Clinical Aspects of Trace Elements: Zinc in Human Nutrition – Zinc Deficiency and Toxicity

Michelle M Pluhator; Alan Br Thomson; Richard N Fedorak

doi:10.1155/1996/492792

Clinical Aspects of Trace Elements: Zinc in Human Nutrition – Zinc Deficiency and Toxicity

Canadian Journal of Gastroenterology ◽

10.1155/1996/492792 ◽

1996 ◽

Vol 10 (2) ◽

pp. 97-103 ◽

Cited By ~ 2

Author(s):

Michelle M Pluhator ◽

Alan Br Thomson ◽

Richard N Fedorak

Keyword(s):

Trace Elements ◽

Gastrointestinal Disease ◽

Well Being ◽

Nutrition Therapy ◽

Human Nutrition ◽

Acrodermatitis Enteropathica ◽

Clinical Aspects ◽

Zinc Toxicity ◽

Malabsorption Syndromes

Available evidence suggests that trace elements, such as zinc, once thought to have no nutritional relevance, are possibly deficient in large sections of the human population. Conditioned deficiencies have been reported to result from malabsorption syndromes, acrodermatitis enteropathica, alcoholism, gastrointestinal disease, thermal injury, chronic diseases (eg, diabetes, sickle cell anemia), and in total parenteral nutrition therapy. Awareness that patients with these problems are at risk has led health professionals to focus increasingly on the importance of zinc therapy in the prevention and treatment of deficiency. More recently zinc toxicity and its role in human nutrition and well-being have come under investigation. Reports have focused on the role of zinc toxicity in causes of copper deficiency, changes in the immune system and alterations in blood lipids. As the numerous challenges presented by the study of zinc in human nutrition are met, more appropriate recommendations for dietary and therapeutic zinc intake are being made.

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Clinical Aspects of Trace Elements: Zinc in Human Nutrition – A Biochemical and Physiological Perspective

Canadian Journal of Gastroenterology ◽

10.1155/1995/384176 ◽

1995 ◽

Vol 9 (5) ◽

pp. 251-256

Author(s):

Michelle M Pluhator ◽

Alan BR Thomson ◽

Richard N Fedorak

Keyword(s):

Trace Elements ◽

Trace Element ◽

Clinical Medicine ◽

Critical Role ◽

Trace Element Analysis ◽

Well Being ◽

Clinical Aspects ◽

Element Analysis ◽

Healthy Humans ◽

Technological Advances

The tremendous technological advances in trace element analysis seen in recent years have stimulated and facilitated research in a number of disciplines including microbiology, nutrition, agriculture, clinical medicine and, most recently, psychology. The importance of trace elements to human health is receiving greater attention as clinical cases of deficiency and toxicity are described. Zinc has been recognized as an essential trace element for humans since the early 1960s. It has been found to play a critical role in the physiological and biochemical well-being of humans. This review discusses the tissue distribution, concentration and intracellular binding of zinc in healthy humans. (Other reviews in this five-part series will appear in following issues.) The biochemical roles of zinc, including its involvement in the actions of metalloenzymes, cell synthesis, wound healing, growth, reproduction, hormone metabolism, cellular structural stability and immunological processes, are highlighted in order to provide an understanding of the unique and extensive role zinc plays in the biochemistry of the human body.

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Preliminary Study on the Homeostatic Role of Organic Silicon and Trace Elements for Osteoarticular Well-Being

10.47363/jbbr/2021(3)132 ◽

2021 ◽

Vol 3 (2) ◽

pp. 1-6

Author(s):

Bruno Riccardi ◽

◽

Sergio Resta ◽

Rita Storelli ◽

◽

...

Keyword(s):

Clinical Trials ◽

Trace Elements ◽

Well Being ◽

Organic Silicon ◽

Prevention And Treatment ◽

Preliminary Study

Numerous evidence and clinical trials have been published in recent years on the role of silicon for the maintenance of general well-being and of bones in particular. However, no study has so far investigated which fundamental contribution to health could provide silicon when taken with other trace elements in cases, very frequent, of their insufficient contribution. In this work we present a preliminary open-air study on a group of patients, using an original and innovative formulation containing organic SI G5 plus other trace elements, for the prevention and treatment of osteoarticular diseases of various origins.

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Clinical Aspects of Trace Elements: Zinc in Human Nutrition – Zinc Metabolism

Canadian Journal of Gastroenterology ◽

10.1155/1995/745794 ◽

1995 ◽

Vol 9 (6) ◽

pp. 327-332

Author(s):

Michelle M Pluhator ◽

Alan BR Thomson ◽

Richard N Fedorak

Keyword(s):

Trace Elements ◽

Trace Element ◽

Intestinal Absorption ◽

Human Body ◽

Intestinal Tract ◽

Human Nutrition ◽

Zinc Homeostasis ◽

Clinical Aspects ◽

Zinc Metabolism ◽

Physiological Conditions

Although zinc has been the most intensely studied trace element, much remains to be learned about its metabolism. Little is known about the normal mechanisms of absorption and transport across the intestinal tract. In addition, numerous unknowns surround the intricacies of bodily zinc homeostasis. Part two of this five-part review presents current views on the normal intestinal absorption, intracellular and extracellular metabolism, transport, excretion and homeostasis of zinc in the human body. The alterations in zinc metabolism that occur with age and changing physiological conditions are also discussed.

