TISSUE ENZYME RESPONSE TO COLD AND TO HYPERPHAGIA IN THE RAT

1964 ◽  
Vol 42 (6) ◽  
pp. 787-791
Author(s):  
John R. Beaton ◽  
V. Feleki
Keyword(s):  
Cold Exposure ◽  
Enzyme Activities ◽  
Alanine Transaminase ◽  
Transaminase Activity ◽  
Apparent Effect ◽  
Nutrient Flow ◽  
Bilateral Ablation ◽  
Phosphate Activated Glutaminase

In rats exposed to cold (5 °C) for 14 days the activities of liver arginase, alanine-transaminase, and glucose-6-phosphatase and of kidney phosphate-activated glutaminase were increased. In animals with a comparable hyperphagia due to bilateral ablation of the ventromedial region of the hypothalamus there was a smaller although significant increase in activity of kidney glutaminase but, in contrast to the effect of cold exposure, there was a significant decrease of liver alanine-transaminase activity and no apparent effect upon the activities of liver arginase or glucose-6-phosphatase. It is concluded that changes of enzyme activities in cold-exposed rats are not simply an adaptation to the increased nutrient flow consequent upon the hyperphagia induced.

LIVER TRANSAMINASE ACTIVITY IN RIBOFLAVIN-DEFICIENT RATS

1962 ◽  
Vol 40 (8) ◽  
pp. 1065-1070 ◽  
Author(s):  
Sailen Mookerjea ◽  
S. C. Jamdar
Keyword(s):  
Protein Concentration ◽  
Flavin Adenine Dinucleotide ◽  
Alanine Transaminase ◽  
Transaminase Activity ◽  
Liver Transaminase ◽  
Liver Size ◽  
Riboflavin Deficient

Rats were deprived of riboflavin until there was established impairment of growth, hepatomegaly, and depletion of flavin–adenine dinucleotide and of catalase in the liver. Under these conditions there were increased concentrations of glutamic–aspartic and glutamic–alanine transaminases in the liver. With dietary depletion and repletion of protein the transaminase levels followed changes in liver size. Since the protein concentration in the liver was not affected, the level of transaminase was directly associated with the degree of anabolism. The changes in the glutamic–alanine transaminase were the more pronounced.

THE RELATION OF DIETARY PROTEIN LEVEL TO LIVER ENZYME ACTIVITIES IN COLD-EXPOSED RATS

1963 ◽  
Vol 41 (1) ◽  
pp. 1871-1877
Author(s):  
John R. Beaton
Keyword(s):  
Cold Exposure ◽  
Dietary Protein ◽  
Protein Level ◽  
Liver Enzymes ◽  
Albino Rats ◽  
Protein Levels ◽  
Dietary Protein Level ◽  
Phosphate Activated Glutaminase ◽  
Relationship Of ◽  
Environmental Temperatures

Male, albino rats were fed diets containing 5%, 20%, and 40% casein by weight for 7 days at environmental temperatures of 22 °C and 2–3 °C. In one experiment, food was provided ad libitum; in a second experiment, all groups were provided with equal amounts of food. At 22 °C, the activities in liver of alanine-glutamic transaminase, phosphate-activated glutaminase, and arginase increased with increasing dietary protein level. At 2–3 °C, activities of the last two enzymes increased with increasing dietary protein level from 5% to 20% but not from 20% to 40% whereas transaminase activities increased throughout the dietary protein range 5% to 40%. No relationship of glucose-6-phosphatase activity to dietary protein level was evident at either environmental temperature. Cold exposure per se increased the activities of alanine-glutamic transaminase and glucose-6-phosphatase in all dietary protein groups but increased the activities of arginase and phosphate-activated glutaminase only in rats fed the 5% and 20% protein diets. It is postulated that increased activities of these liver enzymes during cold exposure result from augmented catabolism of substrates to meet increased energy requirements. As previously observed with respect to other metabolic alterations, it is apparent that cold exposure modifies the response of liver enzymes to changing dietary protein levels.

scholarly journals Prevalence of elevated alanine transaminase activity in dogs treated with CCNU (Lomustine)

2009 ◽  
Vol 7 (4) ◽  
pp. 244-255 ◽  
Author(s):  
K. Hosoya ◽  
L. K. Lord ◽  
A. Lara-Garcia ◽  
W. C. Kisseberth ◽  
C. A. London ◽  
...  
Keyword(s):  
Alanine Transaminase ◽  
Transaminase Activity

Slow progression rate of fibrosis in hepatitis C virus patients with persistently normal alanine transaminase activity

Hepatology ◽  
1998 ◽  
Vol 27 (3) ◽  
pp. 868-872 ◽  
Author(s):  
Philippe Mathurin ◽  
Joseph Moussalli ◽  
Jean-Fran�ois Cadranel ◽  
Vincent Thibault ◽  
Fr�d�ric Charlotte ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Alanine Transaminase ◽  
Progression Rate ◽  
Transaminase Activity ◽  
Slow Progression

The effect of diet on some parameters measured in toxicological studies in the rat

1980 ◽  
Vol 14 (3) ◽  
pp. 253-261 ◽  
Author(s):  
M. J. L. Clapp
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Food Consumption ◽  
Dietary Protein ◽  
Body Weight Gain ◽  
Alanine Transaminase ◽  
Haematological Parameters ◽  
Transaminase Activity ◽  
Histological Studies ◽  
Toxicological Studies

The bodyweight, food consumption and various biochemical and haematological parameters were measured in, and breeding and histological studies made of, groups of rats fed 6 different diets. All diets acceptably supported reproduction. 1 diet restricted body weight gain by 30%, and increased plasma alanine transaminase activity. Nephrocalcinosis was seen in females fed diets with a calcium: phosphorous ratio of <1. Levels of dietary protein were positively correlated with the incidence of renal pelvic dilatation in offspring at 7 weeks of age.

Changes in alanine transaminase activity in the liver of riboflavin-deficient rats

1966 ◽  
Vol 22 (12) ◽  
pp. 794-795 ◽  
Author(s):  
A. K. Chatterjee ◽  
S. C. Jamdar ◽  
B. B. Ghosh
Keyword(s):  
Alanine Transaminase ◽  
Transaminase Activity ◽  
Riboflavin Deficient
Sign in / Sign up

Export Citation Format

Share Document