Algorithmic Differentiation of Code with Multiple Context-Specific Activities

2017 ◽  
Vol 43 (4) ◽  
pp. 1-21 ◽  
Author(s):  
Jan Christian Hückelheim ◽  
Laurent Hascoët ◽  
Jens-Dominik Müller
Keyword(s):  
Algorithmic Differentiation ◽  
Multiple Context ◽  
Specific Activities ◽  
Context Specific

A Thematic Analysis of Overdose Prevention and Response Efforts in States Experiencing Declines in Rates of Opioid-Involved Overdose Deaths

2021 ◽  
pp. 003335492110268
Author(s):  
Amber B. Robinson ◽  
Nida Ali ◽  
Olga Costa ◽  
Cherie Rooks-Peck ◽  
Amy Sorensen-Alawad ◽  
...  
Keyword(s):  
Thematic Analysis ◽  
Prevention Program ◽  
Data Access ◽  
Mortality Rates ◽  
Opioid Overdose ◽  
Overdose Prevention ◽  
Core Elements ◽  
Specific Activities ◽  
Context Specific ◽  
Overdose Deaths

Objective To address the opioid overdose epidemic, it is important to understand the broad scope of efforts under way in states, particularly states in which the rate of opioid-involved overdose deaths is declining. The primary objective of this study was to examine core elements of overdose prevention activities in 4 states with a high rate of opioid-involved overdose deaths that experienced a decrease in opioid-involved overdose deaths from 2016 to 2017. Methods We identified 5 states experiencing decreases in age-adjusted mortality rates for opioid-involved overdoses from 2016 to 2017 and examined their overdose prevention programs via program narratives developed with collaborators from each state’s overdose prevention program. These program narratives used 10 predetermined categories to organize activities: legislative policies; strategic planning; data access, capacity, and dissemination; capacity building; public-facing resources (eg, web-based dashboards); training resources; enhancements and improvements to prescription drug monitoring programs; linkage to care; treatment; and community-focused initiatives. Using qualitative thematic analysis techniques, core elements and context-specific activities emerged. Results In the predetermined categories of programmatic activities, we identified the following core elements of overdose prevention and response: comprehensive state policies; strategic planning; local engagement; data access, capacity, and dissemination; training of professional audiences (eg, prescribers); treatment infrastructure; and harm reduction. Conclusions The identification of core elements and context-specific activities underscores the importance of implementation and adaptation of evidence-based prevention strategies, interdisciplinary partnerships, and collaborations to address opioid overdose. Further evaluation of these state programs and other overdose prevention efforts in states where mortality rates for opioid-involved overdoses declined should focus on impact, optimal timing, and combinations of program activities during the life span of an overdose prevention program.

scholarly journals TRAF3 regulates the oncogenic proteins Pim2 and c-Myc to restrain survival in normal and malignant B cells

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Amy L. Whillock ◽  
Nurbek Mambetsariev ◽  
Wai W. Lin ◽  
Laura L. Stunz ◽  
Gail A. Bishop
Keyword(s):  
Cell Death ◽  
B Cells ◽  
B Cell ◽  
Cell Survival ◽  
Cell Lines ◽  
Adapter Protein ◽  
Protein Levels ◽  
B Cell Survival ◽  
Multiple Context ◽  
Context Specific

Abstract TRAF3 is a versatile intracellular adapter protein with multiple context-specific roles. Uniquely in B cells, TRAF3 deficiency enhances survival and increases the risk of transformation, as loss of TRAF3 is observed in several types of B cell cancers. Here, we report a new mechanism for TRAF3 in the restraint of B cell survival. We found that TRAF3 deficiency was associated with induction of the pro-survival kinase Pim2 in mouse primary B cells and human malignant B cell lines. The increase in Pim2 was independent of NF-κB2 activation but was ameliorated with inhibition of STAT3 expression or function. TRAF3 deficiency also led to a Pim2-dependent increase in c-Myc protein levels and was associated with reduced c-Myc ubiquitination. TRAF3-deficient primary B cells were less sensitive to cell death induced by the Pim inhibitors SGI-1776 and TP-3654. Interestingly, human malignant B cell lines with low expression of TRAF3 were more sensitive to Pim inhibition-induced cell death. Combination treatment of TRAF3-deficient B cells and B cell tumor lines with c-Myc inhibitors enhanced their sensitivity to Pim inhibition, suggesting a possible therapeutic strategy. TRAF3 thus suppresses a Pim2-mediated B cell survival axis, which can be a potential target for treatment of B cell malignancies.