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The Role of Trace Elements in Human Nutrition and Metabolism

ACS Symposium Series - Physiological Effects of Food Carbohydrates ◽

10.1021/bk-1975-0015.ch010 ◽

1975 ◽

pp. 156-177 ◽

Cited By ~ 2

Author(s):

R. W. TUMAN ◽

R. J. DOISY

Keyword(s):

Trace Elements ◽

Human Nutrition

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Social Motives Predict Loneliness During a Developmental Transition

Swiss Journal of Psychology ◽

10.1024/1421-0185/a000201 ◽

2017 ◽

Vol 76 (4) ◽

pp. 145-153 ◽

Cited By ~ 4

Author(s):

Jana Nikitin ◽

Alexandra M. Freund

Keyword(s):

Social Relationships ◽

Well Being ◽

Social Avoidance ◽

Social Approach ◽

Social Motives ◽

Developmental Transitions ◽

Avoidance Motivation ◽

Negative Effect ◽

Low Levels

Abstract. Establishing new social relationships is important for mastering developmental transitions in young adulthood. In a 2-year longitudinal study with four measurement occasions (T1: n = 245, T2: n = 96, T3: n = 103, T4: n = 85), we investigated the role of social motives in college students’ mastery of the transition of moving out of the parental home, using loneliness as an indicator of poor adjustment to the transition. Students with strong social approach motivation reported stable and low levels of loneliness. In contrast, students with strong social avoidance motivation reported high levels of loneliness. However, this effect dissipated relatively quickly as most of the young adults adapted to the transition over a period of several weeks. The present study also provides evidence for an interaction between social approach and social avoidance motives: Social approach motives buffered the negative effect on social well-being of social avoidance motives. These results illustrate the importance of social approach and social avoidance motives and their interplay during developmental transitions.

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Psychological Resilience Provides No Independent Protection From Suicidal Risk

Crisis ◽

10.1027/0227-5910/a000364 ◽

2016 ◽

Vol 37 (2) ◽

pp. 130-139 ◽

Cited By ~ 9

Author(s):

Danica W. Y. Liu ◽

A. Kate Fairweather-Schmidt ◽

Richard Burns ◽

Rachel M. Roberts ◽

Kaarin J. Anstey

Keyword(s):

Risk Factors ◽

Well Being ◽

Current Status ◽

Psychological Resilience ◽

Cross Sectional ◽

Life Project ◽

Resilience Factors ◽

First Time

Abstract. Background: Little is known about the role of resilience in the likelihood of suicidal ideation (SI) over time. Aims: We examined the association between resilience and SI in a young-adult cohort over 4 years. Our objectives were to determine whether resilience was associated with SI at follow-up or, conversely, whether SI was associated with lowered resilience at follow-up. Method: Participants were selected from the Personality and Total Health (PATH) Through Life Project from Canberra and Queanbeyan, Australia, aged 28–32 years at the first time point and 32–36 at the second. Multinomial, linear, and binary regression analyses explored the association between resilience and SI over two time points. Models were adjusted for suicidality risk factors. Results: While unadjusted analyses identified associations between resilience and SI, these effects were fully explained by the inclusion of other suicidality risk factors. Conclusion: Despite strong cross-sectional associations, resilience and SI appear to be unrelated in a longitudinal context, once risk/resilience factors are controlled for. As independent indicators of psychological well-being, suicidality and resilience are essential if current status is to be captured. However, the addition of other factors (e.g., support, mastery) makes this association tenuous. Consequently, resilience per se may not be protective of SI.

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Prospective Memory Development Across the Lifespan

European Psychologist ◽

10.1027/1016-9040/a000380 ◽

2020 ◽

Vol 25 (3) ◽

pp. 162-173 ◽

Cited By ~ 1

Author(s):

Sascha Zuber ◽

Matthias Kliegel

Keyword(s):

Prospective Memory ◽

Healthy Aging ◽

Present Model ◽

Current Knowledge ◽

Well Being ◽

The Elderly ◽

Cognitive Factors ◽

Everyday Functioning ◽

Integrative Framework

Abstract. Prospective Memory (PM; i.e., the ability to remember to perform planned tasks) represents a key proxy of healthy aging, as it relates to older adults’ everyday functioning, autonomy, and personal well-being. The current review illustrates how PM performance develops across the lifespan and how multiple cognitive and non-cognitive factors influence this trajectory. Further, a new, integrative framework is presented, detailing how those processes interplay in retrieving and executing delayed intentions. Specifically, while most previous models have focused on memory processes, the present model focuses on the role of executive functioning in PM and its development across the lifespan. Finally, a practical outlook is presented, suggesting how the current knowledge can be applied in geriatrics and geropsychology to promote healthy aging by maintaining prospective abilities in the elderly.

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