The effect of glucagon on intestinal lymph flow in rats

1978 ◽  
Vol 56 (3) ◽  
pp. 531-532 ◽  
Author(s):  
J. A. Barrowman ◽  
P. Kwan ◽  
C. Mousseau ◽  
S. G. Turner
Keyword(s):  
Blood Flow ◽  
Intravenous Injection ◽  
Lymph Flow ◽  
Splanchnic Blood Flow ◽  
Intestinal Lymph ◽  
Transient Rise ◽  
Protein Output

Intravenous injection of a bolus of 5 μg of glucagon to rats with an intestinal lymph fistula produces a marked, transient rise in lymph flow and protein output from the fistula. The effect is presumably the result of brief enhancement of splanchnic blood flow.

Influence of sodium pentobarbital on splanchnic blood flow and related functions

1959 ◽  
Vol 197 (3) ◽  
pp. 624-626 ◽  
Author(s):  
Ann Evringham ◽  
Edith M. Brenneman ◽  
Steven M. Horvath
Keyword(s):  
Blood Flow ◽  
Oxygen Consumption ◽  
Intravenous Injection ◽  
Anesthetic Agent ◽  
Splanchnic Blood Flow ◽  
Sodium Pentobarbital ◽  
Hepatic Circulation ◽  
Blood Flows

Eleven mongrel dogs were trained to lie quietly while splanchnic blood flows and splanchnic metabolisms were determined. They were then anesthetized by means of intravenous injection of 28.4 mg/kg of sodium pentobarbital and studies of the hepatic circulation continued for an additional 70 minutes. Only minor, transitory alterations were observed in the parameters being measured. It was concluded that with this particular anesthetic agent splanchnic blood flows and oxygen consumption were essentially at control unanesthetized levels within 30–45 minutes postanesthesia.

The effects of cholecystokinin and cholecystokinin-octapeptide on intestinal lymph flow in the rat

1977 ◽  
Vol 55 (6) ◽  
pp. 1393-1396 ◽  
Author(s):  
S. G. Turner ◽  
J. A. Barrowman
Keyword(s):  
Blood Flow ◽  
Protein Transport ◽  
Lymph Flow ◽  
Intestinal Blood Flow ◽  
Concomitant Increase ◽  
Cholecystokinin Octapeptide ◽  
Intestinal Lymph

Intravenous cholecystokinin and its synthetic C-terminal octapeptide were found to cause a transient augmentation of intestinal lymph flow in the rat. Concomitant increase in lymph protein transport suggests that this reflects the increase in intestinal blood flow which is known to occur in response to these agents.

Lymph flow, lymph protein concentration, and protein output from rat small intestine

1985 ◽  
Vol 248 (6) ◽  
pp. G670-G675
Author(s):  
J. S. Lee
Keyword(s):  
Small Intestine ◽  
Water Absorption ◽  
Protein Concentration ◽  
Capillary Permeability ◽  
Lymph Flow ◽  
Rat Small Intestine ◽  
Capillary Filtration ◽  
Intestinal Lymph ◽  
Lymph Duct ◽  
Protein Output

Lymph flow (JL), lymph protein concentration (CL), and protein output (JP) from the main intestinal lymph duct were determined. The basal JL from the mesenteric pedicle alone was the same as that from the mesenteric pedicle attached with a segment of the nonabsorbing intestine, indicating that the basal JL does not originate from the intestine but is totally from the region of the mesenteric pedicle. The basal CL was 3.5-3.8 g/100 ml. When the intestine was absorbing water, JL increased and CL decreased, but JP increased above the basal JP in the initial 20 min of water absorption and then decreased progressively with time. Furthermore, it was estimated that CL in the "excess lymph" (formed during water absorption) was 1.4 +/- 0.2 g/100 ml in the initial 10 min of water absorption and was zero or nearly so in the later periods. From this and other evidence, it is concluded that under various conditions without net water absorption rat small intestine does not produce lymph and that during water absorption there is no significant increase in capillary permeability or capillary filtration. Therefore, the excess lymph could be mostly derived from the fluid absorbed from the lumen of the intestine.