scholarly journals Role of GATA factors in development, differentiation, and homeostasis of the small intestinal epithelium

2014 ◽  
Vol 306 (6) ◽  
pp. G474-G490 ◽  
Author(s):  
Boaz E. Aronson ◽  
Kelly A. Stapleton ◽  
Stephen D. Krasinski
Keyword(s):  
Transcription Factors ◽  
Intestinal Epithelium ◽  
Regulatory Networks ◽  
Small Intestinal Epithelium ◽  
Gata Factors ◽  
Evolution And Development ◽  
Multiple Context ◽  
Small Intestinal ◽  
Context Specific

The small intestinal epithelium develops from embryonic endoderm into a highly specialized layer of cells perfectly suited for the digestion and absorption of nutrients. The development, differentiation, and regeneration of the small intestinal epithelium require complex gene regulatory networks involving multiple context-specific transcription factors. The evolutionarily conserved GATA family of transcription factors, well known for its role in hematopoiesis, is essential for the development of endoderm during embryogenesis and the renewal of the differentiated epithelium in the mature gut. We review the role of GATA factors in the evolution and development of endoderm and summarize our current understanding of the function of GATA factors in the mature small intestine. We offer perspective on the application of epigenetics approaches to define the mechanisms underlying context-specific GATA gene regulation during intestinal development.

scholarly journals COVID-19 and Vaccination Campaigns as “Western Plots” in Pakistan: Government Policies, (Geo-)politics, Local Perceptions, and Beliefs

2021 ◽  
Vol 6 ◽  
Author(s):  
Inayat Ali ◽  
Salma Sadique ◽  
Shahbaz Ali
Keyword(s):  
Routine Vaccination ◽  
Cultural Economic ◽  
Vaccination Programs ◽  
Vaccine Preventable Diseases ◽  
Multiple Context ◽  
Supplementary Immunization Activities ◽  
The Government ◽  
Context Specific ◽  
Vaccination Campaigns ◽  
The Impact

Vaccination encounters multiple context-specific challenges—socio-cultural, economic, and political—that substantially affect its uptake. Likewise, natural disasters and health emergencies considerably impact immunization endeavors, such as the coronaviurs 2019 (COVID-19) pandemic that has overwhelmed the entire world. It was already anticipated that the pandemic would severely affect Pakistan's vaccination programs due to interruptions in routine vaccination and the overstretching of healthcare systems. Consequently, there are anticipations of outbreaks of other vaccine-preventable diseases (VPDs). Yet empirical evidence is missing. Drawing on qualitative research, this article focuses on the impact of COVID-19 on routine vaccination programs in Pakistan. Our data come from a small village located in Pakistan's Sindh province where local people refused the routine polio vaccine that was stopped for a while, then resumed in July 2020. They suspected both the vaccine and COVID-19 to be a “Western plot.” We argue that these perceptions and practices can be seen against the backdrop of economic, socio-cultural, and (geo)political forces, which are encoded in “societal memory.” Not only is there a need to reverse the significant impacts of COVID-19 on routine vaccination by arranging supplementary immunization activities (SIAs), but also the government must deal with other pressing issues that affect the vaccination programs in the country.

scholarly journals Plan-based generalization shapes local implicit adaptation to opposing visuomotor transformations

2018 ◽  
Author(s):  
Raphael Schween ◽  
Jordan Taylor ◽  
Mathias Hegele
Keyword(s):  
Reaching Movements ◽  
Contextual Cues ◽  
Implicit Processes ◽  
Dual Adaptation ◽  
Visuomotor Transformations ◽  
Multiple Context ◽  
Human Ability ◽  
Context Specific ◽  
Distinct Transformation ◽  
Complex Manner

