The role of sodium restriction in the management of hypertension

1986 ◽  
Vol 64 (6) ◽  
pp. 786-792 ◽  
Author(s):  
Trefor Morgan ◽  
Carol Nowson
Keyword(s):  
Blood Pressure ◽  
Moderate Hypertension ◽  
Mild Hypertension ◽  
Population Studies ◽  
Severe Hypertension ◽  
Sodium Intake ◽  
Regression Line ◽  
Elevated Blood ◽  
Sodium Restriction

More than 50 studies have investigated the effect of altered sodium intake on blood pressure. A regression line drawn through the change in blood pressure and change in sodium intake indicates that blood pressure alters about 10 mmHg (1 mmHg = 133.322 Pa) for every 100 mmol/day alteration in sodium intake, a change similar to that observed in between-population "studies." The studies that have failed to show a change in blood pressure have usually been in people with a blood pressure less than 130/90 mmHg. Normotensive people appear to tolerate a higher intake of sodium before blood pressure rises, but if increased sufficiently, blood pressure rises in most people. Sodium restriction reduces blood pressure in people with severe hypertension, moderate hypertension and mild hypertension. It may be the cause of blood pressure increase associated with age and the reason for the higher prevalence of hypertension and vascular disease in Western communities. Sodium restriction should be used to treat people with elevated blood pressure.

scholarly journals DESCRIPTION OF HYPERTENSION LEVELS IN PRIMARY HYPERTENSION ADULTS AND ELDERLY IN KARANGBINANGUN LAMONGAN DISTRICT

2021 ◽  
Vol 2 (1) ◽  
pp. 72
Author(s):  
Iswatun Iswatun ◽  
Endah Sri Wijayanti ◽  
Lailatul Fadliyah ◽  
Cucuk Rahmadi Purwanto ◽  
Iin Rohmawat
Keyword(s):  
Blood Pressure ◽  
Moderate Hypertension ◽  
Mild Hypertension ◽  
Health Workers ◽  
Severe Hypertension ◽  
Simple Random Sampling ◽  
Primary Hypertension ◽  
Pressure Measurements ◽  
Inclusion Criteria ◽  
Normal Limits

Introduction: Hypertension is often a silent killer because it is often without symptoms that warn of a problem. Symptoms that appear are often considered as common disorders, so that the victim is too late to realize that the disease is coming. Hypertension is an increase in blood pressure above normal limits with systolic value of 140 mmHg and diastolic value of 90 mmHg. The purpose of this study was to determine the level of hypertension in patients with primary hypertension in Karangbinangun Lamongan District. Method: This research design using descriptive with a population of 70 respondents then sampled using simple random sampling and get a sample of 64 respondents, in accordance with the inclusion criteria, are healthy patients and willing to sign the informed consent The variable in this study is the level of hypertension. The data of this study were taken from the results of blood pressure measurements by standards WHO. The data is tabulated in the form of frequency distribution by categorizing hypertension into mild, moderate and severe. Result: The results showed that half of the respondents (50%) had mild hypertension, 28.1% moderate hypertension and 21.9% severe hypertension. Conclusion: Seeing the results of this study, that there are still many people who have hypertension, so health education by health workers and family is needed to prevent recurrence.

scholarly journals Hubungan Asupan Natrium dan Status Gizi Terhadap Tingkat Hipertensi Pada Pasien Rawat Jalan Di RSUD Kota Makassar

2018 ◽  
Vol 25 (1) ◽  
pp. 11
Author(s):  
Hasbullah Darmawan ◽  
Abdullah Tamrin ◽  
Nadimin Nadimin
Keyword(s):  
Blood Pressure ◽  
Nutritional Status ◽  
Moderate Hypertension ◽  
Mild Hypertension ◽  
Sodium Intake ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Salt Diet ◽  
Blood Pressure Data ◽  
The Relationship

Hypertension is a big problem, not only in western countries but also in Indonesia. Every year hypertension or high blood pressure contributes to the deaths of nearly 9.4 million people due to heart disease and stroke and if combined these two diseases are the number one cause in the world.This study aims to analyze the relationship between sodium intake and nutritional status to the level of hypertension in outpatients in RSUD Makassar City. This study used cross sectional study design. The sample is outpatient of RSUD Makassar City. Data of sodium intake and nutritional status were obtained by recall 1x24 hours and anthropometry measurement, while blood pressure data were obtained from patient rekammedic data. The results showed that samples with normal sodium intake tended to have mild hypertension that was 12 people (85,7%) while sample with sodium intake was more likely to have moderate hypertension that is 12 people (75%). Samples of normal nutritional status with mild hypertension tends to be 12 people (80%) while the sample with abnormal nutritional status tend to have moderate hypertension is 11 people (73,3%). The relationship between sodium intake and nutritional status to hypertension level. It is recommended to hospital nutritionists to provide further consultation on low-salt diet as well as improved nutritional status. In addition there is also a further understanding of hypertensive patients about the cause of hypertension to be more vigilant against hypertension disease.

