Heterogeneity of neuronal firing type and morphology in retrosplenial cortex of male F344 rats

2020 ◽  
Vol 123 (5) ◽  
pp. 1849-1863 ◽  
Author(s):  
Hanna Yousuf ◽  
Andrew N. Nye ◽  
James R. Moyer
Keyword(s):  
Neuronal Excitability ◽  
Retrosplenial Cortex ◽  
Neuronal Firing ◽  
Cell Type ◽  
Juvenile Rats ◽  
Fast Spiking ◽  
F344 Rats ◽  
Male F344 Rats

This is the first study to demonstrate that granular retrosplenial cortical (gRSC) neurons exhibit five distinctive firing types: regular spiking (RS), regular spiking with an afterdepolarization (RSADP), late spiking (LS), burst spiking (BS), and fast spiking (FS). RSADP neurons were the most frequently observed cell type in adult gRSC neurons. Interestingly, RS neurons without an ADP were most common in gRSC neurons of juvenile rats (PND 14–30). Thus, the ADP property, which was previously shown to enhance neuronal excitability, emerges during development.

scholarly journals Uniquely excitable neurons enable precise and persistent information transmission through the retrosplenial cortex

2019 ◽  
Author(s):  
Ellen K.W. Brennan ◽  
Shyam Kumar Sudhakar ◽  
Izabela Jedrasiak-Cape ◽  
Omar J. Ahmed
Keyword(s):  
Input Resistance ◽  
Retrosplenial Cortex ◽  
Inhibitory Neurons ◽  
Head Direction ◽  
Cell Type ◽  
Intrinsic Properties ◽  
High Input ◽  
Biophysical Models ◽  
High Input Resistance ◽  
Fast Spiking

ABSTRACTThe retrosplenial cortex (RSC) is essential for both memory and navigation, but the neural codes underlying these functions remain largely unknown. Here, we show that the most prominent cell type in layers 2/3 (L2/3) of the granular RSC is a uniquely excitable, small pyramidal cell. These cells have a low rheobase (LR), high input resistance, lack of spike-frequency adaptation, and spike widths intermediate to those of neighboring fast-spiking (FS) inhibitory neurons and regular-spiking (RS) excitatory neurons. LR cells are excitatory but rarely synapse onto neighboring neurons. Instead, L2/3 of RSC is an inhibition-dominated network with dense connectivity between FS cells and from FS to LR neurons. Biophysical models of LR but not RS cells precisely and continuously encode sustained input from afferent postsubicular head-direction cells. Thus, the unique intrinsic properties of LR neurons can support both the precision and persistence necessary to encode information over multiple timescales in the RSC.

scholarly journals Modeling temperature- and Cav3 subtype-dependent alterations in T-type calcium channel mediated burst firing

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Fernando R. Fernandez ◽  
Mircea C. Iftinca ◽  
Gerald W. Zamponi ◽  
Ray W. Turner
Keyword(s):  
Calcium Channel ◽  
Neuronal Excitability ◽  
Neuronal Firing ◽  
Mammalian Brain ◽  
Peripheral Tissues ◽  
Window Current ◽  
Modeling Data ◽  
The Brain ◽  
Firing Neuron ◽  
Cav3 Channel

AbstractT-type calcium channels are important regulators of neuronal excitability. The mammalian brain expresses three T-type channel isoforms (Cav3.1, Cav3.2 and Cav3.3) with distinct biophysical properties that are critically regulated by temperature. Here, we test the effects of how temperature affects spike output in a reduced firing neuron model expressing specific Cav3 channel isoforms. The modeling data revealed only a minimal effect on baseline spontaneous firing near rest, but a dramatic increase in rebound burst discharge frequency for Cav3.1 compared to Cav3.2 or Cav3.3 due to differences in window current or activation/recovery time constants. The reduced response by Cav3.2 could optimize its activity where it is expressed in peripheral tissues more subject to temperature variations than Cav3.1 or Cav3.3 channels expressed prominently in the brain. These tests thus reveal that aspects of neuronal firing behavior are critically dependent on both temperature and T-type calcium channel subtype.

No involvement of β-catenin gene mutation in gastric carcinomas induced by N-methyl-N-nitrosourea in male F344 rats

2003 ◽  
Vol 195 (2) ◽  
pp. 147-152 ◽  
Author(s):  
Masahito Shimizu ◽  
Masumi Suzui ◽  
Hisataka Moriwaki ◽  
Hideki Mori ◽  
Naoki Yoshimi
Keyword(s):  
Gene Mutation ◽  
Gastric Carcinomas ◽  
F344 Rats ◽  
Male F344 Rats

Lack of modifying effects of 6-mercaptopurine in a medium term bioassay system for liver carcinogenesis using male F344 rats

1992 ◽  
Vol 64 (2) ◽  
pp. 99-107
Author(s):  
Toshihiro Amanuma ◽  
Hiroshi Maruyama ◽  
Toshifumi Tsujiuchi ◽  
Masahiro Tsutsumi ◽  
Ayumi Denda ◽  
...  
Keyword(s):  
Liver Carcinogenesis ◽  
Medium Term ◽  
Bioassay System ◽  
F344 Rats ◽  
Male F344 Rats

Dose-dependent enhancing effects of quinacrine on induction of preneoplastic glutathione S-transferase placental form positive liver cell foci in male F344 rats

1991 ◽  
Vol 12 (10) ◽  
pp. 1911-1915 ◽  
Author(s):  
Katsumi Imaida ◽  
Junichi Yoshida ◽  
Chikako Uneyama ◽  
Hiroyuki Ogasawara ◽  
Takayoshi Imazawa ◽  
...  
Keyword(s):  
Liver Cell ◽  
Glutathione S Transferase ◽  
Dose Dependent ◽  
F344 Rats ◽  
Male F344 Rats

Effects of high fat fish oil and high fat corn oil diets on initiation of AOM-induced colonic aberrant crypt foci in male F344 rats

2003 ◽  
Vol 41 (12) ◽  
pp. 1739-1747 ◽  
Author(s):  
Yvonne E.M. Dommels ◽  
Suzanne Heemskerk ◽  
Hans van den Berg ◽  
Gerrit M. Alink ◽  
Peter J. van Bladeren ◽  
...  
Keyword(s):  
Fish Oil ◽  
Corn Oil ◽  
Aberrant Crypt Foci ◽  
High Fat ◽  
F344 Rats ◽  
Male F344 Rats

scholarly journals Cell-Type Specificity of Neuronal Excitability and Morphology in the Central Amygdala

eNeuro ◽  
2020 ◽  
pp. ENEURO.0402-20.2020
Author(s):  
Anisha P. Adke ◽  
Aleisha Khan ◽  
Hye-Sook Ahn ◽  
Jordan J. Becker ◽  
Torri D. Wilson ◽  
...  
Keyword(s):  
Neuronal Excitability ◽  
Cell Type ◽  
Central Amygdala ◽  
Cell Type Specificity
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