AbstractThe human ability to use different tools demonstrates our capability of forming and maintaining multiple, context specific motor memories. Experimentally, this ability has been investigated in dual adaptation, where participants adjust their reaching movements to opposing visuomotor transformations. Adaptation in these paradigms occurs by distinct processes, i.e. the development of explicit aiming strategies for each transformation and/or the implicit acquisition of distinct visuomotor mappings. The presence of distinct, transformation-dependent aftereffects has been interpreted as support for the latter. Alternatively, however, distinct aftereffects could reflect adaptation of a single visuomotor map, which is locally adjusted in different regions of the workspace. Indeed, recent studies suggest that explicit aiming strategies direct where in the workspace implicit adaptation occurs.Disentangling these possibilities is critical to understanding how humans acquire and maintain separate motor memories for different skills and tools. We therefore investigated generalization of explicit and implicit adaptation to different directions after participants practiced two opposing cursor rotations, which were associated with separate visual workspaces. Whereas participants learned to compensate opposing rotations by explicit strategies that were specific to the visual workspace cue, aftereffects were not sensitive to visual workspace cues. Instead, aftereffects displayed bimodal generalization patterns that appeared to reflect locally limited learning of both transformations. By varying target arrangements and instructions, we show that these generalization patterns are consistent with implicit adaptation that generalizes locally around (explicit) movement plans associated with opposing visuomotor transformations. Our findings show that strategies can shape implicit adaptation in a complex manner.New & NoteworthyVisuomotor dual adaptation experiments have identified contextual cues that enable learning of separate visuomotor mappings, but little is known about the underlying representations of learning. We report that visual workspace separation as a contextual cue enables participants to compensate opposing cursor rotations by a combination of explicit and implicit processes: Learners developed context-dependent explicit aiming strategies while an implicit visuomotor map represented dual adaptation independent from context by local adaptation around the explicit movement plan.

scholarly journals Plan-based generalization shapes local implicit adaptation to opposing visuomotor transformations

2018 ◽  
Vol 120 (6) ◽  
pp. 2775-2787 ◽  
Author(s):  
Raphael Schween ◽  
Jordan A. Taylor ◽  
Mathias Hegele
Keyword(s):  
Visual Display ◽  
Contextual Cues ◽  
Implicit Processes ◽  
Dual Adaptation ◽  
Visuomotor Transformations ◽  
Multiple Context ◽  
Human Ability ◽  
Context Specific ◽  
Context Cues ◽  
Distinct Transformation

The human ability to use different tools demonstrates our capability of forming and maintaining multiple, context-specific motor memories. Experimentally, this has been investigated in dual adaptation, where participants adjust their reaching movements to opposing visuomotor transformations. Adaptation in these paradigms occurs by distinct processes, such as strategies for each transformation or the implicit acquisition of distinct visuomotor mappings. Although distinct, transformation-dependent aftereffects have been interpreted as support for the latter, they could reflect adaptation of a single visuomotor map, which is locally adjusted in different regions of the workspace. Indeed, recent studies suggest that explicit aiming strategies direct where in the workspace implicit adaptation occurs, thus potentially serving as a cue to enable dual adaptation. Disentangling these possibilities is critical to understanding how humans acquire and maintain motor memories for different skills and tools. We therefore investigated generalization of explicit and implicit adaptation to untrained movement directions after participants practiced two opposing cursor rotations, which were associated with the visual display being presented in the left or right half of the screen. Whereas participants learned to compensate for opposing rotations by explicit strategies specific to this visual workspace cue, aftereffects were not cue sensitive. Instead, aftereffects displayed bimodal generalization patterns that appeared to reflect locally limited learning of both transformations. By varying target arrangements and instructions, we show that these patterns are consistent with implicit adaptation that generalizes locally around movement plans associated with opposing visuomotor transformations. Our findings show that strategies can shape implicit adaptation in a complex manner. NEW & NOTEWORTHY Visuomotor dual adaptation experiments have identified contextual cues that enable learning of separate visuomotor mappings, but the underlying representations of learning are unclear. We report that visual workspace separation as a contextual cue enables the compensation of opposing cursor rotations by a combination of explicit and implicit processes: Learners developed context-dependent explicit aiming strategies, whereas an implicit visuomotor map represented dual adaptation independent from arbitrary context cues by local adaptation around the explicit movement plan.

