Regional release of [3H] adenosine derivatives from rat brain in vivo: effect of excitatory amino acids, opiate agonists, and benzodiazepines

1980 ◽  
Vol 58 (11) ◽  
pp. 1262-1278 ◽  
Author(s):  
K. Jhamandas ◽  
A. Dumbrille
Keyword(s):  
Amino Acids ◽  
Rat Brain ◽  
Excitatory Amino Acids ◽  
Adenosine Derivatives

scholarly journals Two Distinct Modes of Hypoosmotic Medium-Induced Release of Excitatory Amino Acids and Taurine in the Rat Brain In Vivo

PLoS ONE ◽  
2008 ◽  
Vol 3 (10) ◽  
pp. e3543 ◽  
Author(s):  
Renée E. Haskew-Layton ◽  
Alena Rudkouskaya ◽  
Yiqiang Jin ◽  
Paul J. Feustel ◽  
Harold K. Kimelberg ◽  
...  
Keyword(s):  
Amino Acids ◽  
Rat Brain ◽  
Excitatory Amino Acids

Decreased labeling of amino acids by inhibition of the utilization of [3H,14C]glucose via the hexosemonophosphate shunt in rat brain in vivo

1984 ◽  
Vol 9 (3) ◽  
pp. 367-385 ◽  
Author(s):  
M. K. Gaitonde ◽  
Margaret D. James ◽  
Gwyneth M. Evans
Keyword(s):  
Amino Acids ◽  
Rat Brain

Chronic treatment with sabeluzole protects cultured rat brain neurons from the neurotoxic effects of excitatory amino acids

Synapse ◽  
1992 ◽  
Vol 12 (4) ◽  
pp. 271-280 ◽  
Author(s):  
Petrus J. Pauwels ◽  
Harrie P. Van Assouw ◽  
Luc Peeters ◽  
Marc Moeremans ◽  
Jos�e E. Leysen
Keyword(s):  
Amino Acids ◽  
Rat Brain ◽  
Excitatory Amino Acids ◽  
Chronic Treatment ◽  
Brain Neurons ◽  
Neurotoxic Effects ◽  
Rat Brain Neurons

Excitatory amino acids: new tools for old stories or Pharmacological subtypes of glutamate receptors: electrophysiological studies

1991 ◽  
Vol 69 (7) ◽  
pp. 1123-1128 ◽  
Author(s):  
David Lodge ◽  
Martyn G. Jones ◽  
Andrew J. Palmer
Keyword(s):  
Amino Acids ◽  
Glutamate Receptors ◽  
Binding Sites ◽  
Excitatory Amino Acids ◽  
Channel Blocking ◽  
Electrophysiological Studies ◽  
Spinal Neurones ◽  
Potent Antagonist

Although the N-methyl-D-aspartate (NMDA) subtype of L-glutamate receptor is well characterized, the significance of non-NMDA glutamate-sensitive binding sites is not well documented. In this study, a new tricyclic quinoxalinedione (NBQX) and an arthropod toxin (philanthotoxin) were shown to block responses of spinal neurones in vivo to kainate, quisqualate, and AMPA in parallel but had little effect on responses to NMDA. Philanthotoxin appeared to be a use-dependent antagonist consistent with a channel-blocking mode of action. On cortical wedges in vitro, however, NBQX proved to be a more potent antagonist of AMPA and quisqualate than of kainate (pA2 values of 7.1, 7.0, and 5.6, respectively) with no effect at 10 μM on responses to NMDA. These studies provide evidence that on cortical neurones, but not on spinal neurones, AMPA and kainate depolarize by pharmacologically different mechanisms.Key words: glutamate receptors, quinoxalinediones, philanthotoxin, AMPA, kainate.

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