scholarly journals Effectiveness of interprofessional education in renal physiology curricula for health sciences graduate students

2017 ◽  
Vol 41 (4) ◽  
pp. 594-598 ◽  
Author(s):  
Lisa M. Harrison-Bernard ◽  
Mihran V. Naljayan ◽  
Jane M. Eason ◽  
Donald E. Mercante ◽  
Tina P. Gunaldo
Keyword(s):  
Acute Kidney Injury ◽  
Physical Therapy ◽  
Graduate Students ◽  
Basic Science ◽  
Interprofessional Education ◽  
Kidney Injury ◽  
Renal Physiology ◽  
Graduate Level ◽  
Patient Case ◽  
Behavioral Expectations

The primary purpose of conducting an interprofessional education (IPE) experience during the renal physiology block of a graduate-level course was to provide basic science, physical therapy, and physician assistant graduate students with an opportunity to work as a team in the diagnosis, treatment, and collaborative care of a patient with acute kidney injury. The secondary purpose was to enhance the understanding of basic renal physiology principles with a patient case presentation of renal pathophysiology. The overall purpose was to assess the value of IPE integration within a basic science course by examining student perceptions and program evaluation. Graduate-level students operated in interprofessional teams while working through an acute kidney injury patient case. The following Interprofessional Education Collaborative subcompetencies were targeted: Roles/Responsibilities (RR) Behavioral Expectations (RR1, RR4) and Interprofessional Communication (CC) Behavioral Expectations (CC4). Clinical and IPE stimulus questions were discussed both within and between teams with assistance provided by faculty facilitators. Students were given a pre- and postsurvey to determine their knowledge of IPE. There were statistically significant increases from pre- to postsurvey scores for all six IPE questions for all students. Physical therapy and physician assistant students had a statistically significant increase in pre- to postsurvey scores, indicating a more favorable perception of their interprofessional competence for RR1, RR4, and CC4. No changes were noted in pre- to postsurvey scores for basic science graduate students. Incorporating planned IPE experiences into multidisciplinary health science courses represents an appropriate venue to have students learn and apply interprofessional competencies.

scholarly journals Longitudinal interprofessional education in a graduate physiology course

2019 ◽  
Vol 43 (2) ◽  
pp. 241-245 ◽  
Author(s):  
Lisa M. Harrison-Bernard ◽  
Mihran V. Naljayan ◽  
Donald E. Mercante ◽  
Tina Patel Gunaldo ◽  
Scott Edwards
Keyword(s):  
Basic Science ◽  
Interprofessional Education ◽  
Physical Therapist ◽  
Physician Assistant ◽  
Kidney Injury ◽  
Health Science ◽  
Patient Case ◽  
First Case ◽  
Case Presentations

The primary purpose of conducting two interprofessional education (IPE) experiences during a multidisciplinary physiology graduate-level course was to provide basic science, physical therapy, and physician assistant graduate students opportunities to work as a team in the diagnosis, treatment, and collaborative care when presented with a patient case focused on acute kidney injury (first case) and female athlete triad (second case). The secondary purpose was to apply basic physiology principles to patient case presentations of pathophysiology. The overall purpose was to assess the longitudinal effects and the value of IPE integrated within a basic science course. The following Interprofessional Education Collaborative subcompetencies were targeted: roles/responsibilities (RR1, RR4). Students were given a pre- and postsurvey to assess their IPE perceptions and knowledge of professional roles. There were statistically significant increases from the presurvey renal IPE experience to the presurvey endocrine IPE experience for two perception questions regarding the ability to explain the roles and responsibilities of a physical therapist (PT) and physician assistant using a Likert scale. In addition, student knowledge of the role of a PT increased significantly when comparing the renal IPE presurvey to the endocrine IPE presurvey results to open-ended questions. Students’ perceptions of their knowledge as well as their ability to express, in writing, their newly learned knowledge of the role of a PT was sustained over time. Incorporating multiple IPE experiences into multidisciplinary health science courses represents an appropriate venue to have students learn and apply interprofessional competencies.

scholarly journals MO1031FROM MARCELLO MALPIGHI  THROUGH  JEAN REDMAN OLIVER AND JOSEP TRUETA: A CONTINUING CONTRIBUTION TO THE “BLACK BOX”  CLINICAL PREDICTION MODELS IN NEPHROLOGY

