scholarly journals Biogenic amine neurotransmitters in C. elegans

WormBook ◽  
2007 ◽  
Author(s):  
Dan Chase
Keyword(s):  
Biogenic Amine ◽  
C Elegans ◽  
Amine Neurotransmitters

scholarly journals Deorphanisation of novel biogenic amine-gated ion channels identifies a new serotonin receptor for learning

2020 ◽  
Author(s):  
Julia Morud ◽  
Iris Hardege ◽  
He Liu ◽  
Taihong Wu ◽  
Swaraj Basu ◽  
...  
Keyword(s):  
Ion Channels ◽  
Biogenic Amine ◽  
Pathogenic Bacteria ◽  
Serotonin Receptor ◽  
Neuronal Function ◽  
Olfactory Conditioning ◽  
C Elegans ◽  
Neuronal Processes ◽  
Amine Neurotransmitters ◽  
Gated Ion Channels

SummaryPentameric ligand-gated ion channels (LGCs) play conserved, critical roles in fast synaptic transmission, and changes in LGC expression and localisation are thought to underlie many forms of learning and memory. The C. elegans genome encodes a large number of LGCs without a known ligand or function. Here, we deorphanize five members of a family of Cys-loop LGCs by characterizing their diverse functional properties that are activated by biogenic amine neurotransmitters. To analyse the neuronal function of these LGCs, we show that a novel serotonin-gated cation channel, LGC-50, is essential for aversive olfactory learning. lgc-50 mutants show a specific defect in learned olfactory avoidance of pathogenic bacteria, a process known to depend on serotonergic neurotransmission. Remarkably, the expression of LGC-50 in neuronal processes is enhanced by olfactory conditioning; thus, the regulated expression of these receptors at synapses appears to represent a molecular cornerstone of the learning mechanism.

scholarly journals Biogenic Amine Neurotransmitters Promote Eicosanoid Production And Protein Homeostasis

2020 ◽  
Author(s):  
Kishore K. Joshi ◽  
Tarmie L. Matlack ◽  
Stephanie Pyonteck ◽  
Ralph Menzel ◽  
Christopher Rongo
Keyword(s):  
Biogenic Amines ◽  
Biogenic Amine ◽  
Ubiquitin Proteasome System ◽  
Cytochrome P450 Monooxygenases ◽  
Protein Homeostasis ◽  
C Elegans ◽  
P450 Monooxygenases ◽  
Eicosanoid Production ◽  
Amine Neurotransmitters ◽  
Multicellular Organisms

ABSTRACTMulticellular organisms use multiple pathways to restore protein homeostasis (proteostasis) in response to adverse physiological conditions, changing environment, and developmental aging. The nervous system can regulate proteostasis in different tissues, but it is unclear how it mobilizes proteostasis pathways to offset physiological decline. Here we show that C. elegans employs the humoral biogenic amine neurotransmitters dopamine, serotonin, and tyramine to regulate proteostasis and the activity of the Ubiquitin Proteasome System (UPS) in epithelial tissues. Mutants for biogenic amine synthesis show decreased poly-ubiquitination and turnover of a GFP-based UPS substrate. Using RNA-seq, we determined the expression profile of genes regulated by biogenic amine signaling. We find that biogenic amines promote the expression of a subset of cytochrome P450 monooxygenases involved in eicosanoid production from polyunsaturated fatty acids (PUFAs). Mutants for these P450s share the same UPS phenotype observed in biogenic amine mutants. The production of n-3 PUFAs is required for UPS substrate turnover, whereas mutants that accumulate n-3 PUFAs show accelerated turnover of this GFP-based substrate. Our results suggest that neurosecretory sensory neurons release biogenic amines to modulate the lipid signaling profile, which in turn activates stress response pathways to maintain proteostasis.

scholarly journals Vitis vinifera juice ameliorates depression-like behavior in mice by modulating biogenic amine neurotransmitters

2015 ◽  
Vol 10 (4) ◽  
pp. 753 ◽  
Author(s):  
Muhammad Aslam ◽  
Nuzhat Sultana
Keyword(s):  
Vitis Vinifera ◽  
Biogenic Amine ◽  
High Performance ◽  
Depressive Disorders ◽  
Tail Suspension Test ◽  
Control Groups ◽  
Electrochemical Detector ◽  
Immobility Time ◽  
Swimming Test ◽  
Amine Neurotransmitters

<p class="Abstract">The advantageous effects of <em>Vitis vinifera</em> juice on depressive model mice were examined utilizing a blend of behavioral evaluations and biogenic amine neurotransmitter estimations. During the behavioral evaluations, immobility time on the forced swimming test and tail suspension test were measured in unstressed and immobilization-induced stressed mice. <em>V. vinifera</em> juice (4 mL/kg and 8 mL/kg) and fluoxetine (20 mg/kg) produced a significant decrease in immobility time of both unstressed and stressed mice when compared with their respective saline-treated control groups in both paradigms. Neurotransmitters were measured using high-performance liquid chromatography with electrochemical detector.<em> V. vinifera</em> juice raised the levels of both serotonin (p&lt;0.001) and noradrenalin (p&lt;0.001) in brain tissue. These outcomes give significant mechanistic insights into the protective effect of <em>V. vinifera</em> juice against depressive disorders. Our results showed that<em> V. vinifera</em> juice could relieve depressive manifestations in the rodent model of depression.</p>

scholarly journals LIM homeobox gene-dependent expression of biogenic amine receptors in restricted regions of the C. elegans nervous system

2003 ◽  
Vol 263 (1) ◽  
pp. 81-102 ◽  
Author(s):  
Ephraim L Tsalik ◽  
Timothy Niacaris ◽  
Adam S Wenick ◽  
Kelvin Pau ◽  
Leon Avery ◽  
...  
Keyword(s):  
Nervous System ◽  
Biogenic Amine ◽  
Homeobox Gene ◽  
C Elegans ◽  
Amine Receptors
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