Transient outward potassium channel regulation in healthy and diabetic heartsThis article is one of a selection of papers from the NATO Advanced Research Workshop on Translational Knowledge for Heart Health (published in part 1 of a 2-part Special Issue).

2009 ◽  
Vol 87 (2) ◽  
pp. 77-83 ◽  
Author(s):  
Mónica Gallego ◽  
Aintzane Alday ◽  
Janire Urrutia ◽  
Oscar Casis
Keyword(s):  
Cardiac Arrhythmias ◽  
Functional Expression ◽  
Trophic Factors ◽  
Diabetic Patients ◽  
Special Issue ◽  
Channel Regulation ◽  
Research Workshop ◽  
Sympathetic Nervous ◽  
Selection Of

Diabetic patients have a higher incidence of cardiac arrhythmias, including ventricular fibrillation and sudden death, and show important alterations in the electrocardiogram, most of these related to the repolarization. In myocytes isolated from diabetic hearts, the transient outward K+ current (Ito) is the repolarizing current that is mainly affected. Type 1 diabetes alters Ito at 3 levels: the recovery of inactivation, the responsiveness to physiologic regulators, and the functional expression of the channel. Diabetes slows down Ito recovery of inactivation because it triggers the switching from fast-recovering Kv4.x channels to the slow-recovering Kv1.4. Diabetic animals also have decreased responsiveness of Ito towards the sympathetic nervous system; thus, the diabetic heart develops a resistance to its physiologic regulator. Finally, diabetes impairs support of various trophic factors required for the functional expression of the channel and reduces Ito amplitude by decreasing the amount of Kv4.2 and Kv4.3 proteins.

Introduction: Affixes and bases

2011 ◽  
Vol 4 (2) ◽  
pp. 161-168
Author(s):  
Stela Manova
Keyword(s):  
Special Issue ◽  
Affix Order ◽  
Selection Of ◽  
Affix Ordering

This special issue includes a selection of papers presented at the 2nd Vienna Workshop on Affix Order held in Vienna, Austria on June 4–5, 2009. The workshop was in honor of Wolfgang U. Dressler on the occasion of his 70th birthday. However, this special issue differs from the classical Festschrift dedicated to a renowned scholar and is ‘more special’ in two respects at least: 1) not all authors are Dressler's friends and colleagues, some of them are only indirectly related to him, through his students; and 2) since the papers were presented at a topic-oriented workshop, they are thematically uniform. In other words, this special issue is a kind of scientific genealogy in terms of affix ordering. Thus, the title Affixes and bases should be understood in two ways: literally – affixes and bases as linguistic notions, and metaphorically – affixes and bases as linguists related directly and indirectly to a prominent base: Wolfgang U. Dressler.

Is there a relationship between body composition and insulin regimen modality in type 1 diabetic patients?

2014 ◽  
Author(s):  
Merve Yilmaz ◽  
Arzu Gedik ◽  
Simge Yilmaz ◽  
Belgin Bektas ◽  
Dilek Cimrin ◽  
...  
Keyword(s):  
Body Composition ◽  
Diabetic Patients ◽  
Insulin Regimen ◽  
Type 1 Diabetic Patients

Insulin-mimetic effects of short-term Rapamycin in type 1 diabetic patients prior islet transplantation

2017 ◽  
Author(s):  
Federica Ermetici ◽  
Silvia Briganti ◽  
Stefano Benedini ◽  
Roberto Codella ◽  
Paola Maffi ◽  
...  
Keyword(s):  
Islet Transplantation ◽  
Diabetic Patients ◽  
Short Term ◽  
Insulin Mimetic ◽  
Type 1 Diabetic Patients

Perception of Therapeutic Education in Diabetic Patients at Tit Melil Health Center

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Mory Sanoh
Keyword(s):  
Well Being ◽  
Cross Sectional Study ◽  
Basic Element ◽  
Therapeutic Education ◽  
Diabetic Patients ◽  
Oral Antidiabetics ◽  
Educational Training ◽  
Cross Sectional ◽  
Type 2 Diabetics

Introduction : A chronic condition like diabetes interferes with an individual's well-being, and if some of their needs are not met because of the disease, their quality of life is reduced. In this context, therapeutic education constitutes a basic element in the management of diabetes.Materials and Methods : A cross-sectional study by self-administered questionnaire and interviews which were carried out with all type 1 and type 2 diabetics, consultants at the level of the Tit Mélil Primary Health Care establishment, in 2019 and who benefited from or not therapeutic education, with or without complications.Result : The study included 50 diabetic patients, surveys show us that type 1 diabetic patients were 13 (26%). And type 2.37 (74%). Regarding the organization of care, 74% of patients say they are under treatment with oral antidiabetics, 10% oral antidiabetics and insulins, 6% insulin therapy and others under diet. Speaking of Food, 76.5% of diabetics know the importance and know what foods to avoid.Conclusion : TVE is possible, it will result in a change in the structure of programs and new educational training for caregivers.

GENETIC ROLE OF HLA-G14 BASE PAIR INDEL POLYMORPHIC GENE WITH TYPE 1 DIABETIC PATIENTS

2019 ◽  
Vol 22 (09) ◽  
pp. 154-160
Author(s):  
Hasanain Khaleel Shareef ◽  
Ahmed Adil Ali ◽  
Rafah F. Al-Jebori
Keyword(s):  
Base Pair ◽  
Diabetic Patients ◽  
Polymorphic Gene ◽  
Type 1 Diabetic Patients
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