Decreased labeling of amino acids by inhibition of the utilization of [3H,14C]glucose via the hexosemonophosphate shunt in rat brain in vivo

1984 ◽  
Vol 9 (3) ◽  
pp. 367-385 ◽  
Author(s):  
M. K. Gaitonde ◽  
Margaret D. James ◽  
Gwyneth M. Evans
Keyword(s):  
Amino Acids ◽  
Rat Brain

scholarly journals Two Distinct Modes of Hypoosmotic Medium-Induced Release of Excitatory Amino Acids and Taurine in the Rat Brain In Vivo

PLoS ONE ◽  
2008 ◽  
Vol 3 (10) ◽  
pp. e3543 ◽  
Author(s):  
Renée E. Haskew-Layton ◽  
Alena Rudkouskaya ◽  
Yiqiang Jin ◽  
Paul J. Feustel ◽  
Harold K. Kimelberg ◽  
...  
Keyword(s):  
Amino Acids ◽  
Rat Brain ◽  
Excitatory Amino Acids

The Analysis of Fe3O4 Nanoparticles Combined with Daunorubicin for Neurotoxicity of Rat Brain In Vivo

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 4287-4287
Author(s):  
Peipei Xu ◽  
Bao-An Chen ◽  
Xue-mei Wang ◽  
Jingyuan Li ◽  
Xiao-hui Cai ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Rat Brain ◽  
Anticancer Drug ◽  
Fe3o4 Nanoparticles ◽  
Conflicts Of Interest ◽  
Fe3o4 Nps ◽  
Concentration Changes

Abstract Abstract 4287 Introduction□F The safety of these nano-systems for human body should be carefully studied for the potential clinical application. Here in this report, we firstly study the effect of anticancer drug daunorubicin (DNR) and Fe3O4 nanoparticles (NPs) for the neurotoxicity of rat brain. The microdialysis experiment gave the precise and real-time method to investigate the effect. Method: SD rats(240–250 g) were randomly assigned to three groups containing three rats in each group. Microdialysis Probes were deployed corpus striatum. Then the animals were solitary breed to recovery the wound for about 24 h. The different drugs systems were administered by vena caudalis injection. Amino acids were measured in dialysates by HPLC. Results: The results indicated that the anticancer drug DNR had the serious bad effect for the rat brain to cause the neurotoxicity by influencing the concentration changes of amino acids in which some excitatory amino acids (such as Asp) and the inhibiting amino acid (such as Gly) especially decreased and the inhibiting amino acid GABA increased. For the system of nanocomposites for DNR conjugated with Fe3O4 NPs, the side effect of DNR for these amino acids was visibly cut down, and the time for DNR to affect the side neurotoxicity for the rat brain was shorten. Conclusion□F So these nanocomposites for DNR conjugated with Fe3O4 NPs had the better biocompatibility and biosecurity in the application of cancer therapy in vitro and in vivo. These nanocomposites system had the potential prospect to be further studied and utilized in the clinic therapy. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Studies on cystathionase activity in rat liver and brain during development. Effects of hormones and amino acids in vivo

1973 ◽  
Vol 136 (4) ◽  
pp. 1011-1015 ◽  
Author(s):  
Kirsti Heinonen
Keyword(s):  
Amino Acids ◽  
Enzyme Activity ◽  
Rat Brain ◽  
High Activity ◽  
Rat Liver ◽  
Newborn Rats ◽  
Postnatal Rats

High activity of cystathionase was present in rat liver but only low amounts of activity in rat brain during development. Triamcinolone had no effect on liver cystathionase activity in foetuses but increased the enzyme activity significantly in postnatal rats. l-Thyroxine decreased liver cystathionase activity significantly in newborn rats; administration of pyridoxal 5′-phosphate did not prevent this effect. l-Methionine significantly increased liver cystathionase activity in newborn rats.

Effect of nicotine on levels of extracellular amino acids in regions of the rat brain in vivo

1993 ◽  
Vol 32 (8) ◽  
pp. 827-832 ◽  
Author(s):  
E TOTH ◽  
E VIZI ◽  
A LAJTHA
Keyword(s):  
Amino Acids ◽  
Rat Brain

scholarly journals Incorporation of label from d-β-hydroxy-[14C]butyrate and [3-14C]acetoacetate into amino acids in rat brain in vivo

1971 ◽  
Vol 122 (2) ◽  
pp. 135-138 ◽  
Author(s):  
Jill E. Cremer
Keyword(s):  
Amino Acids ◽  
Rat Brain ◽  
Intravenous Injection ◽  
Ketone Bodies ◽  
Specific Radioactivity ◽  
Total Radioactivity ◽  
Soluble Material ◽  
The Brain

The metabolism of ketone bodies by rat brain was studied in vivo. Rats starved for 48h were given either d-β-hydroxy[3-14C]butyrate or [3-14C]acetoacetate by intravenous injection and killed after 3 or 10min. Total radioactivity in the acid-soluble material of the brain and the specific radioactivities of the brain amino acids glutamate, glutamine, aspartate and γ-aminobutyrate were determined. A group of fed animals were also given d-β-hydroxy[3-14C]butyrate. In the brains of all animals 14C was present in the acid-soluble material and the specific radioactivity of glutamate was greater than that of glutamine.

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