Towards an Understanding of the Mechanism of Action of Cyclic AMP and Cyclic GMP in Smooth Muscle Relaxation

1991 ◽  
Vol 28 (1-3) ◽  
pp. 129-137 ◽  
Author(s):  
Thomas M. Lincoln ◽  
Trudy L. Cornwell
Keyword(s):  
Smooth Muscle ◽  
Cyclic Amp ◽  
Mechanism Of Action ◽  
Cyclic Gmp ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation

scholarly journals The Use of Vasoactive Drugs in the Treatment of Male Erectile Dysfunction: Current Concepts

2020 ◽  
Vol 9 (9) ◽  
pp. 2987
Author(s):  
George T. Kedia ◽  
Stefan Ückert ◽  
Dimitrios Tsikas ◽  
Armin J. Becker ◽  
Markus A. Kuczyk ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Erectile Dysfunction ◽  
Cyclic Gmp ◽  
Muscle Relaxation ◽  
Cyclic Guanosine Monophosphate ◽  
Guanosine Monophosphate ◽  
Smooth Muscle Relaxation ◽  
Vasoactive Drugs ◽  
Erectile Tissue ◽  
Orally Active

It is widely accepted that disorders of the male (uro)genital tract, such as erectile dysfunction (ED) and benign diseases of the prostate (lower urinary tract symptomatology or benign prostatic hyperplasia), can be approached therapeutically by influencing the function of both the vascular and non-vascular smooth muscle of the penile erectile tissue or the transition zone/periurethral region of the prostate, respectively. As a result of the discovery of nitric oxide (NO) and cyclic guanosine monophosphate (GMP) as central mediators of penile smooth muscle relaxation, the use of drugs known to increase the local production of NO and/or elevate the intracellular level of the second messenger cyclic GMP have attracted broad attention in the treatment of ED of various etiologies. Specifically, the introduction of vasoactive drugs, including orally active inhibitors of the cyclic GMP-specific phosphodiesterase (PDE) 5, has offered great advantage in the pharmacotherapy of ED and other diseases of the genitourinary tract. These drugs have been proven efficacious with a fast on-set of action and an improved profile of side-effects. This review summarizes current strategies for the treatment of ED utilizing the application of vasoactive drugs via the oral, transurethral, topical, or self-injection route.

ROLE OF CYCLIC GMP IN CORONARY SMOOTH MUSCLE RELAXATION

Abstracts ◽  
1978 ◽  
pp. 793 ◽  
Author(s):  
S. Holzmann ◽  
A. Wurm ◽  
G. Pöch ◽  
W.R. Kukovetz
Keyword(s):  
Smooth Muscle ◽  
Cyclic Gmp ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation ◽  
Coronary Smooth Muscle

Intracellular cyclic AMP level and intestinal smooth muscle relaxation

1974 ◽  
Vol 26 (1) ◽  
pp. 73-76 ◽  
Author(s):  
Nobuhiro Inatomi ◽  
Issei Takayanagi ◽  
Masaatsu Uchida ◽  
Keijiro Takagi
Keyword(s):  
Smooth Muscle ◽  
Cyclic Amp ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation ◽  
Intestinal Smooth Muscle

Cyclic GMP-Dependent Protein Kinase and Smooth Muscle Relaxation

1992 ◽  
Vol 20 ◽  
pp. S18-S22
Author(s):  
Wolfgang Landgraf ◽  
Peter Ruth ◽  
Alexandra Keilbach ◽  
Boris May ◽  
Andrea Welling ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Protein Kinase ◽  
Cyclic Gmp ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation ◽  
Dependent Protein Kinase ◽  
Dependent Protein
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