PERCENTAGE OF ALPHA-LIPOPROTEINS, TOTAL CHOLESTEROL, AND ATHEROSCLEROSIS

1962 ◽  
Vol 40 (1) ◽  
pp. 1515-1527
Author(s):  
Claude Allard ◽  
Gaston Choquette
Keyword(s):  
Total Cholesterol ◽  
Diagnostic Value ◽  
Rapid Procedure ◽  
Coronary Patient ◽  
Zone Electrophoresis ◽  
Human Sera ◽  
The Mean ◽  
Male Subjects ◽  
Healthy Males

A relatively rapid procedure for the routine estimation of lipoproteins in prestained human sera by zone electrophoresis in paper was described. This technique was employed for the study of the percentage of alpha-lipoproteins in sera of healthy and coronary male subjects of various ages. The mean proportion of alpha-lipoproteins in healthy males (100) was observed to be about 24% in subjects at the age of 20–29 and 16% at the age of 30–59. In the coronary group (105) the mean percentage of alpha-lipoproteins was lower than 13% irrespective of age. From this study, the diagnostic value of alpha-lipoproteins percentage to characterize a coronary patient appeared to be superior to total cholesterol concentrations.

PERCENTAGE OF ALPHA-LIPOPROTEINS, TOTAL CHOLESTEROL, AND ATHEROSCLEROSIS

1962 ◽  
Vol 40 (11) ◽  
pp. 1515-1527 ◽  
Author(s):  
Claude Allard ◽  
Gaston Choquette
Keyword(s):  
Total Cholesterol ◽  
Diagnostic Value ◽  
Rapid Procedure ◽  
Coronary Patient ◽  
Zone Electrophoresis ◽  
Human Sera ◽  
The Mean ◽  
Male Subjects ◽  
Healthy Males

A relatively rapid procedure for the routine estimation of lipoproteins in prestained human sera by zone electrophoresis in paper was described. This technique was employed for the study of the percentage of alpha-lipoproteins in sera of healthy and coronary male subjects of various ages. The mean proportion of alpha-lipoproteins in healthy males (100) was observed to be about 24% in subjects at the age of 20–29 and 16% at the age of 30–59. In the coronary group (105) the mean percentage of alpha-lipoproteins was lower than 13% irrespective of age. From this study, the diagnostic value of alpha-lipoproteins percentage to characterize a coronary patient appeared to be superior to total cholesterol concentrations.

HRA Model for Hypercholesterolemia Based on a Longitudinal Health Database

1998 ◽  
Vol 37 (02) ◽  
pp. 130-133
Author(s):  
T. Kishimoto ◽  
Y. Iida ◽  
K. Yoshida ◽  
M. Miyakawa ◽  
H. Sugimori ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Proportional Hazards ◽  
Proportional Hazards Model ◽  
Model Analysis ◽  
Serum Total Cholesterol ◽  
Hazards Model ◽  
The Mean ◽  
Health Database ◽  
Observation Period

AbstractTo evaluate the risk factors for hypercholesterolemia, we examined 4,371 subjects (3,207 males and 1,164 females) who received medical checkups more than twice at an AMHTS in Tokyo during the period from 1976 through 1991; and whose serum total cholesterol was under 250 mg/dl. The mean follow-up duration was 6.6 years. A self-registering questionnaire was administered at the time of the health checkup. The endpoint of this study was the onset of hypercholesterolemia when the level of serum total cholesterol was 250 mg/dl and over. We compared two prognosis groups (normal and hypercholesterol) in terms of age, examination findings and lifestyle. After assessing each variable, we employed Cox's proportional hazards model analysis to determine the factors related to the occurrence of hypercholesterolemia. According to proportional hazards model analysis, total cholesterol, triglyceride and smoking at the beginning, and hypertension during the observation period were selected in males; and total cholesterol at the beginning and age were selected in females to determine the factors related to the occurrence of hypercholesterolemia.

