Age-dependent hypothalamic expression of neuropeptides in wild-type and melanocortin-4 receptor-deficient mice

2003 ◽  
Vol 16 (1) ◽  
pp. 38-46 ◽  
Author(s):  
Janine Arens ◽  
Kim M. Moar ◽  
Sandra Eiden ◽  
Karin Weide ◽  
Ingrid Schmidt ◽  
...  
Keyword(s):  
Body Fat ◽  
Fat Content ◽  
Wild Type ◽  
Middle Aged ◽  
Aged Mice ◽  
Melanocortin 4 Receptor ◽  
Body Fat Content ◽  
Age Dependent ◽  
Deficient Mice ◽  
Young Mice

In young (35- to 56-day-old) and middle-aged (9-mo-old) wild-type (+/+) and melanocortin-4 receptor (MC4R)-deficient (+/−, −/−) mice, expressions of neuropeptide Y (NPY), agouti-related protein (AGRP), pro-opiomelanocortin (POMC), and cocaine-and-amphetamine-regulated transcript (CART) were analyzed in the arcuate nucleus (ARC) and adjacent regions comprising the dorsomedial (DMN) and ventromedial (VMN) nucleus. In the ARC of young mice, NPY and AGRP expression increased and POMC and CART expression decreased with body fat content. Adjusting for the influence of body fat content by ANCOVA showed that the levels of NPY, POMC, and CART were highest and of AGRP lowest in young −/− mice. In the middle-aged mice, feedback from body fat content was weakened. For −/− mice ANCOVA revealed higher NPY and AGRP, lower POMC, and unchanged CART expression levels relative to young −/− mice. In the DMN and VMN, POMC and AGRP signals were absent at each age. CART was expressed in the DMN independent of age, fat content, and genotype. For NPY expression, an age-dependent induction was found in the DMN and VMN; it was absent in the young but present in the middle-aged mice, showing close positive correlations between body fat content and the numbers of NPY-labeled cells which were further enhanced in −/− mice. Thus MC4R deficiency augments age-induced NPY expression in the DMN and VMN with no feedback from body fat content. Negative feedback control by body fat content on ARC neuropeptide expression is present in young animals but vanishes with age and is modulated by MC4R deficiency.

Leptin responsiveness and gene dosage for leptin receptor mutation (fa) in newborn rats

1999 ◽  
Vol 276 (5) ◽  
pp. E836-E842 ◽  
Author(s):  
Susanne Kraeft ◽  
Knut Schwarzer ◽  
Sandra Eiden ◽  
Barbara Nuesslein-Hildesheim ◽  
Gerald Preibisch ◽  
...  
Keyword(s):  
Body Fat ◽  
Leptin Receptor ◽  
Gene Dosage ◽  
Fat Content ◽  
The Body ◽  
Newborn Rats ◽  
Wild Type ◽  
Rat Pups ◽  
Body Fat Content ◽  
Plasma Leptin

To determine the degree to which the leptin receptor mutation ( fa) influences the responsiveness to leptin during the first postnatal week, we injected recombinant leptin (600 pmol ⋅ g−1 ⋅ day−1sc from day 1 to day 7) into wild-type (+/+), heterozygous (+/ fa), and fatty ( fa/fa) rat pups. Growth and final body fat content of these leptin-treated pups were compared with those of saline-treated littermates of the same genotype. The body mass of the leptin-treated +/+ pups, but not that of the +/ fa and fa/fa pups, increased more slowly than that of their respective controls, and fat content at day 7was reduced by 37% in +/+ pups, by 22% in +/ fa pups, but not at all in fa/fa pups. Plasma leptin remained excessively high throughout the day under this treatment, but a 30-fold lower leptin dose, causing only moderate changes of plasma leptin, still reduced the body fat of +/+ pups significantly. We conclude that leptin participates in the control of even the earliest stages of fat deposition and that the response to supraphysiological doses of leptin is markedly reduced in 1-wk-old pups with one fa allele and absent in pups with two fa alleles.

