Quantitative Aspects of Cyclic AMP and Relaxation in the Rabbit Anterior Mesenteric-Portal Vein

1975 ◽  
Vol 53 (6) ◽  
pp. 989-997 ◽  
Author(s):  
G. A. Collins ◽  
M. C. Sutter
Keyword(s):  
Smooth Muscle ◽  
Cyclic Amp ◽  
Portal Vein ◽  
Muscle Relaxation ◽  
Phosphodiesterase Inhibitors ◽  
Smooth Muscle Relaxation ◽  
Krebs Solution ◽  
Free Solution ◽  
Dibutyryl Cyclic Amp ◽  
Extracellular Sodium

Rabbit anterior mesenteric-portal vein was shown to exhibit a positive correlation between relaxation and cyclic AMP levels using different concentrations of isoproterenol for varying exposure times. No consistent relationship was found between cyclic AMP and relaxation using a series of phosphodiesterase inhibitors (papaverine, SC2964, or RA233). In sodium-free (Tris-substituted) Krebs' solution, the addition of isoproterenol still increased, cyclic AMP levels, but there was no relaxation. Dibutyryl cyclic AMP was also ineffective in sodium-free solution. Under identical conditions, both relaxation and increases in cyclic AMP produced by papaverine and SC2964 were found to be independent of extracellular sodium. We conclude, therefore, that increased cyclic AMP may be involved in isoproterenol-induced relaxation possibly acting via increased Na+–Ca2+ exchange, but plays only a small role, if any, in smooth muscle relaxation produced by papaverine, RA233, or SC2964.

Role of cGMP in relaxation of vascular and other smooth muscle

1989 ◽  
Vol 67 (4) ◽  
pp. 251-262 ◽  
Author(s):  
Kanji Nakatsu ◽  
Jack Diamond
Keyword(s):  
Smooth Muscle ◽  
Muscle Relaxation ◽  
Smooth Muscles ◽  
Phosphodiesterase Inhibitors ◽  
Current Evidence ◽  
Smooth Muscle Relaxation ◽  
Drug Induced ◽  
Intracellular Cgmp ◽  
Tissue Content

The hypothesis that the relaxant action of many drugs on vascular and other smooth muscle is mediated by increases in intracellular cGMP, the "cGMP hypothesis," is gaining wide acceptance. While much information supporting this idea can be found in the literature, there is also a significant amount of information indicating that an elevation in the tissue content of cGMP is by itself insufficient to cause smooth muscle relaxation. The literature is reviewed with reference to the criteria that need to be fulfilled to consider cGMP as the second messenger mediating relaxation of smooth muscle by a drug; i.e., activation of guanylate cyclase, elevation of tissue content of cGMP, potentiation by phosphodiesterase inhibitors, antagonism by inhibitors of cGMP synthesis, and production of relaxation by cGMP analogues. For each criterion, key observations supporting the hypothesis are considered, followed by examples of important observations not consistent with the hypothesis. It is concluded that in some smooth muscles, for example, rat myometrium and vas deferens, cGMP is not a mediator of drug-induced relaxation. In other smooth muscles, including vascular smooth muscle, cGMP appears to play an important role in the relaxation process; but current evidence suggests that other factors are also important and that the cGMP hypothesis may need to be modified.Key words: cGMP, vascular relaxation, smooth muscle relaxation, vasodilators.

Intracellular cyclic AMP level and intestinal smooth muscle relaxation

1974 ◽  
Vol 26 (1) ◽  
pp. 73-76 ◽  
Author(s):  
Nobuhiro Inatomi ◽  
Issei Takayanagi ◽  
Masaatsu Uchida ◽  
Keijiro Takagi
Keyword(s):  
Smooth Muscle ◽  
Cyclic Amp ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation ◽  
Intestinal Smooth Muscle

cAMP-phosphodiesterase inhibitors and tracheal smooth muscle relaxation

1978 ◽  
Vol 27 (5) ◽  
pp. 729-732 ◽  
Author(s):  
David J. Newman ◽  
Donald F. Colella ◽  
Charles B. Spainhour ◽  
Edward G. Brann ◽  
Bogdan Zabko-Potapovich ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Muscle Relaxation ◽  
Phosphodiesterase Inhibitors ◽  
Tracheal Smooth Muscle ◽  
Smooth Muscle Relaxation ◽  
Camp Phosphodiesterase

scholarly journals A.122 Vascular effects of propofol: smooth muscle relaxation in human isolated veins and arteries

1996 ◽  
Vol 76 ◽  
pp. 38-39
Author(s):  
Eric Le Pelley ◽  
Pierre Corbi ◽  
Thierry Chataigneau ◽  
Robert Tricoche ◽  
Jacques Fusciardi
Keyword(s):  
Smooth Muscle ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation ◽  
Vascular Effects

216Acute administration of estradiol induces bladder smooth muscle relaxation through non-genomic pathways

2005 ◽  
Vol 4 (3) ◽  
pp. 56
Author(s):  
M. Dambros ◽  
P. Palma ◽  
C. Riccetto ◽  
R. Fraga ◽  
M. Thiel ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation ◽  
Bladder Smooth Muscle
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