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Enrico Favaro ◽  
Roberta Lazzarin ◽  
Daniela Cremasco ◽  
Erika Pierobon ◽  
Marta Guizzo ◽  
...  
Keyword(s):  
Machine Learning ◽  
Acute Kidney Injury ◽  
Prediction Models ◽  
Kidney Diseases ◽  
Kidney Injury ◽  
Black Box ◽  
Renal Physiology ◽  
Clinical Prediction ◽  
Renal Circulation ◽  
Clinical Prediction Models

Abstract Background and Aims The modern development of the black box approach in clinical nephrology is inconceivable without a logical theory of renal function and a comprehension of anatomical architecture of the kidney, in health and disease: this is the undisputed contribution offered by Malpighi, Oliver and Trueta starting from the seventeenth century. The machine learning model for the prediction of acute kidney injury, progression of renal failure and tubulointerstitial nephritis is a good example of how different knowledge about kidney are an indispensable tool for the interpretation of model itself. Method Historical data were collected from literature, textbooks, encyclopedias, scientific periodicals and laboratory experimental data concerning these three authors. Results The Italian Marcello Malpighi (1628-1694), born in Crevalcore near Bologna, was Professor of anatomy at Bologna, Pisa and Messina. The historic description of the pulmonary capillaries was made in his second epistle to Borelli published in 1661 and intitled De pulmonibus, by means of the frog as “the microscope of nature” (Fig. 1). It is the first description of capillaries in any circulation. William Harvey in De motu cordis in 1628 (year of publication the same of date of birth of Italian anatomist!) could not see the capillary vessels. This thriumphant discovery will serve for the next reconnaissance of characteristic renal rete mirabile.in the corpuscle of Malpighi, lying within the capsule of Bowman. Jean Redman Oliver (1889-1976), a pathologist born and raised in Northern California, was able to bridge the gap between the nephron and collecting system through meticulous dissections, hand drawn illustrations and experiments which underpin our current understanding of renal anatomy and physiology. In the skillful lecture “When is the kidney not a kidney?” (1949) Oliver summarizes his far-sighted vision on renal physiology and disease in the following sentence: the Kidney in health, if you will, but the Nephrons in disease. Because, the “nephron” like the “kidney” is an abstraction that must be qualified in terms of its various parts, its cellular components and the molecular mechanisms involved in each discrete activity (Fig. 2). The Catalan surgeon Josep Trueta I Raspall (1897-1977) was born in the Poblenou neighborhood of Barcelona. His impact of pioneering and visionary contribution to the changes in renal circulation for the pathogenesis of acute kidney injury was pivotal for history of renal physiology. “The kidney has two potential circulatory circulations. Blood may pass either almost exclusively through one or other of two pathways, or to a varying degree through both”. (Studies of the Renal Circulation, published in 1947). Now this diversion of blood from cortex to the less resistant medullary circulation is known with the eponym Trueta shunt. Conclusion The black box approach to the kidney diseases should be considered by practitioners as a further tool to help to inform model update in many clinical setting. The number of machine learning clinical prediction models being published is rising, as new fields of application are being explored in medicine (Fig. 3). A challenge in the clinical nephrology is to explore the “kidney machine” during each therapeutic diagnostic procedure. Always, the intriguing relationship between the set of nephrological syndromes and kidney diseases cannot disregard the precious notions the specific organization of kidney microcirculation, fruit of many scientific contributions of the work by Malpighi, Oliver and Trueta (Fig. 3).

Acute Kidney Injury following Cardiac Surgery

2015 ◽  
pp. 451-480
Author(s):  
Bryan Romito ◽  
Joseph Meltzer
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Surgical Techniques ◽  
Kidney Injury ◽  
Renal Physiology ◽  
General Management ◽  
Novel Biomarkers ◽  
Short And Long Term ◽  
And Function

The primary goal of this chapter is to provide the reader with an overview of basic renal physiology and function and to review the identification, pathogenesis, and treatment of acute kidney injury following cardiac surgery. Particular focus will be directed toward the diagnostic criteria for acute kidney injury, short- and long-term impacts on patient outcomes, role of novel biomarkers, mechanisms of acute renal injury, general management principles, preventative strategies, and the influence of anesthetic and surgical techniques on its development. The content of this chapter will serve to underscore a particularly harmful but likely underappreciated problem affecting patients in the cardiothoracic critical care setting.

