MECHANICAL PROPERTIES AND HISTAMINE AND SEROTONIN CONTENT OF GUINEA PIG LUNGS AS INFLUENCED BY MICROPARTICLES INHALATION

1963 ◽  
Vol 41 (1) ◽  
pp. 2177-2182 ◽  
Author(s):  
Eugène Robillard ◽  
Yves Alarie
Keyword(s):  
Mechanical Properties ◽  
Iron Oxide ◽  
Guinea Pig ◽  
Guinea Pigs ◽  
Oxide Particle ◽  
Iron Oxide Particle ◽  
Serotonin Content ◽  
Particle Inhalation ◽  
Volume Pressure Curves ◽  
Characteristic Volume

In previous experiments, the inhalation of aluminum or iron oxide submicronic particles was shown to possess strong constricting properties, using the method of volume–pressure curves with atelectatic guinea pig lung. The constricting effect of aluminum was prevented by cyproheptadine, an antihistaminic and antiserotonin substance. In the present experiments, determinations of serotonin and histamine in dust-treated lungs were undertaken; the content of serotonin and of histamine was found to be increased after aluminum and after iron oxide particle inhalation respectively. Serotonin and histamine given as aerosols to guinea pigs reproduced the characteristic volume–pressure curves obtained after aluminum or iron oxide microparticle inhalation, respectively.

MECHANICAL PROPERTIES AND HISTAMINE AND SEROTONIN CONTENT OF GUINEA PIG LUNGS AS INFLUENCED BY MICROPARTICLES INHALATION

1963 ◽  
Vol 41 (10) ◽  
pp. 2177-2182 ◽  
Author(s):  
Eugène Robillard ◽  
Yves Alarie
Keyword(s):  
Mechanical Properties ◽  
Iron Oxide ◽  
Guinea Pig ◽  
Guinea Pigs ◽  
Oxide Particle ◽  
Iron Oxide Particle ◽  
Serotonin Content ◽  
Particle Inhalation ◽  
Volume Pressure Curves ◽  
Characteristic Volume

In previous experiments, the inhalation of aluminum or iron oxide submicronic particles was shown to possess strong constricting properties, using the method of volume–pressure curves with atelectatic guinea pig lung. The constricting effect of aluminum was prevented by cyproheptadine, an antihistaminic and antiserotonin substance. In the present experiments, determinations of serotonin and histamine in dust-treated lungs were undertaken; the content of serotonin and of histamine was found to be increased after aluminum and after iron oxide particle inhalation respectively. Serotonin and histamine given as aerosols to guinea pigs reproduced the characteristic volume–pressure curves obtained after aluminum or iron oxide microparticle inhalation, respectively.

PRESSURE–VOLUME CURVES IN ISOLATED ATELECTATIC RAT LUNGS AFTER ALUMINUM OXIDE MICROPARTICLE INHALATION

1963 ◽  
Vol 41 (1) ◽  
pp. 1257-1265 ◽  
Author(s):  
E. Robillard ◽  
Y. Alarie
Keyword(s):  
Guinea Pig ◽  
Aluminum Oxide ◽  
Normal Control ◽  
Oxide Particle ◽  
Aluminum Particles ◽  
Aluminum Oxide Particle ◽  
Rat Lungs ◽  
Particle Inhalation ◽  
Oxide Particles ◽  
Volume Pressure Curves

Volume–pressure curves obtained from isolated atelectatic rat lungs under normal control conditions were compared with those obtained from lungs of animals previously exposed to inhalation of submicronic aluminum oxide particles for various periods of time. A dilating effect was recorded in rat lungs after aluminum oxide particle inhalation contrasting with the constricting effect reported by many authors in guinea pig, dog, cat, and man. Inhalation of fine aluminum particles before or after inhalation of sympathomimetic aerosol resulted in a more intense dilatation. The constricting effect of carbachol was antagonized by prior inhalation of fine aluminum oxide dust and enhanced when the order of inhalations was reversed.

PRESSURE–VOLUME CURVES IN ISOLATED ATELECTATIC RAT LUNGS AFTER ALUMINUM OXIDE MICROPARTICLE INHALATION

1963 ◽  
Vol 41 (5) ◽  
pp. 1257-1265 ◽  
Author(s):  
E. Robillard ◽  
Y. Alarie
Keyword(s):  
Guinea Pig ◽  
Aluminum Oxide ◽  
Normal Control ◽  
Oxide Particle ◽  
Aluminum Particles ◽  
Aluminum Oxide Particle ◽  
Rat Lungs ◽  
Particle Inhalation ◽  
Oxide Particles ◽  
Volume Pressure Curves

Volume–pressure curves obtained from isolated atelectatic rat lungs under normal control conditions were compared with those obtained from lungs of animals previously exposed to inhalation of submicronic aluminum oxide particles for various periods of time. A dilating effect was recorded in rat lungs after aluminum oxide particle inhalation contrasting with the constricting effect reported by many authors in guinea pig, dog, cat, and man. Inhalation of fine aluminum particles before or after inhalation of sympathomimetic aerosol resulted in a more intense dilatation. The constricting effect of carbachol was antagonized by prior inhalation of fine aluminum oxide dust and enhanced when the order of inhalations was reversed.

scholarly journals Iron Oxide Particle-Enhanced MRI Suggests Variability of Brain Inflammation at Early Stages After Ischemic Stroke