Effect of furosemide on thoracic duct lymph flow in the dog

1980 ◽  
Vol 238 (5) ◽  
pp. F363-F371 ◽  
Author(s):  
C. McCaffrey ◽  
M. Levy
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Thoracic Duct ◽  
Interstitial Fluid ◽  
Lymph Flow ◽  
Splanchnic Blood Flow ◽  
Thoracic Duct Lymph ◽  
Plasma Sodium ◽  
Duct Lymph ◽  
Anesthetized Dogs

Furosemide 20 mg/kg was given intravenously to 12 anesthetized dogs with clamped renal pedicles. Thoracic duct lymph flow (TDLF) increased promptly by 38% (P less than 0.05), an increment that lasted 80 min. Because in 6 of 12 dogs there was a transient increase in splanchnic blood flow, in separate groups splanchnic blood flow was either markedly constricted or markedly increased by intravenous isoproterenol. Thoracic duct lymph flow increased by 95 and 90%, respectively, following furosemid despite no further change in splanchnic blood flow. Furosemide had no effect on blood pressure, lymph protein, or plasma sodium. In four chronic caval dogs, TDLF was increased by 400%, yet furosemide produced a further increment in lymph flow of 30% (P less than 0.05). Infusion of a 25% albumin solution to contract the interstitial fluid did not abolish the furosemide effect, but a 10% mannitol solution did. Furosemide increased TDLF even after the infusion of papaverine reduced blood pressure to 60 mmHg. We conclude that furosemide increases TDLF by acting directly on splanchnic capillaries to allow increased filtration of fluid in the absence of increased splanchnic blood flow or capillary hydrostatic pressure.

scholarly journals LYMPHOCYTES IN THORACIC DUCT, INTESTINAL AND HEPATIC LYMPH

Blood ◽  
1950 ◽  
Vol 5 (2) ◽  
pp. 177-190 ◽  
Author(s):  
JOSEPH D. MANN ◽  
GEORGE M. HIGGINS ◽  
EMERY VAN HOOK
Keyword(s):  
Intravenous Injection ◽  
Thoracic Duct ◽  
Rat Plasma ◽  
Lymph Flow ◽  
Thoracic Duct Lymph ◽  
Daily Output ◽  
Intestinal Lymph ◽  
Large Numbers ◽  
Duct Lymph ◽  
Number Of Cells

Abstract In rats whose intestinal or thoracic duct lymph was drained externally for several days, lymphopenia occurred. Large numbers of cells were collected in the lymph each day, as many, apparently, from the intestinal lymph alone as from the thoracic duct. Hepatic lymph contributed relatively few cells. Augmentation of lymph flow decreased the concentration of cells in the lymph but did not affect the total number of cells collected each day. Fasting for several days likewise did not decrease the first day’s output. With each day’s lymph flow, however, the daily output of cells spontaneously decreased. The decrease was not prevented by the intravenous injection of fresh lymph or of fresh rat plasma in large amounts. In view of this unexplained effect, one must be cautious in interpreting the results of experiments on the lymph lymphocyte.

The effect of isradipine in acute altitude hypoxia on cerebral, renal, and splanchnic blood flow evaluated by Doppler measurements

2011 ◽  
Vol 4 (04) ◽  
pp. 212-217 ◽  
Author(s):  
Michel Court-Payen ◽  
Aram Ter Minassian ◽  
Niels Olsen ◽  
Inge Kanstrup ◽  
Claude Dubray ◽  
...  
Keyword(s):  
Blood Flow ◽  
Splanchnic Blood Flow ◽  
Altitude Hypoxia

SPLANCHNIC BLOOD FLOW AND OXYGEN DELIVERY ARE DECREASED IN ALCOHOL (EtOH) AND BURN INJURY.