THE EFFECT OF ALTERATION OF THYROXINE BINDING CAPACITY ON THE DIALYZABLE AND ABSOLUTE FRACTIONS OF TRIIODOTHYRONINE IN CIRCULATION

1973 ◽  
Vol 72 (2) ◽  
pp. 265-271 ◽  
Author(s):  
J. H. Dussault ◽  
D. A. Fisher ◽  
J. T. Nicoloff ◽  
V. V. Row ◽  
R. Volpe
Keyword(s):  
Correlation Coefficient ◽  
Inverse Relationship ◽  
Binding Capacity ◽  
Hormone Concentration ◽  
Thyroxine Binding Globulin ◽  
Serum Thyroxine ◽  
A Value ◽  
The Mean ◽  
Male Subjects ◽  
Female Subjects

ABSTRACT In order to determine the effect of alterations in binding capacity of thyroxine binding globulin (TBG) on triiodothyronine (T3) metabolism, studies were conducted in 10 patients with idiopathically low (7 subjects) or elevated (3 subjects) TBG levels and 10 subjects given norethandrolone (7 male subjects) or oestrogen (3 female subjects). Measurements of serum thyroxine (T4) concentration, maximal T4 binding capacity, serum T3 concentration and per cent dialyzable T3 were conducted. Serum T3 was measured both by chemical and radioimmunoassay methods. In patients with idiopathically low TBG, the mean serum T4 concentration was low (2.4 μg/100 ml), the mean serum T3 level low (55 ng/100 ml), the mean per cent dialyzable T3 increased (0.52%), and the calculated free T3 concentration normal (186 pg/100 ml). In patients with idiopathically high TBG levels the mean T4 concentration was high (10.3 μg/100 ml), the mean T3 level slightly elevated (127 ng/100 ml), the% dialyzable T3 low (0.10%) and the calculated free T3 concentration low normal (123 pg/100 ml). The correlation coefficient between the per cent dialyzable T3 and maximal TBG binding capacity in the 20 subjects was 0.68, a value significant at the P < 0.01 level. Thus, alterations in binding capacity of TBG seem to influence T3 and T4 metabolism similarly; the inverse relationship between the % of dialyzable hormone and total hormone concentration tends to keep the absolue levels of free hormones stable.

STUDIES IN THE RELATION OF THE HEMOLYTIC STREPTOCOCCUS TO RHEUMATIC FEVER

PEDIATRICS ◽  
1949 ◽  
Vol 3 (4) ◽  
pp. 482-503
Author(s):  
T. N. HARRIS ◽  
SUSANNA HARRIS ◽  
RUTH L. NAGLE
Keyword(s):  
Rheumatic Fever ◽  
Streptococcal Infection ◽  
Laboratory Diagnosis ◽  
Diagnostic Value ◽  
The Other ◽  
Streptococcal Infections ◽  
Hemolytic Streptococcus ◽  
Streptococcal Antigens ◽  
The Mean

Titrations of antibodies to four streptococcal antigens have been carried out in the sera of patients with rheumatic fever and of convalescents from streptococcal infections. These antigens are the hyaluronidase, the hemolysin, and two somatic fractions, the cytoplasmic particles and supernate proteins. Mean titers to all of these antigens were elevated in both rheumatic and streptococcal infection. The mean titer was somewhat higher in rheumatic than in streptococcal infection in the case of three of these antibodies. In the case of the fourth, antihyaluronidase, this difference was considerably greater. The antihyaluronidase titer showed better correlation with changes in the activity of the rheumatic infection than did the other tests. There was, however, no striking correlation between this titer and the severity of the illness. Application was made of these findings to the problem of laboratory diagnosis of rheumatic fever by streptococcal serology. A method is presented for assessing the relative usefulness of such tests in terms of the, distribution of their titers in this disease and in health. By this method the antihyaluronidase test was found to be most useful of the four. The comparative diagnostic value for rheumatic fever was studied in the case of the antihyaluronidase test, the antistreptolysin test, and of combinations of both tests.

