RADIATION, THE CELLULAR APPROACH

1960 ◽  
Vol 38 (1) ◽  
pp. 320-325
Author(s):  
Gordon M. Clark ◽  
Donald G. Baker
Keyword(s):  
Cell Division ◽  
Chemical Synthesis ◽  
Dose Rate ◽  
Current Trend ◽  
Biological Action ◽  
Cellular Level ◽  
Chromosome Breaks ◽  
Effect Of Oxygen ◽  
Almost All ◽  
Dose Rate Effect

The basic biological action of radiation must initially involve particular cells. The sensitivity of various cells differs but some of the differences may be due to a dose-rate effect. When cells are irradiated with doses in the lethal range, inhibition of cell division occurs. A notable feature of mitotic inhibition is that it depends not only on dose but on dose rate. Chromosome breaks produced in cells may be a visible manifestation of an interruption in chemical synthesis produced by the passage of ionizing particles. The effect of oxygen is apparently of primary importance in biological changes produced by irradiation. Almost all are decreased in its absence. The current trend in research on the cellular level is towards determining the more obscure injuries which cannot be seen under the microscope.

RADIATION, THE CELLULAR APPROACH

1960 ◽  
Vol 38 (3) ◽  
pp. 320-325
Author(s):  
Gordon M. Clark ◽  
Donald G. Baker
Keyword(s):  
Cell Division ◽  
Chemical Synthesis ◽  
Dose Rate ◽  
Current Trend ◽  
Biological Action ◽  
Cellular Level ◽  
Chromosome Breaks ◽  
Effect Of Oxygen ◽  
Almost All ◽  
Dose Rate Effect

The basic biological action of radiation must initially involve particular cells. The sensitivity of various cells differs but some of the differences may be due to a dose-rate effect. When cells are irradiated with doses in the lethal range, inhibition of cell division occurs. A notable feature of mitotic inhibition is that it depends not only on dose but on dose rate. Chromosome breaks produced in cells may be a visible manifestation of an interruption in chemical synthesis produced by the passage of ionizing particles. The effect of oxygen is apparently of primary importance in biological changes produced by irradiation. Almost all are decreased in its absence. The current trend in research on the cellular level is towards determining the more obscure injuries which cannot be seen under the microscope.

Phase-field simulation of dose rate effect on the Cu precipitation with neutron irradiation

2021 ◽  
Vol 23 (7) ◽  
pp. 4217-4229
Author(s):  
Shahid Maqbool ◽  
Yongsheng Li ◽  
Suleman Muhammad ◽  
Zhengwei Yan ◽  
Shujing Shi
Keyword(s):  
Dose Rate ◽  
Neutron Irradiation ◽  
Phase Field ◽  
Volume Fraction ◽  
Rate Effect ◽  
Phase Field Simulation ◽  
Field Simulation ◽  
Cu Alloys ◽  
Dose Rate Effect

Radiation-enhanced precipitation (REP) in Fe–Cu alloys results in higher volume fraction and radius of Cu precipitates.

scholarly journals Dose-rate effect of low-energy electron beam irradiation on bacterial content in chilled turkey

2021 ◽  
Vol 640 (3) ◽  
pp. 032006
Author(s):  
U A Bliznyuk ◽  
P Yu Borchegovskaya ◽  
A P Chernyaev ◽  
V S Ipatova ◽  
V A Leontiev ◽  
...  
Keyword(s):  
Electron Beam ◽  
Dose Rate ◽  
Electron Beam Irradiation ◽  
Rate Effect ◽  
Low Energy ◽  
Energy Electron ◽  
Beam Irradiation ◽  
Low Energy Electron ◽  
Bacterial Content ◽  
Dose Rate Effect

The conversion model of low dose rate effect in bipolar transistors

2009 ◽  
Author(s):  
V. S. Pershenkov ◽  
D. V. Savchenkov ◽  
A. S. Bakerenkov ◽  
V. N. Ulimov ◽  
A. Y. Nikiforov ◽  
...  
Keyword(s):  
Dose Rate ◽  
Low Dose ◽  
Bipolar Transistors ◽  
Rate Effect ◽  
Conversion Model ◽  
Low Dose Rate ◽  
Dose Rate Effect

scholarly journals Serum Metabolomic Alterations Associated with Cesium-137 Internal Emitter Delivered in Various Dose Rates

