An Artifact in Measurement of Ionized Calcium Concentration from a Heparin Preservative, Benzyl Alcohol

1974 ◽  
Vol 52 (3) ◽  
pp. 720-722 ◽  
Author(s):  
Gerald A. Klassen ◽  
Eva Davidova
Keyword(s):  
Benzyl Alcohol ◽  
Calcium Concentration ◽  
Ionized Calcium ◽  
Serum Ionized Calcium

The previously reported decrease in plasma ionized calcium concentration associated with the presence of heparin has been shown to result largely from the presence of the preservative benzyl alcohol and only partially from heparin. Methanol, ethanol, or benzene did not have an effect on measured serum ionized calcium concentration.

The Effect of the Alkaline Tide on Serum-Ionized Calcium Concentration in Man

Digestion ◽  
1977 ◽  
Vol 15 (3) ◽  
pp. 175-181 ◽  
Author(s):  
W. Hughes ◽  
S. Cohen ◽  
D. Arvan ◽  
B. Seamonds
Keyword(s):  
Calcium Concentration ◽  
Ionized Calcium ◽  
Alkaline Tide ◽  
Serum Ionized Calcium

Measurement of Serum Ionized Calcium with the Ion-Exchange Electrode

1972 ◽  
Vol 18 (12) ◽  
pp. 1459-1462 ◽  
Author(s):  
V L Subryan ◽  
M M Popovtzer ◽  
S D Parks ◽  
E B Reeve
Keyword(s):  
Ion Exchange ◽  
Reproducibility Of Results ◽  
Room Temperature ◽  
Calcium Concentration ◽  
Ionized Calcium ◽  
Control Solution ◽  
Electrode Response ◽  
Serum Ionized Calcium ◽  
Evacuated Tubes

Abstract We found no differences in pH or ionized calcium concentration of serum from blood either collected into evacuated tubes or collected with syringes and separated under oil. Sera can be stored frozen in 1-ml plastic insulin-type syringes for one to three days without significant changes in pH or ionized calcium concentration, whereas storage under oil with or without re-equilibration with CO2 is associated with significant changes in both. Standards prepared with trypsin and triethanolamine give faster electrode response, and their ionized calcium concentrations remain unchanged for 6 h at room temperature. We suggest a not entirely satisfactory control solution of buffered protein, for use in assessing reproducibility of results.

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