Feasibility of context-specific activities for improving physical activity levels among Indian adults with stroke

2021 ◽  
pp. 1-7
Author(s):  
Pradeepa Nayak ◽  
Senthil Kumaran D ◽  
Amreen Mahmood ◽  
Natarajan Manikandan ◽  
Bhaskaran Unnikrishnan ◽  
...  
Keyword(s):  
Physical Activity ◽  
Activity Levels ◽  
Physical Activity Levels ◽  
Specific Activities ◽  
Context Specific

Validation of the Procrastination at Work Scale

2020 ◽  
Vol 36 (5) ◽  
pp. 767-776
Author(s):  
U. Baran Metin ◽  
Toon W. Taris ◽  
Maria C. W. Peeters ◽  
Max Korpinen ◽  
Urška Smrke ◽  
...  
Keyword(s):  
Work Engagement ◽  
Discriminant Validity ◽  
Psychometric Characteristics ◽  
The Czech Republic ◽  
The United Kingdom ◽  
Confirmatory Factor ◽  
And Performance ◽  
Context Specific ◽  
Negative Links ◽  
Office Employees

Abstract. Procrastination at work has been examined relatively scarcely, partly due to the lack of a globally validated and context-specific workplace procrastination scale. This study investigates the psychometric characteristics of the Procrastination at Work Scale (PAWS) among 1,028 office employees from seven countries, namely, Croatia, the Czech Republic, Finland, Slovenia, Turkey, Ukraine, and the United Kingdom. Specifically, it was aimed to test the measurement invariance of the PAWS and explore its discriminant validity by examining its relationships with work engagement and performance. Multi-group confirmatory factor analysis shows that the basic factor structure and item loadings of the PAWS are invariant across countries. Furthermore, the two subdimensions of procrastination at work exhibited different patterns of relationships with work engagement and performance. Whereas soldiering was negatively related to work engagement and task performance, cyberslacking was unrelated to engagement and performance. These results indicate further validity evidence for the PAWS and the psychometric characteristics show invariance across various countries/languages. Moreover, workplace procrastination, especially soldiering, is a problematic behavior that shows negative links with work engagement and performance.

Ambulatory Assessment

2009 ◽  
Vol 14 (2) ◽  
pp. 109-119 ◽  
Author(s):  
Ulrich W. Ebner-Priemer ◽  
Timothy J. Trull
Keyword(s):  
Real Time ◽  
Clinical Psychology ◽  
Real Life ◽  
Ambulatory Assessment ◽  
Computer Assisted ◽  
Affective Valence ◽  
Time Data ◽  
Physiological Processes ◽  
Context Specific ◽  
Questionnaire Studies

Convergent experimental data, autobiographical studies, and investigations on daily life have all demonstrated that gathering information retrospectively is a highly dubious methodology. Retrospection is subject to multiple systematic distortions (i.e., affective valence effect, mood congruent memory effect, duration neglect; peak end rule) as it is based on (often biased) storage and recollection of memories of the original experience or the behavior that are of interest. The method of choice to circumvent these biases is the use of electronic diaries to collect self-reported symptoms, behaviors, or physiological processes in real time. Different terms have been used for this kind of methodology: ambulatory assessment, ecological momentary assessment, experience sampling method, and real-time data capture. Even though the terms differ, they have in common the use of computer-assisted methodology to assess self-reported symptoms, behaviors, or physiological processes, while the participant undergoes normal daily activities. In this review we discuss the main features and advantages of ambulatory assessment regarding clinical psychology and psychiatry: (a) the use of realtime assessment to circumvent biased recollection, (b) assessment in real life to enhance generalizability, (c) repeated assessment to investigate within person processes, (d) multimodal assessment, including psychological, physiological and behavioral data, (e) the opportunity to assess and investigate context-specific relationships, and (f) the possibility of giving feedback in real time. Using prototypic examples from the literature of clinical psychology and psychiatry, we demonstrate that ambulatory assessment can answer specific research questions better than laboratory or questionnaire studies.

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