Role of renal nerves in rats with low-sodium, one-kidney hypertension

1986 ◽  
Vol 250 (2) ◽  
pp. H189-H194 ◽  
Author(s):  
R. C. Vari ◽  
R. H. Freeman ◽  
J. O. Davis ◽  
W. D. Sweet
Keyword(s):  
Blood Pressure ◽  
Experimental Model ◽  
Renal Denervation ◽  
Mild Hypertension ◽  
Subsequent Development ◽  
Renal Nerves ◽  
Sodium Restriction ◽  
Deficient Diet ◽  
Low Sodium

This study examined the role of the renal nerves in both the maintenance and developmental phases of hypertension produced by sodium restriction in one-kidney rats. Results indicate that mild hypertension is sustained through 6 wk after unilateral nephrectomy in rats fed a sodium-deficient diet, with the greatest increase in systolic blood pressure occurring within the first 2 wk. Six weeks after nephrectomy, renal denervation was performed in the sodium-restricted, hypertensive rats, and the blood pressure returned to normotensive levels. Plasma renin activity (PRA) was elevated fourfold after 6 wk of sodium restriction and was unchanged by renal denervation. In another series of experiments that examined the development of hypertension in this experimental model, contralateral renal denervation was performed at the time of nephrectomy, and this prevented the subsequent development of hypertension. PRA was significantly attenuated in these low-sodium, renal-denervated rats that failed to become hypertensive when compared with PRA in hypertensive low-sodium, sham-denervated rats. Kidney norepinephrine content was reduced by 96% after renal denervation in both phases of the hypertension. These data demonstrate that intact renal nerves are necessary for both the development and maintenance of mild hypertension after sodium restriction in one-kidney rats. The pressor contribution of the renal nerves to the hypertension in this experimental model appears to be related, at least in part, to the activation of the renin-angiotensin pressor mechanism.

ROLE OF THE THYROID GLAND IN DEVELOPMENT AND MAINTENANCE OF RENAL HYPERTENSION IN RATS

1960 ◽  
Vol XXXIV (III) ◽  
pp. 411-429 ◽  
Author(s):  
Melvin J. Fregly ◽  
Kenneth M. Cook
Keyword(s):  
Blood Pressure ◽  
Rate Increase ◽  
Renal Hypertension ◽  
The Other ◽  
Elevated Blood Pressure ◽  
Unit Weight ◽  
Elevated Blood ◽  
Inhibition Of Growth ◽  
Testicular Size

ABSTRACT The anti-thyroid drugs, thiouracil, propylthiouracil, and methimazole, prevented both development of elevated blood pressure and cardiac hypertrophy usually accompanying kidney encapsulation with latex envelopes. These drugs also reduced elevated blood pressure of rats with hypertension of 13 to 40 weeks' duration prior to drug administration. Addition of desiccated thyroid powder to diet containing an anti-thyroid drug overcame the anti-hypertensive effect of the latter. Withdrawal of thyroid powder only was followed by return of blood pressure to previous low level within 3 weeks. The results suggest that the anti-hypertensive effect of these drugs is related directly to the hypothyroidism produced rather than to extrathyroidal effects of the drugs. Comparison of potencies of the 3 drugs in terms of anti-hypertensive effect, inhibition of growth rate, increase in testicular size, and increase in thyroid size suggests that propylthiouracil and methimazole are equally potent per unit weight of drug. Thiouracil has approximately half the potency of the other two.

scholarly journals Positive and Negative Aspects of Sodium Intake in Dialysis and Non-Dialysis CKD Patients

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 951
Author(s):  
Yasuyuki Nagasawa
Keyword(s):  
Blood Pressure ◽  
Nutritional Status ◽  
Water Intake ◽  
Salt Intake ◽  
Sodium Intake ◽  
Extracellular Fluid ◽  
Sodium Restriction ◽  
Dialysis Patients ◽  
Positive Effects ◽  
Volume Blood

