Affect, Action, and Ambiguity and the Amygdala-Orbitofrontal Circuit. Focus on “Combined Unilateral Lesions of the Amygdala and Orbital Prefrontal Cortex Impair Affective Processing in Rhesus Monkeys”

2004 ◽  
Vol 91 (5) ◽  
pp. 1938-1939 ◽  
Author(s):  
Geoffrey Schoenbaum
Keyword(s):  
Prefrontal Cortex ◽  
Rhesus Monkeys ◽  
Affective Processing ◽  
Orbital Prefrontal Cortex

Combined Unilateral Lesions of the Amygdala and Orbital Prefrontal Cortex Impair Affective Processing in Rhesus Monkeys

2004 ◽  
Vol 91 (5) ◽  
pp. 2023-2039 ◽  
Author(s):  
Alicia Izquierdo ◽  
Elisabeth A. Murray
Keyword(s):  
Prefrontal Cortex ◽  
Rhesus Monkeys ◽  
Hemispheric Specialization ◽  
Emotional Reactions ◽  
Reward Processing ◽  
Affective Processing ◽  
Processing Abilities ◽  
Combined Lesions ◽  
Reinforcer Devaluation ◽  
Orbital Prefrontal Cortex

The amygdala and orbital prefrontal cortex (PFo) interact as part of a system for affective processing. To assess whether there is a hemispheric functional specialization for the processing of emotion or reward or both in nonhuman primates, rhesus monkeys ( Macaca mulatta) with combined lesions of the amygdala and PFo in one hemisphere, either left or right, were compared with unoperated controls on a battery of tasks that tax affective processing, including two tasks that tax reward processing and two that assess emotional reactions. Although the two operated groups did not differ from each other, monkeys with unilateral lesions, left and right, showed altered reward-processing abilities as evidenced by attenuated reinforcer devaluation effects and an impairment in object reversal learning relative to controls. In addition, both operated groups showed blunted emotional reactions to a rubber snake. By contrast, monkeys with unilateral lesions did not differ from controls in their responses to an unfamiliar human (human “intruder”). Although the results provide no support for a hemispheric specialization of function, they yield the novel finding that unilateral lesions of the amygdala-orbitofrontal cortical circuit in monkeys are sufficient to significantly disrupt affective processing.

Free behavior of rhesus monkeys following lesions of the dorsolateral and orbital prefrontal cortex in infancy

1971 ◽  
Vol 12 (3) ◽  
Author(s):  
DouglasM. Bowden ◽  
PatriciaS. Goldman ◽  
H.Enger Rosvold ◽  
RichardL. Greenstreet
Keyword(s):  
Prefrontal Cortex ◽  
Rhesus Monkeys ◽  
Orbital Prefrontal Cortex ◽  
Free Behavior

Synaptogenesis in the Prefrontal Cortex of Rhesus Monkeys

1994 ◽  
Vol 4 (1) ◽  
pp. 78-96 ◽  
Author(s):  
Jean-Pierre Bourgeois ◽  
Patricia S. Goldman-Rakic ◽  
Pasko Rakic
Keyword(s):  
Prefrontal Cortex ◽  
Rhesus Monkeys
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