Development of a DDT-Tolerant Strain of Laboratory Mice

Nature ◽  
1962 ◽  
Vol 196 (4858) ◽  
pp. 1009-1010 ◽  
Author(s):  
G. W. OZBURN ◽  
F. O. MORRISON
Keyword(s):  
Laboratory Mice ◽  
Tolerant Strain

THE SELECTION OF A DDT-TOLERANT STRAIN OF MICE AND SOME CHARACTERISTICS OF THAT STRAIN

1964 ◽  
Vol 42 (4) ◽  
pp. 519-526 ◽  
Author(s):  
G. W. Ozburn ◽  
F. O. Morrison
Keyword(s):  
Intraperitoneal Injection ◽  
Sesame Oil ◽  
Laboratory Mice ◽  
Tolerant Strain ◽  
Visual Health ◽  
Selection Of

A colony of laboratory mice selected by intraperitoneal injection of DDT in sesame oil developed definite DDT-tolerance by generation 10. This tolerance was found to extend to the related chemicals lindane and dieldrin when administered by intraperitoneal injection. Fecundity, growth, and visual health were unimpaired.

Tolerance of Atmospheric Ammonia by Laboratory Mice

2006 ◽  
Author(s):  
A.R. Green ◽  
C.M. Wathes ◽  
T.G.M. Demmers ◽  
J. MacArthur-Clark ◽  
H. Xin
Keyword(s):  
Laboratory Mice ◽  
Atmospheric Ammonia

scholarly journals The gut microbiome of laboratory mice: considerations and best practices for translational research

2021 ◽  
Author(s):  
Aaron C. Ericsson ◽  
Craig L. Franklin
Keyword(s):  
Human Physiology ◽  
Best Practices ◽  
Gut Microbiota ◽  
Translational Research ◽  
Mouse Models ◽  
Gut Microbiome ◽  
Predictive Power ◽  
Environmental Influences ◽  
Pharmacological Intervention ◽  
Laboratory Mice

AbstractJust as the gut microbiota (GM) is now recognized as an integral mediator of environmental influences on human physiology, susceptibility to disease, and response to pharmacological intervention, so too does the GM of laboratory mice affect the phenotype of research using mouse models. Multiple experimental factors have been shown to affect the composition of the GM in research mice, as well as the model phenotype, suggesting that the GM represents a major component in experimental reproducibility. Moreover, several recent studies suggest that manipulation of the GM of laboratory mice can substantially improve the predictive power or translatability of data generated in mouse models to the human conditions under investigation. This review provides readers with information related to these various factors and practices, and recommendations regarding methods by which issues with poor reproducibility or translatability can be transformed into discoveries.

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