Elevations in Thyroid-Stimulating Hormone in Normal Subjects after Receiving Short-Term Lithium Carbonate

1988 ◽  
Vol 22 (3) ◽  
pp. 202-204 ◽  
Author(s):  
Merlin V. Nelson ◽  
Vickie Tutag-Lehr ◽  
R. Lee Evans
Keyword(s):  
Lithium Carbonate ◽  
Normal Subjects ◽  
Thyroid Stimulating Hormone ◽  
Short Term ◽  
The Mean ◽  
Early Rise ◽  
State Concentration ◽  
Male Subjects ◽  
Stimulating Hormone

Nine normal, healthy male subjects had significantly elevated thyroid-stimulating hormone (TSH) concentrations while receiving oral lithium carbonate for two weeks. The mean minimum lithium serum concentration was 0.765 mEq/L. The TSH concentrations after 15 days on lithium were significantly correlated to the TSH concentration at baseline. No correlation was found between mean minimum lithium steady-state concentration and TSH concentration after 15 days on lithium. Further research is necessary to determine if a high baseline TSH concentration or an early rise in TSH will predict those patients who will eventually develop hypothyroidism after long-term lithium therapy.

scholarly journals The Levels and Bactericidal Capacity of Antibodies Directed against the UspA1 and UspA2 Outer Membrane Proteins ofMoraxella (Branhamella) catarrhalis in Adults and Children

1999 ◽  
Vol 67 (3) ◽  
pp. 1310-1316 ◽  
Author(s):  
Dexiang Chen ◽  
Vicki Barniak ◽  
Karl R. VanDerMeid ◽  
John C. McMichael
Keyword(s):  
Outer Membrane Proteins ◽  
Igg Antibodies ◽  
Serum Iga ◽  
Age Dependent ◽  
Human Sera ◽  
Adults And Children ◽  
The Mean ◽  
Bactericidal Activities ◽  
Branhamella Catarrhalis ◽  
Antigenic Epitopes

ABSTRACT The UspA1 and UspA2 proteins from Moraxella catarrhalisshare antigenic epitopes and are promising vaccine candidates. In this study, the levels and bactericidal activities of antibodies in sera from healthy adults and children toward UspA1 and UspA2 from the O35E strain were measured. Human sera contained antibodies to both proteins, and the levels of immunoglobulin G (IgG) antibodies were age dependent. Adult sera had significantly higher titers of IgG than child sera (P < 0.01). The IgG3 titers to the UspA proteins were higher than the IgG1 titers in the adults’ sera, while the IgG1 titers were higher than the IgG3 titers in the children’s sera (P < 0.05). The IgG antibodies in the sera from 2-month-old children appeared to be maternally derived, since the mean titer was significantly higher than that in sera from 6- to 7-month-old children (P < 0.05). Serum IgA antibodies to both UspA1 and UspA2 were low during the first 7 months of age but thereafter gradually increased along with the IgG titers. Analysis of sera absorbed with UspA1 or UspA2 showed that the antibodies to UspA1 and UspA2 were cross-reactive with each other and associated with serum bactericidal activity. Examination of affinity-purified human antibodies confirmed that naturally acquired antibodies to UspA1 and UspA2 were bactericidal and cross-reactive. These results support using UspA1 and UspA2 in a vaccine to prevent M. catarrhalisinfections.

scholarly journals Cross-sectional study to compare the biochemical parameters in low normal versus high normal plasma glucose levels in euglycemic individuals

2020 ◽  
Vol 7 (6) ◽  
pp. 997
Author(s):  
Dharmendra Jhavar ◽  
Neha Kirti ◽  
Sumit Kumar Vishwakarma ◽  
Umesh Kumar Chandra ◽  
Vinod Verma
Keyword(s):  
Uric Acid ◽  
Total Cholesterol ◽  
General Medicine ◽  
Cross Sectional Study ◽  
Normal Group ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Mean ◽  
The Difference