Metabolites ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 270
Author(s):  
Heng-Hong Li ◽  
Yun-Tien Lin ◽  
Evagelia C. Laiakis ◽  
Maryam Goudarzi ◽  
Waylon Weber ◽  
...  
Keyword(s):  
Dose Rate ◽  
Cumulative Dose ◽  
Low Dose ◽  
Biological Effects ◽  
Serum Samples ◽  
Dose Rates ◽  
Sphingosine 1 Phosphate ◽  
Cesium 137 ◽  
Dose Rate Effect ◽  
Medium Dose

Our laboratory and others have use radiation metabolomics to assess responses in order to develop biomarkers reflecting exposure and level of injury. To expand the types of exposure and compare to previously published results, metabolomic analysis has been carried out using serum samples from mice exposed to 137Cs internal emitters. Animals were injected intraperitoneally with 137CsCl solutions of varying radioactivity, and the absorbed doses were calculated. To determine the dose rate effect, serum samples were collected at 2, 3, 5, 7, and 14 days after injection. Based on the time for each group receiving the cumulative dose of 4 Gy, the dose rate for each group was determined. The dose rates analyzed were 0.16 Gy/day (low), 0.69 Gy/day (medium), and 1.25 Gy/day (high). The results indicated that at a cumulative dose of 4 Gy, the low dose rate group had the least number of statistically significantly differential spectral features. Some identified metabolites showed common changes for different dose rates. For example, significantly altered levels of oleamide and sphingosine 1-phosphate were seen in all three groups. On the other hand, the intensity of three amino acids, Isoleucine, Phenylalanine and Arginine, significantly decreased only in the medium dose rate group. These findings have the potential to be used in assessing the exposure and the biological effects of internal emitters.

scholarly journals Cell Cycle and LET Dependence for Radiation-induced Mutation. A Possible Mechanism for Reversed Dose-rate Effect.

1999 ◽  
Vol 40 (Suppl.) ◽  
pp. 45-52 ◽  
Author(s):  
HIROSHI TAUCHI ◽  
SATORU ENDO ◽  
KIYOMI EGUCHI-KASAI ◽  
YOSHIYA FURUSAWA ◽  
MASAO SUZUKI ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dose Rate ◽  
Rate Effect ◽  
Induced Mutation ◽  
Radiation Induced ◽  
Dose Rate Effect

“True” Dose Rate Effect of the ELDRS Conversion Model

2019 ◽  
pp. 61-65
Author(s):  
V. S. Pershenkov ◽  
A. S. Bakerenkov ◽  
V. A. Telets ◽  
V. V. Belyakov ◽  
V. A. Felitsyn ◽  
...  
Keyword(s):  
Dose Rate ◽  
Rate Effect ◽  
Conversion Model ◽  
Dose Rate Effect

Radiolysis of aqueous 2,2,2-tribromoethanol solutions

1970 ◽  
Vol 48 (16) ◽  
pp. 2542-2548 ◽  
Author(s):  
V. G. Sorensen ◽  
V. M. Bhale ◽  
K. J. McCallum ◽  
R. J. Woods
Keyword(s):  
Carbon Dioxide ◽  
Dose Rate ◽  
Glycolic Acid ◽  
Hydrogen Bromide ◽  
Photochemical Decomposition ◽  
Bromide Ion ◽  
Presence And Absence ◽  
Effect Of Oxygen

Hydrogen bromide, glycolic acid, and carbon dioxide have been identified as products of the γ-radiolysis of aqueous 2,2,2-tribromoethanol solutions. The effect of oxygen, tribromoethanol concentration, and dose rate upon the yields of bromide ion and acid have been determined, and partial radiolysis mechanisms are proposed for reaction in the presence and absence of oxygen. Dibromoacetaldehyde, reported to be a product of the photochemical decomposition of tribromoethanol solutions, was not detected in the radiolysis experiments or in tribromoethanol solutions exposed to sunlight.

High Dose Rate Effect of Focused-Ion-Beam Boron Implantation into Silicon

1984 ◽  
Vol 23 (Part 2, No. 6) ◽  
pp. L417-L420 ◽  
Author(s):  
Masao Tamura ◽  
Shoji Shukuri ◽  
Tohru Ishitani ◽  
Masakazu Ichikawa ◽  
Takahisa Doi
Keyword(s):  
Dose Rate ◽  
Focused Ion Beam ◽  
Ion Beam ◽  
High Dose Rate ◽  
Rate Effect ◽  
High Dose ◽  
Boron Implantation ◽  
Dose Rate Effect
Sign in / Sign up

Export Citation Format

Share Document