"The role of ventral and orbital prefrontal cortex in conditional visuomotor learning and strategy use in rhesus monkeys (Macaca mulatto)": Correction to Bussey et al (2001).

2001 ◽  
Vol 115 (6) ◽  
pp. 1317-1317
Author(s):  
Timothy J. Bussey ◽  
Steven P. Wise ◽  
Elisabeth A. Murray
Keyword(s):  
Prefrontal Cortex ◽  
Rhesus Monkeys ◽  
Strategy Use ◽  
Visuomotor Learning ◽  
Macaca Mulatto ◽  
Orbital Prefrontal Cortex

Free behavior of rhesus monkeys following lesions of the dorsolateral and orbital prefrontal cortex in infancy

1971 ◽  
Vol 12 (3) ◽  
Author(s):  
DouglasM. Bowden ◽  
PatriciaS. Goldman ◽  
H.Enger Rosvold ◽  
RichardL. Greenstreet
Keyword(s):  
Prefrontal Cortex ◽  
Rhesus Monkeys ◽  
Orbital Prefrontal Cortex ◽  
Free Behavior

Role of the orbital prefrontal cortex in choice between delayed and uncertain reinforcers: a quantitative analysis

2003 ◽  
Vol 64 (3) ◽  
pp. 239-250 ◽  
Author(s):  
S Kheramin ◽  
S Body ◽  
M.-Y Ho ◽  
D.N Velázquez-Martinez ◽  
C.M Bradshaw ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Quantitative Analysis ◽  
Orbital Prefrontal Cortex

Combined Unilateral Lesions of the Amygdala and Orbital Prefrontal Cortex Impair Affective Processing in Rhesus Monkeys

2004 ◽  
Vol 91 (5) ◽  
pp. 2023-2039 ◽  
Author(s):  
Alicia Izquierdo ◽  
Elisabeth A. Murray
Keyword(s):  
Prefrontal Cortex ◽  
Rhesus Monkeys ◽  
Hemispheric Specialization ◽  
Emotional Reactions ◽  
Reward Processing ◽  
Affective Processing ◽  
Processing Abilities ◽  
Combined Lesions ◽  
Reinforcer Devaluation ◽  
Orbital Prefrontal Cortex

The amygdala and orbital prefrontal cortex (PFo) interact as part of a system for affective processing. To assess whether there is a hemispheric functional specialization for the processing of emotion or reward or both in nonhuman primates, rhesus monkeys ( Macaca mulatta) with combined lesions of the amygdala and PFo in one hemisphere, either left or right, were compared with unoperated controls on a battery of tasks that tax affective processing, including two tasks that tax reward processing and two that assess emotional reactions. Although the two operated groups did not differ from each other, monkeys with unilateral lesions, left and right, showed altered reward-processing abilities as evidenced by attenuated reinforcer devaluation effects and an impairment in object reversal learning relative to controls. In addition, both operated groups showed blunted emotional reactions to a rubber snake. By contrast, monkeys with unilateral lesions did not differ from controls in their responses to an unfamiliar human (human “intruder”). Although the results provide no support for a hemispheric specialization of function, they yield the novel finding that unilateral lesions of the amygdala-orbitofrontal cortical circuit in monkeys are sufficient to significantly disrupt affective processing.

scholarly journals The human amygdala and orbital prefrontal cortex in behavioural regulation

2007 ◽  
Vol 362 (1481) ◽  
pp. 787-799 ◽  
Author(s):  
R.J Dolan
Keyword(s):  
Prefrontal Cortex ◽  
Physiological State ◽  
Complex Environments ◽  
Learning From Experience ◽  
Current State ◽  
Future Events ◽  
Experimental Approaches ◽  
Orbital Prefrontal Cortex ◽  
Behavioural Strategies

Survival in complex environments depends on an ability to optimize future behaviour based on past experience. Learning from experience enables an organism to generate predictive expectancies regarding probable future states of the world, enabling deployment of flexible behavioural strategies. However, behavioural flexibility cannot rely on predictive expectancies alone and options for action need to be deployed in a manner that is responsive to a changing environment. Important moderators on learning-based predictions include those provided by context and inputs regarding an organism's current state, including its physiological state. In this paper, I consider human experimental approaches using functional magnetic resonance imaging that have addressed the role of the amygdala and prefrontal cortex (PFC), in particular the orbital PFC, in acquiring predictive information regarding the probable value of future events, updating this information, and shaping behaviour and decision processes on the basis of these value representations.

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