Aggressive Fibromatosis

Objective To study the clinicopathological features and differential diagnosis of gastrofibromatosis-like undifferentiated carcinoma (GFLUC). Methods Three patients with GFLUC underwent histological and immunophenotypic analyses and fluorescence in situ hybridization to detect human epidermal growth factor receptor ( HER2) gene amplification. Results Among the three patients (2 male [36 and 44 years old], 1 female [58 years old]), two had lesions in the gastric body and one had lesions in the gastric antrum. Histological analysis revealed mixtures of aggressive fibromatosis and undifferentiated carcinoma in all three cases. Highly invasive fibromatous tissue, consisting of fibroblasts, proliferating myofibroblasts, and collagenous fibrous tissues, accounted for >90% of the tumor, with undifferentiated cancerous tissue accounting for <10% scattered in the gaps within the invasive fibromatous tissue, with no glandular ducts or nests. Immunophenotypic analysis showed that the undifferentiated cancerous cells were positive for pan-cytokeratin, CDX2, villin, and p53, while the cytoplasm of invasive fibromatous cells was positive for vimentin, β-catenin, and smooth muscle actin. No HER2 gene amplification was detected. Conclusions Unlike other gastric carcinomas, GFLUC shows specific histological, biological, and immunophenotypic characteristics.

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Diagnostic Approach of Juvenile Aggressive Fibromatosis of Mandible

Journal of Oral and Maxillofacial Surgery Medicine and Pathology ◽

10.1016/j.ajoms.2021.08.002 ◽

2021 ◽

Author(s):

Shamala Sivanandham ◽

Devika Kollara Vidhyadharan ◽

Durairaj Duraisamy ◽

Arvind Babu Rajendra Santosh

Keyword(s):

Aggressive Fibromatosis ◽

Diagnostic Approach

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Poster 066: Current Management of Aggressive Fibromatosis of the Head and Neck

Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.joms.2007.06.335 ◽

2007 ◽

Vol 65 (9) ◽

pp. 43.e38-43.e39

Author(s):

Jonathan L. Voiner

Keyword(s):

Head And Neck ◽

Aggressive Fibromatosis ◽

Current Management

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Expression of FAP, ADAM12, WISP1, and SOX11 is heterogeneous in aggressive fibromatosis and spatially relates to the histologic features of tumor activity

Cancer Medicine ◽

10.1002/cam4.160 ◽

2013 ◽

Vol 3 (1) ◽

pp. 81-90 ◽

Cited By ~ 9

Author(s):

Benjamin S. Misemer ◽

Amy P. N. Skubitz ◽

J. Carlos Manivel ◽

Stephen C. Schmechel ◽

Edward Y. Cheng ◽

...

Keyword(s):

Aggressive Fibromatosis

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