Stroke ◽  
2007 ◽  
Vol 38 (10) ◽  
pp. 2733-2737 ◽  
Author(s):  
Andreas Saleh ◽  
Michael Schroeter ◽  
Adrian Ringelstein ◽  
Hans-Peter Hartung ◽  
Mario Siebler ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Iron Oxide ◽  
Oxide Particle ◽  
Brain Inflammation ◽  
Iron Oxide Particle ◽  
Early Stages ◽  
Enhanced Mri

STATIC VOLUME–PRESSURE RELATIONS IN GUINEA PIG LUNGS AFTER INHALATION OF ALUMINUM OR IRON OXIDE PARTICLES AND BRONCHODILATOR AEROSOLS

1963 ◽  
Vol 41 (2) ◽  
pp. 461-468 ◽  
Author(s):  
E. Robillard ◽  
Y. Alarie
Keyword(s):  
Iron Oxide ◽  
Guinea Pig ◽  
Aluminum Oxide ◽  
Previous Exposure ◽  
Iron Oxide Particles ◽  
Antagonistic Action ◽  
Low Concentration ◽  
Oxide Particles ◽  
The Right ◽  
Volume Pressure Curves

Volume–pressure curves obtained from isolated atelectatic guinea pig lungs under normal controlled conditions are compared with those obtained from animals having inhaled fine aluminum or iron oxide particles. After particles inhalation, the inflation curves are deviated to the right, showing a constricting effect. Previous exposure to low concentration of isoproterenol aerosol fails to reverse completely the constricting effect induced by a prior inhalation of aluminum oxide particles although in combination with diphenhydramine or at a higher concentration an antagonistic action appears. Cyproheptadine aerosolation also prevents the constricting effect of inhaled aluminum oxide particles The constricting effect of iron oxide was not prevented by those dilating aerosols at concentrations used.

scholarly journals Soluble iron modulates iron oxide particle-induced inflammatory responses via prostaglandin E2 synthesis: In vitro and in vivo studies

2009 ◽  
Vol 6 (1) ◽  
pp. 34 ◽  
Author(s):  
Ingrid Beck-Speier ◽  
Wolfgang G Kreyling ◽  
Konrad L Maier ◽  
Niru Dayal ◽  
Mette C Schladweiler ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Prostaglandin E2 ◽  
Inflammatory Responses ◽  
Oxide Particle ◽  
In Vivo Studies ◽  
Iron Oxide Particle ◽  
Soluble Iron

Pressure overload changes cardiac skinned-fiber mechanics in rats, not in guinea pigs

1988 ◽  
Vol 254 (3) ◽  
pp. H517-H524 ◽  
Author(s):  
R. Ventura-Clapier ◽  
H. Mekhfi ◽  
P. Oliviero ◽  
B. Swynghedauw
Keyword(s):  
Mechanical Properties ◽  
Guinea Pig ◽  
Guinea Pigs ◽  
Turnover Rate ◽  
Pressure Overload ◽  
Heart Weight ◽  
Papillary Muscles ◽  
Shortening Velocity ◽  
Abdominal Aortic ◽  
Tension Recovery

The mechanical properties of detergent-treated skinned fibers from pressure-overloaded rat and guinea pig hearts have been compared with those of sham-operated animals. Overload was obtained 4 wk after abdominal aortic stenosis, an intervention that increases ventricular weight by 56% in rats and 57% in guinea pigs. The time constant (T, in ms) for tension recovery after a quick stretch was significantly lower in normal guinea pig than in rat. It was lengthened by the process of overload in both species, but this was much more pronounced in rats where T increases by 84% than in guinea pig where it was only slightly augmented by 14% for a doubling of the heart weight. By contrast the maximum tension obtained at pCa 4.5, the stiffness, and the sensitivity to calcium of the fibers were unmodified by chronic overload. In rat, not in guinea pig, a slight decrease in MgATP sensitivity was also observed, whereas no change in creatine kinase efficiency was seen. These results are interpreted as indicating that the slowing of the turnover rate of cross-bridge cycling explains the drop in shortening velocity observed on papillary muscles in rat but not in guinea pig; a species in which membrane modifications must be predominant in the process of adaptation.

High transversal relaxivities of silica coated multicore iron oxide nanoparticles suitable for magnetic resonance imaging

2010 ◽  
Vol 1257 ◽  
Author(s):  
Anna Roig ◽  
Elena Taboada ◽  
Elisenda Rodríguez
Keyword(s):  
Iron Oxide ◽  
Sol Gel ◽  
Oxide Particle ◽  
Silica Shell ◽  
Composite Particles ◽  
Iron Oxide Particle ◽  
Maghemite Nanoparticles ◽  
High Temperature Process ◽  
Reaction Media ◽  
Very High

AbstractWe report on high transversal relaxivity values of composite iron oxide-silica nanoparticles. To obtain the material, pre-formed maghemite nanoparticles were coated with silica by sol-gel chemistry, using supercritical fluids as the reaction media. The composite particles were monodisperse and consisted of a core of several maghemite nanoparticles, surrounded by a thick silica shell. The high pressure and high temperature process did not affect the iron oxide particle size but induced an increase on their saturation magnetization values, possibly due to an improvement of the particle crystallinity. These iron oxide-based materials present very high transversal relaxivity values which can be correlated to the magnetic moment and to the silica shell width of the composite particles. Moreover, composite particles are not cytotoxic and they are dispersable in polar solvents.

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