The effects of propylthiouracil, thyroxine, and hypophysectomy on the iodinating activity of the rat thyroid gland

1968 ◽  
Vol 46 (3) ◽  
pp. 449-452 ◽  
Author(s):  
A. E. Zimmerman ◽  
C. C. Yip
Keyword(s):  
Drinking Water ◽  
Thyroid Gland ◽  
Thyroid Stimulating Hormone ◽  
Rapid Decrease ◽  
Daily Injection ◽  
The Third ◽  
Thyroxine Treatment ◽  
Rat Thyroid ◽  
Rat Thyroid Gland ◽  
Stimulating Hormone

The effects of increasing or decreasing the endogenous secretion of thyroid-stimulating hormone on the iodinating activity of the rat thyroid gland were investigated. The thyroid iodinating activity of rats on 0.01% propylthiouracil in the drinking water increased linearly for 3 days and reached a maximum of 230 to 240% of the control on or about the fourth day of treatment. The daily injection of thyroxine (10 μg/100 g intraperitoneally) or hypophysectomy resulted in a rapid decrease in the iodinating activity between the first and second day, approaching a basal level by the third day. When the iodinating activity was suppressed for 4 days by daily injections of thyroxine, the activity began to rise on the fifth day after termination of thyroxine treatment.

A MICROGEL ELECTROPHORETIC ANALYSIS OF THE COLLOID IN SINGLE RAT THYROID FOLLICLES DURING THYROXINE SUPPRESSION

1977 ◽  
Vol 84 (2) ◽  
pp. 303-313 ◽  
Author(s):  
Staffan Smeds ◽  
Bo Anderberg
Keyword(s):  
Thyroid Gland ◽  
Preliminary Data ◽  
Protein Fraction ◽  
Protein Composition ◽  
Electrophoretic Analysis ◽  
The Third ◽  
Sequential Study ◽  
Rat Thyroid ◽  
Almost All ◽  
Rat Thyroid Gland

ABSTRACT A sequential study of the effect of thyroxine (T4) on the protein composition of the colloid in the rat thyroid gland has been carried out in 24 rats. Daily ip injections of 20 μg thyroxine were given and the colloid was analyzed after 1, 2, 3 and 4 days and 1, 2 and 3 weeks. The protein constituents were separated by microgel electrophoresis and measured by microdensitometry. The incorporation of [3H]leucine into the thyroglobulin fraction and into the albumin-like protein in the homogenate of the gland was analyzed after T4 suppression for 2 days. The 2 h thyroidal iodine uptake was analyzed during the first week of T4 administration. During the second and the third day of T4 administration, the amount of 27S and larger complexes of thyroglobulin was reduced by 30–40 per cent and the amount of the albumin-like protein was significantly increased and present in almost all samples. Preliminary data indicated that during the same period the relative amount of [3H]leucine activity was increased in the albumin-like protein fraction compared to the thyroglobulin fraction in the thyroid. It is concluded that the exocytotic vesicles contain the albumin-like protein. The results further indicate that the administration of T4 temporarily changes the relative rates of formation of thyroglobulin and of the albumin-like protein in the follicle.

scholarly journals Protective role of ascorbic acid on lead-induced damage to the thyroid gland in the rat

2020 ◽  
Vol 9 (5) ◽  
pp. 632-635
Author(s):  
Denisse Calderón-Vallejo ◽  
María del Carmen Díaz-Galindo ◽  
Andrés Quintanar-Stephano ◽  
Carlos Olvera-Sandoval ◽  
J Luis Quintanar
Keyword(s):  
Ascorbic Acid ◽  
Drinking Water ◽  
Thyroid Gland ◽  
Lead Poisoning ◽  
Lead Acetate ◽  
Protective Action ◽  
Protective Role ◽  
Thyroid Stimulating Hormone ◽  
Stimulating Hormone

Abstract Lead exposure is known to affect the pituitary-thyroid axis. Likewise, ascorbic acid (AA) has a protective action against lead poisoning. We examine the protective role of AA in lead-induced damage to the thyroid gland. The Wistar rats were divided into three groups: control that received 0.2% AA in drinking water throughout the experiment (15 days), intoxicated with lead acetate (20 mg/kg) intraperitoneally every 48 h for 15 days, and the experimental group treated with lead acetate and 0.2% AA in drinking water throughout the experiment. Plasma thyroid-stimulating hormone, triiodothyronine, thyroxine, and lead were determined. The thyroid gland was weighed, then epithelial cell height and nuclear volume were measured on histological slides. The results show that AA reduced the thyroid atrophy caused by lead acetate, as well as the loss of weight of the gland. In addition, it prevented the decrease of the hormone triiodothyronine, although the thyroxine hormone remained lower than the control values ​​and the thyroid-stimulating hormone remains high. Our results indicated that AA could play a protective role in lead poisoning in the thyroid gland.

INSENSITIVITY OF OVARIAN MUCOPOLYSACCHARIDES TO SYSTEMIC L- AND D-THYROXINE TREATMENT

1962 ◽  
Vol 41 (3) ◽  
pp. 448-456 ◽  
Author(s):  
Hans Thorsøe
Keyword(s):  
Thyroid Gland ◽  
Histological Examination ◽  
Thyroid Stimulating Hormone ◽  
Ovarian Weight ◽  
Thyroxine Treatment ◽  
Loss Of Weight ◽  
Stimulating Hormone

ABSTRACT The effect of 1-thyroxine and d-thyroxine on the content of mucopolysaccharides in rabbit ovaries was studied histologically and biochemically. The doses of 1-thyroxine and d-thyroxine completely blocked the pituitary release of thyroid-stimulating hormone (TSH) as shown by the inhibition of 131I release from the thyroid gland. The treatment with 1-thyroxine as well as with d-thyroxine was continued for 15 and 30 days respectively. 1-Thyroxine brought about a loss of weight in the rabbits and caused a decrease in ovarian weight. d-Thyroxine produced no loss of weight and did not affect the ovarian weight. Neither 1-thyroxine nor d-thyroxine altered the gross appearance of the ovaries. Histological examination showed the quantity, distribution, and intensity of metachromatic substance to be identical in all experimental groups. Autoradiography showed no changes in the distribution of the 35S-containing mucopolysaccharides. Neither 1-thyroxine nor d-thyroxine altered the ovarian concentration of water or hexosamine, or the uptake of 35S-sulphate.

Effects of toxic doses of a novel histamine (H2) antagonist on the rat thyroid gland

1987 ◽  
Vol 25 (10) ◽  
pp. 787-794 ◽  
Author(s):  
C.G. Brown ◽  
R.F. Harland ◽  
I.R. Major ◽  
C.K. Atterwill
Keyword(s):  
Thyroid Gland ◽  
H2 Antagonist ◽  
Histamine H2 Antagonist ◽  
Rat Thyroid ◽  
Rat Thyroid Gland
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