Changes in alanine transaminase activity in the liver of riboflavin-deficient rats

1966 ◽  
Vol 22 (12) ◽  
pp. 794-795 ◽  
Author(s):  
A. K. Chatterjee ◽  
S. C. Jamdar ◽  
B. B. Ghosh
Keyword(s):  
Alanine Transaminase ◽  
Transaminase Activity ◽  
Riboflavin Deficient

LIVER TRANSAMINASE ACTIVITY IN RIBOFLAVIN-DEFICIENT RATS

1962 ◽  
Vol 40 (8) ◽  
pp. 1065-1070 ◽  
Author(s):  
Sailen Mookerjea ◽  
S. C. Jamdar
Keyword(s):  
Protein Concentration ◽  
Flavin Adenine Dinucleotide ◽  
Alanine Transaminase ◽  
Transaminase Activity ◽  
Liver Transaminase ◽  
Liver Size ◽  
Riboflavin Deficient

Rats were deprived of riboflavin until there was established impairment of growth, hepatomegaly, and depletion of flavin–adenine dinucleotide and of catalase in the liver. Under these conditions there were increased concentrations of glutamic–aspartic and glutamic–alanine transaminases in the liver. With dietary depletion and repletion of protein the transaminase levels followed changes in liver size. Since the protein concentration in the liver was not affected, the level of transaminase was directly associated with the degree of anabolism. The changes in the glutamic–alanine transaminase were the more pronounced.

LIVER TRANSAMINASE ACTIVITY IN RIBOFLAVIN-DEFICIENT RATS

1962 ◽  
Vol 40 (1) ◽  
pp. 1065-1070 ◽  
Author(s):  
Sailen Mookerjea ◽  
S. C. Jamdar
Keyword(s):  
Protein Concentration ◽  
Flavin Adenine Dinucleotide ◽  
Alanine Transaminase ◽  
Transaminase Activity ◽  
Liver Transaminase ◽  
Liver Size ◽  
Riboflavin Deficient

Rats were deprived of riboflavin until there was established impairment of growth, hepatomegaly, and depletion of flavin–adenine dinucleotide and of catalase in the liver. Under these conditions there were increased concentrations of glutamic–aspartic and glutamic–alanine transaminases in the liver. With dietary depletion and repletion of protein the transaminase levels followed changes in liver size. Since the protein concentration in the liver was not affected, the level of transaminase was directly associated with the degree of anabolism. The changes in the glutamic–alanine transaminase were the more pronounced.

scholarly journals Prevalence of elevated alanine transaminase activity in dogs treated with CCNU (Lomustine)

2009 ◽  
Vol 7 (4) ◽  
pp. 244-255 ◽  
Author(s):  
K. Hosoya ◽  
L. K. Lord ◽  
A. Lara-Garcia ◽  
W. C. Kisseberth ◽  
C. A. London ◽  
...  
Keyword(s):  
Alanine Transaminase ◽  
Transaminase Activity

Slow progression rate of fibrosis in hepatitis C virus patients with persistently normal alanine transaminase activity

Hepatology ◽  
1998 ◽  
Vol 27 (3) ◽  
pp. 868-872 ◽  
Author(s):  
Philippe Mathurin ◽  
Joseph Moussalli ◽  
Jean-Fran�ois Cadranel ◽  
Vincent Thibault ◽  
Fr�d�ric Charlotte ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Alanine Transaminase ◽  
Progression Rate ◽  
Transaminase Activity ◽  
Slow Progression

The effect of diet on some parameters measured in toxicological studies in the rat

1980 ◽  
Vol 14 (3) ◽  
pp. 253-261 ◽  
Author(s):  
M. J. L. Clapp
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Food Consumption ◽  
Dietary Protein ◽  
Body Weight Gain ◽  
Alanine Transaminase ◽  
Haematological Parameters ◽  
Transaminase Activity ◽  
Histological Studies ◽  
Toxicological Studies