Sodium intake theoretically has dual effects on both non-dialysis chronic kidney disease (CKD) patients and dialysis patients. One negatively affects mortality by increasing proteinuria and blood pressure. The other positively affects mortality by ameliorating nutritional status through appetite induced by salt intake and the amount of food itself, which is proportional to the amount of salt under the same salty taste. Sodium restriction with enough water intake easily causes hyponatremia in CKD and dialysis patients. Moreover, the balance of these dual effects in dialysis patients is likely different from their balance in non-dialysis CKD patients because dialysis patients lose kidney function. Sodium intake is strongly related to water intake via the thirst center. Therefore, sodium intake is strongly related to extracellular fluid volume, blood pressure, appetite, nutritional status, and mortality. To decrease mortality in both non-dialysis and dialysis CKD patients, sodium restriction is an essential and important factor that can be changed by the patients themselves. However, under sodium restriction, it is important to maintain the balance of negative and positive effects from sodium intake not only in dialysis and non-dialysis CKD patients but also in the general population.

scholarly journals The Effects of Short-Term Changes in Sodium Intake on Plasma Marinobufagenin Levels in Patients with Primary Salt-Sensitive and Salt-Insensitive Hypertension

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1502
Author(s):  
Katarzyna Łabno-Kirszniok ◽  
Agata Kujawa-Szewieczek ◽  
Andrzej Wiecek ◽  
Grzegorz Piecha
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Sodium Intake ◽  
Left Ventricular ◽  
Primary Hypertension ◽  
Dietary Sodium ◽  
Sodium Restriction ◽  
Short Term ◽  
Salt Loading ◽  
Dietary Sodium Restriction

Increased marinobufagenin (MBG) synthesis has been suggested in response to high dietary salt intake. The aim of this study was to determine the effects of short-term changes in sodium intake on plasma MBG levels in patients with primary salt-sensitive and salt-insensitive hypertension. In total, 51 patients with primary hypertension were evaluated during acute sodium restriction and sodium loading. Plasma or serum concentrations of MBG, natriuretic pro-peptides, aldosterone, sodium, potassium, as well as hematocrit (Hct) value, plasma renin activity (PRA) and urinary sodium and potassium excretion were measured. Ambulatory blood pressure monitoring (ABPM) and echocardiography were performed at baseline. In salt-sensitive patients with primary hypertension plasma MBG correlated positively with diastolic blood pressure (ABPM) and serum NT-proANP concentration at baseline and with serum NT-proANP concentration after dietary sodium restriction. In this subgroup plasma MBG concentration decreased during sodium restriction, and a parallel increase of PRA was observed. Acute salt loading further decreased plasma MBG concentration in salt-sensitive subjects in contrast to salt insensitive patients. No correlation was found between plasma MBG concentration and left ventricular mass index. In conclusion, in salt-sensitive hypertensive patients plasma MBG concentration correlates with 24-h diastolic blood pressure and dietary sodium restriction reduces plasma MBG levels. Decreased MBG secretion in response to acute salt loading may play an important role in the pathogenesis of salt sensitivity.

scholarly journals Role of community health volunteers in identifying people with elevated blood pressure for diagnosis and monitoring of hypertension in Malawi: a qualitative study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Elvis Safary ◽  
Micrina Mwandeti ◽  
Beatrice Matanje ◽  
Claudia Beiersmann ◽  
Caroline Mtaita ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Community Health ◽  
Communicable Diseases ◽  
Health Facilities ◽  
Elevated Blood Pressure ◽  
Elevated Blood ◽  
Structured Interviews ◽  
Community Health Volunteers ◽  
Provision Of Services

