THE SELECTION OF A DDT-TOLERANT STRAIN OF MICE AND SOME CHARACTERISTICS OF THAT STRAIN

1964 ◽  
Vol 42 (4) ◽  
pp. 519-526 ◽  
Author(s):  
G. W. Ozburn ◽  
F. O. Morrison
Keyword(s):  
Intraperitoneal Injection ◽  
Sesame Oil ◽  
Laboratory Mice ◽  
Tolerant Strain ◽  
Visual Health ◽  
Selection Of

A colony of laboratory mice selected by intraperitoneal injection of DDT in sesame oil developed definite DDT-tolerance by generation 10. This tolerance was found to extend to the related chemicals lindane and dieldrin when administered by intraperitoneal injection. Fecundity, growth, and visual health were unimpaired.

Development of a DDT-Tolerant Strain of Laboratory Mice

Nature ◽  
1962 ◽  
Vol 196 (4858) ◽  
pp. 1009-1010 ◽  
Author(s):  
G. W. OZBURN ◽  
F. O. MORRISON
Keyword(s):  
Laboratory Mice ◽  
Tolerant Strain

scholarly journals Selection of Laboratory Mice for the High Scores of Logic Task Solutions: The Correlated Changes in Behavior

2014 ◽  
Vol 05 (04) ◽  
pp. 294-300 ◽  
Author(s):  
Olga V. Perepelkina ◽  
Vassilissa A. Golibrodo ◽  
Irina G. Lilp ◽  
Inga I. Poletaeva
Keyword(s):  
Laboratory Mice ◽  
Selection Of

scholarly journals Selection of Laboratory Mice for Improved Reproductive Performance at High Environmental Temperature

1979 ◽  
Vol 32 (1) ◽  
pp. 133 ◽  
Author(s):  
Pamela R Pennycuik
Keyword(s):  
Reproductive Performance ◽  
Reproductive Output ◽  
Environmental Temperature ◽  
Laboratory Mice ◽  
Next Generation ◽  
Hot Environment ◽  
High Environmental Temperature ◽  
Selection Of ◽  
Mouse Lines

When mice are transferred from a 'temperate' to a hot environment their reproductive output is reduced. To test whether this reduction could be countered by selection, three mouse lines, housed permanently as 32�C, were selected for increase in the numbers of young reared to 3 weeks when pairs were allowed to remain together for 12 weeks. In one line (R95) in which all fertile pairs contributed to the next generation, no improvement was observed in 19 generations. In two other lines (W21 and W34) in which only half the pairs in one generation contributed to the next, productivity returned, in about 12 generations, to almost the same levels as those of controls housed at 21�C.

scholarly journals VARIETY OF TUMOR MODELS FOR TESTING ANTITUM TREATMENT ACTIVITY OF SUBSTANCES IN MICE

2020 ◽  
Vol 66 (4) ◽  
pp. 353-363
Author(s):  
Tatyana Nekhaeva ◽  
A. Chernov ◽  
Yana Toropova ◽  
Mikhail Galagudza ◽  
Irina Baldueva
Keyword(s):  
Mouse Models ◽  
Mechanisms Of Action ◽  
Experimental Models ◽  
Genetically Engineered ◽  
Antitumor Drugs ◽  
Laboratory Mice ◽  
Metabolism Study ◽  
New Anticancer Drugs ◽  
Treatment Activity ◽  
Selection Of

Selection of tolerated and toxic doses, schemes of therapy for new anticancer drugs, assessment of its toxicity, pharmacokinetics, metabolism, study of the mechanism of action and tumor sensitivity are carried out using models of human tumors in mice. The review contains a diverse description of experimental models (transplantable, genetically engineered, humanized, autochthonous, orthotopic, heterotopic and metastatic) tumors using laboratory mice. The advantages, disadvantages, directions and specific features of the use of mouse models, their role in the study of mechanisms of action of antitumor drugs are considered on the examples of recent research.

