scholarly journals Physical therapy-induced rhabdomyolysis and acute kidney injury associated with reduced activity of muscle lactate dehydrogenase A

2011 ◽  
Vol 63 (12) ◽  
pp. 1782-1786 ◽  
Author(s):  
Benjamin J. Lee ◽  
Ladan Zand ◽  
Nisha J. Manek ◽  
Li-Li Hsiao ◽  
Dusica Babovic-Vuksanovic ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Lactate Dehydrogenase ◽  
Physical Therapy ◽  
Kidney Injury ◽  
Muscle Lactate ◽  
Reduced Activity

An Unusual Cause of Myoglobinuria

2018 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Skeletal Muscle ◽  
Acute Kidney Injury ◽  
Lactate Dehydrogenase ◽  
Physical Therapy ◽  
Muscle Cell ◽  
Rare Case ◽  
Creatine Phosphokinase ◽  
Kidney Injury ◽  
Acute Rhabdomyolysis ◽  
Specific Muscle

Rhabdomyolysis is characterized by the acute breakdown of skeletal muscle, resulting in the release of muscle cell contents like myoglobin, creatine phosphokinase (CK) and lactate dehydrogenase, which can lead to acute kidney injury in severe cases. A number of etiologies have been identified in acute rhabdomyolysis including hereditary and acquired of which drugs and trauma account for the majority of cases [1]. Physical therapy is frequently prescribed and generally considered safe for weakness; deconditioning and non - specific muscle aches. Rhabdomyolysis following a massage session is unheard of. However we report a rare case of rhabdomyolysis with acute kidney injury following an aggressive massage session.

scholarly journals Nicotinamide and acute kidney injury

2021 ◽  
Author(s):  
Miguel Fontecha-Barriuso ◽  
Ana Lopez-Diaz ◽  
Sol Carriazo ◽  
Alberto Ortiz ◽  
Ana Belen Sanz
Keyword(s):  
Acute Kidney Injury ◽  
Glomerular Filtration ◽  
Kidney Injury ◽  
Kynurenine Pathway ◽  
Vitamin B3 ◽  
Nicotinamide Riboside ◽  
Nicotinamide Mononucleotide ◽  
Nad Synthesis ◽  
The Impact ◽  
Reduced Activity

ABSTRACT In a recent issue of ckj, Piedrafita et al reported that urine tryptophan and kynurenine are reduced in cardiac bypass surgery patients that develop acute kidney injury (AKI), suggesting reduced activity of the kynurenine pathway of nicotinamide adenine dinucleotide (NAD+) synthesis from tryptophan. However, nicotinamide (NAM) supplementation aiming at repleting NAD+ did not replete kidney NAD+ and did not improve glomerular filtration or reduce histological injury in ischemic-reperfusion kidney injury in mice. The lack of improvement of kidney injury is partially at odds with prior reports that did not study kidney NAD+, glomerular filtration or histology in NAM-treated wild-type mice with AKI. We now present an overview of research on therapy with vitamin B3 vitamers and derivate molecules [niacin, NAM, nicotinamide riboside (NR), NRH and nicotinamide mononucleotide (NMN)] in kidney injury, including an overview of ongoing clinical trials, and discuss the potential explanations for diverging reports on the impact of these therapeutic approaches on preclinical acute and chronic kidney disease.

scholarly journals Effectiveness of interprofessional education in renal physiology curricula for health sciences graduate students

2017 ◽  
Vol 41 (4) ◽  
pp. 594-598 ◽  
Author(s):  
Lisa M. Harrison-Bernard ◽  
Mihran V. Naljayan ◽  
Jane M. Eason ◽  
Donald E. Mercante ◽  
Tina P. Gunaldo
Keyword(s):  
Acute Kidney Injury ◽  
Physical Therapy ◽  
Graduate Students ◽  
Basic Science ◽  
Interprofessional Education ◽  
Kidney Injury ◽  
Renal Physiology ◽  
Graduate Level ◽  
Patient Case ◽  
Behavioral Expectations

The primary purpose of conducting an interprofessional education (IPE) experience during the renal physiology block of a graduate-level course was to provide basic science, physical therapy, and physician assistant graduate students with an opportunity to work as a team in the diagnosis, treatment, and collaborative care of a patient with acute kidney injury. The secondary purpose was to enhance the understanding of basic renal physiology principles with a patient case presentation of renal pathophysiology. The overall purpose was to assess the value of IPE integration within a basic science course by examining student perceptions and program evaluation. Graduate-level students operated in interprofessional teams while working through an acute kidney injury patient case. The following Interprofessional Education Collaborative subcompetencies were targeted: Roles/Responsibilities (RR) Behavioral Expectations (RR1, RR4) and Interprofessional Communication (CC) Behavioral Expectations (CC4). Clinical and IPE stimulus questions were discussed both within and between teams with assistance provided by faculty facilitators. Students were given a pre- and postsurvey to determine their knowledge of IPE. There were statistically significant increases from pre- to postsurvey scores for all six IPE questions for all students. Physical therapy and physician assistant students had a statistically significant increase in pre- to postsurvey scores, indicating a more favorable perception of their interprofessional competence for RR1, RR4, and CC4. No changes were noted in pre- to postsurvey scores for basic science graduate students. Incorporating planned IPE experiences into multidisciplinary health science courses represents an appropriate venue to have students learn and apply interprofessional competencies.

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