Background: Since a long time ago, the experts have realized that determination of cut-off point for diagnosing diabetes will be revised over time with the lower blood glucose level as the more sensitive diagnosis for detecting the occurring complication and biochemical changes.Methods: This cross sectional study was carried out in the department of medicine, M.G.M. Medical College and M.Y. Hospital Indore from July, 2016 to August, 2017 in 200 individuals and patients having euglycemic status attending General Medicine OPD.Results: In the low and high normal group 2 (2.0%) and 8 (8.0%) were having abnormal total cholesterol (TC) level respectively. The mean total cholesterol in the low normal group was 117.16±26.94mg/dl and it was 154.74±28.38mg/dl in the high normal group. The difference was found to be statistically significant (p value 0.000). In the low and high normal group, 4 (4.0%) and 17 (17.0%) were having abnormal triglyceride (TG) levels respectively. The mean TG levels in the low and high normal group were 96.93±22.64mg/dl and 110.55±32.37mg/dl respectively. The difference was found to be statistically significant (p value 0.001). In the low and high normal group, 6 (6.0%) and 14 (14.0%) patient was having abnormal uric acid levels respectively. The mean uric acid levels in the low and high normal group was 4.88±1.10mg/dl and 5.31±1.31mg/dl respectively. The difference was found to be statistically significant (p value 0.013).Conclusions: Higher levels of Cholesterol and Triglycerides were found more commonly in high normal euglycemic group compared to low normal euglycemic group. Mean cholesterol and mean triglyceride levels were higher in high normal euglycemic group.

scholarly journals The Effect of Urtica Dioica Extract on Blood Lipids Profile in Patients with Type 2 Diabetes: A Randomized Double-blinded Clinical Trial

2021 ◽  
Author(s):  
Roya Khajeh Mehrizi ◽  
Hassan Mozaffari-Khosravi ◽  
Parisa Aboee
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Clinical Trial ◽  
Total Cholesterol ◽  
Density Lipoprotein ◽  
Urtica Dioica ◽  
Significant Difference ◽  
The Mean ◽  
Double Blinded

Background: Diabetes is an endocrine disorder that is strongly associated with cardiovascular disease. The use of alternative therapy has recently increased and medicinal plants are one of the alternative therapies for diabetic patients. This study aimed to evaluate the protective effect of Urtica dioica (Nettle) on lipid profile in patients with type 2 diabetes (T2D). Method: This parallel randomized double-blinded clinical trial was conducted on 60 men and women with T2D for an 8-week period. The participants were randomly assigned to received 100mg/kg/day extract of Urtica Dioica (UG) and the placebo group (PG). Blood triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDLc) and high density lipoprotein cholesterol (HDLc) were measured at baseline and end of the study. The data were analyzed using SPSS 16.0 and P < 0.05 was considered significant. Results: The mean difference of total cholesterol showed no significant difference in the UG compared to the PG which were -10.56±40.5 and -19.5± 35.9 (P = 0.14), respectively. The study also showed no significant difference between TG and LDLc in the UG compared to the PG (-39.8±171.5 vs. -23.37±72.3 (P = 0.68) and -3.16±33.4 vs. -11.2±35.6 (P = 0.15), respectively). The mean difference of HDLc in the UG and PG were -2.68±8.11 and 2.62±10.6 (P = 0.05), respectively, indicating a significant increase in the UG compared to the PG. Conclusion: The results demonstrated that consumption of 100mg/kg/day extract of UD for 8 weeks by increasing HDL concentration can decrease the risk of cardiovascular disease in patients with T2D.

scholarly journals Evaluation of the effect of a modified proprietary poultry feed on cholesterol excretion in laying birds

