PRESSURE–VOLUME CURVES IN ISOLATED ATELECTATIC RAT LUNGS AFTER ALUMINUM OXIDE MICROPARTICLE INHALATION

1963 ◽  
Vol 41 (5) ◽  
pp. 1257-1265 ◽  
Author(s):  
E. Robillard ◽  
Y. Alarie
Keyword(s):  
Guinea Pig ◽  
Aluminum Oxide ◽  
Normal Control ◽  
Oxide Particle ◽  
Aluminum Particles ◽  
Aluminum Oxide Particle ◽  
Rat Lungs ◽  
Particle Inhalation ◽  
Oxide Particles ◽  
Volume Pressure Curves

Volume–pressure curves obtained from isolated atelectatic rat lungs under normal control conditions were compared with those obtained from lungs of animals previously exposed to inhalation of submicronic aluminum oxide particles for various periods of time. A dilating effect was recorded in rat lungs after aluminum oxide particle inhalation contrasting with the constricting effect reported by many authors in guinea pig, dog, cat, and man. Inhalation of fine aluminum particles before or after inhalation of sympathomimetic aerosol resulted in a more intense dilatation. The constricting effect of carbachol was antagonized by prior inhalation of fine aluminum oxide dust and enhanced when the order of inhalations was reversed.

PRESSURE–VOLUME CURVES IN ISOLATED ATELECTATIC RAT LUNGS AFTER ALUMINUM OXIDE MICROPARTICLE INHALATION

1963 ◽  
Vol 41 (1) ◽  
pp. 1257-1265 ◽  
Author(s):  
E. Robillard ◽  
Y. Alarie
Keyword(s):  
Guinea Pig ◽  
Aluminum Oxide ◽  
Normal Control ◽  
Oxide Particle ◽  
Aluminum Particles ◽  
Aluminum Oxide Particle ◽  
Rat Lungs ◽  
Particle Inhalation ◽  
Oxide Particles ◽  
Volume Pressure Curves

Volume–pressure curves obtained from isolated atelectatic rat lungs under normal control conditions were compared with those obtained from lungs of animals previously exposed to inhalation of submicronic aluminum oxide particles for various periods of time. A dilating effect was recorded in rat lungs after aluminum oxide particle inhalation contrasting with the constricting effect reported by many authors in guinea pig, dog, cat, and man. Inhalation of fine aluminum particles before or after inhalation of sympathomimetic aerosol resulted in a more intense dilatation. The constricting effect of carbachol was antagonized by prior inhalation of fine aluminum oxide dust and enhanced when the order of inhalations was reversed.

STATIC VOLUME–PRESSURE RELATIONS IN GUINEA PIG LUNGS AFTER INHALATION OF ALUMINUM OR IRON OXIDE PARTICLES AND BRONCHODILATOR AEROSOLS

1963 ◽  
Vol 41 (2) ◽  
pp. 461-468 ◽  
Author(s):  
E. Robillard ◽  
Y. Alarie
Keyword(s):  
Iron Oxide ◽  
Guinea Pig ◽  
Aluminum Oxide ◽  
Previous Exposure ◽  
Iron Oxide Particles ◽  
Antagonistic Action ◽  
Low Concentration ◽  
Oxide Particles ◽  
The Right ◽  
Volume Pressure Curves

Volume–pressure curves obtained from isolated atelectatic guinea pig lungs under normal controlled conditions are compared with those obtained from animals having inhaled fine aluminum or iron oxide particles. After particles inhalation, the inflation curves are deviated to the right, showing a constricting effect. Previous exposure to low concentration of isoproterenol aerosol fails to reverse completely the constricting effect induced by a prior inhalation of aluminum oxide particles although in combination with diphenhydramine or at a higher concentration an antagonistic action appears. Cyproheptadine aerosolation also prevents the constricting effect of inhaled aluminum oxide particles The constricting effect of iron oxide was not prevented by those dilating aerosols at concentrations used.

