Guest editors' introduction to special issue on the first INFORMS simulation society research workshop

2010 ◽  
Vol 20 (1) ◽  
pp. 1-3
Author(s):  
Stephen E. Chick ◽  
Enver Yücesan
Keyword(s):  
Special Issue ◽  
Research Workshop ◽  
Society Research

Transient outward potassium channel regulation in healthy and diabetic heartsThis article is one of a selection of papers from the NATO Advanced Research Workshop on Translational Knowledge for Heart Health (published in part 1 of a 2-part Special Issue).

2009 ◽  
Vol 87 (2) ◽  
pp. 77-83 ◽  
Author(s):  
Mónica Gallego ◽  
Aintzane Alday ◽  
Janire Urrutia ◽  
Oscar Casis
Keyword(s):  
Cardiac Arrhythmias ◽  
Functional Expression ◽  
Trophic Factors ◽  
Diabetic Patients ◽  
Special Issue ◽  
Channel Regulation ◽  
Research Workshop ◽  
Sympathetic Nervous ◽  
Selection Of

Diabetic patients have a higher incidence of cardiac arrhythmias, including ventricular fibrillation and sudden death, and show important alterations in the electrocardiogram, most of these related to the repolarization. In myocytes isolated from diabetic hearts, the transient outward K+ current (Ito) is the repolarizing current that is mainly affected. Type 1 diabetes alters Ito at 3 levels: the recovery of inactivation, the responsiveness to physiologic regulators, and the functional expression of the channel. Diabetes slows down Ito recovery of inactivation because it triggers the switching from fast-recovering Kv4.x channels to the slow-recovering Kv1.4. Diabetic animals also have decreased responsiveness of Ito towards the sympathetic nervous system; thus, the diabetic heart develops a resistance to its physiologic regulator. Finally, diabetes impairs support of various trophic factors required for the functional expression of the channel and reduces Ito amplitude by decreasing the amount of Kv4.2 and Kv4.3 proteins.

scholarly journals Optimizing the Future of Innovative Technologies and Infinite Data

2019 ◽  
Vol 38 (4) ◽  
pp. 403-413 ◽  
Author(s):  
Kristen L. Walker ◽  
George R. Milne ◽  
Bruce D. Weinberg
Keyword(s):  
Public Policy ◽  
Data Use ◽  
Complex Relationship ◽  
Special Issue ◽  
Innovative Technologies ◽  
Societal Expectations ◽  
And Control ◽  
Technology Marketing ◽  
Insight Into ◽  
Society Research

The coeditors provide an overview of the insightful and pioneering articles included in this special issue, “Marketing and Public Policy in a Technology-Integrated Society.” The articles fall into three broad technological influences: agility and connection, use and abuse, and control and access. These influences provide context for a novel framework about technology-integrated society research, showing the complex relationship between data use, data exposure and regulatory (self- and mandated) protection of data and people. Presently, technology is driving innovation and societal expectations, often with creepy connotations and invasive implications. The articles in this special issue illustrate the ambiguous areas concerning technology, marketing, and public policy, offering insight into amplified risks and the processes that will help temper potential vulnerability, harm, and risk in a technology-integrated society.

Quants and Poets: Advancing Methods and Methodologies in Business and Society Research

2017 ◽  
Vol 57 (1) ◽  
pp. 3-25 ◽  
Author(s):  
Andrew Crane ◽  
Irene Henriques ◽  
Bryan W. Husted
Keyword(s):  
Empirical Research ◽  
Business And Society ◽  
Special Issue ◽  
Research Methodologies ◽  
Research Challenges ◽  
Methodological Challenges ◽  
Introductory Article ◽  
Society Research

Business and society research has increasingly moved from the margins to the mainstream. Although this progression has benefited from advances in empirical research, the field continues to suffer from considerable methodological challenges that hamper its development. In this introductory article to the special issue, we review how far our field has come in advancing methods and methodologies in business and society research. We also highlight the methods and methodologies covered by the contributors to this special issue and how they help address key shortcomings in our field. Finally, we suggest some promising research methodologies that can address important business and society research challenges going forward.

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