scholarly journals Regulation of mRNA translation in renal physiology and disease

2009 ◽  
Vol 297 (5) ◽  
pp. F1153-F1165 ◽  
Author(s):  
Balakuntalam S. Kasinath ◽  
Denis Feliers ◽  
Kavithalakshmi Sataranatarajan ◽  
Goutam Ghosh Choudhury ◽  
Myung Ja Lee ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Protein Synthesis ◽  
Messenger Rna ◽  
Kidney Injury ◽  
Mrna Translation ◽  
Renal Physiology ◽  
Physiological Adaptation ◽  
Three Stages ◽  
A Site

Translation, a process of generating a peptide from the codons present in messenger RNA, can be a site of independent regulation of protein synthesis; it has not been well studied in the kidney. Translation occurs in three stages (initiation, elongation, and termination), each with its own set of regulatory factors. Mechanisms controlling translation include small inhibitory RNAs such as microRNAs, binding proteins, and signaling reactions. Role of translation in renal injury in diabetes, endoplasmic reticulum stress, acute kidney injury, and, in physiological adaptation to loss of nephrons is reviewed here. Contribution of mRNA translation to physiology and disease is not well understood. Because it is involved in such diverse areas as development and cancer, it should prove a fertile field for investigation in renal science.

Renal disorders

2019 ◽  
pp. 341-346
Author(s):  
Carl Waldmann ◽  
Andrew Rhodes ◽  
Neil Soni ◽  
Jonathan Handy
Keyword(s):  
Acute Kidney Injury ◽  
Volume Expansion ◽  
Kidney Injury ◽  
Renal Perfusion ◽  
Oxygen Radical ◽  
Renal Physiology ◽  
Renal Metabolism ◽  
Renal Disorders ◽  
Renal Regeneration ◽  
Radical Damage

This chapter discusses renal disorders and includes discussion on prevention of acute kidney injury, including optimizing renal perfusion with the use of volume expansion, inotropic, vasopressor, and vasodilator medications; modulation of renal physiology, including renal metabolism, tubular obstruction, oxygen radical damage, and renal regeneration and repair. This chapter also discusses the diagnosis of acute kidney injury, including parameters of glomerular function, urine analyses, biomarkers, ultrasound, autoimmune profiling, and renal biopsy.

scholarly journals A basic science view of acute kidney injury biomarkers

2014 ◽  
Vol 29 (7) ◽  
pp. 1301-1311 ◽  
Author(s):  
J. R. Charlton ◽  
D. Portilla ◽  
M. D. Okusa
Keyword(s):  
Acute Kidney Injury ◽  
Basic Science ◽  
Kidney Injury

An Unusual Cause of Myoglobinuria

2018 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Skeletal Muscle ◽  
Acute Kidney Injury ◽  
Lactate Dehydrogenase ◽  
Physical Therapy ◽  
Muscle Cell ◽  
Rare Case ◽  
Creatine Phosphokinase ◽  
Kidney Injury ◽  
Acute Rhabdomyolysis ◽  
Specific Muscle

Rhabdomyolysis is characterized by the acute breakdown of skeletal muscle, resulting in the release of muscle cell contents like myoglobin, creatine phosphokinase (CK) and lactate dehydrogenase, which can lead to acute kidney injury in severe cases. A number of etiologies have been identified in acute rhabdomyolysis including hereditary and acquired of which drugs and trauma account for the majority of cases [1]. Physical therapy is frequently prescribed and generally considered safe for weakness; deconditioning and non - specific muscle aches. Rhabdomyolysis following a massage session is unheard of. However we report a rare case of rhabdomyolysis with acute kidney injury following an aggressive massage session.

scholarly journals Physical therapy-induced rhabdomyolysis and acute kidney injury associated with reduced activity of muscle lactate dehydrogenase A

2011 ◽  
Vol 63 (12) ◽  
pp. 1782-1786 ◽  
Author(s):  
Benjamin J. Lee ◽  
Ladan Zand ◽  
Nisha J. Manek ◽  
Li-Li Hsiao ◽  
Dusica Babovic-Vuksanovic ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Lactate Dehydrogenase ◽  
Physical Therapy ◽  
Kidney Injury ◽  
Muscle Lactate ◽  
Reduced Activity
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