2019 ◽  
Vol 30 (2) ◽  
pp. 113-116
Author(s):  
Chris Oche Ikese ◽  
Simon Terver Ubwa ◽  
Sunday Ogakwu Adoga ◽  
Stephen Inegedu Audu ◽  
Michael Akor
Keyword(s):  
Total Cholesterol ◽  
Rice Bran ◽  
Colorimetric Method ◽  
Cholesterol Content ◽  
Poultry Feed ◽  
Control Group ◽  
Feeding Programs ◽  
Before And After ◽  
Cholesterol Excretion ◽  
The Mean

Abstract The effect of modified proprietary poultry feed on cholesterol excretion in laying birds was evaluated. The study sort to lower the cholesterol content of eggs at the point of their physiological formation via a modification of the proprietary feed fed to laying poultry birds. This was with a view to lower the net cholesterol content in their eggs, thereby lowering the cholesterol levels available in such eggs for intake upon consumption. A 20% rice bran modification of the proprietary feed was made. Animal subjects were divided into experimental and control groups and the mean total cholesterol in their faecal droppings where determined before and after varying their feeding programs. Whereas the experimental group was fed with the modified feed, the control group was maintained on the unmodified feed. Enzymatic colorimetric method was used for the determination of mean total cholesterol in the dried faecal droppings of each group of birds under investigation. The results showed that the mean total cholesterol excretion before and after the modified feed regimen were 5.97±0.16 mg/g and 9.99±0.47 mg/g respectively and were found to be significantly different when compared using a t-test at p > 0.05 and 49 degree of freedom The results also showed that the modified proprietary poultry feed increased total cholesterol excretion in the faecal droppings of laying birds fed with the modified feed by 67.3%, and this was found to be statistically significant at p > 0.05. Hence, a 20% rice-bran modification of the proprietary feed yields a modified feed with a proven potency in elevating total cholesterol excretion while producing no drastic deviation from the proximate composition of the unmodified proprietary feed and is thus likely to have no adverse effect on the productivity of laying birds.

scholarly journals Gender and Stature Estimate Based on Facial Measurements: an Anthropometric Study in Southwest Iranian Population

2021 ◽  
Vol 11 (1) ◽  
pp. 22-33
Author(s):  
Alireza Eftekhari Moghadam ◽  
Forouzan Absalan ◽  
Jafar Rezaian ◽  
Kimia Pirzad ◽  
Atefeh Zahedi
Keyword(s):  
Descriptive Analysis ◽  
Diagnostic Value ◽  
Cross Sectional Study ◽  
Iranian Population ◽  
Female Group ◽  
Cross Sectional ◽  
Facial Height ◽  
Discriminative Value ◽  
And Gender ◽  
Male Subjects

This study was aimed to evaluate the facial dimensions and their relation with gender and stature in the Iranian southwest population. A cross-sectional study was conducted among 300 southwest Iranian cases age 20-50 years (150 males and 150 females). Studied variables through physical anthropometry in both genders were Upper facial height (UFH), Total facial height (TFH), Facial Height (FH), Facial Width (FW), and intercanthal width (IC) using a standard sliding caliper and Collis. Regarding the sex and age of the individuals, general descriptive analysis of facial dimensions was determined. All measurements, except TFH and FH, were different between men and women (p≤ 0.01). In male subjects, the Pearson’s correlation coefficient (r) revealed that IC (0.72 ⃰ ⃰ ), FW (0.58 ⃰ ⃰ ) and UFH (0.18 ⃰⃰ ⃰ ) parameters had a positive correlation with stature. In the female group, none of the facial parameters had a significant correlation with stature. Regarding the value of each facial diameter in discriminating male and female stature and gender, the highest discriminative value was specified to the FW (cutoff: 11.89, sensitivity: 89%, specificity: 11%) and IC (cutoff: 2.26, sensitivity: 98%, specificity: 0.04%) respectively. This study showed a significant association of some facial measurements with stature and gender in the southwest Iranian population. IC and FW had the most diagnostic value for gender and stature definition. It is shown a useful reference for the adult southwest Iranian population for facial recognition and that the subject’s sex should be considered during body identification procedures.

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