Cognitive gadgets and cognitive priors

2019 ◽  
Vol 42 ◽  
Author(s):  
Gian Domenico Iannetti ◽  
Giorgio Vallortigara
Keyword(s):  
Cognitive Neuroscience ◽  
Selection Of

Abstract Some of the foundations of Heyes’ radical reasoning seem to be based on a fractional selection of available evidence. Using an ethological perspective, we argue against Heyes’ rapid dismissal of innate cognitive instincts. Heyes’ use of fMRI studies of literacy to claim that culture assembles pieces of mental technology seems an example of incorrect reverse inferences and overlap theories pervasive in cognitive neuroscience.

Note on Selection of Coordinate Systems for Geodynamics

1975 ◽  
Vol 26 ◽  
pp. 395-407
Author(s):  
S. Henriksen
Keyword(s):  
Sea Level ◽  
The Other ◽  
Coordinate Systems ◽  
Mean Sea Level ◽  
The Earth ◽  
The One ◽  
Static Systems ◽  
Selection Of

The first question to be answered, in seeking coordinate systems for geodynamics, is: what is geodynamics? The answer is, of course, that geodynamics is that part of geophysics which is concerned with movements of the Earth, as opposed to geostatics which is the physics of the stationary Earth. But as far as we know, there is no stationary Earth – epur sic monere. So geodynamics is actually coextensive with geophysics, and coordinate systems suitable for the one should be suitable for the other. At the present time, there are not many coordinate systems, if any, that can be identified with a static Earth. Certainly the only coordinate of aeronomic (atmospheric) interest is the height, and this is usually either as geodynamic height or as pressure. In oceanology, the most important coordinate is depth, and this, like heights in the atmosphere, is expressed as metric depth from mean sea level, as geodynamic depth, or as pressure. Only for the earth do we find “static” systems in use, ana even here there is real question as to whether the systems are dynamic or static. So it would seem that our answer to the question, of what kind, of coordinate systems are we seeking, must be that we are looking for the same systems as are used in geophysics, and these systems are dynamic in nature already – that is, their definition involvestime.

Measurements of the Cape Astrometric Survey of the Southern Hemisphere

1978 ◽  
Vol 48 ◽  
pp. 515-521
Author(s):  
W. Nicholson
Keyword(s):  
Southern Hemisphere ◽  
Automatic Measuring ◽  
Measuring Machine ◽  
Final Selection ◽  
Selection Of

SummaryA routine has been developed for the processing of the 5820 plates of the survey. The plates are measured on the automatic measuring machine, GALAXY, and the measures are subsequently processed by computer, to edit and then refer them to the SAO catalogue. A start has been made on measuring the plates, but the final selection of stars to be made is still a matter for discussion.

Basal Lamina Formation in DMBA Induced Mammary Carcinoma

1977 ◽  
Vol 35 ◽  
pp. 534-535
Author(s):  
I. Russo ◽  
J. Saby ◽  
J. Russo
Keyword(s):  
Mammary Carcinoma ◽  
Virgin Female ◽  
Mammary Glands ◽  
Sesame Oil ◽  
Female Rats ◽  
Ultrastructural Changes ◽  
Post Inoculation ◽  
Intermediate Type ◽  
Sprague Dawley ◽  
Intercellular Spaces

It has been previously demonstrated that DMBA-induced rat mammary carcinoma originates in the terminal end bud (TEB) of the mammary gland by proliferation of intermediate type cells (1). The earliest lesion identified is the intraductal proliferation (IDP), which gives rise to intraductal carcinomas. These evolve to cribriform, papillary and comedo types (2). In the present work, we report the ultrastructural changes that take place in the IDP for the formation of a cribriform pattern.Fifty-five-day-old Sprague Dawley virgin female rats were inoculated intra- gastrically with 20 mg 7,12-dimethylbenz(a)anthracene (DMBA) in 1 ml sesame oil. Non-inoculated, age-matched females were used as controls. Mammary glands from both control and experimental rats were removed weekly from the time of inoculation until 86 days post-inoculation. The glands were fixed and processed for electron microscopy (2).The first change observed in IDP's was the widening of intercellular spaces and the secretion of an electron dense material into these spaces (Fig. 1).

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