Role of the Pyloric Antrum in Regulation of Gastric Secretion

1960 ◽  
Vol 40 (3) ◽  
pp. 490-504 ◽  
Author(s):  
E. R. Woodward ◽  
L. R. Dragstedt
Keyword(s):  
Gastric Secretion ◽  
Pyloric Antrum

A new role of phosphopeptides as bioactive peptides released during milk casein digestion in the young mammal: Regulation of gastric secretion

Peptides ◽  
2009 ◽  
Vol 30 (12) ◽  
pp. 2221-2227 ◽  
Author(s):  
Paul Guilloteau ◽  
Véronique Romé ◽  
Luc Delaby ◽  
François Mendy ◽  
Loic Roger ◽  
...  
Keyword(s):  
Gastric Secretion ◽  
Bioactive Peptides ◽  
Milk Casein

Alterations in gastric secretion following hypothalamic lesions producing hyperphagia

1965 ◽  
Vol 209 (2) ◽  
pp. 319-323 ◽  
Author(s):  
Peter T. Ridley ◽  
Frank P. Brooks
Keyword(s):  
Food Intake ◽  
Gastric Secretion ◽  
Neural Control ◽  
Neural Mechanisms ◽  
Gastric Fistula ◽  
Central Regulation ◽  
Pepsin Secretion ◽  
Insulin Hypoglycemia ◽  
Hypothalamic Lesions

Fasting gastric secretion and secretion during insulin hypoglycemia were collected from hypothalamic hyperphagic rats equipped with chronic gastric fistula in an attempt to correlate the hypothalamic neural mechanisms controlling food intake with gastric secretion. The interdigestive or basal fasting secretion of rats rendered hyperphagic by stereotaxic ablation of the ventromedial nuclei was significantly increased in volume, acid concentration and output, and pepsin output when compared with control and sham-operated rats and rats with hypothalamic lesions without hyperphagia. Hypothalamic hyperphagic rats did not show a significant increase in gastric secretion during insulin hypoglycemia, whereas the other groups did. The levels of hypoglycemia induced by insulin were comparable in all groups. These studies suggest an important role of the ventromedial nuclei in the central regulation of acid and pepsin secretion, and also relate the hypothalamic neural control of gastric secretion to that of food intake. The results also indicate that this nucleus is involved either as a "center" or pathway in the augmentation of gastric secretion by insulin hypoglycemia.

scholarly journals Effects of the amount and type of food eaten on secretion from fundic abomasal pouches of sheep

1974 ◽  
Vol 32 (2) ◽  
pp. 375-387 ◽  
Author(s):  
L. M. McLeay ◽  
D. A. Titchen
Keyword(s):  
Gastric Secretion ◽  
Acid Concentration ◽  
Dry Matter ◽  
Acid Output ◽  
Pyloric Antrum

1. The effects on gastric secretion of altering the amount and type of food eaten were examined in sheep with fundic abomasal pouches and in sheep which also had the antral region of the abomasum isolated into a pouch or removed (antrectomy). Secretion, which was continuous in all preparations, was collected over 24 h periods, and daily determinations of its acid and pepsin concentrations were made for periods of up to 10 weeks.2. Experimental diets consisting of chaffed lucerne, meadow and wheaten hays were fed on ad lib. or restricted regimens.3. Raising and lowering the dry matter (DM) intakes of lucerne chaff increased and decreased respectively the volume, acidity and acid and pepsin outputs (volume x concentration of acid or pepsin) of fundic pouch secretion.4. Increases of 27–64% in the amount of lucerne chaff eaten, after changing from restricted to ad lib. feeding, were followed by increases in the volume (19–66%), acid concentration (4–10 mequiv. H+/l, 3–9%) and acid output (18–76%) of pouch secretion.5. With DM intakes of mixed lucerne and wheaten chaffs between 88 and 107% of those of lucerne, the secretion from the pouches was reduced to 45–88% of the volume and 39–77% of the acid output observed with the lucerne diet. Acid concentration was least affected, being unchanged in one series of observations and decreased by, at the most, 13 mequiv. H+/l (12%) in another. Reverting to a diet of lucerne chaff reversed these effects: the volume was increased by 30–49%, acid concentration by 2–15 mequiv. H+/l (2–14%), acid output by 38–68% and pepsin output by 30–43% although the intake of DM was the same or 6% less than that on the wheaten chaff mixture.6. Secretion was greater when animals ate lucerne chaff than when they ate meadow chaff.7. The changes in secretion according to diet were obtained in animals with antral pouches and antrectomy as well as in those with only fundic pouches.8. It is argued in discussion that the markedly different abomasal secretions on different diets arise from abomasal stimulation due to the nature rather than the amount of digesta entering it and that although the pyloric antrum contributes to these changes it is not essential for their occurrence.

Sign in / Sign up

Export Citation Format

Share Document