Kinetic and Adsorption Studies of Biogenic Amine Neurotransmitters at Polycrystalline Diamond Microelectrodes

2019 ◽  
Vol 3 (28) ◽  
pp. 47-57 ◽  
Author(s):  
Jeffrey M. Halpern ◽  
Songtao Xie ◽  
Jessica L. Schreiber ◽  
Heidi B. Martin
Keyword(s):  
Biogenic Amine ◽  
Polycrystalline Diamond ◽  
Adsorption Studies ◽  
Amine Neurotransmitters

scholarly journals Deorphanisation of novel biogenic amine-gated ion channels identifies a new serotonin receptor for learning

2020 ◽  
Author(s):  
Julia Morud ◽  
Iris Hardege ◽  
He Liu ◽  
Taihong Wu ◽  
Swaraj Basu ◽  
...  
Keyword(s):  
Ion Channels ◽  
Biogenic Amine ◽  
Pathogenic Bacteria ◽  
Serotonin Receptor ◽  
Neuronal Function ◽  
Olfactory Conditioning ◽  
C Elegans ◽  
Neuronal Processes ◽  
Amine Neurotransmitters ◽  
Gated Ion Channels

SummaryPentameric ligand-gated ion channels (LGCs) play conserved, critical roles in fast synaptic transmission, and changes in LGC expression and localisation are thought to underlie many forms of learning and memory. The C. elegans genome encodes a large number of LGCs without a known ligand or function. Here, we deorphanize five members of a family of Cys-loop LGCs by characterizing their diverse functional properties that are activated by biogenic amine neurotransmitters. To analyse the neuronal function of these LGCs, we show that a novel serotonin-gated cation channel, LGC-50, is essential for aversive olfactory learning. lgc-50 mutants show a specific defect in learned olfactory avoidance of pathogenic bacteria, a process known to depend on serotonergic neurotransmission. Remarkably, the expression of LGC-50 in neuronal processes is enhanced by olfactory conditioning; thus, the regulated expression of these receptors at synapses appears to represent a molecular cornerstone of the learning mechanism.

scholarly journals Vitis vinifera juice ameliorates depression-like behavior in mice by modulating biogenic amine neurotransmitters

2015 ◽  
Vol 10 (4) ◽  
pp. 753 ◽  
Author(s):  
Muhammad Aslam ◽  
Nuzhat Sultana
Keyword(s):  
Vitis Vinifera ◽  
Biogenic Amine ◽  
High Performance ◽  
Depressive Disorders ◽  
Tail Suspension Test ◽  
Control Groups ◽  
Electrochemical Detector ◽  
Immobility Time ◽  
Swimming Test ◽  
Amine Neurotransmitters

<p class="Abstract">The advantageous effects of <em>Vitis vinifera</em> juice on depressive model mice were examined utilizing a blend of behavioral evaluations and biogenic amine neurotransmitter estimations. During the behavioral evaluations, immobility time on the forced swimming test and tail suspension test were measured in unstressed and immobilization-induced stressed mice. <em>V. vinifera</em> juice (4 mL/kg and 8 mL/kg) and fluoxetine (20 mg/kg) produced a significant decrease in immobility time of both unstressed and stressed mice when compared with their respective saline-treated control groups in both paradigms. Neurotransmitters were measured using high-performance liquid chromatography with electrochemical detector.<em> V. vinifera</em> juice raised the levels of both serotonin (p&lt;0.001) and noradrenalin (p&lt;0.001) in brain tissue. These outcomes give significant mechanistic insights into the protective effect of <em>V. vinifera</em> juice against depressive disorders. Our results showed that<em> V. vinifera</em> juice could relieve depressive manifestations in the rodent model of depression.</p>

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