scholarly journals Subjective Cognitive Decline: Mapping Functional and Structural Brain Changes—A Combined Resting-State Functional and Structural MR Imaging Study

Radiology ◽  
2016 ◽  
Vol 281 (1) ◽  
pp. 185-192 ◽  
Author(s):  
Yu Sun ◽  
Zhengjia Dai ◽  
Yuxia Li ◽  
Can Sheng ◽  
Hongyan Li ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Cognitive Decline ◽  
Resting State ◽  
Imaging Study ◽  
Subjective Cognitive Decline ◽  
Brain Changes ◽  
Structural Brain

scholarly journals Resting-State Static and Dynamic Functional Abnormalities in Active Professional Fighters With Repetitive Head Trauma and With Neuropsychological Impairments

2020 ◽  
Vol 11 ◽  
Author(s):  
Xiaowei Zhuang ◽  
Virendra Mishra ◽  
Rajesh Nandy ◽  
Zhengshi Yang ◽  
Karthik Sreenivasan ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Visual Attention ◽  
Association Analysis ◽  
Head Trauma ◽  
Resting State ◽  
Brain Abnormalities ◽  
Dynamic Functional Connectivity ◽  
Brain Changes ◽  
Neuropsychological Impairments ◽  
Structural Brain

Previous neuroimaging studies have identified structural brain abnormalities in active professional fighters with repetitive head trauma and correlated these changes with fighters' neuropsychological impairments. However, functional brain changes in these fighters derived using neuroimaging techniques remain unclear. In this study, both static and dynamic functional connectivity alterations were investigated (1) between healthy normal control subjects (NC) and fighters and (2) between non-impaired and impaired fighters. Resting-state fMRI data were collected on 35 NC and 133 active professional fighters, including 68 impaired fighters and 65 non-impaired fighters, from the Professional Fighters Brain Health Study at our center. Impaired fighters performed worse on processing speed (PSS) tasks with visual-attention and working-memory demands. The static functional connectivity (sFC) matrix was estimated for every pair of regions of interest (ROI) using a subject-specific parcellation. The dynamic functional connectivity (dFC) was estimated using a sliding-window method, where the variability of each ROI pair across all windows represented the temporal dynamics. A linear regression model was fitted for all 168 subjects, and different t-contrast vectors were used for between-group comparisons. An association analysis was further conducted to evaluate FC changes associated with PSS task performances without creating artificial impairment group-divisions in fighters. Following corrections for multiple comparisons using network-based statistics, our study identified significantly reduced long-range frontal-temporal, frontal-occipital, temporal-occipital, and parietal-occipital sFC strengths in fighters than in NCs, corroborating with previously observed structural damages in corresponding white matter tracts in subjects experiencing repetitive head trauma. In impaired fighters, significantly decreased sFC strengths were found among key regions involved in visual-attention, executive and cognitive process, as compared to non-impaired fighters. Association analysis further reveals similar sFC deficits to worse PSS task performances in all 133 fighters. With our choice of dFC indices, we were not able to observe any significant dFC changes beyond a trend-level increased temporal variability among similar regions with weaker sFC strengths in impaired fighters. Collectively, our functional brain findings supplement previously reported structural brain abnormalities in fighters and are important to comprehensively understand brain changes in fighters with repetitive head trauma.

O5-06-05: Mapping functional and structural brain imaging in subjective cognitive decline

2015 ◽  
Vol 11 (7S_Part_7) ◽  
pp. P329-P330
Author(s):  
Yu Sun ◽  
Zhengjia Dai ◽  
Xiaodan Chen ◽  
Yong He ◽  
Ying Han
Keyword(s):  
Cognitive Decline ◽  
Brain Imaging ◽  
Subjective Cognitive Decline ◽  
Structural Brain ◽  
Structural Brain Imaging

scholarly journals White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study

Oncotarget ◽  
2016 ◽  
Vol 7 (34) ◽  
pp. 54405-54414 ◽  
Author(s):  
Xuan-yu Li ◽  
Zhen-chao Tang ◽  
Yu Sun ◽  
Jie Tian ◽  
Zhen-yu Liu ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Cognitive Decline ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
Subjective Cognitive Decline ◽  
White Matter Degeneration ◽  
Diffusion Tensor Imaging Study

scholarly journals Convergent abnormalities of β-amyloid deposition, glucose metabolism, and fMRI activity in the dorsal precuneus in subjective cognitive decline

2021 ◽  
Author(s):  
Xuan-Yu Li ◽  
Li-Xia Yuan ◽  
Fei-Fan Zhou ◽  
Chang-Chang Ding ◽  
Teng-Fei Guo ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Cognitive Decline ◽  
Resting State ◽  
Low Frequency ◽  
Development Program ◽  
Functional Brain Imaging ◽  
Subjective Cognitive Decline ◽  
Resting State Functional Connectivity ◽  
Positron Emission ◽  
Β Amyloid

Background: There has been no report on convergent local abnormalities of multiple functional brain imaging modalities including β-amyloid (Aβ) deposition, glucose metabolism, and resting-state functional magnetic resonance imaging (RS-fMRI) activities for participants with subjective cognitive decline (SCD). Methods: Fifty participants with SCD and 15 normal controls (NC) were scanned with both [18F]-florbetapir positron emission tomography (PET) and [18F]-fluorodeoxyglucose PET, each PET sacn accompanied with simultaneous RS-fMRI. Voxel-wise metrics were analyzed, including Aβ deposition, glucose metabolism, and three local metrics for RS-fMRI, i.e., amplitude of low frequency fluctuation (ALFF), regional homogeneity (ReHo), and degree centrality (DC). Results: The SCD group showed increased Aβ deposition and increased glucose metabolism (P < 0.05, corrected), as well as decreased ALFF, ReHo, and DC (P < 0.05, uncorrected) in the same area of the left dorsal precuneus (dPCu). The dPCu showed negative resting state functional connectivity (RSFC) with the default mode network (DMN). Regarding global Aβ deposition positivity, the Aβ deposition in the dPCu showed a gradient change, i.e., SCD+ > SCD- > NC-. Further, both SCD+ and SCD- showed increased glucose metabolism and decreased RS-fMRI metrics in the dPCu. Conclusions: The convergent abnormal activities in the dPCu of SCD indicate that the dPCu is an early vulnerable region. The anti-RSFC of the dPCu with DMN supports that the earliest symptoms might be more related to other cognitive functions (e.g., unfocused attention) than episodic memory. (Funded by the National Key Research and Development Program of China and others; ClinicalTrials.gov number, NCT03370744.)

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