MECHANICAL PROPERTIES AND HISTAMINE AND SEROTONIN CONTENT OF GUINEA PIG LUNGS AS INFLUENCED BY MICROPARTICLES INHALATION

1963 ◽  
Vol 41 (1) ◽  
pp. 2177-2182 ◽  
Author(s):  
Eugène Robillard ◽  
Yves Alarie
Keyword(s):  
Mechanical Properties ◽  
Iron Oxide ◽  
Guinea Pig ◽  
Guinea Pigs ◽  
Oxide Particle ◽  
Iron Oxide Particle ◽  
Serotonin Content ◽  
Particle Inhalation ◽  
Volume Pressure Curves ◽  
Characteristic Volume

In previous experiments, the inhalation of aluminum or iron oxide submicronic particles was shown to possess strong constricting properties, using the method of volume–pressure curves with atelectatic guinea pig lung. The constricting effect of aluminum was prevented by cyproheptadine, an antihistaminic and antiserotonin substance. In the present experiments, determinations of serotonin and histamine in dust-treated lungs were undertaken; the content of serotonin and of histamine was found to be increased after aluminum and after iron oxide particle inhalation respectively. Serotonin and histamine given as aerosols to guinea pigs reproduced the characteristic volume–pressure curves obtained after aluminum or iron oxide microparticle inhalation, respectively.

STATIC VOLUME–PRESSURE RELATIONS IN GUINEA PIG LUNGS AFTER INHALATION OF ALUMINUM OR IRON OXIDE PARTICLES AND BRONCHODILATOR AEROSOLS

1963 ◽  
Vol 41 (1) ◽  
pp. 461-468 ◽  
Author(s):  
E. Robillard ◽  
Y. Alarie
Keyword(s):  
Iron Oxide ◽  
Guinea Pig ◽  
Aluminum Oxide ◽  
Previous Exposure ◽  
Iron Oxide Particles ◽  
Antagonistic Action ◽  
Low Concentration ◽  
Oxide Particles ◽  
The Right ◽  
Volume Pressure Curves

Volume–pressure curves obtained from isolated atelectatic guinea pig lungs under normal controlled conditions are compared with those obtained from animals having inhaled fine aluminum or iron oxide particles. After particles inhalation, the inflation curves are deviated to the right, showing a constricting effect. Previous exposure to low concentration of isoproterenol aerosol fails to reverse completely the constricting effect induced by a prior inhalation of aluminum oxide particles although in combination with diphenhydramine or at a higher concentration an antagonistic action appears. Cyproheptadine aerosolation also prevents the constricting effect of inhaled aluminum oxide particles The constricting effect of iron oxide was not prevented by those dilating aerosols at concentrations used.

MECHANICAL PROPERTIES AND HISTAMINE AND SEROTONIN CONTENT OF GUINEA PIG LUNGS AS INFLUENCED BY MICROPARTICLES INHALATION

1963 ◽  
Vol 41 (10) ◽  
pp. 2177-2182 ◽  
Author(s):  
Eugène Robillard ◽  
Yves Alarie
Keyword(s):  
Mechanical Properties ◽  
Iron Oxide ◽  
Guinea Pig ◽  
Guinea Pigs ◽  
Oxide Particle ◽  
Iron Oxide Particle ◽  
Serotonin Content ◽  
Particle Inhalation ◽  
Volume Pressure Curves ◽  
Characteristic Volume

In previous experiments, the inhalation of aluminum or iron oxide submicronic particles was shown to possess strong constricting properties, using the method of volume–pressure curves with atelectatic guinea pig lung. The constricting effect of aluminum was prevented by cyproheptadine, an antihistaminic and antiserotonin substance. In the present experiments, determinations of serotonin and histamine in dust-treated lungs were undertaken; the content of serotonin and of histamine was found to be increased after aluminum and after iron oxide particle inhalation respectively. Serotonin and histamine given as aerosols to guinea pigs reproduced the characteristic volume–pressure curves obtained after aluminum or iron oxide microparticle inhalation, respectively.

Fractal Dimension Analysis of Aluminum Oxide Particle for Sandblasting Dental Use

1993 ◽  
Vol 3 (3) ◽  
pp. 117-126 ◽  
Author(s):  
Yoshiki Oshida ◽  
Carlos A. Munoz ◽  
Mark M. Winkler ◽  
Azza Hashem ◽  
Michio Itoh
Keyword(s):  
Fractal Dimension ◽  
Aluminum Oxide ◽  
Oxide Particle ◽  
Aluminum Oxide Particle ◽  
Dimension Analysis ◽  
Fractal Dimension Analysis
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