Shock ◽  
2004 ◽  
Vol 21 ◽  
pp. 3-4
Author(s):  
M. A. Choudhry ◽  
Z. F. Ba ◽  
S. Rana ◽  
I. H. Chaudry
Keyword(s):  
Blood Flow ◽  
Oxygen Delivery ◽  
Burn Injury ◽  
Splanchnic Blood Flow

Splanchnic blood flow, O2 consumption, removal of lactate, and output of glucose in highlanders

1977 ◽  
Vol 43 (2) ◽  
pp. 204-210 ◽  
Author(s):  
A. Capderou ◽  
J. Polianski ◽  
J. Mensch-Dechene ◽  
L. Drouet ◽  
G. Antezana ◽  
...  
Keyword(s):  
Blood Flow ◽  
Oxygen Consumption ◽  
Splanchnic Blood Flow ◽  
O2 Consumption ◽  
Arterial Lactate ◽  
Oxygen Breathing ◽  
Arterial Blood ◽  
Splanchnic Hemodynamics ◽  
Arterial Blood Glucose ◽  
Arteriovenous Difference

An impairment of gluconeogenesis has been proposed to explain the low arterial blood glucose of highlanders. Therefore, we studied splanchnic blood flow, splanchnic uptake of oxygen and lactate, and output of glucose in nine normal and six anemic highlanders at an altitude of 3,750 m. Splanchnic blood flow, arteriovenous difference for oxygen, and oxygen consumption were comparable at rest in both groups and in lowlanders from the literature, whereas splanchnic output of glucose, and uptake of lactate were approximately twice those in lowlanders. After 10 min of mild exercise in 12 subjects (7 normals, 5 anemic), no significant changes in splanchnic hemodynamics and metabolism were found. During 29% oxygen breathing in 8 subjects (5 normals, 3 anemics), arterial lactate, splanchnic uptake of lactate and output of glucose fell to normal sea-level values. We concluded that splanchnic hemodynamics are similar in adapted highlanders and in lowlanders, and that there is no evidence of an impaired gluconeogenesis at the altitude of the present study.

Stimulation of regional lymphatic and blood flow by epicutaneous oxazolone

2002 ◽  
Vol 93 (3) ◽  
pp. 966-973 ◽  
Author(s):  
Chufa He ◽  
Alan J. Young ◽  
Charles A. West ◽  
Mei Su ◽  
Moritz A. Konerding ◽  
...  
Keyword(s):  
Blood Flow ◽  
Visible Spectrum ◽  
Lymphatic Drainage ◽  
Lymph Flow ◽  
Vascular Network ◽  
Corrosion Casting ◽  
Subsequent Increase ◽  
Clinical Appearance ◽  
Early Increase ◽  
Lymph Duct

The application of the epicutaneous antigen oxazolone results in persistent induration and erythema; however, the relative changes in lymph and blood flow in the inflammatory skin are largely unknown. To define the contribution of lymph and blood flow to the clinical appearance of cutaneous inflammation, we studied the sheep ear after the application of oxazolone. As a model for the study of these changes, the sheep ear had several experimental advantages: 1) a simplified superficial vascular network, 2) defined lymphatic drainage, and 3) an avascular and alymphatic cartilaginous barrier. Lymph flow was continuously monitored by cannulation of the prescapular efferent lymph duct. Blood flow, as reflected by cutaneous erythema, was noninvasively measured by use of a visible-spectrum spectrophotometer. The application of the epicutaneous oxazolone resulted in increased ear thickness for >7 days. The lymph flow from the oxazolone-stimulated ear peaked between 24 and 48 h after oxazolone stimulation. Spectrophotometric evaluation indicated that the cutaneous erythema peaked 72–96 h after application of oxazolone. Corrosion casting and scanning electron microscopy of the microcirculation at 96 h after antigen stimulation demonstrated significant dilatation of the superficial vascular network. These results suggest a biphasic response to oxazolone stimulation: 1) an early increase in vascular permeability associated with increased lymph flow and 2) a subsequent increase in relative blood flow associated with a dilated inflammatory microcirculation.

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