scholarly journals Clostridium difficile-Associated Diarrhea — The New Scourge of the Health Care Facility

2000 ◽  
Vol 11 (1) ◽  
pp. 25-27 ◽  
Author(s):  
JM Conly
Keyword(s):  
Health Care ◽  
Clostridium Difficile ◽  
Care Facility ◽  
Health Care Facility ◽  
Clostridium Difficile Associated Diarrhea

Analysis of two Clostridium difficile outbreaks in an acute health care facility

2016 ◽  
Vol 1 (2) ◽  
pp. 23-31
Author(s):  
Yanal M Murad ◽  
Justo Perez ◽  
Gustavo Ybazeta ◽  
Brenda Dewar ◽  
Sebastien Lefebvre ◽  
...  
Keyword(s):  
Health Care ◽  
Clostridium Difficile ◽  
Care Facility ◽  
Health Care Facility ◽  
Acute Health Care

scholarly journals Risk Factors and Clinical Outcomes of Cancer Patients with Clostridium difficile Associated Diarrhea Co-infected with a Second Enteropathogen

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S362-S363
Author(s):  
Harika Yalamanchili ◽  
Andrew Chao ◽  
Eduardo Yepez Guevara ◽  
Samuel L Aitken ◽  
Micah Bhatti ◽  
...  
Keyword(s):  
Risk Factors ◽  
Health Care ◽  
Cancer Patients ◽  
Clinical Symptoms ◽  
Care Facility ◽  
Health Care Facility ◽  
Exact Test ◽  
Increased Risk ◽  
Clostridium Difficile Associated Diarrhea ◽  
The Impact

Abstract Background Cancer patients are at an increased risk for C. difficile infection (CDI) which is often identified along with other enteropathogens. The impact of co-infections on outcomes has not been established in this population. We compared the risk factors and clinical characteristics of patients with CDI monoinfection (CDIM) and patients coinfected with bacterial (CDIB) or viral (CDIV) enteropathogens. Methods Adult patients presenting with primary or recurrent CDI (n = 88) identified on a two-step GI multiplex assay (Biofire) followed by toxin A/B EIA, were classified into CDIM (n = 66), CDIB (n = 12), and CDIV (n = 10) groups. Demographic and clinical data were collected and risk factors and outcomes compared by Fisher’s exact test, ANOVA, and the Kruskal–Wallis test. CDI severity was determined using Zar’s criteria, presence of bacteremia, and ICU stay. Results During the study period, 2,017 diarrheal samples were submitted to the microbiology laboratory. An enteric pathogen was identified in 311 (15%) patients. CDI was identified in 88 cases of which 22 (25%) had a second pathogen. CDIM was found in 66 (21%), CDIB in 12 (4%), and CDIV in 10 (3%) subjects. The most common co-pathogens identified were diarrheagenic E. coli in the CDIB group (9/12, 75%) and norovirus in the CDIV group (8/10, 80%). Groups were similar in terms of demographics, number of recurrences, health care acquisition, co-morbidities, disease severity, serum creatinine at presentation, presence of toxin by EIA, and mortality. Patients with CDIM were more likely to have a recent hospitalization than the CDIB group (44/66 67% vs.. 3/12 25%, P = 0.01). Clinical symptoms at presentation were similar for the three groups except for nausea which was more common in the CDIV group when compared with CDIM (8/10, 80% vs. 25/66, 38%; P = 0.02). The use of proton pump inhibitors was similar in the three groups. There was however, a higher proportion of patients taking GABA-like drugs within 90 days among the CDIB patients (10/12, 83%) than the group with CDIM (26/66, 40%) P = 0.01. Conclusion In CDI cancer patients, co-infection with other enteropathogens is common. Patients with CDIB were less likely to have a recent admission to a health care facility. The use of GABA-like drugs was associated with a higher risk of bacterial co-infection. Disclosures All authors: No reported disclosures.

Correlation between hospital-level antibiotic consumption and incident health care facility-onset Clostridium difficile infection

2018 ◽  
Vol 46 (3) ◽  
pp. 270-275 ◽  
Author(s):  
Page E. Crew ◽  
Nathaniel J. Rhodes ◽  
J. Nicholas O'Donnell ◽  
Cristina Miglis ◽  
Elise M. Gilbert ◽  
...  
Keyword(s):  
Health Care ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Care Facility ◽  
Health Care Facility ◽  
Antibiotic Consumption ◽  
Hospital Level

scholarly journals Tea and RecurrentClostridium difficileInfection

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Martin Oman Evans II ◽  
Brad Starley ◽  
Jack Carl Galagan ◽  
Joseph Michael Yabes ◽  
Sara Evans ◽  
...  
Keyword(s):  
Health Care ◽  
Clostridium Difficile ◽  
Rank Correlation ◽  
Care Facility ◽  
Health Care Facility ◽  
Primary Outcome Measure ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Spearman’S Rank Correlation ◽  
Survey Responses

Background and Aims. Studies have shown effects of diet on gut microbiota. We aimed to identify foods associated with recurrentClostridium difficileinfection (CDI).Methods. In this cross-sectional survey, consecutive patients diagnosed with CDI were identified by electronic medical records. Colitis symptoms and positiveClostridium difficileassay were confirmed. Health-care onset-health-care facility associated CDI was excluded. Food surveys were mailed to 411 patients. Survey responses served as the primary outcome measure. Spearman’s rank correlation identified risk factors for CDI recurrence.Results. Surveys were returned by 68 patients. Nineteen patients experienced CDI recurrence. Compared to patients without CDI recurrence, patients with CDI recurrence had more antibiotics prescribed preceding their infection (p=0.003). Greater numbers of the latter also listed tea (p=0.002), coffee (p=0.013), and eggs (p=0.013), on their 24-hour food recall. Logistic regression identified tea as the only food risk factor for CDI recurrence (adjusted OR: 5.71; 95% CI: 1.26–25.89).Conclusion. The present results indicate a possible association between tea and CDI recurrence. Additional studies are needed to characterize and confirm this association.

National point prevalence of Clostridium difficile in US health care facility inpatients, 2008

2009 ◽  
Vol 37 (4) ◽  
pp. 263-270 ◽  
Author(s):  
William R. Jarvis ◽  
JoAnn Schlosser ◽  
Ashley A. Jarvis ◽  
Raymond Y. Chinn
Keyword(s):  
Health Care ◽  
Clostridium Difficile ◽  
Care Facility ◽  
Health Care Facility ◽  
Point Prevalence

scholarly journals No Impact of Probiotics to Reduce Clostridium difficile Infection in Hospitalized Patients: A Real-world Experience

2018 ◽  
Vol 5 (12) ◽  
Author(s):  
Maggie J Box ◽  
Kristine N Ortwine ◽  
Miguel Goicoechea ◽  
Keyword(s):  
Health Care ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Real World ◽  
Care Facility ◽  
Health Care Facility ◽  
Hospitalized Patients ◽  
P 16

Abstract We assessed the effectiveness of a Lactobacillus probiotic on rates of health care facility–onset Clostridium difficile infection (HO-CDI) in patients receiving antibiotics. A total of 1576 patients were evaluated. There was no difference in the HO-CDI incidence between those who received probiotics and those who did not (1.8% vs 0.9%; P = .16).

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