Total body fat content and fat topography are associated differently with in vivo glucose metabolism in nonobese and obese nondiabetic women

Diabetes ◽  
1992 ◽  
Vol 41 (9) ◽  
pp. 1151-1159 ◽  
Author(s):  
E. Bonora ◽  
S. Del Prato ◽  
R. C. Bonadonna ◽  
G. Gulli ◽  
A. Solini ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Body Fat ◽  
Fat Content ◽  
Body Fat Content ◽  
Total Body Fat ◽  
Total Body

scholarly journals Effect of ambient temperature on the productive and carcass traits of growing rabbits divergently selected for body fat content

animal ◽  
2020 ◽  
pp. 100096
Author(s):  
Z. Matics ◽  
Z. Gerencsér ◽  
R. Kasza ◽  
K. Terhes ◽  
I. Nagy ◽  
...  
Keyword(s):  
Ambient Temperature ◽  
Body Fat ◽  
Carcass Traits ◽  
Fat Content ◽  
Body Fat Content

Whole body fat: Content and distribution

2013 ◽  
Vol 73 ◽  
pp. 56-80 ◽  
Author(s):  
E.L. Thomas ◽  
J.A. Fitzpatrick ◽  
S.J. Malik ◽  
S.D. Taylor-Robinson ◽  
J.D. Bell
Keyword(s):  
Body Fat ◽  
Fat Content ◽  
Whole Body ◽  
Body Fat Content

scholarly journals Total Body Fat Content versus BMI in 4-Year-Old Healthy Swedish Children

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Elisabet Forsum ◽  
Eva Flinke Carlsson ◽  
Hanna Henriksson ◽  
Pontus Henriksson ◽  
Marie Löf
Keyword(s):  
Body Composition ◽  
Body Fat ◽  
Fat Content ◽  
Overweight And Obesity ◽  
Air Displacement Plethysmography ◽  
High Body ◽  
Childhood Overweight And Obesity ◽  
Body Fat Content ◽  
Measurement Session ◽  
Total Body

Childhood overweight and obesity, a worldwide problem, is generally identified using BMI (body mass index). However, this application of BMI has been little investigated in children below 5 years of age due to a lack of appropriate methods to assess body composition. Therefore, we used air displacement plethysmography (ADP) to study 4.4-year old boys and girls since this method is accurate in young children if they accept the requirements of the measurement. The purpose was to analyze the relationship between BMI and body fat in these children. Body composition was assessed in 76 (43 boys, 33 girls) of the 84 children brought to the measurement session. Boys and girls contained25.2±4.7and26.8±4.0% body fat, respectively. BMI-based cut-offs for overweight could not effectively identify children with a high body fat content. There was a significant (P<0.001) but weak (r=0.39) correlation between BMI and body fat (%). In conclusion, requirements associated with a successful assessment of body composition by means of ADP were accepted by most 4-year-olds. Furthermore, BMI-based cut-offs for overweight did not effectively identify children with a high body fatness and BMI explained only a small proportion of the variation in body fat (%) in this age group.

Body fat content and serum lipid levels

1980 ◽  
Vol 77 (2) ◽  
pp. 149-152 ◽  
Author(s):  
SHARLEEN MATTER ◽  
ARTHUR WELTMAN ◽  
BRYANT A. STAMFORD
Keyword(s):  
Body Fat ◽  
Serum Lipid ◽  
Fat Content ◽  
Lipid Levels ◽  
Serum Lipid Levels ◽  
Body Fat Content

Body Fat Content Does Not Affect Body's Maximal Muscle Strength

2016 ◽  
Vol 34 (2) ◽  
pp. 153 ◽  
Author(s):  
Jonguk Choi ◽  
Sunghoon Kim ◽  
Sunghoon Hur ◽  
Jongsam Lee
Keyword(s):  
Muscle Strength ◽  
Body Fat ◽  
Fat Content ◽  
Body Fat Content ◽  
Maximal Muscle Strength

scholarly journals Liver cytokine production and ICAM-1 expression following bone fracture, tissue trauma, and hemorrhage in middle-aged mice

