◽  
Hdl Cholesterol ◽  
Aromatic Aldehydes ◽  
Qsar Study ◽  
Software Application ◽  
Quinazolinone Derivatives ◽  
The Relationship ◽  
Derivatives Of ◽  
Microwave Assisted Method

We describe here an easy and efficient method to obtainS-alkylated derivatives of thio-quinazolinone using different alkylating agents via a solvent-free microwave-assisted method. The alkylated thio quinazolinones were further sequentially condensed with hydrazine hydrate and different aromatic aldehydes to get the hydrazones, which were studied for QSAR. The synthesized compounds were subjected to a prediction of biological activities. A software application (PASS) was used for this purpose. The relationship between structure and different biological activities was studied and the different derivatives were recommended for the screening of some specific activities like anti-tuberculosic, anti-mycobacterial and HDL cholesterol increasing activities.

scholarly journals Synthesis of Some New 2-Methyl -1,4-benzothiazine-3(1H)- one Derivatives as Potential Vasodilators

2004 ◽  
Vol 1 (4) ◽  
pp. 206-210 ◽  
Author(s):  
M. B. Deshmukh ◽  
A. R. Mulik ◽  
Savita Dhongade-Desai
Keyword(s):  
Blood Flow ◽  
Biological Activities ◽  
Local Environment ◽  
Internal Diameter ◽  
Fresh Blood ◽  
Software Application ◽  
Wide Range ◽  
Normal Metabolism ◽  
Cardiac Disorders ◽  
The Relationship

The increase in the internal diameter of a blood vessel that results from relaxation of smooth muscle within the wall of the vessel is vasodilation. This causes an increase in blood flow and a decrease in systemic vascular resistance. Some substances produced by tissue deprived of fresh blood seem to be responsible for the dilation. Many products of metabolism bring about the action, CO2and acids are among them. Dilation of vessels is necessary to restore local environment of tissues and normal metabolism. It may prove to be potential in the treatment of different cardiac disorders like atherosclerosis, where, the blood vessels are narrowed due to deposition of plaque of substances like cholesterol etc. 1,4-benzothiazines have been reported to possess wide range of pharmacological and biological activities. Here, we report the synthesis and biological activity of some new arylidenehydrazino-(1H)-1,4-benzothiazines. The synthesized compounds were subjected to a prediction of biological activities. A software application (PASS) was used for this purpose. The relationship between structure and different biological activities was studied and it was found that the arylidenehydrazino-(1H)-1,4-benzothiazines are expected to be potential vasodilators.

Microwave-assisted solvent-free synthesis and luminescence properties of 2-substituted-4,5-di(2-furyl)-1H-imidazoles

2015 ◽  
Vol 69 (2) ◽  
Author(s):  
Jian Zhang ◽  
Tian-Qi Zhao ◽  
Yao Chen ◽  
Xiao-Dong Chen ◽  
Hai-Kun Chang ◽  
...  
Keyword(s):  
Ammonium Acetate ◽  
Solvent Free ◽  
Luminescence Properties ◽  
Microwave Assisted ◽  
Ft Ir ◽  
Acidic Alumina ◽  
Solvent Free Synthesis ◽  
Microwave Assisted Method

AbstractA solvent-free microwave-assisted method for the synthesis of 2-substituted-4,5-di(2-furyl)-1H-imidazoles was developed. Imidazoles with moderate to good yields were produced by condensation of furil with aldehydes over acidic alumina impregnated with ammonium acetate, and they were characterized by FT-IR, HRMS,

scholarly journals Microwave Assisted Solvent-Free Synthesis of Some Imine Derivatives

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Yunus Bekdemir ◽  
Kürşat Efil
Keyword(s):  
Microwave Heating ◽  
Aromatic Amines ◽  
Environmentally Friendly ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Molar Ratio ◽  
Microwave Assisted ◽  
Solvent Free Conditions ◽  
Solvent Free Synthesis ◽  
Environmentally Friendly Method

Some imine derivatives (1a–7d) were synthesized using a rapid and an environmentally friendly method with reaction of aromatic aldehydes (a–d) and aromatic amines (1–7) (in 1 : 1 molar ratio) in the presence of β-ethoxyethanol as a wetting reagent (2 drops) under solvent-free conditions using microwave heating.

Microwave assisted solvent-free synthesis and biological activities of novel imines (Schiff bases)

2009 ◽  
Vol 44 (5) ◽  
pp. 428-434 ◽  
Author(s):  
Aditi Kundu ◽  
Najam Akhtar Shakil ◽  
Dinesh B. Saxena ◽  
Pankaj ◽  
Jitendra Kumar ◽  
...  
Keyword(s):  
Schiff Bases ◽  
Biological Activities ◽  
Solvent Free ◽  
Microwave Assisted ◽  
Solvent Free Synthesis

Iodine-catalyzed efficient synthesis of chalcones by grinding under solvent-free conditions

2009 ◽  
Vol 87 (9) ◽  
pp. 1209-1212 ◽  
Author(s):  
Hongshe Wang ◽  
June Zeng
Keyword(s):  
Organic Synthesis ◽  
Room Temperature ◽  
Biological Activities ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Efficient Synthesis ◽  
Solvent Free Conditions ◽  
High Yields

Chalcones are useful intermediates in organic synthesis and exhibit a large number of different biological activities. Chalcones have been synthesized in high yields by Claisen–Schmidt condensation of substituted acetophenones with various aromatic aldehydes in the presence of 10 mol% of iodine at room temperature by grinding under solvent-free conditions.

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