Abstract Background In recent years, there has been greater recognition of the important role of community health volunteers in many countries and their important role informs many health programs. This include health education, provision of services such as screening, monitoring and referral to health facilities. Their roles are better understood in the areas of communicable diseases like HIV infection, Tuberculosis and Malaria however little is known about their role in non-communicable diseases. This study seeks to explore perception of CHVs’ functions, tasks, and their fulfilment in identifying people with elevated blood pressure for diagnosis and monitoring of hypertension in Lilongwe, Malawi. Methods This was a qualitative naturalistic research design utilizing observation and semi-structured interviews with community health volunteers working in Lilongwe, Malawi. Interviews were carried out with the researcher. Participants were recruited from the ZaMaC project. An interview guide was developed with a category-guided deductive approach. The interviews were recorded through note taking. Data analysis was performed using content analysis approach. Results Community health volunteers have multiple roles in prevention and monitoring of hypertension. They act as health educators and provide lifestyle counselling. They screened for hypertension and monitored blood pressure and assisted community members to navigate the health system such as linkage to health facilities. These roles were shaped in response to community needs. Conclusion This study indicates the complexities of the roles of community health volunteer in identifying people with elevated BP for diagnosis and monitoring of hypertension. Understanding community health volunteers’ roles provides insight into their required competencies in provision of their daily activities as well as required training to fill in their knowledge gaps.

scholarly journals An Obesity-RelatedFTOVariant and the Risk of Preeclampsia in a Finnish Study Population

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Miira Klemetti ◽  
Leena M. Hiltunen ◽  
Sanna Heino ◽  
Seppo Heinonen ◽  
Eero Kajantie ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Early Onset ◽  
Elevated Blood ◽  
Study Population ◽  
Normotensive Pregnancy ◽  
Finnish Study ◽  
Risk Of Preeclampsia

Previous studies have demonstrated a common variant of the obesity and fat mass-relatedFTOgene, rs9939609, to be associated with obesity, type 2 diabetes, and elevated blood pressure. We investigated whether theFTOSNP rs9939609 is associated with the risk of preeclampsia (PE) in a Finnish study population. 485 women with prior PE and 449 women who had given birth after a normotensive pregnancy were genotyped (TaqMan) for the SNP rs9939609. The prevalences of genotypes AA, AT, and TT were 15%, 53%, and 32%, respectively, among the PE cases, and 16%, 47%, and 37%, respectively, among the controls (P=0.199). We found no evidence of an association between theFTOSNP rs9939609 and PE. However, our cases were dominated by severe, early-onset PE. Thus, we are unable to exclude an association with the milder, later-onset form of the disease in which the role of maternal metabolic predisposition could be more significant.Erratum to “An Obesity-RelatedFTOVariant and the Risk of Preeclampsia in a Finnish Study Population”

scholarly journals Nitric oxide synthase-mediated blood pressure regulation in obese melanocortin-4 receptor-deficient pregnant rats

2016 ◽  
Vol 311 (5) ◽  
pp. R851-R857 ◽  
Author(s):  
Frank T. Spradley ◽  
Jennifer M. Sasser ◽  
Jacqueline B. Musall ◽  
Jennifer C. Sullivan ◽  
Joey P. Granger
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Mesenteric Arteries ◽  
Elevated Blood Pressure ◽  
Pressure Regulation ◽  
Elevated Blood ◽  
Pregnant Rats ◽  
Melanocortin 4 Receptor ◽  
Regulation Of Blood Pressure

Although obesity increases the risk for hypertension in pregnancy, the mechanisms responsible are unknown. Increased nitric oxide (NO) production results in vasodilation and reduced blood pressure during normal pregnancy in lean rats; however, the role of NO is less clear during obese pregnancies. We examined the impact of obesity on NO synthase (NOS)-mediated regulation of blood pressure during pregnancy by testing the hypothesis that NOS activity, expression, and regulation of vascular tone and blood pressure are reduced in obese pregnant rats. At gestational day 19, melanocortin-4 receptor (MC4R)-deficient obese rats (MC4R) had greater body weight and fat mass with elevated blood pressure and circulating sFlt-1 levels compared with MC4R pregnant rats. MC4R pregnant rats also had less circulating cGMP levels and reduced total NOS enzymatic activity and expression in mesenteric arteries. Despite decreased biochemical measures of NO/NOS in MC4R rats, NOS inhibition enhanced vasoconstriction only in mesenteric arteries from MC4R rats, suggesting greater NOS-mediated tone. To examine the role of NOS on blood pressure regulation in obese pregnant rats, MC4R and MC4R pregnant rats were administered the nonselective NOS inhibitor NG-nitro-l-arginine methyl ester (l-NAME, 100 mg/l) from gestational day 14 to 19 in drinking water. The degree by which l-NAME raised blood pressure was similar between obese and lean pregnant rats. Although MC4R obese pregnant rats had elevated blood pressure associated with reduced total NOS activity and expression, they had enhanced NOS-mediated attenuation of vasoconstriction, with no evidence of alterations in NOS-mediated regulation of blood pressure.

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