2007 ◽  
Vol 292 (1) ◽  
pp. G268-G274 ◽  
Author(s):  
Takeshi Matsutani ◽  
Shih-Ching Kang ◽  
Masao Miyashita ◽  
Koji Sasajima ◽  
Mashkoor A. Choudhry ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Bone Fracture ◽  
Hepatic Damage ◽  
Middle Aged ◽  
Soft Tissue Trauma ◽  
Midline Laparotomy ◽  
Aged Mice ◽  
Lower Leg Fracture ◽  
Tissue Trauma ◽  
Young Mice

Although studies have indicated that hemorrhagic shock and resuscitation produces hepatic damage by mechanisms involving adhesion molecules in endothelial cells and hepatocytes, it is not known if there is any difference in the extent of hepatic damage following bone fracture, soft tissue trauma, and hemorrhage (Fx-TH) between young and middle-aged animals. To study this, young (6–8 wk) and middle-aged (∼12 mo) C3H/HeN male mice were subjected to a right lower leg fracture, soft tissue trauma, (i.e., midline laparotomy), and hemorrhage (blood withdrawal to decrease the blood pressure to 35 ± 5 mmHg for 90 min) followed by resuscitation with four times the shed blood volume in the form of lactated Ringer solution. Mice were euthanized 24 h later, and liver tissues were harvested. Total bilirubin levels in the hepatocyte extract increased markedly following Fx-TH in both groups of mice; however, the increase in middle-aged mice was significantly higher compared with young mice. TNF-α and IL-6 levels in the hepatocyte extract following Fx-TH increased significantly in middle-aged mice but remained unchanged in young mice. IL-10 levels significantly decreased in middle-aged mice following Fx-TH but remained unchanged in young mice. Kupffer cells from middle-aged mice produced significantly higher IL-6 and IL-10 levels compared with young mice. Protein levels and mRNA expression of ICAM-1 in hepatocytes were also significantly higher in middle-aged mice compared with young mice following Fx-TH. These results collectively suggest that the extent of hepatic damage following Fx-TH is dependent on the age of the subject.

The relationship between thyroid hormone and lipid metabolism/body fat content in euthyroid male patients with type 2 diabetes mellitus in China: A cross-sectional study

2020 ◽  
Author(s):  
Xia Sun ◽  
Liping Chen ◽  
Rongzhen Wu ◽  
Dan Zhang ◽  
Yinhui He
Keyword(s):  
Body Fat ◽  
Visceral Fat ◽  
Fat Content ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Body Fat Content ◽  
Male Patients ◽  
The Relationship ◽  
Visceral Fat Content

Abstract Background: This study compared the relationship between thyroid hormones and lipid metabolism/body fat content in euthyroid male patients with type 2 diabetes mellitus (T2DM) in China. Methods: A total of 64 male patients who were diagnosed as T2DM and 64 non-diabetic males who underwent health examination were matched according to age at a 1:1 ratio. Results: The 32 subjects in each sub-group showed differences in age, body mass index (BMI), mean arterial pressure, waist circumference, visceral fat content, body fat percentage, HbA1c, HOMA-IR, FT3, TSH, HDL-c, adiponectin, leptin, visfatin and TNF-α (all P < 0.05). In the overall population, FT3 was positively correlated with body fat percentage (r=0.21, P=0.02), and negatively correlated with HOMA-IR (r=-0.18, P=0.04) and visfatin (r=-0.47, P <0.01); TSH was positively correlated with body fat percentage (r=0.23, P=0.01). In the T2DM-OB group FT3 was positively correlated with BMI (r=0.45, P <0.05), visceral fat content (r=0.50, P <0.05), and body fat percentage (r=0.44, P <0.05); FT4 was positively correlated with visceral fat content (r=0.38, P <0.05); and TSH was positively correlated with HOMA-IR (r=0.39, P <0.05). Conclusion: TSH increased in obese people and FT3 was lower in patients with T2DM.

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