PERFUSION PRESSURE IN RELATION TO THE PRODUCTION AND CESSATION OF EXPERIMENTAL CARDIAC ARRHYTHMIAS

1964 ◽  
Vol 42 (1) ◽  
pp. 21-24 ◽  
Author(s):  
J.-C. Panisset ◽  
R. Carle ◽  
A. Beaulnes
Keyword(s):  
Ventricular Fibrillation ◽  
Firing Rate ◽  
Cardiac Arrhythmias ◽  
Coronary Flow ◽  
Perfusion Pressure ◽  
Rabbit Heart ◽  
Effect Of Pressure ◽  
Isolated Rabbit Heart ◽  
Myocardial Temperature ◽  
Low Pressures

The influence of perfusion pressure on ventricular fibrillation was studied in the isolated rabbit heart. Sudden drops in perfusion pressure inhibit ventricular fibrillation in a few minutes, whereas a slow decrease of the pressure does not stop the fibrillation, but nevertheless reduces the ventricular firing rate. High perfusion pressures facilitate the induction of fibrillation; low pressures delay the production of arrhythmias and shorten their duration. It is postulated that this effect of pressure is primarily mechanical and not strictly dependent upon changes in the coronary flow or in the myocardial temperature.

Effects of Cytochalasin D on Electrical Restitution and the Dynamics of Ventricular Fibrillation in Isolated Rabbit Heart

2003 ◽  
Vol 14 (10) ◽  
pp. 1077-1084 ◽  
Author(s):  
HIDEKI HAYASHI ◽  
YASUSHI MIYAUCHI ◽  
CHUNG‐CHUAN CHOU ◽  
HRAYR S. KARAGUEUZIAN ◽  
PENG‐SHENG CHEN ◽  
...  
Keyword(s):  
Ventricular Fibrillation ◽  
Rabbit Heart ◽  
Cytochalasin D ◽  
Isolated Rabbit Heart

scholarly journals VENTRICULAR FIBRILLATION IN THE ISOLATED RABBIT HEART

1957 ◽  
Vol 12 (2) ◽  
pp. 215-218 ◽  
Author(s):  
A. K. ARMITAGE ◽  
J. H. BURN ◽  
A. J. GUNNING
Keyword(s):  
Ventricular Fibrillation ◽  
Rabbit Heart ◽  
Isolated Rabbit Heart

scholarly journals Quantification of Effects of Global Ischemia on Dynamics of Ventricular Fibrillation in Isolated Rabbit Heart

Circulation ◽  
1998 ◽  
Vol 98 (16) ◽  
pp. 1688-1696 ◽  
Author(s):  
Ravi Mandapati ◽  
Yukio Asano ◽  
William T. Baxter ◽  
Richard Gray ◽  
Jorge Davidenko ◽  
...  
Keyword(s):  
Ventricular Fibrillation ◽  
Rabbit Heart ◽  
Global Ischemia ◽  
Isolated Rabbit Heart

Reduction of the Risk of Ventricular Fibrillation in the Isolated Rabbit Heart by Small Additions of Electrolytes to Non-Ionic Monomeric Contrast Media

1989 ◽  
Vol 30 (3) ◽  
pp. 327-333 ◽  
Author(s):  
L. Bååth ◽  
T. Almén
Keyword(s):  
Ventricular Fibrillation ◽  
Contrast Media ◽  
Electrolyte Concentration ◽  
Intermediate Frequency ◽  
Rabbit Heart ◽  
Krebs Solution ◽  
Isolated Rabbit Heart ◽  
Small Risk ◽  
Ionic Contrast ◽  
The Media

Perfusion of the isolated rabbit heart with solutions (350 mg I/ml) of the non-ionic contrast media iohexol and iopentol, both containing NaCl (20 mmol/l), caused a significantly lower frequency of ventricular fibrillation (VF) than solutions without NaCl. Iohexol or iopentol with NaCl (10 mmol/l) caused an intermediate frequency of VF. Iohexol with 10 or 20 mmol NaCl/l caused about the same frequency of VF as iohexol solutions with about the same total electrolyte concentration but with electrolyte composition as that of Krebs' solution. At 320 mg I/ml, solutions of iohexol (20 mmol NaCl/l), iodixanol (20 mmol NaCl/l) and ioxaglate (155 mmol Na/l) all produced a significantly lower frequency of VF than iohexol without NaCl. Ioxaglate caused the largest and iodixanol the smallest decrease in contractile force of the media. The investigation suggests that the small risk of VF from non-ionic monomeric media can be further reduced by adding a small amount of sodium chloride or of the electrolytes of Krebs' solution.

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