Caloric Restriction and Cardiovascular Health: the Good, the Bad, and the Renin-Angiotensin System

Physiology ◽  
2021 ◽  
Vol 36 (4) ◽  
pp. 220-234
Author(s):  
Aline M. A. de Souza ◽  
Carolyn M. Ecelbarger ◽  
Kathryn Sandberg
Keyword(s):  
Caloric Restriction ◽  
Experimental Animal ◽  
Cardiovascular Health ◽  
Population Studies ◽  
Negative Impact ◽  
Renin Angiotensin System ◽  
Cardiovascular Physiology ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Physiological Research

Much excitement exists over the cardioprotective and life-extending effects of caloric restriction (CR). This review integrates population studies with experimental animal research to address the positive and negative impact of mild and severe CR on cardiovascular physiology and pathophysiology, with a particular focus on the renin-angiotensin system (RAS). We also highlight the gaps in knowledge and areas ripe for future physiological research.

scholarly journals Involvement of ACE2/Ang-(1-7)/MAS1 Axis in the Regulation of Ovarian Function in Mammals

2020 ◽  
Vol 21 (13) ◽  
pp. 4572
Author(s):  
Kamila Domińska
Keyword(s):  
Animal Species ◽  
Ovarian Function ◽  
Negative Impact ◽  
Current Knowledge ◽  
Polycystic Ovary ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Angiotensin Peptides ◽  
Reproductive Processes

In addition to the classic, endocrine renin-angiotensin system, local renin-angiotensin system (RAS) has been documented in many tissues and organs, including the ovaries. The localization and functional activity of the two opposing axes of the system, viz. ACE1/Ang II/AT1 and ACE2/Ang-(1-7)/MAS1, differs between animal species and varied according to the stage of follicle development. It appears that the angiotensin peptides and their receptors participate in reproductive processes such as folliculogenesis, steroidogenesis, oocyte maturation, and ovulation. In addition, changes in the constituent compounds of local RAS may contribute to pathological conditions, such as polycystic ovary syndrome, ovarian hyperstimulation syndrome, and ovarian cancer. This review article examines the expression, localization, metabolism, and activity of individual elements of the ACE2/Ang-(1-7)/MAS1 axis in the ovaries of various animal species. The manuscript also presents the relationship between the secretion of gonadotropins and sex hormones and expression of Ang-(1-7) and MAS1 receptors. It also summarizes current knowledge regarding the positive and negative impact of ACE2/Ang-(1-7)/MAS1 axis on ovarian function.

Role of genetic variability in the renin-angiotensin system in diabetic and nondiabetic renal disease

2001 ◽  
Vol 21 (6) ◽  
pp. 580-592 ◽  
Author(s):  
Arnold Boonstra ◽  
Dick de Zeeuw ◽  
Paul E. de Jong ◽  
Gerjan Navis
Keyword(s):  
Genetic Variability ◽  
Renal Disease ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin
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