The bodyweight, food consumption and various biochemical and haematological parameters were measured in, and breeding and histological studies made of, groups of rats fed 6 different diets. All diets acceptably supported reproduction. 1 diet restricted body weight gain by 30%, and increased plasma alanine transaminase activity. Nephrocalcinosis was seen in females fed diets with a calcium: phosphorous ratio of <1. Levels of dietary protein were positively correlated with the incidence of renal pelvic dilatation in offspring at 7 weeks of age.

scholarly journals Reduced inflammatory response and increased microcirculatory disturbances during hepatic ischemia-reperfusion injury in steatotic livers of ob/ob mice

2007 ◽  
Vol 292 (5) ◽  
pp. G1385-G1395 ◽  
Author(s):  
Tadashi Hasegawa ◽  
Yoshiya Ito ◽  
Jayanthika Wijeweera ◽  
Jie Liu ◽  
Ernst Malle ◽  
...  
Keyword(s):  
Blood Flow ◽  
Inflammatory Response ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Oxidant Stress ◽  
Liver Blood Flow ◽  
Alanine Transaminase ◽  
Transaminase Activity ◽  
Hepatic Ischemia

Steatosis is a major risk factor for complications after liver surgery. Since neutrophil cytotoxicity is critical for ischemia-reperfusion injury in normal livers, the aim of the present study was to evaluate whether an exaggerated inflammatory response could cause the increased injury in steatotic livers. In C57Bl/6 mice, 60 min of warm hepatic ischemia triggered a gradual increase in hepatic neutrophil accumulation during reperfusion with peak levels of 100-fold over baseline at 12 h of reperfusion. Neutrophil extravasation and a specific neutrophil-induced oxidant stress (immunostaining for hypochlorous acid-modified epitopes) started at 6 h of reperfusion and peaked at 12–24 h. Ob/ob mice, which had a severe macrovesicular steatosis, suffered significantly higher injury (alanine transaminase activity: 18,000 ± 2,100 U/l; 65% necrosis) compared with lean littermates (alanine transaminase activity: 4,900 ± 720 U/l; 24% necrosis) at 6 h of reperfusion. However, 62% fewer neutrophils accumulated in steatotic livers. This correlated with an attenuated increase in mRNA levels of several proinflammatory genes in ob/ob mice during reperfusion. In contrast, sham-operated ob/ob mice had a 50% reduction in liver blood flow and 35% fewer functional sinusoids compared with lean littermates. These deficiencies in liver blood flow and the microcirculation were further aggravated only in ob/ob mice during reperfusion. The attenuated inflammatory response and reduced neutrophil-induced oxidant stress observed in steatotic livers during reperfusion cannot be responsible for the dramatically increased injury in ob/ob mice. In contrast, the aggravated injury appears to be mediated by ischemic necrosis due to massive impairment of blood and oxygen supply in the steatotic livers.

TISSUE ENZYME RESPONSE TO COLD AND TO HYPERPHAGIA IN THE RAT

1964 ◽  
Vol 42 (6) ◽  
pp. 787-791
Author(s):  
John R. Beaton ◽  
V. Feleki
Keyword(s):  
Cold Exposure ◽  
Enzyme Activities ◽  
Alanine Transaminase ◽  
Transaminase Activity ◽  
Apparent Effect ◽  
Nutrient Flow ◽  
Bilateral Ablation ◽  
Phosphate Activated Glutaminase

In rats exposed to cold (5 °C) for 14 days the activities of liver arginase, alanine-transaminase, and glucose-6-phosphatase and of kidney phosphate-activated glutaminase were increased. In animals with a comparable hyperphagia due to bilateral ablation of the ventromedial region of the hypothalamus there was a smaller although significant increase in activity of kidney glutaminase but, in contrast to the effect of cold exposure, there was a significant decrease of liver alanine-transaminase activity and no apparent effect upon the activities of liver arginase or glucose-6-phosphatase. It is concluded that changes of enzyme activities in cold-exposed rats are not simply an adaptation to the increased nutrient flow consequent upon the hyperphagia induced.

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