scholarly journals No Impact of Probiotics to Reduce Clostridium difficile Infection in Hospitalized Patients: A Real-world Experience

2018 ◽  
Vol 5 (12) ◽  
Author(s):  
Maggie J Box ◽  
Kristine N Ortwine ◽  
Miguel Goicoechea ◽  
Keyword(s):  
Health Care ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Real World ◽  
Care Facility ◽  
Health Care Facility ◽  
Hospitalized Patients ◽  
P 16

Abstract We assessed the effectiveness of a Lactobacillus probiotic on rates of health care facility–onset Clostridium difficile infection (HO-CDI) in patients receiving antibiotics. A total of 1576 patients were evaluated. There was no difference in the HO-CDI incidence between those who received probiotics and those who did not (1.8% vs 0.9%; P = .16).

Correlation between hospital-level antibiotic consumption and incident health care facility-onset Clostridium difficile infection

2018 ◽  
Vol 46 (3) ◽  
pp. 270-275 ◽  
Author(s):  
Page E. Crew ◽  
Nathaniel J. Rhodes ◽  
J. Nicholas O'Donnell ◽  
Cristina Miglis ◽  
Elise M. Gilbert ◽  
...  
Keyword(s):  
Health Care ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Care Facility ◽  
Health Care Facility ◽  
Antibiotic Consumption ◽  
Hospital Level

Impact of an electronic sepsis initiative on antibiotic use and health care facility–onset Clostridium difficile infection rates

2017 ◽  
Vol 45 (10) ◽  
pp. 1091-1100 ◽  
Author(s):  
Robert Hiensch ◽  
Jashvant Poeran ◽  
Patricia Saunders-Hao ◽  
Victoria Adams ◽  
Charles A. Powell ◽  
...  
Keyword(s):  
Health Care ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Care Facility ◽  
Health Care Facility ◽  
Antibiotic Use ◽  
Infection Rates

Incidence and outcomes of hospitalized patients with gastrointestinal malignancies and Clostridium difficile infection: A nationwide analysis.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 704-704
Author(s):  
Arjun Gupta ◽  
Raseen Tariq ◽  
Nivedita Arora ◽  
Ryan D. Frank ◽  
Muhammad S. Beg ◽  
...  
Keyword(s):  
Clostridium Difficile ◽  
Hospital Mortality ◽  
Cancer Patients ◽  
Clostridium Difficile Infection ◽  
Care Facility ◽  
Hospitalized Patients ◽  
National Database ◽  
Gastrointestinal Malignancies ◽  
Gi Cancer ◽  
The Impact

704 Background: Inpatients with gastrointestinal (GI) malignancies are at a high risk for Clostridium difficile infection (CDI) but the impact of CDI on outcomes in these patients needs elucidation. We analyzed the incidence of CDI and its impact on outcomes in GI cancer patients using the National Hospital Discharge Survey (NHDS) database from 2001 - 2010. Methods: NHDS collects clinical information on patients dismissed from non-Federal short-stay United States hospitals. Demographics, diagnoses (GI malignancies, CDI and comorbidities), length of stay (LOS), and dismissal information were abstracted using ICD-9 diagnosis and procedure codes. Weighted analyses were performed using SAS version 9.4. Results: Of an estimated 317.9 million unique hospitalizations; 4.6 million had a diagnosis of a GI malignancy (1.4%); median age 68 years, 46.1% female. CDI was more common in patients with GI malignancies compared to patients with no GI malignancy (1.05% vs 0.69%, aOR 1.16, 95% CI 1.15- 1.17, p < 0.0001). There was a significant increase in CDI incidence in GI cancer patients over the 10-year study period (72.7 in 2001-2002 to 109.1 in 2009-2010, per 10,000 discharges, p < 0001). In multivariable analysis, compared to GI cancer patients without CDI, GI cancer patients with CDI had a longer mean LOS (3.94 more days, 95% CI 3.31-4.56) and dismissal to a care facility (adjusted OR, 1.75; 95% CI, 1.71-1.79), but lower all-cause in-hospital mortality (adjusted OR, 0.76; 95% CI, 0.74-0.79), all p < 0.0001 Conclusions: In this national database of hospitalized patients, an increasing incidence of CDI in patients with GI malignancies was noted over the study period. CDI prolonged hospitalization, and was associated with increased dismissal to a care-facility. Lower rates of in-hospital mortality may represent early diagnosis due to vigilance or a milder form of CDI. Despite increased attention over the last few decades, CDI remained a serious infection in GI cancer patients, and merits appropriate prevention, management and follow-up.

Analysis of two Clostridium difficile outbreaks in an acute health care facility

2016 ◽  
Vol 1 (2) ◽  
pp. 23-31
Author(s):  
Yanal M Murad ◽  
Justo Perez ◽  
Gustavo Ybazeta ◽  
Brenda Dewar ◽  
Sebastien Lefebvre ◽  
...  
Keyword(s):  
Health Care ◽  
Clostridium Difficile ◽  
Care Facility ◽  
Health Care Facility ◽  
Acute Health Care

scholarly journals Tea and RecurrentClostridium difficileInfection

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Martin Oman Evans II ◽  
Brad Starley ◽  
Jack Carl Galagan ◽  
Joseph Michael Yabes ◽  
Sara Evans ◽  
...  
Keyword(s):  
Health Care ◽  
Clostridium Difficile ◽  
Rank Correlation ◽  
Care Facility ◽  
Health Care Facility ◽  
Primary Outcome Measure ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Spearman’S Rank Correlation ◽  
Survey Responses

Background and Aims. Studies have shown effects of diet on gut microbiota. We aimed to identify foods associated with recurrentClostridium difficileinfection (CDI).Methods. In this cross-sectional survey, consecutive patients diagnosed with CDI were identified by electronic medical records. Colitis symptoms and positiveClostridium difficileassay were confirmed. Health-care onset-health-care facility associated CDI was excluded. Food surveys were mailed to 411 patients. Survey responses served as the primary outcome measure. Spearman’s rank correlation identified risk factors for CDI recurrence.Results. Surveys were returned by 68 patients. Nineteen patients experienced CDI recurrence. Compared to patients without CDI recurrence, patients with CDI recurrence had more antibiotics prescribed preceding their infection (p=0.003). Greater numbers of the latter also listed tea (p=0.002), coffee (p=0.013), and eggs (p=0.013), on their 24-hour food recall. Logistic regression identified tea as the only food risk factor for CDI recurrence (adjusted OR: 5.71; 95% CI: 1.26–25.89).Conclusion. The present results indicate a possible association between tea and CDI recurrence. Additional studies are needed to characterize and confirm this association.

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